YML098W / TAF13

TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors

Zygosity: Heterozygous strain
fixedexpanded
Profile for YML098W / TAF13

Click on Significant Values for Screen Details ID:SGTC_141|Compound:0443-0274|FD-Score:-5.38|P-value:8.72E-10 ID:SGTC_147|Compound:4466-0538|FD-Score:3.76|P-value:1.42E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:5.86|P-value:3.26E-11 ID:SGTC_175|Compound:3793-3120|FD-Score:4.70|P-value:8.16E-8 ID:SGTC_394|Compound:menadione|FD-Score:3.20|P-value:1.82E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.25|P-value:1.46E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.78|P-value:9.09E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:2.92|P-value:5.68E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-2.94|P-value:4.87E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.19|P-value:1.89E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:2.95|P-value:5.13E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:2.97|P-value:4.65E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.69|P-value:1.98E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.01|P-value:3.95E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.11|P-value:2.66E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:2.81|P-value:8.76E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:2.88|P-value:6.65E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:-2.91|P-value:5.56E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.44|P-value:5.73E-5 ID:SGTC_1333|Compound:1482-0047|FD-Score:2.87|P-value:6.89E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-2.84|P-value:7.17E-4 ID:SGTC_2074|Compound:5212007|FD-Score:2.93|P-value:5.47E-4 ID:SGTC_2255|Compound:7941087|FD-Score:2.96|P-value:4.85E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.12|P-value:2.59E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.21|P-value:1.63E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:3.14|P-value:2.38E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.47|P-value:5.57E-5 ID:SGTC_2806|Compound:7952793|FD-Score:2.97|P-value:4.76E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.05|P-value:3.37E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.63|P-value:2.34E-5 ID:SGTC_2940|Compound:9060638|FD-Score:-4.95|P-value:1.54E-8 ID:SGTC_2966|Compound:9084041|FD-Score:3.46|P-value:5.83E-5 ID:SGTC_3010|Compound:9080089|FD-Score:4.21|P-value:1.35E-6 ID:SGTC_3062|Compound:9077494|FD-Score:-4.71|P-value:6.60E-8 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.38|P-value:8.72E-10 ID:SGTC_147|Compound:4466-0538|FD-Score:3.76|P-value:1.42E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:5.86|P-value:3.26E-11 ID:SGTC_175|Compound:3793-3120|FD-Score:4.70|P-value:8.16E-8 ID:SGTC_394|Compound:menadione|FD-Score:3.20|P-value:1.82E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.25|P-value:1.46E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.78|P-value:9.09E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:2.92|P-value:5.68E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-2.94|P-value:4.87E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.19|P-value:1.89E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:2.95|P-value:5.13E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:2.97|P-value:4.65E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.69|P-value:1.98E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.01|P-value:3.95E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.11|P-value:2.66E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:2.81|P-value:8.76E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:2.88|P-value:6.65E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:-2.91|P-value:5.56E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.44|P-value:5.73E-5 ID:SGTC_1333|Compound:1482-0047|FD-Score:2.87|P-value:6.89E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-2.84|P-value:7.17E-4 ID:SGTC_2074|Compound:5212007|FD-Score:2.93|P-value:5.47E-4 ID:SGTC_2255|Compound:7941087|FD-Score:2.96|P-value:4.85E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.12|P-value:2.59E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.21|P-value:1.63E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:3.14|P-value:2.38E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.47|P-value:5.57E-5 ID:SGTC_2806|Compound:7952793|FD-Score:2.97|P-value:4.76E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.05|P-value:3.37E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.63|P-value:2.34E-5 ID:SGTC_2940|Compound:9060638|FD-Score:-4.95|P-value:1.54E-8 ID:SGTC_2966|Compound:9084041|FD-Score:3.46|P-value:5.83E-5 ID:SGTC_3010|Compound:9080089|FD-Score:4.21|P-value:1.35E-6 ID:SGTC_3062|Compound:9077494|FD-Score:-4.71|P-value:6.60E-8

Top fitness defect scores for YML098W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_155 k072-0202 5.86 43.6 µM 3.26E-11 2 2.37E-9 0.20
2 SGTC_175 3793-3120 4.70 23.7 µM 8.16E-8 1 1.32E-6 0.45
3 SGTC_3010 9080089 4.21 71.4 µM 1.35E-6 2 1.28E-5 1.01
4 SGTC_147 4466-0538 3.76 29.2 µM 1.42E-5 ergosterol biosynthesis 11 8.62E-5 0.03
5 SGTC_958 1222-0007 3.69 33.0 µM 1.98E-5 7 1.13E-4 0.07
6 SGTC_2752 diclazuril 3.47 33.1 µM 5.57E-5 14 2.61E-4 6.96E-4
7 SGTC_2966 9084041 3.46 48.0 µM 5.83E-5 6 2.71E-4 0.00
8 SGTC_404 fumagillin 3.25 50.0 µM 1.46E-4 14 5.72E-4 0.07
9 SGTC_394 menadione 3.20 8.3 µM 1.82E-4 superoxide 13 6.85E-4 0.14
10 SGTC_685 1278-0033 3.19 54.9 µM 1.89E-4 60S ribosome export 14 7.06E-4 0.03
11 SGTC_2641 levomentholum 3.14 100.0 µM 2.38E-4 2 8.54E-4 0.24
12 SGTC_2574 2',4'-dihydroxychalcone 3.12 14.6 µM 2.59E-4 23 9.15E-4 0.07
13 SGTC_1086 cerivastatin 3.11 2.2 µM 2.66E-4 azole & statin 9 9.35E-4 0.24
14 SGTC_2811 7967822 3.05 32.5 µM 3.37E-4 16 0.00113 0.01
15 SGTC_1059 3448-6867 3.01 171.0 µM 3.95E-4 16 0.00129 0.03
16 SGTC_927 2425-1185 2.97 123.0 µM 4.65E-4 18 0.00147 0.08
17 SGTC_2806 7952793 2.97 58.4 µM 4.76E-4 14 0.00150 0.01
18 SGTC_2255 7941087 2.96 197.4 µM 4.85E-4 14 0.00152 0.02
19 SGTC_855 0428-0020 2.95 25.0 µM 5.13E-4 Golgi 18 0.00160 0.08
20 SGTC_2074 5212007 2.93 75.4 µM 5.47E-4 9 0.00168 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.197 1.21E-30 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.173 5.86E-24 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.170 4.15E-23 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.167 2.48E-22 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.161 6.25E-21 YGR140W CBF2 het Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; relative distribution to the spindle pole body decreases upon DNA replication stress
0.152 8.35E-19 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.145 3.60E-17 YGL142C GPI10 het Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog
0.143 7.07E-17 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.143 1.02E-16 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.142 1.62E-16 YLR105C SEN2 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
0.137 1.40E-15 YKL036C_d YKL036C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W
0.133 8.56E-15 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.130 3.43E-14 YKL083W_d YKL083W_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14
0.127 1.32E-13 YIL063C YRB2 het Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential
0.125 3.51E-13 YBR193C MED8 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation