YML107C / PML39

Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes

Zygosity: Homozygous strain
fixedexpanded
Profile for YML107C / PML39

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:3.19|P-value:5.57E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.85|P-value:6.09E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.26|P-value:5.86E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.42|P-value:2.48E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.52|P-value:1.68E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.41|P-value:3.39E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.56|P-value:1.93E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.07|P-value:1.72E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.46|P-value:2.84E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:3.67|P-value:9.28E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:5.62|P-value:5.90E-9 ID:SGTC_748|Compound:0136-0228|FD-Score:3.93|P-value:3.17E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.73|P-value:7.78E-12 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.42|P-value:3.48E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.33|P-value:4.52E-4 ID:SGTC_1610|Compound:st001799|FD-Score:4.21|P-value:9.00E-6 ID:SGTC_1621|Compound:st003705|FD-Score:3.46|P-value:2.09E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.25|P-value:4.47E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.38|P-value:2.85E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.36|P-value:3.03E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-4.95|P-value:3.62E-7 ID:SGTC_1733|Compound:st037357|FD-Score:3.86|P-value:4.23E-5 ID:SGTC_1745|Compound:st081495|FD-Score:4.57|P-value:1.68E-6 ID:SGTC_1754|Compound:st042065|FD-Score:5.19|P-value:6.81E-8 ID:SGTC_1818|Compound:st052136|FD-Score:3.61|P-value:1.15E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.55|P-value:1.51E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.33|P-value:4.61E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.46|P-value:2.11E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.43|P-value:2.36E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.70|P-value:8.01E-5 ID:SGTC_2168|Compound:5727979|FD-Score:-3.15|P-value:8.59E-4 ID:SGTC_2202|Compound:7226349|FD-Score:-3.59|P-value:1.73E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.30|P-value:5.02E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.33|P-value:3.36E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.39|P-value:5.81E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.32|P-value:3.52E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.68|P-value:9.81E-7 ID:SGTC_2715|Compound:st079500|FD-Score:-3.38|P-value:3.75E-4 ID:SGTC_2716|Compound:st080858|FD-Score:4.20|P-value:9.57E-6 ID:SGTC_2805|Compound:7950783|FD-Score:4.40|P-value:3.88E-6 ID:SGTC_2829|Compound:7992743|FD-Score:5.24|P-value:5.03E-8 ID:SGTC_2831|Compound:7999036|FD-Score:3.09|P-value:8.11E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.98|P-value:2.57E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:3.19|P-value:5.57E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.85|P-value:6.09E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.26|P-value:5.86E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.42|P-value:2.48E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.52|P-value:1.68E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.41|P-value:3.39E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.56|P-value:1.93E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.07|P-value:1.72E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.46|P-value:2.84E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:3.67|P-value:9.28E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:5.62|P-value:5.90E-9 ID:SGTC_748|Compound:0136-0228|FD-Score:3.93|P-value:3.17E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.73|P-value:7.78E-12 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.42|P-value:3.48E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.33|P-value:4.52E-4 ID:SGTC_1610|Compound:st001799|FD-Score:4.21|P-value:9.00E-6 ID:SGTC_1621|Compound:st003705|FD-Score:3.46|P-value:2.09E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.25|P-value:4.47E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.38|P-value:2.85E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.36|P-value:3.03E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-4.95|P-value:3.62E-7 ID:SGTC_1733|Compound:st037357|FD-Score:3.86|P-value:4.23E-5 ID:SGTC_1745|Compound:st081495|FD-Score:4.57|P-value:1.68E-6 ID:SGTC_1754|Compound:st042065|FD-Score:5.19|P-value:6.81E-8 ID:SGTC_1818|Compound:st052136|FD-Score:3.61|P-value:1.15E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.55|P-value:1.51E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.33|P-value:4.61E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.46|P-value:2.11E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.43|P-value:2.36E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.70|P-value:8.01E-5 ID:SGTC_2168|Compound:5727979|FD-Score:-3.15|P-value:8.59E-4 ID:SGTC_2202|Compound:7226349|FD-Score:-3.59|P-value:1.73E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.30|P-value:5.02E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.33|P-value:3.36E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.39|P-value:5.81E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.32|P-value:3.52E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.68|P-value:9.81E-7 ID:SGTC_2715|Compound:st079500|FD-Score:-3.38|P-value:3.75E-4 ID:SGTC_2716|Compound:st080858|FD-Score:4.20|P-value:9.57E-6 ID:SGTC_2805|Compound:7950783|FD-Score:4.40|P-value:3.88E-6 ID:SGTC_2829|Compound:7992743|FD-Score:5.24|P-value:5.03E-8 ID:SGTC_2831|Compound:7999036|FD-Score:3.09|P-value:8.11E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.98|P-value:2.57E-5

Top fitness defect scores for YML107C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_734 2023-0417 5.62 80.0 µM 5.90E-9 ergosterol biosynthesis 2 9.76E-9
2 SGTC_2829 7992743 5.24 58.4 µM 5.03E-8 12 7.93E-8
3 SGTC_1754 st042065 5.19 16.1 µM 6.81E-8 NEO1-PIK1 118 1.06E-7
4 SGTC_2651 1327-0036 4.68 5.0 µM 9.81E-7 128 1.44E-6
5 SGTC_1745 st081495 4.57 74.0 µM 1.68E-6 RNA processing & uracil transport 56 2.45E-6
6 SGTC_1383 3049-0032 4.42 20.7 µM 3.48E-6 60S ribosome export 14 4.97E-6
7 SGTC_2805 7950783 4.40 58.4 µM 3.88E-6 19 5.52E-6
8 SGTC_1610 st001799 4.21 48.1 µM 9.00E-6 9 1.26E-5
9 SGTC_2716 st080858 4.20 38.6 µM 9.57E-6 60S ribosome export 16 1.33E-5
10 SGTC_453 enantio-paf c16 4.07 10.0 µM 1.72E-5 133 2.37E-5
11 SGTC_3011 9081274 3.98 71.4 µM 2.57E-5 17 3.50E-5
12 SGTC_748 0136-0228 3.93 77.9 µM 3.17E-5 redox potentiating 80 4.30E-5
13 SGTC_1733 st037357 3.86 54.9 µM 4.23E-5 60S ribosome export 28 5.69E-5
14 SGTC_2119 5528445 3.70 120.6 µM 8.01E-5 28 1.06E-4
15 SGTC_693 4161-2696 3.67 114.0 µM 9.28E-5 13 1.23E-4
16 SGTC_1818 st052136 3.61 56.3 µM 1.15E-4 NEO1-PIK1 70 1.50E-4
17 SGTC_1823 3-hydroxy-2-naphthoic acid 3.55 106.0 µM 1.51E-4 29 1.96E-4
18 SGTC_337 1315-0038 3.52 354.0 µM 1.68E-4 amide catabolism 36 2.19E-4
19 SGTC_1621 st003705 3.46 32.4 µM 2.09E-4 calcium & mitochondrial duress 37 2.70E-4
20 SGTC_1878 temozolomide 3.46 1.0 mM 2.11E-4 17 2.73E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.210 6.69E-35 YML106W URA5 hom Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication
0.202 3.09E-32 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.168 1.26E-22 YLL038C ENT4 hom Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome
0.154 2.50E-19 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.148 5.73E-18 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.147 8.71E-18 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.141 2.93E-16 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.140 3.24E-16 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.139 5.49E-16 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.138 1.21E-15 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.138 1.22E-15 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.132 1.98E-14 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.125 3.12E-13 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.125 4.15E-13 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.125 4.25E-13 YKR073C_d YKR073C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data