YML088W / UFO1

F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation

Zygosity: Homozygous strain
fixedexpanded
Profile for YML088W / UFO1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:5.22|P-value:1.36E-8 ID:SGTC_74|Compound:000s-0487|FD-Score:3.01|P-value:6.72E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.16|P-value:3.86E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.48|P-value:1.07E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:-2.97|P-value:7.16E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.96|P-value:1.21E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:2.91|P-value:9.67E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.38|P-value:1.58E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.37|P-value:1.50E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.63|P-value:5.49E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:3.39|P-value:1.51E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:4.60|P-value:4.68E-7 ID:SGTC_1196|Compound:1588-0294|FD-Score:4.75|P-value:2.08E-7 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.33|P-value:1.96E-4 ID:SGTC_1630|Compound:st005209|FD-Score:5.85|P-value:2.20E-10 ID:SGTC_1673|Compound:st016611|FD-Score:6.79|P-value:2.24E-13 ID:SGTC_1784|Compound:st039334|FD-Score:3.34|P-value:1.89E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.26|P-value:2.61E-4 ID:SGTC_1846|Compound:st056244|FD-Score:2.96|P-value:8.12E-4 ID:SGTC_1866|Compound:st057638|FD-Score:2.95|P-value:8.48E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.89|P-value:1.75E-5 ID:SGTC_1946|Compound:st076057|FD-Score:3.11|P-value:4.69E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.17|P-value:3.67E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.30|P-value:2.30E-6 ID:SGTC_2143|Compound:5623677|FD-Score:2.94|P-value:8.77E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.16|P-value:3.52E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-4.12|P-value:5.07E-6 ID:SGTC_2308|Compound:7584454|FD-Score:3.28|P-value:2.38E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.24|P-value:3.12E-6 ID:SGTC_2324|Compound:6149169|FD-Score:4.90|P-value:8.93E-8 ID:SGTC_2439|Compound:5492030|FD-Score:2.94|P-value:8.75E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.88|P-value:1.82E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.15|P-value:3.95E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.22|P-value:2.79E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.70|P-value:2.73E-7 ID:SGTC_2928|Compound:9011484|FD-Score:4.78|P-value:1.73E-7 ID:SGTC_2929|Compound:9013348|FD-Score:-4.75|P-value:1.79E-7 ID:SGTC_2931|Compound:9014674|FD-Score:-4.55|P-value:5.49E-7 ID:SGTC_2994|Compound:9053520|FD-Score:2.94|P-value:8.69E-4 ID:SGTC_3029|Compound:9088683|FD-Score:6.43|P-value:3.46E-12 ID:SGTC_3045|Compound:9092950|FD-Score:3.30|P-value:2.22E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.66|P-value:4.84E-5 ID:SGTC_3117|Compound:9124945|FD-Score:3.01|P-value:6.85E-4 ID:SGTC_3127|Compound:9126946|FD-Score:5.96|P-value:1.05E-10 ID:SGTC_3139|Compound:9095020|FD-Score:3.02|P-value:6.60E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.10|P-value:6.26E-6 ID:SGTC_65|Compound:0798-0905|FD-Score:5.22|P-value:1.36E-8 ID:SGTC_74|Compound:000s-0487|FD-Score:3.01|P-value:6.72E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.16|P-value:3.86E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.48|P-value:1.07E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:-2.97|P-value:7.16E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.96|P-value:1.21E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:2.91|P-value:9.67E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.38|P-value:1.58E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.37|P-value:1.50E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.63|P-value:5.49E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:3.39|P-value:1.51E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:4.60|P-value:4.68E-7 ID:SGTC_1196|Compound:1588-0294|FD-Score:4.75|P-value:2.08E-7 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.33|P-value:1.96E-4 ID:SGTC_1630|Compound:st005209|FD-Score:5.85|P-value:2.20E-10 ID:SGTC_1673|Compound:st016611|FD-Score:6.79|P-value:2.24E-13 ID:SGTC_1784|Compound:st039334|FD-Score:3.34|P-value:1.89E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.26|P-value:2.61E-4 ID:SGTC_1846|Compound:st056244|FD-Score:2.96|P-value:8.12E-4 ID:SGTC_1866|Compound:st057638|FD-Score:2.95|P-value:8.48E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.89|P-value:1.75E-5 ID:SGTC_1946|Compound:st076057|FD-Score:3.11|P-value:4.69E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.17|P-value:3.67E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.30|P-value:2.30E-6 ID:SGTC_2143|Compound:5623677|FD-Score:2.94|P-value:8.77E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.16|P-value:3.52E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-4.12|P-value:5.07E-6 ID:SGTC_2308|Compound:7584454|FD-Score:3.28|P-value:2.38E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.24|P-value:3.12E-6 ID:SGTC_2324|Compound:6149169|FD-Score:4.90|P-value:8.93E-8 ID:SGTC_2439|Compound:5492030|FD-Score:2.94|P-value:8.75E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.88|P-value:1.82E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.15|P-value:3.95E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.22|P-value:2.79E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.70|P-value:2.73E-7 ID:SGTC_2928|Compound:9011484|FD-Score:4.78|P-value:1.73E-7 ID:SGTC_2929|Compound:9013348|FD-Score:-4.75|P-value:1.79E-7 ID:SGTC_2931|Compound:9014674|FD-Score:-4.55|P-value:5.49E-7 ID:SGTC_2994|Compound:9053520|FD-Score:2.94|P-value:8.69E-4 ID:SGTC_3029|Compound:9088683|FD-Score:6.43|P-value:3.46E-12 ID:SGTC_3045|Compound:9092950|FD-Score:3.30|P-value:2.22E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.66|P-value:4.84E-5 ID:SGTC_3117|Compound:9124945|FD-Score:3.01|P-value:6.85E-4 ID:SGTC_3127|Compound:9126946|FD-Score:5.96|P-value:1.05E-10 ID:SGTC_3139|Compound:9095020|FD-Score:3.02|P-value:6.60E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.10|P-value:6.26E-6

Top fitness defect scores for YML088W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1673 st016611 6.79 27.3 µM 2.24E-13 12 5.58E-12
2 SGTC_3029 9088683 6.43 49.5 µM 3.46E-12 3 6.22E-11
3 SGTC_3127 9126946 5.96 49.5 µM 1.05E-10 ERG2 3 1.26E-9
4 SGTC_1630 st005209 5.85 31.3 µM 2.20E-10 4 2.41E-9
5 SGTC_65 0798-0905 5.22 35.0 µM 1.36E-8 calcium & mitochondrial duress 48 9.16E-8
6 SGTC_2324 6149169 4.90 200.0 µM 8.93E-8 9 4.81E-7
7 SGTC_2928 9011484 4.78 9.8 µM 1.73E-7 heme biosynthesis & mitochondrial translocase 20 8.63E-7
8 SGTC_1196 1588-0294 4.75 184.0 µM 2.08E-7 5 1.01E-6
9 SGTC_2924 9010168 4.70 62.8 µM 2.73E-7 cell wall signaling 23 1.29E-6
10 SGTC_1073 triclabendazole 4.60 3.1 µM 4.68E-7 17 2.07E-6
11 SGTC_2086 5274770 4.30 176.6 µM 2.30E-6 16 8.46E-6
12 SGTC_2318 6029776 4.24 164.0 µM 3.12E-6 19 1.11E-5
13 SGTC_3142 9086498 4.10 49.5 µM 6.26E-6 iron homeostasis 35 2.05E-5
14 SGTC_183 3914-0051 3.96 30.6 µM 1.21E-5 60S ribosome export 23 3.68E-5
15 SGTC_1911 st060208 3.89 74.3 µM 1.75E-5 37 5.08E-5
16 SGTC_2583 asiatic acid 3.88 100.0 µM 1.82E-5 38 5.26E-5
17 SGTC_3052 9092717 3.66 49.5 µM 4.84E-5 39 1.25E-4
18 SGTC_919 tnp00227 3.63 403.6 nM 5.49E-5 RNA pol III & RNase P/MRP 48 1.40E-4
19 SGTC_130 0136-0219 3.48 337.7 µM 1.07E-4 38 2.52E-4
20 SGTC_965 1291-5240 3.39 308.0 µM 1.51E-4 48 3.43E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.48E-14 YNL086W_p SNN1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes
0.118 6.65E-12 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.116 1.39E-11 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.106 8.69E-10 YLL023C POM33 hom Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress
0.103 2.46E-9 YKR043C SHB17 hom Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus
0.102 2.85E-9 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.100 5.86E-9 YMR326C_d YMR326C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13
0.100 7.22E-9 YBL094C_d YBL094C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W
0.099 9.53E-9 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.096 2.80E-8 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.095 3.26E-8 YHL010C ETP1 hom Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.094 4.51E-8 YOR303W CPA1 hom Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader
0.093 6.18E-8 YBR217W ATG12 hom Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
0.092 9.51E-8 YGR185C TYS1 het Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
0.092 9.74E-8 YAL051W OAF1 hom Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication