YML110C / COQ5

2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes

Zygosity: Homozygous strain
fixedexpanded
Profile for YML110C / COQ5

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:19.20|P-value:1.22E-60 ID:SGTC_64|Compound:000l-0018|FD-Score:12.50|P-value:1.01E-26 ID:SGTC_67|Compound:0335-0847|FD-Score:6.08|P-value:9.42E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:16.10|P-value:2.32E-43 ID:SGTC_104|Compound:0074-0074|FD-Score:6.06|P-value:1.06E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:3.91|P-value:3.94E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:6.46|P-value:1.60E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:5.42|P-value:1.68E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:-5.17|P-value:6.15E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:9.53|P-value:1.95E-16 ID:SGTC_158|Compound:k038-0087|FD-Score:12.50|P-value:8.20E-27 ID:SGTC_173|Compound:1273-0061|FD-Score:5.35|P-value:2.26E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:6.80|P-value:2.92E-9 ID:SGTC_216|Compound:k038-0035|FD-Score:6.92|P-value:1.62E-9 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.97|P-value:3.25E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:14.50|P-value:1.80E-35 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.83|P-value:5.04E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.71|P-value:2.69E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:3.59|P-value:9.97E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.95|P-value:3.46E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.83|P-value:4.92E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.88|P-value:5.30E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.17|P-value:6.17E-6 ID:SGTC_720|Compound:r052-1644|FD-Score:3.76|P-value:6.15E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.73|P-value:6.73E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:7.66|P-value:2.83E-11 ID:SGTC_851|Compound:0394-0702|FD-Score:4.95|P-value:1.07E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:4.49|P-value:5.71E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:6.40|P-value:2.14E-8 ID:SGTC_1001|Compound:4048-4355|FD-Score:-4.35|P-value:1.19E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.97|P-value:3.25E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:5.55|P-value:9.72E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.59|P-value:4.11E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:6.57|P-value:9.39E-9 ID:SGTC_1318|Compound:1280-3875|FD-Score:6.05|P-value:1.10E-7 ID:SGTC_1426|Compound:4048-4480|FD-Score:4.20|P-value:1.53E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:4.51|P-value:5.41E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.75|P-value:2.69E-11 ID:SGTC_1800|Compound:st050079|FD-Score:-4.16|P-value:2.24E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.28|P-value:1.54E-4 ID:SGTC_1871|Compound:st057448|FD-Score:-3.67|P-value:9.92E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-4.52|P-value:6.76E-5 ID:SGTC_2086|Compound:5274770|FD-Score:4.22|P-value:1.46E-4 ID:SGTC_2122|Compound:5258151|FD-Score:4.70|P-value:2.72E-5 ID:SGTC_2171|Compound:5739187|FD-Score:4.47|P-value:6.30E-5 ID:SGTC_2323|Compound:6148992|FD-Score:3.87|P-value:4.42E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-4.62|P-value:4.82E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.77|P-value:7.52E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.89|P-value:4.18E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.40|P-value:7.86E-5 ID:SGTC_2696|Compound:st077691|FD-Score:4.08|P-value:2.30E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.83|P-value:5.03E-4 ID:SGTC_2805|Compound:7950783|FD-Score:4.76|P-value:2.25E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.69|P-value:7.54E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.27|P-value:1.58E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-5.30|P-value:3.73E-6 ID:SGTC_2934|Compound:9036370|FD-Score:5.96|P-value:1.67E-7 ID:SGTC_2937|Compound:9044753|FD-Score:6.16|P-value:6.48E-8 ID:SGTC_3019|Compound:9081971|FD-Score:3.71|P-value:7.16E-4 ID:SGTC_3028|Compound:9087778|FD-Score:4.74|P-value:2.34E-5 ID:SGTC_3203|Compound:9113543|FD-Score:4.49|P-value:5.89E-5 ID:SGTC_3303|Compound:9125618|FD-Score:-4.91|P-value:1.68E-5 ID:SGTC_3347|Compound:9188721|FD-Score:4.29|P-value:1.13E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:19.20|P-value:1.22E-60 ID:SGTC_64|Compound:000l-0018|FD-Score:12.50|P-value:1.01E-26 ID:SGTC_67|Compound:0335-0847|FD-Score:6.08|P-value:9.42E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:16.10|P-value:2.32E-43 ID:SGTC_104|Compound:0074-0074|FD-Score:6.06|P-value:1.06E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:3.91|P-value:3.94E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:6.46|P-value:1.60E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:5.42|P-value:1.68E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:-5.17|P-value:6.15E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:9.53|P-value:1.95E-16 ID:SGTC_158|Compound:k038-0087|FD-Score:12.50|P-value:8.20E-27 ID:SGTC_173|Compound:1273-0061|FD-Score:5.35|P-value:2.26E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:6.80|P-value:2.92E-9 ID:SGTC_216|Compound:k038-0035|FD-Score:6.92|P-value:1.62E-9 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.97|P-value:3.25E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:14.50|P-value:1.80E-35 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.83|P-value:5.04E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.71|P-value:2.69E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:3.59|P-value:9.97E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.95|P-value:3.46E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.83|P-value:4.92E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.88|P-value:5.30E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.17|P-value:6.17E-6 ID:SGTC_720|Compound:r052-1644|FD-Score:3.76|P-value:6.15E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.73|P-value:6.73E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:7.66|P-value:2.83E-11 ID:SGTC_851|Compound:0394-0702|FD-Score:4.95|P-value:1.07E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:4.49|P-value:5.71E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:6.40|P-value:2.14E-8 ID:SGTC_1001|Compound:4048-4355|FD-Score:-4.35|P-value:1.19E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.97|P-value:3.25E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:5.55|P-value:9.72E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.59|P-value:4.11E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:6.57|P-value:9.39E-9 ID:SGTC_1318|Compound:1280-3875|FD-Score:6.05|P-value:1.10E-7 ID:SGTC_1426|Compound:4048-4480|FD-Score:4.20|P-value:1.53E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:4.51|P-value:5.41E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.75|P-value:2.69E-11 ID:SGTC_1800|Compound:st050079|FD-Score:-4.16|P-value:2.24E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.28|P-value:1.54E-4 ID:SGTC_1871|Compound:st057448|FD-Score:-3.67|P-value:9.92E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-4.52|P-value:6.76E-5 ID:SGTC_2086|Compound:5274770|FD-Score:4.22|P-value:1.46E-4 ID:SGTC_2122|Compound:5258151|FD-Score:4.70|P-value:2.72E-5 ID:SGTC_2171|Compound:5739187|FD-Score:4.47|P-value:6.30E-5 ID:SGTC_2323|Compound:6148992|FD-Score:3.87|P-value:4.42E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-4.62|P-value:4.82E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.77|P-value:7.52E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.89|P-value:4.18E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.40|P-value:7.86E-5 ID:SGTC_2696|Compound:st077691|FD-Score:4.08|P-value:2.30E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.83|P-value:5.03E-4 ID:SGTC_2805|Compound:7950783|FD-Score:4.76|P-value:2.25E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.69|P-value:7.54E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.27|P-value:1.58E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-5.30|P-value:3.73E-6 ID:SGTC_2934|Compound:9036370|FD-Score:5.96|P-value:1.67E-7 ID:SGTC_2937|Compound:9044753|FD-Score:6.16|P-value:6.48E-8 ID:SGTC_3019|Compound:9081971|FD-Score:3.71|P-value:7.16E-4 ID:SGTC_3028|Compound:9087778|FD-Score:4.74|P-value:2.34E-5 ID:SGTC_3203|Compound:9113543|FD-Score:4.49|P-value:5.89E-5 ID:SGTC_3303|Compound:9125618|FD-Score:-4.91|P-value:1.68E-5 ID:SGTC_3347|Compound:9188721|FD-Score:4.29|P-value:1.13E-4

Top fitness defect scores for YML110C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_36 0335-0881 19.20 14.2 µM 1.22E-60 ubiquinone biosynthesis & proteasome 5 1.46E-82
2 SGTC_86 0417-1630 16.10 471.9 µM 2.32E-43 ubiquinone biosynthesis & proteasome 15 8.62E-59
3 SGTC_236 1509-0011 14.50 5.3 µM 1.80E-35 109 6.06E-48
4 SGTC_158 k038-0087 12.50 26.4 µM 8.20E-27 ubiquinone biosynthesis & proteasome 18 4.75E-36
5 SGTC_64 000l-0018 12.50 272.1 µM 1.01E-26 ubiquinone biosynthesis & proteasome 28 6.29E-36
6 SGTC_142 0335-0849 9.53 62.7 µM 1.95E-16 ubiquinone biosynthesis & proteasome 35 8.09E-22
7 SGTC_794 k038-0031 7.66 316.0 µM 2.83E-11 ubiquinone biosynthesis & proteasome 36 9.30E-15
8 SGTC_216 k038-0035 6.92 28.4 µM 1.62E-9 ubiquinone biosynthesis & proteasome 16 2.32E-12
9 SGTC_200 k038-0079 6.80 37.5 µM 2.92E-9 ubiquinone biosynthesis & proteasome 21 5.20E-12
10 SGTC_1137 ixabepilone 6.57 100.0 µM 9.39E-9 4 2.55E-11
11 SGTC_118 0083-0097 6.46 135.3 µM 1.60E-8 translation 12 5.27E-11
12 SGTC_996 3970-0799 6.40 1.8 µM 2.14E-8 30 7.83E-11
13 SGTC_2937 9044753 6.16 11.3 µM 6.48E-8 60S ribosome export 6 3.54E-10
14 SGTC_67 0335-0847 6.08 266.0 µM 9.42E-8 ubiquinone biosynthesis & proteasome 67 5.89E-10
15 SGTC_104 0074-0074 6.06 591.0 µM 1.06E-7 3 6.95E-10
16 SGTC_1318 1280-3875 6.05 124.0 µM 1.10E-7 3 7.23E-10
17 SGTC_2934 9036370 5.96 36.9 µM 1.67E-7 11 1.28E-9
18 SGTC_1125 tnp00248 5.55 1.3 µM 9.72E-7 7 1.40E-8
19 SGTC_119 0121-0043 5.42 24.8 µM 1.68E-6 mitochondrial stress 35 2.95E-8
20 SGTC_173 1273-0061 5.35 2.7 µM 2.26E-6 mitochondrial stress 133 4.41E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.607 0 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.593 1.75E-318 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.549 7.63E-264 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.547 2.46E-261 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.540 8.93E-254 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.535 1.14E-247 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.532 4.00E-245 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.513 4.92E-224 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.496 2.46E-207 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.454 4.10E-170 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.430 3.86E-151 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.423 9.95E-146 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.412 1.18E-137 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.411 4.82E-137 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.403 3.73E-131 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes