Alpha 2 subunit of the 20S proteasome
Zygosity: Heterozygous strain

Cofit Genes
Download Cofitness data (
tab-delimited text) (
excel)
Correlation | pval | ORF | Gene | Zygosity | Description |
---|
0.493 |
8.04E-205 |
YMR314W |
PRE5 |
het |
Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress |
0.468 |
9.67E-182 |
YER094C |
PUP3 |
het |
Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 |
0.423 |
2.10E-145 |
YFR050C |
PRE4 |
het |
Beta 7 subunit of the 20S proteasome |
0.415 |
1.79E-139 |
YOR362C |
PRE10 |
het |
Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress |
0.414 |
7.32E-139 |
YER012W |
PRE1 |
het |
Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle |
0.409 |
2.96E-135 |
YGL011C |
SCL1 |
het |
Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria |
0.381 |
3.36E-116 |
YOL038W |
PRE6 |
het |
Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress |
0.337 |
1.43E-89 |
YGR253C |
PUP2 |
het |
Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta |
0.329 |
5.67E-85 |
YBL041W |
PRE7 |
het |
Beta 6 subunit of the 20S proteasome |
0.273 |
3.49E-58 |
YJL001W |
PRE3 |
het |
Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides |
0.267 |
1.08E-55 |
YPR103W |
PRE2 |
het |
Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome |
0.257 |
9.28E-52 |
YLR021W |
IRC25 |
hom |
Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions |
0.241 |
2.24E-45 |
YNL111C |
CYB5 |
hom |
Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation |
0.234 |
5.84E-43 |
YDR086C |
SSS1 |
het |
Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p |
0.229 |
4.20E-41 |
YJL165C |
HAL5 |
hom |
Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication |