YML094W / GIM5

Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it

Zygosity: Homozygous strain
fixedexpanded
Profile for YML094W / GIM5

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:3.40|P-value:6.07E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.34|P-value:7.35E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-5.75|P-value:7.27E-8 ID:SGTC_98|Compound:0074-0023|FD-Score:4.39|P-value:1.63E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-5.90|P-value:3.31E-8 ID:SGTC_138|Compound:0850-0259|FD-Score:3.59|P-value:3.29E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:4.83|P-value:2.56E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:4.22|P-value:3.28E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:3.92|P-value:1.03E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:7.14|P-value:1.04E-11 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.40|P-value:6.13E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.47|P-value:1.18E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.21|P-value:3.44E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.75|P-value:1.89E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.33|P-value:2.11E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.55|P-value:1.70E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.98|P-value:7.92E-11 ID:SGTC_362|Compound:0310-0100|FD-Score:-4.54|P-value:1.74E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:4.52|P-value:9.59E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:3.80|P-value:1.56E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.57|P-value:3.44E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-5.26|P-value:7.88E-7 ID:SGTC_704|Compound:1310-0270|FD-Score:4.17|P-value:3.97E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.81|P-value:1.52E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.53|P-value:9.30E-6 ID:SGTC_804|Compound:1595-0054|FD-Score:3.43|P-value:5.51E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-4.13|P-value:8.71E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:-4.61|P-value:1.34E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.86|P-value:2.31E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:4.06|P-value:6.02E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:4.54|P-value:9.10E-6 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.98|P-value:1.34E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.87|P-value:2.20E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.41|P-value:5.98E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.36|P-value:6.89E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.91|P-value:1.77E-6 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.49|P-value:4.62E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:4.65|P-value:5.60E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.13|P-value:1.38E-6 ID:SGTC_1802|Compound:st050112|FD-Score:3.82|P-value:1.45E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.57|P-value:3.54E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-4.56|P-value:1.59E-5 ID:SGTC_1980|Compound:st071811|FD-Score:3.27|P-value:9.41E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.77|P-value:1.75E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.78|P-value:1.70E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-4.16|P-value:7.79E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:8.56|P-value:5.39E-16 ID:SGTC_2472|Compound:5377652|FD-Score:3.66|P-value:2.56E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:6.48|P-value:5.79E-10 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-4.22|P-value:6.23E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.36|P-value:2.17E-7 ID:SGTC_2591|Compound:skatole|FD-Score:3.71|P-value:2.18E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.17|P-value:3.96E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.81|P-value:1.51E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-3.60|P-value:5.55E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-7.26|P-value:1.39E-11 ID:SGTC_2964|Compound:9083345|FD-Score:3.49|P-value:4.56E-4 ID:SGTC_3100|Compound:9120536|FD-Score:4.60|P-value:7.03E-6 ID:SGTC_3107|Compound:9121808|FD-Score:3.42|P-value:5.68E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.07|P-value:5.77E-5 ID:SGTC_3213|Compound:9129884|FD-Score:3.33|P-value:7.66E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.66|P-value:2.55E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.14|P-value:4.48E-5 ID:SGTC_3285|Compound:9112818|FD-Score:-4.29|P-value:4.78E-5 ID:SGTC_3287|Compound:9117173|FD-Score:-5.00|P-value:2.50E-6 ID:SGTC_3345|Compound:9148410|FD-Score:-3.53|P-value:6.94E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.40|P-value:6.07E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.34|P-value:7.35E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-5.75|P-value:7.27E-8 ID:SGTC_98|Compound:0074-0023|FD-Score:4.39|P-value:1.63E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-5.90|P-value:3.31E-8 ID:SGTC_138|Compound:0850-0259|FD-Score:3.59|P-value:3.29E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:4.83|P-value:2.56E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:4.22|P-value:3.28E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:3.92|P-value:1.03E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:7.14|P-value:1.04E-11 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.40|P-value:6.13E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.47|P-value:1.18E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.21|P-value:3.44E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.75|P-value:1.89E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.33|P-value:2.11E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.55|P-value:1.70E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.98|P-value:7.92E-11 ID:SGTC_362|Compound:0310-0100|FD-Score:-4.54|P-value:1.74E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:4.52|P-value:9.59E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:3.80|P-value:1.56E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.57|P-value:3.44E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-5.26|P-value:7.88E-7 ID:SGTC_704|Compound:1310-0270|FD-Score:4.17|P-value:3.97E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:3.81|P-value:1.52E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.53|P-value:9.30E-6 ID:SGTC_804|Compound:1595-0054|FD-Score:3.43|P-value:5.51E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-4.13|P-value:8.71E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:-4.61|P-value:1.34E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.86|P-value:2.31E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:4.06|P-value:6.02E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:4.54|P-value:9.10E-6 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.98|P-value:1.34E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.87|P-value:2.20E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.41|P-value:5.98E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.36|P-value:6.89E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.91|P-value:1.77E-6 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.49|P-value:4.62E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:4.65|P-value:5.60E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.13|P-value:1.38E-6 ID:SGTC_1802|Compound:st050112|FD-Score:3.82|P-value:1.45E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.57|P-value:3.54E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-4.56|P-value:1.59E-5 ID:SGTC_1980|Compound:st071811|FD-Score:3.27|P-value:9.41E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.77|P-value:1.75E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.78|P-value:1.70E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-4.16|P-value:7.79E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:8.56|P-value:5.39E-16 ID:SGTC_2472|Compound:5377652|FD-Score:3.66|P-value:2.56E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:6.48|P-value:5.79E-10 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:-4.22|P-value:6.23E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.36|P-value:2.17E-7 ID:SGTC_2591|Compound:skatole|FD-Score:3.71|P-value:2.18E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.17|P-value:3.96E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.81|P-value:1.51E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-3.60|P-value:5.55E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-7.26|P-value:1.39E-11 ID:SGTC_2964|Compound:9083345|FD-Score:3.49|P-value:4.56E-4 ID:SGTC_3100|Compound:9120536|FD-Score:4.60|P-value:7.03E-6 ID:SGTC_3107|Compound:9121808|FD-Score:3.42|P-value:5.68E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.07|P-value:5.77E-5 ID:SGTC_3213|Compound:9129884|FD-Score:3.33|P-value:7.66E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.66|P-value:2.55E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.14|P-value:4.48E-5 ID:SGTC_3285|Compound:9112818|FD-Score:-4.29|P-value:4.78E-5 ID:SGTC_3287|Compound:9117173|FD-Score:-5.00|P-value:2.50E-6 ID:SGTC_3345|Compound:9148410|FD-Score:-3.53|P-value:6.94E-4

Top fitness defect scores for YML094W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2417 cerulenin 8.56 830.0 nM 5.39E-16 4 5.82E-18
2 SGTC_212 3807-4682 7.14 38.8 µM 1.04E-11 tubulin folding & SWR complex 17 4.77E-13
3 SGTC_2489 cantharidin 6.48 73.4 µM 5.79E-10 cell wall signaling 6 4.73E-11
4 SGTC_2582 agaric acid 5.36 100.0 µM 2.17E-7 redox potentiating 201 4.11E-8
5 SGTC_1012 4112-3522 4.98 18.0 µM 1.34E-6 11 3.26E-7
6 SGTC_1168 k815-0004 4.91 80.5 µM 1.77E-6 DNA damage response 4 4.46E-7
7 SGTC_140 0062-0056 4.83 502.5 µM 2.56E-6 9 6.80E-7
8 SGTC_1294 1000-1494 4.65 117.0 µM 5.60E-6 17 1.65E-6
9 SGTC_3100 9120536 4.60 49.5 µM 7.03E-6 5 2.14E-6
10 SGTC_996 3970-0799 4.54 1.8 µM 9.10E-6 62 2.87E-6
11 SGTC_800 3448-7362 4.53 155.0 µM 9.30E-6 translation 115 2.94E-6
12 SGTC_368 fentichlor 4.52 4.6 µM 9.59E-6 19 3.05E-6
13 SGTC_241 5hr heat shock (37°C) + cantharidin 4.47 155.4 µM 1.18E-5 cell wall signaling 58 3.85E-6
14 SGTC_98 0074-0023 4.39 107.7 µM 1.63E-5 Golgi 30 5.57E-6
15 SGTC_264 promethazine 4.33 12.5 mM 2.11E-5 DNA intercalators 41 7.44E-6
16 SGTC_149 3970-0822 4.22 46.1 µM 3.28E-5 tubulin folding & SWR complex 82 1.23E-5
17 SGTC_243 5hr heat shock (37°C) + splitomicin 4.21 1.0 µM 3.44E-5 heat shock/prefoldin 43 1.30E-5
18 SGTC_2741 miltefosine 4.17 3.0 µM 3.96E-5 40 1.52E-5
19 SGTC_704 1310-0270 4.17 142.0 µM 3.97E-5 28 1.53E-5
20 SGTC_3282 9108498 4.14 15.5 µM 4.48E-5 26 1.75E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.186 1.56E-27 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.168 1.12E-22 YAL047C SPC72 hom Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization
0.163 2.09E-21 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.155 1.85E-19 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.153 4.40E-19 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.152 8.30E-19 YOR141C ARP8 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity
0.150 2.16E-18 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.147 9.68E-18 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.144 5.94E-17 YJL179W PFD1 hom Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin
0.138 8.03E-16 YPL017C IRC15 hom Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci
0.134 6.07E-15 YGR078C PAC10 hom Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
0.129 6.00E-14 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.128 1.15E-13 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.126 2.12E-13 YDR318W MCM21 hom Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2
0.125 4.23E-13 YLR448W RPL6B hom Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication