YML099C / ARG81

Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p

Zygosity: Homozygous strain
fixedexpanded
Profile for YML099C / ARG81

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:-6.15|P-value:1.96E-9 ID:SGTC_42|Compound:0133-0086|FD-Score:4.40|P-value:9.65E-6 ID:SGTC_49|Compound:0717-0965|FD-Score:3.54|P-value:2.87E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:6.15|P-value:1.33E-9 ID:SGTC_73|Compound:0327-0325|FD-Score:3.58|P-value:2.47E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.32|P-value:6.27E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.60|P-value:2.36E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.20|P-value:9.34E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.30|P-value:6.71E-4 ID:SGTC_417|Compound:st075190|FD-Score:4.01|P-value:4.94E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:3.74|P-value:1.37E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.60|P-value:2.36E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:4.55|P-value:5.03E-6 ID:SGTC_702|Compound:1488-0190|FD-Score:4.68|P-value:2.80E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:3.39|P-value:4.94E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.60|P-value:2.34E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.84|P-value:9.65E-5 ID:SGTC_1481|Compound:3346-2004|FD-Score:4.25|P-value:1.84E-5 ID:SGTC_1609|Compound:st001574|FD-Score:5.29|P-value:1.48E-7 ID:SGTC_1675|Compound:st018485|FD-Score:3.80|P-value:1.13E-4 ID:SGTC_1701|Compound:st028638|FD-Score:4.25|P-value:1.83E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.89|P-value:7.87E-5 ID:SGTC_1978|Compound:st071761|FD-Score:3.60|P-value:2.34E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.27|P-value:7.28E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-5.39|P-value:1.24E-7 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.26|P-value:9.46E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.28|P-value:7.09E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.17|P-value:2.55E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.42|P-value:5.63E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.31|P-value:6.46E-4 ID:SGTC_2903|Compound:5923464|FD-Score:3.71|P-value:1.54E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-3.37|P-value:6.49E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.52|P-value:3.97E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.48|P-value:4.48E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.39|P-value:4.85E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-5.68|P-value:2.76E-8 ID:SGTC_3329|Compound:9141233|FD-Score:7.24|P-value:1.25E-12 ID:SGTC_3332|Compound:9141069|FD-Score:3.37|P-value:5.30E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-4.13|P-value:4.05E-5 ID:SGTC_3335|Compound:9143315|FD-Score:-5.97|P-value:5.46E-9 ID:SGTC_37|Compound:0566-0070|FD-Score:-6.15|P-value:1.96E-9 ID:SGTC_42|Compound:0133-0086|FD-Score:4.40|P-value:9.65E-6 ID:SGTC_49|Compound:0717-0965|FD-Score:3.54|P-value:2.87E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:6.15|P-value:1.33E-9 ID:SGTC_73|Compound:0327-0325|FD-Score:3.58|P-value:2.47E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.32|P-value:6.27E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.60|P-value:2.36E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.20|P-value:9.34E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.30|P-value:6.71E-4 ID:SGTC_417|Compound:st075190|FD-Score:4.01|P-value:4.94E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:3.74|P-value:1.37E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.60|P-value:2.36E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:4.55|P-value:5.03E-6 ID:SGTC_702|Compound:1488-0190|FD-Score:4.68|P-value:2.80E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:3.39|P-value:4.94E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.60|P-value:2.34E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.84|P-value:9.65E-5 ID:SGTC_1481|Compound:3346-2004|FD-Score:4.25|P-value:1.84E-5 ID:SGTC_1609|Compound:st001574|FD-Score:5.29|P-value:1.48E-7 ID:SGTC_1675|Compound:st018485|FD-Score:3.80|P-value:1.13E-4 ID:SGTC_1701|Compound:st028638|FD-Score:4.25|P-value:1.83E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.89|P-value:7.87E-5 ID:SGTC_1978|Compound:st071761|FD-Score:3.60|P-value:2.34E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.27|P-value:7.28E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-5.39|P-value:1.24E-7 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.26|P-value:9.46E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.28|P-value:7.09E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.17|P-value:2.55E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.42|P-value:5.63E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.31|P-value:6.46E-4 ID:SGTC_2903|Compound:5923464|FD-Score:3.71|P-value:1.54E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-3.37|P-value:6.49E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.52|P-value:3.97E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.48|P-value:4.48E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.39|P-value:4.85E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-5.68|P-value:2.76E-8 ID:SGTC_3329|Compound:9141233|FD-Score:7.24|P-value:1.25E-12 ID:SGTC_3332|Compound:9141069|FD-Score:3.37|P-value:5.30E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-4.13|P-value:4.05E-5 ID:SGTC_3335|Compound:9143315|FD-Score:-5.97|P-value:5.46E-9

Top fitness defect scores for YML099C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3329 9141233 7.24 27.6 µM 1.25E-12 1 2.27E-13
2 SGTC_67 0335-0847 6.15 266.0 µM 1.33E-9 ubiquinone biosynthesis & proteasome 66 3.98E-10
3 SGTC_1609 st001574 5.29 46.4 µM 1.48E-7 3 6.19E-8
4 SGTC_702 1488-0190 4.68 94.0 µM 2.80E-6 amide catabolism 4 1.43E-6
5 SGTC_695 3505-6186 4.55 243.0 µM 5.03E-6 17 2.67E-6
6 SGTC_42 0133-0086 4.40 60.6 µM 9.65E-6 18 5.35E-6
7 SGTC_1701 st028638 4.25 40.4 µM 1.83E-5 11 1.06E-5
8 SGTC_1481 3346-2004 4.25 36.0 µM 1.84E-5 7 1.07E-5
9 SGTC_2659 sanguinarine 4.17 24.2 µM 2.55E-5 21 1.51E-5
10 SGTC_417 st075190 4.01 100.0 µM 4.94E-5 8 3.05E-5
11 SGTC_1852 st056254 3.89 31.4 µM 7.87E-5 10 5.02E-5
12 SGTC_1335 1486-0900 3.84 202.0 µM 9.65E-5 29 6.24E-5
13 SGTC_1675 st018485 3.80 24.5 µM 1.13E-4 60S ribosome export 30 7.36E-5
14 SGTC_432 NS 1619 3.74 61.3 µM 1.37E-4 37 9.09E-5
15 SGTC_2903 5923464 3.71 63.9 µM 1.54E-4 11 1.02E-4
16 SGTC_1158 4092-0494 3.60 91.8 µM 2.34E-4 24 1.60E-4
17 SGTC_1978 st071761 3.60 42.0 µM 2.34E-4 TSC3-RPN4 20 1.60E-4
18 SGTC_260 nsc-65238 3.60 4.0 µM 2.36E-4 endomembrane recycling 26 1.62E-4
19 SGTC_618 k072-0232 3.60 33.2 µM 2.36E-4 60S ribosome export 11 1.62E-4
20 SGTC_73 0327-0325 3.58 16.2 µM 2.47E-4 DNA damage response 66 1.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 1.59E-17 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.133 1.20E-14 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.133 1.31E-14 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.119 4.32E-12 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.105 1.21E-9 YNL130C CPT1 hom Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication
0.104 1.76E-9 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.104 1.77E-9 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.104 1.80E-9 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.103 2.33E-9 YOR213C SAS5 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
0.103 2.58E-9 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.102 3.52E-9 YPL070W MUK1 hom Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation
0.101 5.36E-9 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100 6.01E-9 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.097 2.12E-8 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.095 4.16E-8 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated