YML091C / RPM2

Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus

Zygosity: Heterozygous strain
fixedexpanded
Profile for YML091C / RPM2

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.97|P-value:1.79E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:7.57|P-value:4.51E-12 ID:SGTC_124|Compound:0136-0217|FD-Score:6.05|P-value:2.53E-8 ID:SGTC_131|Compound:0141-0277|FD-Score:3.64|P-value:5.37E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.25|P-value:6.68E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:4.52|P-value:2.43E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.58|P-value:6.59E-4 ID:SGTC_444|Compound:curcumin|FD-Score:6.10|P-value:1.95E-8 ID:SGTC_623|Compound:k072-0108|FD-Score:4.97|P-value:3.87E-6 ID:SGTC_632|Compound:0781-2353|FD-Score:6.14|P-value:1.58E-8 ID:SGTC_745|Compound:0469-0705|FD-Score:3.90|P-value:2.29E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.65|P-value:1.47E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:3.91|P-value:2.23E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:4.96|P-value:4.05E-6 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.40|P-value:9.36E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.92|P-value:4.88E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.77|P-value:2.86E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.73|P-value:4.12E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:4.44|P-value:3.26E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:3.88|P-value:2.51E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.62|P-value:5.76E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.96|P-value:4.14E-6 ID:SGTC_2309|Compound:7664088|FD-Score:-3.68|P-value:3.84E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.60|P-value:6.25E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.75|P-value:9.77E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:6.29|P-value:7.22E-9 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.73|P-value:8.28E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:-4.37|P-value:3.42E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-3.71|P-value:3.51E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.78|P-value:2.81E-4 ID:SGTC_2799|Compound:7812892|FD-Score:4.42|P-value:3.50E-5 ID:SGTC_3217|Compound:9129673|FD-Score:3.73|P-value:4.01E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:3.97|P-value:1.79E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:7.57|P-value:4.51E-12 ID:SGTC_124|Compound:0136-0217|FD-Score:6.05|P-value:2.53E-8 ID:SGTC_131|Compound:0141-0277|FD-Score:3.64|P-value:5.37E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.25|P-value:6.68E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:4.52|P-value:2.43E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.58|P-value:6.59E-4 ID:SGTC_444|Compound:curcumin|FD-Score:6.10|P-value:1.95E-8 ID:SGTC_623|Compound:k072-0108|FD-Score:4.97|P-value:3.87E-6 ID:SGTC_632|Compound:0781-2353|FD-Score:6.14|P-value:1.58E-8 ID:SGTC_745|Compound:0469-0705|FD-Score:3.90|P-value:2.29E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.65|P-value:1.47E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:3.91|P-value:2.23E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:4.96|P-value:4.05E-6 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.40|P-value:9.36E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.92|P-value:4.88E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.77|P-value:2.86E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.73|P-value:4.12E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:4.44|P-value:3.26E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:3.88|P-value:2.51E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.62|P-value:5.76E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.96|P-value:4.14E-6 ID:SGTC_2309|Compound:7664088|FD-Score:-3.68|P-value:3.84E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.60|P-value:6.25E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.75|P-value:9.77E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:6.29|P-value:7.22E-9 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.73|P-value:8.28E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:-4.37|P-value:3.42E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-3.71|P-value:3.51E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.78|P-value:2.81E-4 ID:SGTC_2799|Compound:7812892|FD-Score:4.42|P-value:3.50E-5 ID:SGTC_3217|Compound:9129673|FD-Score:3.73|P-value:4.01E-4

Top fitness defect scores for YML091C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_63 0099-0242 7.57 26.7 µM 4.51E-12 mitochondrial stress 8 1.91E-14 0.14
2 SGTC_2607 solasodine 6.29 47.4 µM 7.22E-9 3 1.56E-10 0.68
3 SGTC_632 0781-2353 6.14 4.7 µM 1.58E-8 Golgi 5 4.06E-10 0.92
4 SGTC_444 curcumin 6.10 90.4 µM 1.95E-8 iron homeostasis 1 5.24E-10 0.49
5 SGTC_124 0136-0217 6.05 7.1 µM 2.53E-8 mitochondrial stress 7 7.19E-10 0.12
6 SGTC_623 k072-0108 4.97 16.9 µM 3.87E-6 heme biosynthesis & mitochondrial translocase 11 3.31E-7 0.10
7 SGTC_966 1300-0360 4.96 30.2 µM 4.05E-6 heme requiring 7 3.51E-7 0.01
8 SGTC_1952 st077036 4.96 64.1 µM 4.14E-6 7 3.60E-7 0.03
9 SGTC_1113 artemisinin 4.92 1.2 µM 4.88E-6 heme biosynthesis & mitochondrial translocase 23 4.40E-7 0.15
10 SGTC_2575 plumbagin 4.75 510.0 nM 9.77E-6 superoxide 20 1.02E-6 0.21
11 SGTC_769 0302-0231 4.65 76.0 µM 1.47E-5 7 1.68E-6 0.51
12 SGTC_177 1327-0068 4.52 8.4 µM 2.43E-5 17 3.11E-6 0.18
13 SGTC_1575 cyproterone acetate 4.44 48.0 µM 3.26E-5 3 4.43E-6 0.01
14 SGTC_2799 7812892 4.42 81.8 µM 3.50E-5 superoxide 13 4.84E-6 0.01
15 SGTC_173 1273-0061 4.25 2.7 µM 6.68E-5 mitochondrial stress 24 1.06E-5 0.24
16 SGTC_1 0258-0098 3.97 57.4 µM 1.79E-4 heme biosynthesis & mitochondrial translocase 18 3.53E-5 0.18
17 SGTC_851 0394-0702 3.91 453.0 µM 2.23E-4 mitochondrial processes 24 4.60E-5 0.02
18 SGTC_745 0469-0705 3.90 296.0 µM 2.29E-4 mitochondrial processes 18 4.76E-5 0.06
19 SGTC_1588 farnesol 3.88 29.9 µM 2.51E-4 7 5.32E-5 0.16
20 SGTC_3217 9129673 3.73 49.5 µM 4.01E-4 13 9.40E-5 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.251 1.92E-49 YKL195W MIA40 het Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.245 4.55E-47 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.201 7.65E-32 YJL031C BET4 het Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.174 3.01E-24 YMR203W TOM40 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.155 1.32E-19 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.148 6.88E-18 YDR016C DAD1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.142 1.29E-16 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.127 1.42E-13 YLR354C TAL1 hom Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate
0.126 2.04E-13 YLR355C ILV5 het Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids
0.126 2.33E-13 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.119 4.82E-12 YPL266W DIM1 het Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
0.119 5.54E-12 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.115 2.53E-11 YBR268W MRPL37 hom Mitochondrial ribosomal protein of the large subunit
0.114 4.37E-11 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.111 1.21E-10 YDR427W RPN9 het Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress