YML090W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source

Zygosity: Homozygous strain
fixedexpanded
Profile for YML090W / YML090W

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.61|P-value:1.20E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.63|P-value:1.05E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.32|P-value:3.66E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.35|P-value:4.64E-11 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.08|P-value:8.57E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.61|P-value:1.14E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.27|P-value:4.24E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:4.87|P-value:3.31E-7 ID:SGTC_650|Compound:1328-0195|FD-Score:4.01|P-value:2.09E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:-4.39|P-value:3.98E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:3.76|P-value:6.26E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:4.83|P-value:4.14E-7 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.12|P-value:7.56E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.44|P-value:2.21E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.59|P-value:1.24E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-3.68|P-value:9.19E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.66|P-value:9.51E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.59|P-value:1.32E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.23|P-value:4.92E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.78|P-value:6.12E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.11|P-value:7.71E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.18|P-value:6.10E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.97|P-value:2.50E-5 ID:SGTC_2071|Compound:5230951|FD-Score:-7.27|P-value:6.65E-14 ID:SGTC_2075|Compound:5212009|FD-Score:3.73|P-value:7.10E-5 ID:SGTC_2092|Compound:5303694|FD-Score:-3.14|P-value:7.10E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.35|P-value:3.14E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.94|P-value:2.88E-5 ID:SGTC_2371|Compound:9071574|FD-Score:3.10|P-value:7.76E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.53|P-value:1.62E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.04|P-value:9.46E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.04|P-value:9.95E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.88|P-value:3.71E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.06|P-value:8.80E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.23|P-value:4.91E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.94|P-value:2.84E-5 ID:SGTC_2819|Compound:7996655|FD-Score:-3.78|P-value:6.06E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.38|P-value:2.79E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.51|P-value:1.70E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-3.13|P-value:7.25E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.36|P-value:3.15E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.74|P-value:7.12E-5 ID:SGTC_3095|Compound:9117207|FD-Score:-3.87|P-value:4.10E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.04|P-value:9.42E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.61|P-value:1.20E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.63|P-value:1.05E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.32|P-value:3.66E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.35|P-value:4.64E-11 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.08|P-value:8.57E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.61|P-value:1.14E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.27|P-value:4.24E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:4.87|P-value:3.31E-7 ID:SGTC_650|Compound:1328-0195|FD-Score:4.01|P-value:2.09E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:-4.39|P-value:3.98E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:3.76|P-value:6.26E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:4.83|P-value:4.14E-7 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.12|P-value:7.56E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.44|P-value:2.21E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.59|P-value:1.24E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-3.68|P-value:9.19E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.66|P-value:9.51E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.59|P-value:1.32E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.23|P-value:4.92E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.78|P-value:6.12E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.11|P-value:7.71E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.18|P-value:6.10E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.97|P-value:2.50E-5 ID:SGTC_2071|Compound:5230951|FD-Score:-7.27|P-value:6.65E-14 ID:SGTC_2075|Compound:5212009|FD-Score:3.73|P-value:7.10E-5 ID:SGTC_2092|Compound:5303694|FD-Score:-3.14|P-value:7.10E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.35|P-value:3.14E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.94|P-value:2.88E-5 ID:SGTC_2371|Compound:9071574|FD-Score:3.10|P-value:7.76E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.53|P-value:1.62E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.04|P-value:9.46E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.04|P-value:9.95E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.88|P-value:3.71E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.06|P-value:8.80E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.23|P-value:4.91E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.94|P-value:2.84E-5 ID:SGTC_2819|Compound:7996655|FD-Score:-3.78|P-value:6.06E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.38|P-value:2.79E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.51|P-value:1.70E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-3.13|P-value:7.25E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.36|P-value:3.15E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.74|P-value:7.12E-5 ID:SGTC_3095|Compound:9117207|FD-Score:-3.87|P-value:4.10E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.04|P-value:9.42E-4

Top fitness defect scores for YML090W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 6.35 5.3 µM 4.64E-11 284 1.06E-10
2 SGTC_536 3852-0578 4.87 10.6 µM 3.31E-7 11 5.47E-7
3 SGTC_882 0843-0131 4.83 351.0 µM 4.14E-7 6 6.80E-7
4 SGTC_650 1328-0195 4.01 38.0 µM 2.09E-5 17 2.97E-5
5 SGTC_1999 st074831 3.97 12.5 µM 2.50E-5 plasma membrane duress 31 3.53E-5
6 SGTC_2721 ifenprodil 3.94 61.4 µM 2.84E-5 plasma membrane duress 16 4.00E-5
7 SGTC_2353 9059630 3.94 146.7 µM 2.88E-5 19 4.04E-5
8 SGTC_2571 chrysanthemic acid 3.88 100.0 µM 3.71E-5 20 5.16E-5
9 SGTC_841 0251-0215 3.76 91.2 µM 6.26E-5 78 8.55E-5
10 SGTC_2075 5212009 3.73 200.0 µM 7.10E-5 12 9.65E-5
11 SGTC_1293 1000-1278 3.66 195.0 µM 9.51E-5 17 1.28E-4
12 SGTC_67 0335-0847 3.63 266.0 µM 1.05E-4 ubiquinone biosynthesis & proteasome 138 1.41E-4
13 SGTC_310 1273-0058 3.61 1.1 µM 1.14E-4 mitochondrial stress 274 1.52E-4
14 SGTC_1225 1216-0074 3.59 20.6 µM 1.24E-4 36 1.65E-4
15 SGTC_2999 9069765 3.51 71.4 µM 1.70E-4 amide catabolism 48 2.24E-4
16 SGTC_1216 1165-0504 3.44 9.7 µM 2.21E-4 25 2.88E-4
17 SGTC_2989 9073649 3.38 71.4 µM 2.79E-4 66 3.61E-4
18 SGTC_2102 5377816 3.35 72.8 µM 3.14E-4 40 4.04E-4
19 SGTC_423 5-fluorouracil 3.27 457.0 µM 4.24E-4 exosome 51 5.40E-4
20 SGTC_2665 lovastatin 3.23 100.0 µM 4.91E-4 36 6.23E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.227 2.75E-40 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.218 1.96E-37 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.213 1.02E-35 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.205 4.00E-33 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.203 1.77E-32 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.202 2.97E-32 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.197 1.49E-30 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.192 4.03E-29 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.191 7.74E-29 YGR112W SHY1 hom Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
0.190 1.81E-28 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.189 2.76E-28 YHL038C CBP2 hom Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
0.187 9.76E-28 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.186 1.61E-27 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.185 2.50E-27 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.185 4.20E-27 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p