YML092C / PRE8

Alpha 2 subunit of the 20S proteasome

Zygosity: Heterozygous strain
fixedexpanded
Profile for YML092C / PRE8

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:13.20|P-value:1.67E-28 ID:SGTC_137|Compound:0438-0332|FD-Score:6.96|P-value:3.53E-9 ID:SGTC_143|Compound:4032-1194|FD-Score:-4.86|P-value:1.47E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:-4.40|P-value:7.47E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:5.59|P-value:1.79E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:5.36|P-value:4.54E-6 ID:SGTC_187|Compound:1488-2104|FD-Score:8.46|P-value:8.63E-13 ID:SGTC_195|Compound:4234-0266|FD-Score:-3.61|P-value:8.82E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:6.54|P-value:2.78E-8 ID:SGTC_201|Compound:4262-0159|FD-Score:6.84|P-value:6.60E-9 ID:SGTC_216|Compound:k038-0035|FD-Score:5.49|P-value:2.74E-6 ID:SGTC_253|Compound:dyclonine|FD-Score:5.44|P-value:3.36E-6 ID:SGTC_263|Compound:alizarin|FD-Score:5.22|P-value:7.73E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:3.79|P-value:9.10E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.70|P-value:6.85E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.47|P-value:1.12E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.65|P-value:6.14E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:4.14|P-value:3.29E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.73|P-value:4.64E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.78|P-value:5.38E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:5.84|P-value:6.48E-7 ID:SGTC_444|Compound:curcumin|FD-Score:3.95|P-value:5.85E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.91|P-value:6.49E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.41|P-value:1.39E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-5.08|P-value:6.36E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:5.09|P-value:1.28E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:4.77|P-value:4.05E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:3.90|P-value:6.68E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.83|P-value:8.21E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:6.26|P-value:1.03E-7 ID:SGTC_743|Compound:1275-0778|FD-Score:-5.04|P-value:7.52E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.71|P-value:5.02E-7 ID:SGTC_779|Compound:1360-0071|FD-Score:3.91|P-value:6.58E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:4.96|P-value:2.04E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.85|P-value:4.39E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.83|P-value:8.17E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.60|P-value:7.27E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.81|P-value:3.56E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:-4.11|P-value:1.97E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:4.93|P-value:2.33E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-4.07|P-value:2.19E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-5.05|P-value:7.25E-6 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.99|P-value:2.87E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-5.13|P-value:5.19E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.67|P-value:5.83E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.32|P-value:9.78E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:11.40|P-value:5.57E-22 ID:SGTC_1605|Compound:st000082|FD-Score:-3.72|P-value:6.43E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-4.06|P-value:2.30E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.83|P-value:4.60E-4 ID:SGTC_1712|Compound:st032288|FD-Score:9.55|P-value:7.68E-16 ID:SGTC_1724|Compound:st037281|FD-Score:4.76|P-value:4.27E-5 ID:SGTC_1775|Compound:st081588|FD-Score:4.88|P-value:2.72E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-5.19|P-value:4.20E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.95|P-value:3.28E-4 ID:SGTC_1831|Compound:st055328|FD-Score:-3.60|P-value:9.24E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:10.10|P-value:1.50E-17 ID:SGTC_1919|Compound:st067113|FD-Score:6.62|P-value:1.93E-8 ID:SGTC_1931|Compound:st074438|FD-Score:4.89|P-value:2.66E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.88|P-value:7.02E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.73|P-value:6.28E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-6.14|P-value:7.46E-8 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.51|P-value:5.13E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.29|P-value:2.05E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:9.60|P-value:5.66E-16 ID:SGTC_2263|Compound:7948595|FD-Score:5.30|P-value:5.67E-6 ID:SGTC_2268|Compound:7933382|FD-Score:5.99|P-value:3.37E-7 ID:SGTC_2275|Compound:7947463|FD-Score:5.07|P-value:1.38E-5 ID:SGTC_2277|Compound:7947813|FD-Score:10.40|P-value:2.47E-18 ID:SGTC_2279|Compound:7948423|FD-Score:5.61|P-value:1.68E-6 ID:SGTC_2316|Compound:5844804|FD-Score:5.33|P-value:5.12E-6 ID:SGTC_2318|Compound:6029776|FD-Score:3.86|P-value:7.48E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.94|P-value:3.35E-4 ID:SGTC_2324|Compound:6149169|FD-Score:5.30|P-value:5.63E-6 ID:SGTC_2358|Compound:9037157|FD-Score:4.09|P-value:3.79E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.82|P-value:8.35E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.71|P-value:6.70E-4 ID:SGTC_2460|Compound:5552655|FD-Score:7.27|P-value:7.43E-10 ID:SGTC_2466|Compound:5983409|FD-Score:4.75|P-value:4.30E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.47|P-value:5.87E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.65|P-value:7.86E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.92|P-value:3.57E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.49|P-value:5.60E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.99|P-value:2.82E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.89|P-value:2.64E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.62|P-value:8.71E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.51|P-value:9.82E-5 ID:SGTC_2712|Compound:st079126|FD-Score:-4.37|P-value:8.39E-5 ID:SGTC_2713|Compound:st079149|FD-Score:-4.03|P-value:2.51E-4 ID:SGTC_2780|Compound:5215298|FD-Score:5.29|P-value:5.91E-6 ID:SGTC_2791|Compound:5663188|FD-Score:4.62|P-value:6.76E-5 ID:SGTC_2802|Compound:7925815|FD-Score:4.18|P-value:2.83E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.03|P-value:4.54E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-4.66|P-value:3.03E-5 ID:SGTC_2908|Compound:7930301|FD-Score:4.15|P-value:3.15E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.38|P-value:7.97E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.89|P-value:6.86E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.77|P-value:4.12E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:13.20|P-value:1.67E-28 ID:SGTC_137|Compound:0438-0332|FD-Score:6.96|P-value:3.53E-9 ID:SGTC_143|Compound:4032-1194|FD-Score:-4.86|P-value:1.47E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:-4.40|P-value:7.47E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:5.59|P-value:1.79E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:5.36|P-value:4.54E-6 ID:SGTC_187|Compound:1488-2104|FD-Score:8.46|P-value:8.63E-13 ID:SGTC_195|Compound:4234-0266|FD-Score:-3.61|P-value:8.82E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:6.54|P-value:2.78E-8 ID:SGTC_201|Compound:4262-0159|FD-Score:6.84|P-value:6.60E-9 ID:SGTC_216|Compound:k038-0035|FD-Score:5.49|P-value:2.74E-6 ID:SGTC_253|Compound:dyclonine|FD-Score:5.44|P-value:3.36E-6 ID:SGTC_263|Compound:alizarin|FD-Score:5.22|P-value:7.73E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:3.79|P-value:9.10E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.70|P-value:6.85E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.47|P-value:1.12E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.65|P-value:6.14E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:4.14|P-value:3.29E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.73|P-value:4.64E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.78|P-value:5.38E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:5.84|P-value:6.48E-7 ID:SGTC_444|Compound:curcumin|FD-Score:3.95|P-value:5.85E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.91|P-value:6.49E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.41|P-value:1.39E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-5.08|P-value:6.36E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:5.09|P-value:1.28E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:4.77|P-value:4.05E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:3.90|P-value:6.68E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.83|P-value:8.21E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:6.26|P-value:1.03E-7 ID:SGTC_743|Compound:1275-0778|FD-Score:-5.04|P-value:7.52E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.71|P-value:5.02E-7 ID:SGTC_779|Compound:1360-0071|FD-Score:3.91|P-value:6.58E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:4.96|P-value:2.04E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.85|P-value:4.39E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.83|P-value:8.17E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.60|P-value:7.27E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.81|P-value:3.56E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:-4.11|P-value:1.97E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:4.93|P-value:2.33E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-4.07|P-value:2.19E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-5.05|P-value:7.25E-6 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.99|P-value:2.87E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-5.13|P-value:5.19E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.67|P-value:5.83E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.32|P-value:9.78E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:11.40|P-value:5.57E-22 ID:SGTC_1605|Compound:st000082|FD-Score:-3.72|P-value:6.43E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-4.06|P-value:2.30E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.83|P-value:4.60E-4 ID:SGTC_1712|Compound:st032288|FD-Score:9.55|P-value:7.68E-16 ID:SGTC_1724|Compound:st037281|FD-Score:4.76|P-value:4.27E-5 ID:SGTC_1775|Compound:st081588|FD-Score:4.88|P-value:2.72E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-5.19|P-value:4.20E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.95|P-value:3.28E-4 ID:SGTC_1831|Compound:st055328|FD-Score:-3.60|P-value:9.24E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:10.10|P-value:1.50E-17 ID:SGTC_1919|Compound:st067113|FD-Score:6.62|P-value:1.93E-8 ID:SGTC_1931|Compound:st074438|FD-Score:4.89|P-value:2.66E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.88|P-value:7.02E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.73|P-value:6.28E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-6.14|P-value:7.46E-8 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.51|P-value:5.13E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.29|P-value:2.05E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:9.60|P-value:5.66E-16 ID:SGTC_2263|Compound:7948595|FD-Score:5.30|P-value:5.67E-6 ID:SGTC_2268|Compound:7933382|FD-Score:5.99|P-value:3.37E-7 ID:SGTC_2275|Compound:7947463|FD-Score:5.07|P-value:1.38E-5 ID:SGTC_2277|Compound:7947813|FD-Score:10.40|P-value:2.47E-18 ID:SGTC_2279|Compound:7948423|FD-Score:5.61|P-value:1.68E-6 ID:SGTC_2316|Compound:5844804|FD-Score:5.33|P-value:5.12E-6 ID:SGTC_2318|Compound:6029776|FD-Score:3.86|P-value:7.48E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.94|P-value:3.35E-4 ID:SGTC_2324|Compound:6149169|FD-Score:5.30|P-value:5.63E-6 ID:SGTC_2358|Compound:9037157|FD-Score:4.09|P-value:3.79E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.82|P-value:8.35E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.71|P-value:6.70E-4 ID:SGTC_2460|Compound:5552655|FD-Score:7.27|P-value:7.43E-10 ID:SGTC_2466|Compound:5983409|FD-Score:4.75|P-value:4.30E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.47|P-value:5.87E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.65|P-value:7.86E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.92|P-value:3.57E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.49|P-value:5.60E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.99|P-value:2.82E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.89|P-value:2.64E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.62|P-value:8.71E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.51|P-value:9.82E-5 ID:SGTC_2712|Compound:st079126|FD-Score:-4.37|P-value:8.39E-5 ID:SGTC_2713|Compound:st079149|FD-Score:-4.03|P-value:2.51E-4 ID:SGTC_2780|Compound:5215298|FD-Score:5.29|P-value:5.91E-6 ID:SGTC_2791|Compound:5663188|FD-Score:4.62|P-value:6.76E-5 ID:SGTC_2802|Compound:7925815|FD-Score:4.18|P-value:2.83E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.03|P-value:4.54E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-4.66|P-value:3.03E-5 ID:SGTC_2908|Compound:7930301|FD-Score:4.15|P-value:3.15E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.38|P-value:7.97E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.89|P-value:6.86E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.77|P-value:4.12E-5

Top fitness defect scores for YML092C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_64 000l-0018 13.20 272.1 µM 1.67E-28 ubiquinone biosynthesis & proteasome 9 7.67E-40 2.27
2 SGTC_1597 7-benzyloxygramine 11.40 47.5 µM 5.57E-22 calcium & mitochondrial duress 14 1.29E-30 0.68
3 SGTC_2277 7947813 10.40 106.9 µM 2.47E-18 RSC complex & mRNA processing 2 1.86E-25 1.91
4 SGTC_1880 MG-132 10.10 525.0 µM 1.50E-17 3 2.37E-24 2.34
5 SGTC_2250 alverine citrate 9.60 130.0 µM 5.66E-16 9 4.04E-22 0.46
6 SGTC_1712 st032288 9.55 53.4 µM 7.68E-16 calcium & mitochondrial duress 3 6.23E-22 0.41
7 SGTC_187 1488-2104 8.46 32.7 µM 8.63E-13 calcium & mitochondrial duress 1 1.29E-17 1.51
8 SGTC_2460 5552655 7.27 174.2 µM 7.43E-10 amide catabolism 1 1.84E-13 1.64
9 SGTC_137 0438-0332 6.96 85.4 µM 3.53E-9 ubiquinone biosynthesis & proteasome 16 1.67E-12 0.12
10 SGTC_201 4262-0159 6.84 12.8 µM 6.60E-9 ergosterol depletion effects on membrane 5 4.04E-12 0.75
11 SGTC_1919 st067113 6.62 52.3 µM 1.93E-8 TSC3-RPN4 2 1.85E-11 1.08
12 SGTC_200 k038-0079 6.54 37.5 µM 2.78E-8 ubiquinone biosynthesis & proteasome 4 3.09E-11 1.25
13 SGTC_635 k038-0028 6.26 24.7 µM 1.03E-7 ubiquinone biosynthesis & proteasome 5 1.96E-10 0.69
14 SGTC_2268 7933382 5.99 153.8 µM 3.37E-7 3 1.05E-9 0.31
15 SGTC_388 3',4'-dichloroisocoumarin 5.84 16.7 µM 6.48E-7 2 2.65E-9 0.85
16 SGTC_2279 7948423 5.61 32.9 µM 1.68E-6 1 1.02E-8 0.59
17 SGTC_158 k038-0087 5.59 26.4 µM 1.79E-6 ubiquinone biosynthesis & proteasome 15 1.11E-8 0.07
18 SGTC_216 k038-0035 5.49 28.4 µM 2.74E-6 ubiquinone biosynthesis & proteasome 7 2.04E-8 0.02
19 SGTC_253 dyclonine 5.44 31.2 µM 3.36E-6 amide catabolism 1 2.72E-8 0.86
20 SGTC_165 k038-0023 5.36 64.4 µM 4.54E-6 ubiquinone biosynthesis & proteasome 10 4.16E-8 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.493 8.04E-205 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.468 9.67E-182 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.423 2.10E-145 YFR050C PRE4 het Beta 7 subunit of the 20S proteasome
0.415 1.79E-139 YOR362C PRE10 het Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.414 7.32E-139 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.409 2.96E-135 YGL011C SCL1 het Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
0.381 3.36E-116 YOL038W PRE6 het Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
0.337 1.43E-89 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.329 5.67E-85 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.273 3.49E-58 YJL001W PRE3 het Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
0.267 1.08E-55 YPR103W PRE2 het Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
0.257 9.28E-52 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.241 2.24E-45 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.234 5.84E-43 YDR086C SSS1 het Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
0.229 4.20E-41 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication