YML111W / BUL2

Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YML111W / BUL2

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:2.94|P-value:9.42E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.78|P-value:3.10E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:4.43|P-value:1.41E-6 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.94|P-value:1.50E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.97|P-value:1.33E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.00|P-value:7.42E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.42|P-value:1.49E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.01|P-value:7.30E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:-2.97|P-value:8.26E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:-3.29|P-value:2.48E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.28|P-value:2.62E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.59|P-value:7.34E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:-2.94|P-value:9.16E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.10|P-value:7.12E-6 ID:SGTC_1088|Compound:bifonazole|FD-Score:5.80|P-value:4.28E-10 ID:SGTC_1222|Compound:0366-0074|FD-Score:-3.30|P-value:2.42E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.13|P-value:4.56E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.01|P-value:7.23E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.72|P-value:4.15E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:-4.47|P-value:1.14E-6 ID:SGTC_1513|Compound:0337-0559|FD-Score:-4.72|P-value:3.00E-7 ID:SGTC_1522|Compound:st012842|FD-Score:3.82|P-value:2.59E-5 ID:SGTC_1847|Compound:st056231|FD-Score:-4.28|P-value:2.98E-6 ID:SGTC_1861|Compound:st057647|FD-Score:3.60|P-value:7.07E-5 ID:SGTC_1886|Compound:st057356|FD-Score:2.99|P-value:7.87E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.01|P-value:7.28E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.86|P-value:2.17E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.84|P-value:1.54E-7 ID:SGTC_2432|Compound:5630864|FD-Score:5.16|P-value:2.44E-8 ID:SGTC_2478|Compound:5763493|FD-Score:-3.08|P-value:5.59E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.13|P-value:4.68E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.03|P-value:6.79E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.07|P-value:5.82E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.47|P-value:1.18E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.79|P-value:2.97E-5 ID:SGTC_2591|Compound:skatole|FD-Score:-4.06|P-value:8.52E-6 ID:SGTC_2601|Compound:securinine|FD-Score:-3.33|P-value:2.14E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.93|P-value:1.58E-5 ID:SGTC_2900|Compound:5328528|FD-Score:-3.54|P-value:8.83E-5 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.07|P-value:5.79E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.22|P-value:3.26E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.50|P-value:1.07E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.03|P-value:6.70E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.08|P-value:5.48E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.56|P-value:8.21E-5 ID:SGTC_3201|Compound:9113999|FD-Score:-3.60|P-value:6.83E-5 ID:SGTC_3204|Compound:9114183|FD-Score:3.57|P-value:7.89E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-4.14|P-value:5.84E-6 ID:SGTC_3303|Compound:9125618|FD-Score:3.33|P-value:2.09E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-2.93|P-value:9.54E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.66|P-value:5.35E-5 ID:SGTC_3318|Compound:9139014|FD-Score:2.96|P-value:8.72E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:2.94|P-value:9.42E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.78|P-value:3.10E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:4.43|P-value:1.41E-6 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.94|P-value:1.50E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.97|P-value:1.33E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.00|P-value:7.42E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.42|P-value:1.49E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.01|P-value:7.30E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:-2.97|P-value:8.26E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:-3.29|P-value:2.48E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.28|P-value:2.62E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.59|P-value:7.34E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:-2.94|P-value:9.16E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.10|P-value:7.12E-6 ID:SGTC_1088|Compound:bifonazole|FD-Score:5.80|P-value:4.28E-10 ID:SGTC_1222|Compound:0366-0074|FD-Score:-3.30|P-value:2.42E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.13|P-value:4.56E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.01|P-value:7.23E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.72|P-value:4.15E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:-4.47|P-value:1.14E-6 ID:SGTC_1513|Compound:0337-0559|FD-Score:-4.72|P-value:3.00E-7 ID:SGTC_1522|Compound:st012842|FD-Score:3.82|P-value:2.59E-5 ID:SGTC_1847|Compound:st056231|FD-Score:-4.28|P-value:2.98E-6 ID:SGTC_1861|Compound:st057647|FD-Score:3.60|P-value:7.07E-5 ID:SGTC_1886|Compound:st057356|FD-Score:2.99|P-value:7.87E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.01|P-value:7.28E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.86|P-value:2.17E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.84|P-value:1.54E-7 ID:SGTC_2432|Compound:5630864|FD-Score:5.16|P-value:2.44E-8 ID:SGTC_2478|Compound:5763493|FD-Score:-3.08|P-value:5.59E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.13|P-value:4.68E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.03|P-value:6.79E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.07|P-value:5.82E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.47|P-value:1.18E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.79|P-value:2.97E-5 ID:SGTC_2591|Compound:skatole|FD-Score:-4.06|P-value:8.52E-6 ID:SGTC_2601|Compound:securinine|FD-Score:-3.33|P-value:2.14E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.93|P-value:1.58E-5 ID:SGTC_2900|Compound:5328528|FD-Score:-3.54|P-value:8.83E-5 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.07|P-value:5.79E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.22|P-value:3.26E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.50|P-value:1.07E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.03|P-value:6.70E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.08|P-value:5.48E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.56|P-value:8.21E-5 ID:SGTC_3201|Compound:9113999|FD-Score:-3.60|P-value:6.83E-5 ID:SGTC_3204|Compound:9114183|FD-Score:3.57|P-value:7.89E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-4.14|P-value:5.84E-6 ID:SGTC_3303|Compound:9125618|FD-Score:3.33|P-value:2.09E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-2.93|P-value:9.54E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.66|P-value:5.35E-5 ID:SGTC_3318|Compound:9139014|FD-Score:2.96|P-value:8.72E-4

Top fitness defect scores for YML111W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1088 bifonazole 5.80 369.0 nM 4.28E-10 2 3.39E-9
2 SGTC_2432 5630864 5.16 12.2 µM 2.44E-8 7 1.27E-7
3 SGTC_435 c-PAF 4.43 6.7 µM 1.41E-6 27 4.80E-6
4 SGTC_1065 prochlorperazine maleate 4.10 2.5 µM 7.12E-6 11 2.06E-5
5 SGTC_503 tyrphostin 8 3.94 294.0 µM 1.50E-5 TSC3-RPN4 26 4.01E-5
6 SGTC_2760 etidronate 3.93 98.0 µM 1.58E-5 27 4.21E-5
7 SGTC_2416 tofa 3.86 880.0 nM 2.17E-5 sphingolipid biosynthesis & PDR1 54 5.59E-5
8 SGTC_1522 st012842 3.82 45.6 µM 2.59E-5 RNA pol III & RNase P/MRP 29 6.55E-5
9 SGTC_342 k048-0088 3.78 23.3 µM 3.10E-5 RSC & ERG11 23 7.69E-5
10 SGTC_3315 9136395 3.66 68.5 µM 5.35E-5 12 1.26E-4
11 SGTC_1861 st057647 3.60 17.4 µM 7.07E-5 32 1.62E-4
12 SGTC_895 0964-0006 3.59 13.7 µM 7.34E-5 23 1.67E-4
13 SGTC_3204 9114183 3.57 49.5 µM 7.89E-5 47 1.78E-4
14 SGTC_3187 9109394 3.56 49.5 µM 8.21E-5 Golgi 39 1.85E-4
15 SGTC_2950 9072895 3.50 21.5 µM 1.07E-4 61 2.34E-4
16 SGTC_567 1080-0542 3.42 68.4 µM 1.49E-4 29 3.16E-4
17 SGTC_3303 9125618 3.33 40.6 µM 2.09E-4 69 4.27E-4
18 SGTC_665 3914-0008 3.28 307.0 µM 2.62E-4 41 5.25E-4
19 SGTC_1307 1187-1599 3.13 12.2 µM 4.56E-4 PDR1 31 8.63E-4
20 SGTC_2513 baicalein 3.13 25.6 µM 4.68E-4 calcium & mitochondrial duress 55 8.83E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.04E-12 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.103 2.25E-9 YDL127W PCL2 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth
0.101 4.52E-9 YHR124W NDT80 hom Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)
0.100 6.46E-9 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.087 4.08E-7 YPL243W SRP68 het Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.084 1.09E-6 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.084 1.17E-6 YHR028C DAP2 hom Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p
0.074 1.65E-5 YPL216W_p YPL216W_p hom Putative protein of unknown function; YPL216W is not an essential gene
0.074 1.78E-5 YNL311C SKP2 hom F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments
0.073 2.58E-5 YKL009W MRT4 hom Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
0.072 2.73E-5 YIL011W TIR3 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
0.070 5.49E-5 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.069 6.51E-5 YLL015W BPT1 hom ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p
0.069 6.91E-5 YBR080C SEC18 het ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF
0.068 7.55E-5 YDR327W_d YDR327W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1