YML116W-A_d

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YML116W-A / YML116W-A

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.15|P-value:8.62E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:2.71|P-value:6.33E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:2.97|P-value:2.00E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.10|P-value:1.14E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.34|P-value:3.42E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:2.68|P-value:6.93E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.09|P-value:1.15E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-2.79|P-value:4.69E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.54|P-value:1.22E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.20|P-value:3.32E-10 ID:SGTC_826|Compound:1683-5028|FD-Score:2.69|P-value:6.69E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:2.91|P-value:2.60E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.79|P-value:3.20E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:2.72|P-value:5.95E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-4.30|P-value:1.62E-7 ID:SGTC_970|Compound:1315-0089|FD-Score:-2.79|P-value:4.61E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-2.98|P-value:1.99E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-4.51|P-value:4.31E-8 ID:SGTC_1370|Compound:2001-0092|FD-Score:2.81|P-value:4.01E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:2.62|P-value:8.92E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.32|P-value:3.86E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:2.67|P-value:7.28E-4 ID:SGTC_1751|Compound:st044839|FD-Score:2.92|P-value:2.53E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-2.83|P-value:3.87E-4 ID:SGTC_1917|Compound:st066507|FD-Score:2.83|P-value:3.74E-4 ID:SGTC_1978|Compound:st071761|FD-Score:-3.23|P-value:6.41E-5 ID:SGTC_2051|Compound:5263410|FD-Score:-3.57|P-value:1.11E-5 ID:SGTC_2058|Compound:5236698|FD-Score:-3.53|P-value:1.37E-5 ID:SGTC_2166|Compound:5933061|FD-Score:3.00|P-value:1.73E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.51|P-value:1.51E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.16|P-value:3.58E-7 ID:SGTC_2701|Compound:st077767|FD-Score:2.66|P-value:7.72E-4 ID:SGTC_2716|Compound:st080858|FD-Score:2.79|P-value:4.47E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.91|P-value:2.52E-9 ID:SGTC_2785|Compound:7756463|FD-Score:2.93|P-value:2.36E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-2.69|P-value:6.98E-4 ID:SGTC_2999|Compound:9069765|FD-Score:2.79|P-value:4.49E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.80|P-value:3.02E-6 ID:SGTC_3073|Compound:9114972|FD-Score:3.31|P-value:4.04E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-4.92|P-value:2.60E-9 ID:SGTC_3314|Compound:9135860|FD-Score:3.24|P-value:5.68E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.15|P-value:8.62E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:2.71|P-value:6.33E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:2.97|P-value:2.00E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.10|P-value:1.14E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.34|P-value:3.42E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:2.68|P-value:6.93E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.09|P-value:1.15E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-2.79|P-value:4.69E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.54|P-value:1.22E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.20|P-value:3.32E-10 ID:SGTC_826|Compound:1683-5028|FD-Score:2.69|P-value:6.69E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:2.91|P-value:2.60E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.79|P-value:3.20E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:2.72|P-value:5.95E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-4.30|P-value:1.62E-7 ID:SGTC_970|Compound:1315-0089|FD-Score:-2.79|P-value:4.61E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-2.98|P-value:1.99E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-4.51|P-value:4.31E-8 ID:SGTC_1370|Compound:2001-0092|FD-Score:2.81|P-value:4.01E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:2.62|P-value:8.92E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.32|P-value:3.86E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:2.67|P-value:7.28E-4 ID:SGTC_1751|Compound:st044839|FD-Score:2.92|P-value:2.53E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-2.83|P-value:3.87E-4 ID:SGTC_1917|Compound:st066507|FD-Score:2.83|P-value:3.74E-4 ID:SGTC_1978|Compound:st071761|FD-Score:-3.23|P-value:6.41E-5 ID:SGTC_2051|Compound:5263410|FD-Score:-3.57|P-value:1.11E-5 ID:SGTC_2058|Compound:5236698|FD-Score:-3.53|P-value:1.37E-5 ID:SGTC_2166|Compound:5933061|FD-Score:3.00|P-value:1.73E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.51|P-value:1.51E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.16|P-value:3.58E-7 ID:SGTC_2701|Compound:st077767|FD-Score:2.66|P-value:7.72E-4 ID:SGTC_2716|Compound:st080858|FD-Score:2.79|P-value:4.47E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.91|P-value:2.52E-9 ID:SGTC_2785|Compound:7756463|FD-Score:2.93|P-value:2.36E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-2.69|P-value:6.98E-4 ID:SGTC_2999|Compound:9069765|FD-Score:2.79|P-value:4.49E-4 ID:SGTC_3069|Compound:9117009|FD-Score:3.80|P-value:3.02E-6 ID:SGTC_3073|Compound:9114972|FD-Score:3.31|P-value:4.04E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-4.92|P-value:2.60E-9 ID:SGTC_3314|Compound:9135860|FD-Score:3.24|P-value:5.68E-5

Top fitness defect scores for YML116W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2763 lisinopril 4.91 49.3 µM 2.52E-9 5 4.55E-7
2 SGTC_2584 androsterone 4.16 48.7 µM 3.58E-7 cell wall 120 1.57E-5
3 SGTC_3069 9117009 3.80 49.5 µM 3.02E-6 60S ribosome export 10 7.23E-5
4 SGTC_922 1866-0035 3.79 480.0 µM 3.20E-6 excess fatty acid 67 7.54E-5
5 SGTC_638 3970-0837 3.54 4.1 µM 1.22E-5 54 1.97E-4
6 SGTC_426 0988-0037 3.34 14.6 µM 3.42E-5 ERAD & cell cycle 61 4.14E-4
7 SGTC_1685 st024049 3.32 53.1 µM 3.86E-5 TSC3-RPN4 31 4.52E-4
8 SGTC_3073 9114972 3.31 49.5 µM 4.04E-5 60S ribosome export 28 4.67E-4
9 SGTC_3314 9135860 3.24 59.4 µM 5.68E-5 40 5.97E-4
10 SGTC_58 0957-0393 3.15 9.0 µM 8.62E-5 cell wall 474 8.07E-4
11 SGTC_453 enantio-paf c16 3.09 10.0 µM 1.15E-4 232 9.94E-4
12 SGTC_2166 5933061 3.00 31.5 µM 1.73E-4 tubulin folding & SWR complex 88 0.00134
13 SGTC_158 k038-0087 2.97 26.4 µM 2.00E-4 ubiquinone biosynthesis & proteasome 216 0.00148
14 SGTC_2785 7756463 2.93 72.7 µM 2.36E-4 81 0.00167
15 SGTC_1751 st044839 2.92 27.2 µM 2.53E-4 Golgi 34 0.00176
16 SGTC_910 3454-3003 2.91 490.0 µM 2.60E-4 70 0.00179
17 SGTC_1917 st066507 2.83 28.5 µM 3.74E-4 Golgi 118 0.00233
18 SGTC_1370 2001-0092 2.81 44.6 µM 4.01E-4 107 0.00245
19 SGTC_2716 st080858 2.79 38.6 µM 4.47E-4 60S ribosome export 65 0.00265
20 SGTC_2999 9069765 2.79 71.4 µM 4.49E-4 amide catabolism 97 0.00266

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.225 1.40E-39 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.199 1.93E-31 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.186 1.32E-27 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.180 7.28E-26 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.167 2.59E-22 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.165 7.24E-22 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.162 3.12E-21 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.157 5.66E-20 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.156 8.42E-20 YLL060C GTT2 hom Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress
0.155 1.32E-19 YMR136W GAT2 hom Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
0.153 4.31E-19 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.150 1.84E-18 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.148 7.02E-18 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.146 1.77E-17 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.140 3.48E-16 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event