YML103C / NUP188

Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188

Zygosity: Homozygous strain
fixedexpanded
Profile for YML103C / NUP188

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:-3.21|P-value:9.72E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:12.30|P-value:1.54E-34 ID:SGTC_210|Compound:3551-0445|FD-Score:6.20|P-value:3.23E-10 ID:SGTC_300|Compound:r073-0011|FD-Score:4.41|P-value:5.01E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:3.77|P-value:7.77E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:3.09|P-value:9.15E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.85|P-value:6.11E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:3.57|P-value:1.66E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.08|P-value:9.64E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.72|P-value:2.20E-6 ID:SGTC_759|Compound:3486-0358|FD-Score:4.28|P-value:8.76E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:3.83|P-value:5.99E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.64|P-value:1.74E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.24|P-value:8.81E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.07|P-value:4.06E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.46|P-value:2.52E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.20|P-value:6.29E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.60|P-value:1.46E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.23|P-value:5.72E-4 ID:SGTC_2359|Compound:9039622|FD-Score:4.03|P-value:2.64E-5 ID:SGTC_2363|Compound:9053361|FD-Score:3.25|P-value:5.23E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:21.40|P-value:8.05E-100 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.90|P-value:8.06E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:8.61|P-value:5.69E-18 ID:SGTC_2799|Compound:7812892|FD-Score:4.96|P-value:3.56E-7 ID:SGTC_2834|Compound:9001755|FD-Score:-5.07|P-value:3.98E-7 ID:SGTC_2858|Compound:9025781|FD-Score:5.19|P-value:1.05E-7 ID:SGTC_2876|Compound:9059903|FD-Score:3.33|P-value:3.93E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.75|P-value:8.22E-5 ID:SGTC_2979|Compound:9012552|FD-Score:-3.88|P-value:8.63E-5 ID:SGTC_2984|Compound:9022109|FD-Score:-4.24|P-value:1.92E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.45|P-value:4.22E-6 ID:SGTC_3337|Compound:9144342|FD-Score:3.23|P-value:5.76E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-3.21|P-value:9.72E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:12.30|P-value:1.54E-34 ID:SGTC_210|Compound:3551-0445|FD-Score:6.20|P-value:3.23E-10 ID:SGTC_300|Compound:r073-0011|FD-Score:4.41|P-value:5.01E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:3.77|P-value:7.77E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:3.09|P-value:9.15E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.85|P-value:6.11E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:3.57|P-value:1.66E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.08|P-value:9.64E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.72|P-value:2.20E-6 ID:SGTC_759|Compound:3486-0358|FD-Score:4.28|P-value:8.76E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:3.83|P-value:5.99E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.64|P-value:1.74E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.24|P-value:8.81E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.07|P-value:4.06E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.46|P-value:2.52E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.20|P-value:6.29E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.60|P-value:1.46E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.23|P-value:5.72E-4 ID:SGTC_2359|Compound:9039622|FD-Score:4.03|P-value:2.64E-5 ID:SGTC_2363|Compound:9053361|FD-Score:3.25|P-value:5.23E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:21.40|P-value:8.05E-100 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.90|P-value:8.06E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:8.61|P-value:5.69E-18 ID:SGTC_2799|Compound:7812892|FD-Score:4.96|P-value:3.56E-7 ID:SGTC_2834|Compound:9001755|FD-Score:-5.07|P-value:3.98E-7 ID:SGTC_2858|Compound:9025781|FD-Score:5.19|P-value:1.05E-7 ID:SGTC_2876|Compound:9059903|FD-Score:3.33|P-value:3.93E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.75|P-value:8.22E-5 ID:SGTC_2979|Compound:9012552|FD-Score:-3.88|P-value:8.63E-5 ID:SGTC_2984|Compound:9022109|FD-Score:-4.24|P-value:1.92E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.45|P-value:4.22E-6 ID:SGTC_3337|Compound:9144342|FD-Score:3.23|P-value:5.76E-4

Top fitness defect scores for YML103C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 21.40 100.0 µM 8.05E-100 redox potentiating 1 6.38E-102
2 SGTC_58 0957-0393 12.30 9.0 µM 1.54E-34 cell wall 50 4.41E-35
3 SGTC_2651 1327-0036 8.61 5.0 µM 5.69E-18 33 3.67E-18
4 SGTC_210 3551-0445 6.20 56.8 µM 3.23E-10 25 2.90E-10
5 SGTC_2858 9025781 5.19 9.0 µM 1.05E-7 sphingolipid biosynthesis & PDR1 62 1.03E-7
6 SGTC_2799 7812892 4.96 81.8 µM 3.56E-7 superoxide 17 3.57E-7
7 SGTC_513 4245-1575 4.85 41.7 µM 6.11E-7 unfolded protein response 81 6.16E-7
8 SGTC_839 0122-0028 4.64 230.0 µM 1.74E-6 RSC complex & mRNA processing 21 1.78E-6
9 SGTC_3059 1327-0034 4.45 3.0 µM 4.22E-6 43 4.37E-6
10 SGTC_300 r073-0011 4.41 5.0 µM 5.01E-6 12 5.19E-6
11 SGTC_759 3486-0358 4.28 89.3 µM 8.76E-6 15 9.14E-6
12 SGTC_2359 9039622 4.03 200.0 µM 2.64E-5 endomembrane recycling 22 2.79E-5
13 SGTC_766 1391-0721 3.83 126.0 µM 5.99E-5 16 6.38E-5
14 SGTC_352 k048-0007 3.77 5.1 µM 7.77E-5 ERAD & cell cycle 84 8.30E-5
15 SGTC_2978 9011784 3.75 43.0 µM 8.22E-5 37 8.79E-5
16 SGTC_2096 5468907 3.60 200.0 µM 1.46E-4 15 1.57E-4
17 SGTC_514 4466-0038 3.57 2.6 nM 1.66E-4 cell wall 178 1.79E-4
18 SGTC_1369 1866-0067 3.46 208.0 µM 2.52E-4 RPP1 & pyrimidine depletion 58 2.72E-4
19 SGTC_2876 9059903 3.33 26.0 µM 3.93E-4 29 4.27E-4
20 SGTC_2363 9053361 3.25 176.0 µM 5.23E-4 Golgi 59 5.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.438 3.99E-157 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.424 7.84E-146 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.422 1.95E-145 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.409 2.45E-135 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.404 8.48E-132 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.394 6.14E-125 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.373 2.15E-111 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.372 1.34E-110 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.367 1.02E-107 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.361 4.45E-104 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.356 9.36E-101 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.349 7.75E-97 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.345 1.15E-94 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.335 4.79E-89 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
0.327 1.92E-84 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication