HIPHOP chemogenomics database
YML111W / BUL2 
Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YML111W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.121 | 2.04E-12 | YKR028W | SAP190 | hom | Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication |
| 0.103 | 2.25E-9 | YDL127W | PCL2 | hom | Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth |
| 0.101 | 4.52E-9 | YHR124W | NDT80 | hom | Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) |
| 0.100 | 6.46E-9 | YIL019W | FAF1 | het | Protein required for pre-rRNA processing and 40S ribosomal subunit assembly |
| 0.087 | 4.08E-7 | YPL243W | SRP68 | het | Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress |
| 0.084 | 1.09E-6 | YIR012W | SQT1 | het | Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress |
| 0.084 | 1.17E-6 | YHR028C | DAP2 | hom | Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p |
| 0.074 | 1.65E-5 | YPL216W_p | YPL216W_p | hom | Putative protein of unknown function; YPL216W is not an essential gene |
| 0.074 | 1.78E-5 | YNL311C | SKP2 | hom | F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments |
| 0.073 | 2.58E-5 | YKL009W | MRT4 | hom | Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus |
| 0.072 | 2.73E-5 | YIL011W | TIR3 | hom | Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth |
| 0.070 | 5.49E-5 | YDL199C_p | YDL199C_p | hom | Putative transporter, member of the sugar porter family |
| 0.069 | 6.51E-5 | YLL015W | BPT1 | hom | ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p |
| 0.069 | 6.91E-5 | YBR080C | SEC18 | het | ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF |
| 0.068 | 7.55E-5 | YDR327W_d | YDR327W_d | het | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1 |