YML086C / ALO1

D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YML086C / ALO1

Click on Significant Values for Screen Details ID:SGTC_32|Compound:0928-0142|FD-Score:3.16|P-value:2.20E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.79|P-value:1.21E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-2.84|P-value:7.85E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-4.09|P-value:2.62E-6 ID:SGTC_324|Compound:1315-0088|FD-Score:3.21|P-value:1.75E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.20|P-value:1.82E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:2.96|P-value:4.97E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.07|P-value:3.20E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.34|P-value:9.89E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.18|P-value:1.97E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:2.86|P-value:7.24E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.09|P-value:2.91E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.69|P-value:2.01E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.54|P-value:4.08E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.20|P-value:1.83E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.50|P-value:4.91E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.09|P-value:2.86E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.05|P-value:3.31E-6 ID:SGTC_1520|Compound:flindersine|FD-Score:3.35|P-value:9.71E-5 ID:SGTC_1626|Compound:st003712|FD-Score:2.86|P-value:7.18E-4 ID:SGTC_1630|Compound:st005209|FD-Score:5.49|P-value:5.00E-10 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-2.90|P-value:6.31E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-4.79|P-value:4.95E-8 ID:SGTC_1637|Compound:st007924|FD-Score:-3.47|P-value:5.54E-5 ID:SGTC_1705|Compound:st027868|FD-Score:-2.79|P-value:9.43E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-5.49|P-value:4.90E-10 ID:SGTC_1794|Compound:st048918|FD-Score:2.86|P-value:7.17E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.01|P-value:4.04E-4 ID:SGTC_1975|Compound:st070967|FD-Score:2.98|P-value:4.53E-4 ID:SGTC_2037|Compound:5169046|FD-Score:2.80|P-value:9.01E-4 ID:SGTC_2271|Compound:7849410|FD-Score:2.97|P-value:4.78E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.90|P-value:6.26E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:2.94|P-value:5.38E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.00|P-value:4.26E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.02|P-value:3.87E-4 ID:SGTC_2930|Compound:9013230|FD-Score:5.39|P-value:1.01E-9 ID:SGTC_2936|Compound:9038235|FD-Score:-3.10|P-value:2.83E-4 ID:SGTC_2938|Compound:9059746|FD-Score:5.04|P-value:9.92E-9 ID:SGTC_2947|Compound:9072639|FD-Score:3.48|P-value:5.24E-5 ID:SGTC_3075|Compound:9116269|FD-Score:-3.51|P-value:4.75E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-3.75|P-value:1.53E-5 ID:SGTC_3318|Compound:9139014|FD-Score:-2.94|P-value:5.30E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:3.16|P-value:2.20E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.79|P-value:1.21E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-2.84|P-value:7.85E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-4.09|P-value:2.62E-6 ID:SGTC_324|Compound:1315-0088|FD-Score:3.21|P-value:1.75E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.20|P-value:1.82E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:2.96|P-value:4.97E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.07|P-value:3.20E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.34|P-value:9.89E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.18|P-value:1.97E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:2.86|P-value:7.24E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.09|P-value:2.91E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.69|P-value:2.01E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.54|P-value:4.08E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.20|P-value:1.83E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.50|P-value:4.91E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.09|P-value:2.86E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.05|P-value:3.31E-6 ID:SGTC_1520|Compound:flindersine|FD-Score:3.35|P-value:9.71E-5 ID:SGTC_1626|Compound:st003712|FD-Score:2.86|P-value:7.18E-4 ID:SGTC_1630|Compound:st005209|FD-Score:5.49|P-value:5.00E-10 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-2.90|P-value:6.31E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-4.79|P-value:4.95E-8 ID:SGTC_1637|Compound:st007924|FD-Score:-3.47|P-value:5.54E-5 ID:SGTC_1705|Compound:st027868|FD-Score:-2.79|P-value:9.43E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-5.49|P-value:4.90E-10 ID:SGTC_1794|Compound:st048918|FD-Score:2.86|P-value:7.17E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.01|P-value:4.04E-4 ID:SGTC_1975|Compound:st070967|FD-Score:2.98|P-value:4.53E-4 ID:SGTC_2037|Compound:5169046|FD-Score:2.80|P-value:9.01E-4 ID:SGTC_2271|Compound:7849410|FD-Score:2.97|P-value:4.78E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.90|P-value:6.26E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:2.94|P-value:5.38E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.00|P-value:4.26E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.02|P-value:3.87E-4 ID:SGTC_2930|Compound:9013230|FD-Score:5.39|P-value:1.01E-9 ID:SGTC_2936|Compound:9038235|FD-Score:-3.10|P-value:2.83E-4 ID:SGTC_2938|Compound:9059746|FD-Score:5.04|P-value:9.92E-9 ID:SGTC_2947|Compound:9072639|FD-Score:3.48|P-value:5.24E-5 ID:SGTC_3075|Compound:9116269|FD-Score:-3.51|P-value:4.75E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-3.75|P-value:1.53E-5 ID:SGTC_3318|Compound:9139014|FD-Score:-2.94|P-value:5.30E-4

Top fitness defect scores for YML086C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1630 st005209 5.49 31.3 µM 5.00E-10 6 2.02E-8
2 SGTC_2930 9013230 5.39 14.9 µM 1.01E-9 heme biosynthesis & mitochondrial translocase 12 3.57E-8
3 SGTC_2938 9059746 5.04 27.3 µM 9.92E-9 fatty acid desaturase (OLE1) 20 2.29E-7
4 SGTC_1229 0139-0193 3.69 12.2 µM 2.01E-5 RSC complex & mRNA processing 16 1.13E-4
5 SGTC_1347 1493-0251 3.54 600.0 nM 4.08E-5 mitochondrial response to ROS 25 2.01E-4
6 SGTC_1453 4237-0541 3.50 195.0 µM 4.91E-5 heme biosynthesis & mitochondrial translocase 39 2.33E-4
7 SGTC_2947 9072639 3.48 7.7 µM 5.24E-5 tubulin folding & SWR complex 61 2.46E-4
8 SGTC_1520 flindersine 3.35 88.0 µM 9.71E-5 50 4.07E-4
9 SGTC_994 3910-0338 3.34 138.0 µM 9.89E-5 calcium & mitochondrial duress 77 4.13E-4
10 SGTC_324 1315-0088 3.21 19.6 µM 1.75E-4 RSC & ERG11 24 6.58E-4
11 SGTC_703 3875-0075 3.20 71.8 µM 1.82E-4 21 6.80E-4
12 SGTC_1452 4194-0072 3.20 190.0 µM 1.83E-4 40 6.83E-4
13 SGTC_1044 1222-0021 3.18 1.8 µM 1.97E-4 heme biosynthesis & mitochondrial translocase 69 7.25E-4
14 SGTC_32 0928-0142 3.16 34.1 µM 2.20E-4 TSC3-RPN4 25 7.94E-4
15 SGTC_1456 k015-0012 3.09 13.0 µM 2.86E-4 71 9.86E-4
16 SGTC_1225 1216-0074 3.09 20.6 µM 2.91E-4 64 9.99E-4
17 SGTC_852 0418-0143 3.07 439.0 µM 3.20E-4 calcium & mitochondrial duress 127 0.00108
18 SGTC_1946 st076057 3.01 65.1 µM 4.04E-4 24 0.00131
19 SGTC_1975 st070967 2.98 30.8 µM 4.53E-4 85 0.00144
20 SGTC_2271 7849410 2.97 118.6 µM 4.78E-4 42 0.00150

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.246 1.36E-47 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.149 3.75E-18 YJR108W ABM1 hom Protein of unknown function, required for normal microtubule organization
0.147 1.36E-17 YKR032W_d YKR032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.141 3.31E-16 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.140 3.30E-16 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.131 2.09E-14 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.128 9.66E-14 YFR017C IGD1 hom Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication
0.128 9.46E-14 YFR015C GSY1 hom Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.126 2.38E-13 YLR267W_p BOP2_p hom Protein of unknown function
0.118 5.70E-12 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.118 8.16E-12 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.115 2.62E-11 YDR502C SAM2 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication
0.115 2.67E-11 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.108 3.52E-10 YJL031C BET4 het Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.107 6.41E-10 YLR053C_p YLR053C_p hom Putative protein of unknown function