YML096W_p

Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10

Zygosity: Homozygous strain
fixedexpanded
Profile for YML096W / YML096W

Click on Significant Values for Screen Details ID:SGTC_160|Compound:3453-0671|FD-Score:4.63|P-value:1.20E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:5.18|P-value:1.17E-6 ID:SGTC_286|Compound:k060-0067|FD-Score:5.38|P-value:4.74E-7 ID:SGTC_288|Compound:1315-0019|FD-Score:-5.51|P-value:3.63E-7 ID:SGTC_293|Compound:4049-0273|FD-Score:3.94|P-value:1.64E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:4.86|P-value:4.70E-6 ID:SGTC_346|Compound:4513-0042|FD-Score:6.10|P-value:1.43E-8 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.70|P-value:4.56E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.52|P-value:2.43E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:3.62|P-value:4.73E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:5.07|P-value:1.94E-6 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.56|P-value:7.11E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:-3.75|P-value:3.85E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.45|P-value:9.90E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.64|P-value:5.54E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.59|P-value:5.15E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.65|P-value:1.11E-5 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.62|P-value:4.73E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.96|P-value:1.52E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.71|P-value:8.89E-6 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.97|P-value:1.44E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.50|P-value:7.01E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-3.82|P-value:3.07E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-3.75|P-value:3.89E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.82|P-value:2.46E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.40|P-value:9.34E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.91|P-value:1.81E-4 ID:SGTC_2478|Compound:5763493|FD-Score:4.07|P-value:1.04E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.44|P-value:8.39E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.79|P-value:2.69E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.79|P-value:3.41E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.89|P-value:1.91E-4 ID:SGTC_2967|Compound:9089538|FD-Score:-5.15|P-value:1.83E-6 ID:SGTC_2968|Compound:9090663|FD-Score:-4.19|P-value:8.49E-5 ID:SGTC_2973|Compound:9094665|FD-Score:-6.12|P-value:1.79E-8 ID:SGTC_3081|Compound:9117243|FD-Score:-3.56|P-value:6.96E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-3.84|P-value:2.89E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.76|P-value:3.04E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.61|P-value:4.91E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:4.63|P-value:1.20E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:5.18|P-value:1.17E-6 ID:SGTC_286|Compound:k060-0067|FD-Score:5.38|P-value:4.74E-7 ID:SGTC_288|Compound:1315-0019|FD-Score:-5.51|P-value:3.63E-7 ID:SGTC_293|Compound:4049-0273|FD-Score:3.94|P-value:1.64E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:4.86|P-value:4.70E-6 ID:SGTC_346|Compound:4513-0042|FD-Score:6.10|P-value:1.43E-8 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.70|P-value:4.56E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.52|P-value:2.43E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:3.62|P-value:4.73E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:5.07|P-value:1.94E-6 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.56|P-value:7.11E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:-3.75|P-value:3.85E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.45|P-value:9.90E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.64|P-value:5.54E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.59|P-value:5.15E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.65|P-value:1.11E-5 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.62|P-value:4.73E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.96|P-value:1.52E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.71|P-value:8.89E-6 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.97|P-value:1.44E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.50|P-value:7.01E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-3.82|P-value:3.07E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-3.75|P-value:3.89E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.82|P-value:2.46E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.40|P-value:9.34E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.91|P-value:1.81E-4 ID:SGTC_2478|Compound:5763493|FD-Score:4.07|P-value:1.04E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.44|P-value:8.39E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.79|P-value:2.69E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.79|P-value:3.41E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.89|P-value:1.91E-4 ID:SGTC_2967|Compound:9089538|FD-Score:-5.15|P-value:1.83E-6 ID:SGTC_2968|Compound:9090663|FD-Score:-4.19|P-value:8.49E-5 ID:SGTC_2973|Compound:9094665|FD-Score:-6.12|P-value:1.79E-8 ID:SGTC_3081|Compound:9117243|FD-Score:-3.56|P-value:6.96E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-3.84|P-value:2.89E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.76|P-value:3.04E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.61|P-value:4.91E-4

Top fitness defect scores for YML096W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_346 4513-0042 6.10 7.2 µM 1.43E-8 azole & statin 9 5.34E-10
2 SGTC_286 k060-0067 5.38 22.9 µM 4.74E-7 tubulin folding & SWR complex 9 3.66E-8
3 SGTC_282 k297-0036 5.18 65.7 µM 1.17E-6 1 1.08E-7
4 SGTC_574 1315-0397 5.07 40.0 µM 1.94E-6 11 2.00E-7
5 SGTC_344 k064-0035 4.86 6.4 µM 4.70E-6 60S ribosome export 14 5.81E-7
6 SGTC_1357 1503-1303 4.71 39.5 µM 8.89E-6 14 1.25E-6
7 SGTC_1049 3226-0134 4.65 66.0 µM 1.11E-5 16 1.64E-6
8 SGTC_160 3453-0671 4.63 289.7 µM 1.20E-5 25 1.80E-6
9 SGTC_2478 5763493 4.07 32.3 µM 1.04E-4 23 2.39E-5
10 SGTC_1367 1812-0510 3.97 76.9 µM 1.44E-4 20 3.55E-5
11 SGTC_1350 1495-0454 3.96 146.0 µM 1.52E-4 28 3.78E-5
12 SGTC_293 4049-0273 3.94 38.5 µM 1.64E-4 13 4.15E-5
13 SGTC_2404 5161160 3.91 200.0 µM 1.81E-4 21 4.65E-5
14 SGTC_2966 9084041 3.89 48.0 µM 1.91E-4 35 4.99E-5
15 SGTC_2119 5528445 3.82 120.6 µM 2.46E-4 22 6.75E-5
16 SGTC_2785 7756463 3.79 72.7 µM 2.69E-4 35 7.49E-5
17 SGTC_3286 9117135 3.76 37.2 µM 3.04E-4 18 8.66E-5
18 SGTC_572 0960-0087 3.62 17.7 µM 4.73E-4 38 1.47E-4
19 SGTC_1185 1319-0113 3.62 81.3 µM 4.73E-4 DNA damage response 17 1.47E-4
20 SGTC_3295 9122362 3.61 53.6 µM 4.91E-4 21 1.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.090 1.99E-7 YDR520C_p URC2_p hom Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism
0.088 3.85E-7 YPL260W YPL260W hom Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress
0.081 3.03E-6 YDL087C LUC7 het Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA
0.079 4.54E-6 YHR048W_p YHK8_p hom Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
0.079 5.18E-6 YER144C UBP5 hom Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck
0.078 6.82E-6 YPL192C PRM3 hom Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body
0.074 1.65E-5 YOL029C_p YOL029C_p hom Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens
0.072 2.69E-5 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.072 3.47E-5 YOL059W GPD2 hom NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1
0.070 4.44E-5 YDR083W RRP8 hom Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1
0.070 4.48E-5 YKL046C DCW1 hom Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
0.070 4.49E-5 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.069 6.53E-5 YKR017C HEL1 hom RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU)
0.068 7.74E-5 YJL216C IMA5 hom Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose
0.067 9.44E-5 YBR265W TSC10 het 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family