YML085C / TUB1

Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YML085C / TUB1

Click on Significant Values for Screen Details ID:SGTC_107|Compound:0358-0022|FD-Score:6.42|P-value:1.23E-8 ID:SGTC_115|Compound:0527-0192|FD-Score:3.69|P-value:6.15E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:7.49|P-value:4.26E-11 ID:SGTC_146|Compound:3448-8650|FD-Score:5.09|P-value:4.72E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:-4.11|P-value:2.69E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:12.40|P-value:5.68E-27 ID:SGTC_171|Compound:k064-0041|FD-Score:6.31|P-value:2.15E-8 ID:SGTC_227|Compound:fluconazole|FD-Score:9.02|P-value:3.05E-15 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.29|P-value:2.12E-6 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.57|P-value:8.93E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:-5.42|P-value:2.23E-6 ID:SGTC_270|Compound:tamoxifen|FD-Score:8.26|P-value:4.16E-13 ID:SGTC_288|Compound:1315-0019|FD-Score:-5.89|P-value:3.04E-7 ID:SGTC_301|Compound:4119-0100|FD-Score:4.75|P-value:1.77E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.86|P-value:3.69E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.91|P-value:4.95E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:-4.10|P-value:2.73E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.03|P-value:3.46E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:-6.75|P-value:4.95E-9 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.44|P-value:5.32E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.01|P-value:2.27E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.97|P-value:2.59E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.67|P-value:4.04E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.57|P-value:8.87E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-4.11|P-value:2.63E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:4.87|P-value:1.11E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:-4.54|P-value:6.34E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:5.98|P-value:1.00E-7 ID:SGTC_584|Compound:0986-0246|FD-Score:9.29|P-value:4.60E-16 ID:SGTC_684|Compound:1140-0066|FD-Score:3.71|P-value:5.89E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.77|P-value:2.08E-9 ID:SGTC_827|Compound:3253-0474|FD-Score:3.88|P-value:3.48E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:7.11|P-value:3.53E-10 ID:SGTC_882|Compound:0843-0131|FD-Score:3.55|P-value:9.23E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.84|P-value:6.12E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:4.85|P-value:1.19E-5 ID:SGTC_917|Compound:harmaline|FD-Score:-4.54|P-value:6.42E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:4.36|P-value:7.10E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:5.76|P-value:2.77E-7 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.62|P-value:7.53E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:-4.31|P-value:1.38E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.41|P-value:5.95E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:7.25|P-value:1.62E-10 ID:SGTC_1084|Compound:voriconazole|FD-Score:7.83|P-value:5.91E-12 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.19|P-value:1.28E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.74|P-value:5.28E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.68|P-value:6.35E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:6.18|P-value:4.00E-8 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.90|P-value:3.21E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:6.75|P-value:2.31E-9 ID:SGTC_1390|Compound:3413-2614|FD-Score:5.28|P-value:2.13E-6 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.77|P-value:4.84E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.75|P-value:5.24E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:4.75|P-value:1.76E-5 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.85|P-value:3.84E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.92|P-value:3.07E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.30|P-value:8.81E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:5.05|P-value:5.58E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:9.71|P-value:2.23E-17 ID:SGTC_1658|Compound:st012944|FD-Score:5.40|P-value:1.34E-6 ID:SGTC_1673|Compound:st016611|FD-Score:4.94|P-value:8.57E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:-6.27|P-value:5.28E-8 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.02|P-value:6.22E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:6.86|P-value:1.31E-9 ID:SGTC_1771|Compound:st048882|FD-Score:5.99|P-value:9.68E-8 ID:SGTC_1800|Compound:st050079|FD-Score:5.05|P-value:5.57E-6 ID:SGTC_1876|Compound:myriocin|FD-Score:7.20|P-value:2.15E-10 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.72|P-value:5.72E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:4.19|P-value:1.27E-4 ID:SGTC_1909|Compound:st060837|FD-Score:4.52|P-value:3.96E-5 ID:SGTC_1914|Compound:st062367|FD-Score:4.94|P-value:8.32E-6 ID:SGTC_1940|Compound:st075990|FD-Score:4.54|P-value:3.77E-5 ID:SGTC_2198|Compound:6589944|FD-Score:3.84|P-value:3.86E-4 ID:SGTC_2200|Compound:6600604|FD-Score:-4.89|P-value:1.76E-5 ID:SGTC_2352|Compound:9027995|FD-Score:4.17|P-value:1.35E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.87|P-value:3.54E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-3.81|P-value:6.72E-4 ID:SGTC_2397|Compound:5161689|FD-Score:4.65|P-value:2.56E-5 ID:SGTC_2401|Compound:5128683|FD-Score:5.69|P-value:3.70E-7 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.95|P-value:2.80E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-5.46|P-value:1.86E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:-7.85|P-value:1.21E-11 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.04|P-value:3.32E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.83|P-value:6.40E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:8.26|P-value:4.22E-13 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:7.59|P-value:2.34E-11 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.19|P-value:1.25E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.64|P-value:7.18E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.71|P-value:5.77E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.14|P-value:1.48E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.95|P-value:8.14E-6 ID:SGTC_2792|Compound:7535235|FD-Score:-10.40|P-value:5.39E-19 ID:SGTC_2799|Compound:7812892|FD-Score:-4.51|P-value:6.94E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.77|P-value:4.92E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.76|P-value:4.99E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.42|P-value:5.70E-5 ID:SGTC_2950|Compound:9072895|FD-Score:5.75|P-value:2.84E-7 ID:SGTC_2961|Compound:9083290|FD-Score:4.42|P-value:5.81E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-4.43|P-value:9.13E-5 ID:SGTC_2974|Compound:9094440|FD-Score:4.11|P-value:1.64E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.73|P-value:8.38E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-4.91|P-value:1.66E-5 ID:SGTC_3081|Compound:9117243|FD-Score:-4.23|P-value:1.81E-4 ID:SGTC_3142|Compound:9086498|FD-Score:13.20|P-value:3.50E-30 ID:SGTC_3219|Compound:9131112|FD-Score:-7.59|P-value:5.46E-11 ID:SGTC_3232|Compound:9132874|FD-Score:3.55|P-value:9.37E-4 ID:SGTC_3288|Compound:9119690|FD-Score:5.39|P-value:1.36E-6 ID:SGTC_3304|Compound:9125678|FD-Score:5.82|P-value:2.16E-7 ID:SGTC_107|Compound:0358-0022|FD-Score:6.42|P-value:1.23E-8 ID:SGTC_115|Compound:0527-0192|FD-Score:3.69|P-value:6.15E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:7.49|P-value:4.26E-11 ID:SGTC_146|Compound:3448-8650|FD-Score:5.09|P-value:4.72E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:-4.11|P-value:2.69E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:12.40|P-value:5.68E-27 ID:SGTC_171|Compound:k064-0041|FD-Score:6.31|P-value:2.15E-8 ID:SGTC_227|Compound:fluconazole|FD-Score:9.02|P-value:3.05E-15 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.29|P-value:2.12E-6 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.57|P-value:8.93E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:-5.42|P-value:2.23E-6 ID:SGTC_270|Compound:tamoxifen|FD-Score:8.26|P-value:4.16E-13 ID:SGTC_288|Compound:1315-0019|FD-Score:-5.89|P-value:3.04E-7 ID:SGTC_301|Compound:4119-0100|FD-Score:4.75|P-value:1.77E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.86|P-value:3.69E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.91|P-value:4.95E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:-4.10|P-value:2.73E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.03|P-value:3.46E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:-6.75|P-value:4.95E-9 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.44|P-value:5.32E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.01|P-value:2.27E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.97|P-value:2.59E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.67|P-value:4.04E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.57|P-value:8.87E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-4.11|P-value:2.63E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:4.87|P-value:1.11E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:-4.54|P-value:6.34E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:5.98|P-value:1.00E-7 ID:SGTC_584|Compound:0986-0246|FD-Score:9.29|P-value:4.60E-16 ID:SGTC_684|Compound:1140-0066|FD-Score:3.71|P-value:5.89E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.77|P-value:2.08E-9 ID:SGTC_827|Compound:3253-0474|FD-Score:3.88|P-value:3.48E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:7.11|P-value:3.53E-10 ID:SGTC_882|Compound:0843-0131|FD-Score:3.55|P-value:9.23E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.84|P-value:6.12E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:4.85|P-value:1.19E-5 ID:SGTC_917|Compound:harmaline|FD-Score:-4.54|P-value:6.42E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:4.36|P-value:7.10E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:5.76|P-value:2.77E-7 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.62|P-value:7.53E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:-4.31|P-value:1.38E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.41|P-value:5.95E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:7.25|P-value:1.62E-10 ID:SGTC_1084|Compound:voriconazole|FD-Score:7.83|P-value:5.91E-12 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.19|P-value:1.28E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.74|P-value:5.28E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.68|P-value:6.35E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:6.18|P-value:4.00E-8 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.90|P-value:3.21E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:6.75|P-value:2.31E-9 ID:SGTC_1390|Compound:3413-2614|FD-Score:5.28|P-value:2.13E-6 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.77|P-value:4.84E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.75|P-value:5.24E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:4.75|P-value:1.76E-5 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.85|P-value:3.84E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.92|P-value:3.07E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.30|P-value:8.81E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:5.05|P-value:5.58E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:9.71|P-value:2.23E-17 ID:SGTC_1658|Compound:st012944|FD-Score:5.40|P-value:1.34E-6 ID:SGTC_1673|Compound:st016611|FD-Score:4.94|P-value:8.57E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:-6.27|P-value:5.28E-8 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.02|P-value:6.22E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:6.86|P-value:1.31E-9 ID:SGTC_1771|Compound:st048882|FD-Score:5.99|P-value:9.68E-8 ID:SGTC_1800|Compound:st050079|FD-Score:5.05|P-value:5.57E-6 ID:SGTC_1876|Compound:myriocin|FD-Score:7.20|P-value:2.15E-10 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.72|P-value:5.72E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:4.19|P-value:1.27E-4 ID:SGTC_1909|Compound:st060837|FD-Score:4.52|P-value:3.96E-5 ID:SGTC_1914|Compound:st062367|FD-Score:4.94|P-value:8.32E-6 ID:SGTC_1940|Compound:st075990|FD-Score:4.54|P-value:3.77E-5 ID:SGTC_2198|Compound:6589944|FD-Score:3.84|P-value:3.86E-4 ID:SGTC_2200|Compound:6600604|FD-Score:-4.89|P-value:1.76E-5 ID:SGTC_2352|Compound:9027995|FD-Score:4.17|P-value:1.35E-4 ID:SGTC_2362|Compound:9071156|FD-Score:3.87|P-value:3.54E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-3.81|P-value:6.72E-4 ID:SGTC_2397|Compound:5161689|FD-Score:4.65|P-value:2.56E-5 ID:SGTC_2401|Compound:5128683|FD-Score:5.69|P-value:3.70E-7 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.95|P-value:2.80E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-5.46|P-value:1.86E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:-7.85|P-value:1.21E-11 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.04|P-value:3.32E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.83|P-value:6.40E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:8.26|P-value:4.22E-13 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:7.59|P-value:2.34E-11 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.19|P-value:1.25E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.64|P-value:7.18E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.71|P-value:5.77E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.14|P-value:1.48E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.95|P-value:8.14E-6 ID:SGTC_2792|Compound:7535235|FD-Score:-10.40|P-value:5.39E-19 ID:SGTC_2799|Compound:7812892|FD-Score:-4.51|P-value:6.94E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.77|P-value:4.92E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.76|P-value:4.99E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.42|P-value:5.70E-5 ID:SGTC_2950|Compound:9072895|FD-Score:5.75|P-value:2.84E-7 ID:SGTC_2961|Compound:9083290|FD-Score:4.42|P-value:5.81E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-4.43|P-value:9.13E-5 ID:SGTC_2974|Compound:9094440|FD-Score:4.11|P-value:1.64E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.73|P-value:8.38E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-4.91|P-value:1.66E-5 ID:SGTC_3081|Compound:9117243|FD-Score:-4.23|P-value:1.81E-4 ID:SGTC_3142|Compound:9086498|FD-Score:13.20|P-value:3.50E-30 ID:SGTC_3219|Compound:9131112|FD-Score:-7.59|P-value:5.46E-11 ID:SGTC_3232|Compound:9132874|FD-Score:3.55|P-value:9.37E-4 ID:SGTC_3288|Compound:9119690|FD-Score:5.39|P-value:1.36E-6 ID:SGTC_3304|Compound:9125678|FD-Score:5.82|P-value:2.16E-7

Top fitness defect scores for YML085C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3142 9086498 13.20 49.5 µM 3.50E-30 iron homeostasis 4 7.77E-40 0.47
2 SGTC_163 1327-0036 12.40 7.5 µM 5.68E-27 7 1.64E-35 0.17
3 SGTC_1597 7-benzyloxygramine 9.71 47.5 µM 2.23E-17 calcium & mitochondrial duress 17 1.32E-22 0.13
4 SGTC_584 0986-0246 9.29 15.4 µM 4.60E-16 heme requiring 2 7.66E-21 1.25
5 SGTC_227 fluconazole 9.02 33.5 µM 3.05E-15 azole & statin 14 9.68E-20 0.09
6 SGTC_270 tamoxifen 8.26 5.5 µM 4.16E-13 NEO1 2 7.04E-17 1.81
7 SGTC_2651 1327-0036 8.26 5.0 µM 4.22E-13 19 7.18E-17 0.03
8 SGTC_1084 voriconazole 7.83 435.0 nM 5.91E-12 azole & statin 2 2.46E-15 0.15
9 SGTC_2658 polymyxin b sulfate 7.59 77.0 µM 2.34E-11 NEO1 5 1.55E-14 1.53
10 SGTC_117 lucigenin 7.49 22.1 µM 4.26E-11 redox potentiating 3 3.46E-14 1.32
11 SGTC_1067 clotrimazole 7.25 1.4 µM 1.62E-10 azole & statin 6 2.06E-13 0.95
12 SGTC_1876 myriocin 7.20 605.0 nM 2.15E-10 3 3.00E-13 1.42
13 SGTC_832 4083-0019 7.11 164.0 µM 3.53E-10 translation 4 5.83E-13 0.09
14 SGTC_1681 tripelennamine 6.86 100.0 µM 1.31E-9 2 3.34E-12 1.06
15 SGTC_800 3448-7362 6.77 155.0 µM 2.08E-9 translation 17 6.22E-12 0.08
16 SGTC_1310 1188-0297 6.75 994.0 nM 2.31E-9 azole & statin 5 7.17E-12 0.47
17 SGTC_107 0358-0022 6.42 2.7 µM 1.23E-8 SWF1 & branched chain AA biosynthesis 3 6.69E-11 1.62
18 SGTC_171 k064-0041 6.31 9.7 µM 2.15E-8 heme requiring 7 1.40E-10 0.44
19 SGTC_1258 0671-0043 6.18 57.1 µM 4.00E-8 1 3.21E-10 0.99
20 SGTC_1771 st048882 5.99 4.2 µM 9.68E-8 RPP1 & pyrimidine depletion 4 1.04E-9 1.47

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.293 2.90E-67 YFL039C ACT1 het Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
0.168 9.51E-23 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.163 1.68E-21 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.160 1.08E-20 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.151 1.23E-18 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.149 4.61E-18 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.147 8.99E-18 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.144 5.86E-17 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.141 1.84E-16 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.141 2.00E-16 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.138 1.13E-15 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.138 1.33E-15 YFR050C PRE4 het Beta 7 subunit of the 20S proteasome
0.135 3.98E-15 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.134 5.98E-15 YDL119C_p YDL119C_p hom Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
0.134 7.28E-15 YPL237W SUI3 het Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding