YML122C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YML122C / YML122C

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:5.00|P-value:4.90E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:4.77|P-value:8.45E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:4.75|P-value:8.79E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:8.20|P-value:2.78E-8 ID:SGTC_50|Compound:0929-0078|FD-Score:8.27|P-value:2.15E-8 ID:SGTC_54|Compound:0159-0055|FD-Score:-4.63|P-value:8.74E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:11.00|P-value:1.48E-13 ID:SGTC_58|Compound:0957-0393|FD-Score:8.08|P-value:4.36E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:5.24|P-value:2.77E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:6.84|P-value:3.04E-6 ID:SGTC_95|Compound:0471-0001|FD-Score:-4.82|P-value:5.59E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-5.70|P-value:6.01E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:7.49|P-value:3.52E-7 ID:SGTC_129|Compound:0088-0017|FD-Score:7.20|P-value:9.40E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:4.99|P-value:5.01E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:5.54|P-value:1.29E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:5.91|P-value:4.74E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:7.72|P-value:1.58E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:-6.00|P-value:2.66E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:5.89|P-value:5.01E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:6.92|P-value:2.33E-6 ID:SGTC_548|Compound:1436-0017|FD-Score:8.23|P-value:2.49E-8 ID:SGTC_733|Compound:4069-0007|FD-Score:-5.01|P-value:3.55E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:4.95|P-value:5.48E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.30|P-value:2.38E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:5.68|P-value:8.88E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:7.92|P-value:7.99E-8 ID:SGTC_879|Compound:0831-1030|FD-Score:8.00|P-value:5.94E-8 ID:SGTC_974|Compound:1326-0144|FD-Score:5.30|P-value:2.37E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:6.40|P-value:1.17E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.76|P-value:8.66E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:6.19|P-value:2.15E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:5.36|P-value:2.02E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:7.98|P-value:6.23E-8 ID:SGTC_1193|Compound:1488-0126|FD-Score:6.10|P-value:2.79E-5 ID:SGTC_1210|Compound:3013-0140|FD-Score:-5.21|P-value:2.18E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:-5.70|P-value:6.09E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:6.96|P-value:2.09E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:14.80|P-value:3.81E-23 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.95|P-value:5.49E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:5.25|P-value:2.69E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:5.20|P-value:2.99E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:-5.28|P-value:1.84E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:4.92|P-value:5.98E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:8.31|P-value:1.84E-8 ID:SGTC_1547|Compound:harmine|FD-Score:-4.60|P-value:9.38E-4 ID:SGTC_1616|Compound:st002734|FD-Score:8.66|P-value:4.82E-9 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:5.01|P-value:4.74E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-8.38|P-value:8.87E-9 ID:SGTC_1637|Compound:st007924|FD-Score:-7.20|P-value:6.43E-7 ID:SGTC_1687|Compound:st020778|FD-Score:17.20|P-value:2.01E-30 ID:SGTC_1694|Compound:st024011|FD-Score:5.58|P-value:1.16E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-5.12|P-value:2.72E-4 ID:SGTC_1850|Compound:st056238|FD-Score:5.97|P-value:4.04E-5 ID:SGTC_1855|Compound:st056195|FD-Score:-5.24|P-value:2.03E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:7.51|P-value:3.32E-7 ID:SGTC_1877|Compound:wortmannin|FD-Score:7.48|P-value:3.71E-7 ID:SGTC_1884|Compound:5633444|FD-Score:4.78|P-value:8.13E-4 ID:SGTC_1909|Compound:st060837|FD-Score:6.60|P-value:6.38E-6 ID:SGTC_1919|Compound:st067113|FD-Score:-5.66|P-value:6.81E-5 ID:SGTC_1934|Compound:st074720|FD-Score:5.40|P-value:1.85E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.82|P-value:7.49E-4 ID:SGTC_2053|Compound:5265679|FD-Score:4.86|P-value:6.84E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-5.43|P-value:1.25E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:7.99|P-value:6.12E-8 ID:SGTC_2268|Compound:7933382|FD-Score:5.57|P-value:1.17E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-5.88|P-value:3.67E-5 ID:SGTC_2276|Compound:7947513|FD-Score:6.25|P-value:1.81E-5 ID:SGTC_2293|Compound:7624732|FD-Score:7.10|P-value:1.34E-6 ID:SGTC_2296|Compound:7971656|FD-Score:5.20|P-value:3.03E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-5.30|P-value:1.74E-4 ID:SGTC_2312|Compound:7706453|FD-Score:5.08|P-value:4.02E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-5.25|P-value:1.98E-4 ID:SGTC_2411|Compound:st077133|FD-Score:15.80|P-value:4.56E-26 ID:SGTC_2415|Compound:st077333|FD-Score:9.74|P-value:5.40E-11 ID:SGTC_2437|Compound:5741531|FD-Score:4.70|P-value:9.92E-4 ID:SGTC_2472|Compound:5377652|FD-Score:11.50|P-value:1.03E-14 ID:SGTC_2486|Compound:5283202|FD-Score:5.19|P-value:3.09E-4 ID:SGTC_2488|Compound:5268135|FD-Score:7.41|P-value:4.64E-7 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:4.78|P-value:8.13E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:6.67|P-value:5.13E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:6.63|P-value:5.90E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.28|P-value:2.47E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:-5.75|P-value:5.22E-5 ID:SGTC_2695|Compound:st077686|FD-Score:5.65|P-value:9.71E-5 ID:SGTC_2701|Compound:st077767|FD-Score:5.99|P-value:3.77E-5 ID:SGTC_2713|Compound:st079149|FD-Score:5.48|P-value:1.51E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:7.90|P-value:8.55E-8 ID:SGTC_2781|Compound:5567276|FD-Score:5.27|P-value:2.54E-4 ID:SGTC_2783|Compound:7738165|FD-Score:6.62|P-value:5.95E-6 ID:SGTC_2789|Compound:5281112|FD-Score:6.83|P-value:3.10E-6 ID:SGTC_2820|Compound:7989630|FD-Score:5.07|P-value:4.16E-4 ID:SGTC_2845|Compound:9003024|FD-Score:6.10|P-value:2.77E-5 ID:SGTC_2852|Compound:9023854|FD-Score:5.88|P-value:5.12E-5 ID:SGTC_2860|Compound:9025725|FD-Score:5.49|P-value:1.46E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-4.82|P-value:5.63E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-5.74|P-value:5.42E-5 ID:SGTC_2980|Compound:9014342|FD-Score:7.04|P-value:1.62E-6 ID:SGTC_2981|Compound:9013952|FD-Score:7.21|P-value:9.17E-7 ID:SGTC_3065|Compound:9113888|FD-Score:5.14|P-value:3.52E-4 ID:SGTC_3098|Compound:9119039|FD-Score:6.55|P-value:7.38E-6 ID:SGTC_3119|Compound:9125183|FD-Score:7.60|P-value:2.41E-7 ID:SGTC_3168|Compound:9103419|FD-Score:4.97|P-value:5.30E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.73|P-value:9.23E-4 ID:SGTC_3237|Compound:9133362|FD-Score:4.91|P-value:6.05E-4 ID:SGTC_5|Compound:0352-0601|FD-Score:5.00|P-value:4.90E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:4.77|P-value:8.45E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:4.75|P-value:8.79E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:8.20|P-value:2.78E-8 ID:SGTC_50|Compound:0929-0078|FD-Score:8.27|P-value:2.15E-8 ID:SGTC_54|Compound:0159-0055|FD-Score:-4.63|P-value:8.74E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:11.00|P-value:1.48E-13 ID:SGTC_58|Compound:0957-0393|FD-Score:8.08|P-value:4.36E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:5.24|P-value:2.77E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:6.84|P-value:3.04E-6 ID:SGTC_95|Compound:0471-0001|FD-Score:-4.82|P-value:5.59E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-5.70|P-value:6.01E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:7.49|P-value:3.52E-7 ID:SGTC_129|Compound:0088-0017|FD-Score:7.20|P-value:9.40E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:4.99|P-value:5.01E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:5.54|P-value:1.29E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:5.91|P-value:4.74E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:7.72|P-value:1.58E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:-6.00|P-value:2.66E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:5.89|P-value:5.01E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:6.92|P-value:2.33E-6 ID:SGTC_548|Compound:1436-0017|FD-Score:8.23|P-value:2.49E-8 ID:SGTC_733|Compound:4069-0007|FD-Score:-5.01|P-value:3.55E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:4.95|P-value:5.48E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.30|P-value:2.38E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:5.68|P-value:8.88E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:7.92|P-value:7.99E-8 ID:SGTC_879|Compound:0831-1030|FD-Score:8.00|P-value:5.94E-8 ID:SGTC_974|Compound:1326-0144|FD-Score:5.30|P-value:2.37E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:6.40|P-value:1.17E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.76|P-value:8.66E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:6.19|P-value:2.15E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:5.36|P-value:2.02E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:7.98|P-value:6.23E-8 ID:SGTC_1193|Compound:1488-0126|FD-Score:6.10|P-value:2.79E-5 ID:SGTC_1210|Compound:3013-0140|FD-Score:-5.21|P-value:2.18E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:-5.70|P-value:6.09E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:6.96|P-value:2.09E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:14.80|P-value:3.81E-23 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.95|P-value:5.49E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:5.25|P-value:2.69E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:5.20|P-value:2.99E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:-5.28|P-value:1.84E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:4.92|P-value:5.98E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:8.31|P-value:1.84E-8 ID:SGTC_1547|Compound:harmine|FD-Score:-4.60|P-value:9.38E-4 ID:SGTC_1616|Compound:st002734|FD-Score:8.66|P-value:4.82E-9 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:5.01|P-value:4.74E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-8.38|P-value:8.87E-9 ID:SGTC_1637|Compound:st007924|FD-Score:-7.20|P-value:6.43E-7 ID:SGTC_1687|Compound:st020778|FD-Score:17.20|P-value:2.01E-30 ID:SGTC_1694|Compound:st024011|FD-Score:5.58|P-value:1.16E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-5.12|P-value:2.72E-4 ID:SGTC_1850|Compound:st056238|FD-Score:5.97|P-value:4.04E-5 ID:SGTC_1855|Compound:st056195|FD-Score:-5.24|P-value:2.03E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:7.51|P-value:3.32E-7 ID:SGTC_1877|Compound:wortmannin|FD-Score:7.48|P-value:3.71E-7 ID:SGTC_1884|Compound:5633444|FD-Score:4.78|P-value:8.13E-4 ID:SGTC_1909|Compound:st060837|FD-Score:6.60|P-value:6.38E-6 ID:SGTC_1919|Compound:st067113|FD-Score:-5.66|P-value:6.81E-5 ID:SGTC_1934|Compound:st074720|FD-Score:5.40|P-value:1.85E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.82|P-value:7.49E-4 ID:SGTC_2053|Compound:5265679|FD-Score:4.86|P-value:6.84E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-5.43|P-value:1.25E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:7.99|P-value:6.12E-8 ID:SGTC_2268|Compound:7933382|FD-Score:5.57|P-value:1.17E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-5.88|P-value:3.67E-5 ID:SGTC_2276|Compound:7947513|FD-Score:6.25|P-value:1.81E-5 ID:SGTC_2293|Compound:7624732|FD-Score:7.10|P-value:1.34E-6 ID:SGTC_2296|Compound:7971656|FD-Score:5.20|P-value:3.03E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-5.30|P-value:1.74E-4 ID:SGTC_2312|Compound:7706453|FD-Score:5.08|P-value:4.02E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-5.25|P-value:1.98E-4 ID:SGTC_2411|Compound:st077133|FD-Score:15.80|P-value:4.56E-26 ID:SGTC_2415|Compound:st077333|FD-Score:9.74|P-value:5.40E-11 ID:SGTC_2437|Compound:5741531|FD-Score:4.70|P-value:9.92E-4 ID:SGTC_2472|Compound:5377652|FD-Score:11.50|P-value:1.03E-14 ID:SGTC_2486|Compound:5283202|FD-Score:5.19|P-value:3.09E-4 ID:SGTC_2488|Compound:5268135|FD-Score:7.41|P-value:4.64E-7 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:4.78|P-value:8.13E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:6.67|P-value:5.13E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:6.63|P-value:5.90E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.28|P-value:2.47E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:-5.75|P-value:5.22E-5 ID:SGTC_2695|Compound:st077686|FD-Score:5.65|P-value:9.71E-5 ID:SGTC_2701|Compound:st077767|FD-Score:5.99|P-value:3.77E-5 ID:SGTC_2713|Compound:st079149|FD-Score:5.48|P-value:1.51E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:7.90|P-value:8.55E-8 ID:SGTC_2781|Compound:5567276|FD-Score:5.27|P-value:2.54E-4 ID:SGTC_2783|Compound:7738165|FD-Score:6.62|P-value:5.95E-6 ID:SGTC_2789|Compound:5281112|FD-Score:6.83|P-value:3.10E-6 ID:SGTC_2820|Compound:7989630|FD-Score:5.07|P-value:4.16E-4 ID:SGTC_2845|Compound:9003024|FD-Score:6.10|P-value:2.77E-5 ID:SGTC_2852|Compound:9023854|FD-Score:5.88|P-value:5.12E-5 ID:SGTC_2860|Compound:9025725|FD-Score:5.49|P-value:1.46E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-4.82|P-value:5.63E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-5.74|P-value:5.42E-5 ID:SGTC_2980|Compound:9014342|FD-Score:7.04|P-value:1.62E-6 ID:SGTC_2981|Compound:9013952|FD-Score:7.21|P-value:9.17E-7 ID:SGTC_3065|Compound:9113888|FD-Score:5.14|P-value:3.52E-4 ID:SGTC_3098|Compound:9119039|FD-Score:6.55|P-value:7.38E-6 ID:SGTC_3119|Compound:9125183|FD-Score:7.60|P-value:2.41E-7 ID:SGTC_3168|Compound:9103419|FD-Score:4.97|P-value:5.30E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.73|P-value:9.23E-4 ID:SGTC_3237|Compound:9133362|FD-Score:4.91|P-value:6.05E-4

Top fitness defect scores for YML122C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1687 st020778 17.20 55.4 µM 2.01E-30 13 3.07E-66
2 SGTC_2411 st077133 15.80 39.9 µM 4.56E-26 RNA pol III & RNase P/MRP 1 1.83E-56
3 SGTC_1287 0971-0001 14.80 34.6 µM 3.81E-23 sphingolipid biosynthesis & PDR1 4 6.57E-50
4 SGTC_2472 5377652 11.50 49.4 µM 1.03E-14 TRP & mitochondrial translation 7 5.12E-31
5 SGTC_56 0957-0365 11.00 83.2 µM 1.48E-13 Golgi 4 2.00E-28
6 SGTC_2415 st077333 9.74 57.7 µM 5.40E-11 1 1.06E-22
7 SGTC_1616 st002734 8.66 56.1 µM 4.82E-9 3 2.38E-18
8 SGTC_1511 0906-3109 8.31 28.5 µM 1.84E-8 excess fatty acid 8 4.69E-17
9 SGTC_50 0929-0078 8.27 56.4 µM 2.15E-8 14 6.67E-17
10 SGTC_548 1436-0017 8.23 110.0 µM 2.49E-8 TSC3-RPN4 5 9.19E-17
11 SGTC_48 0382-0018 8.20 55.0 µM 2.78E-8 1 1.17E-16
12 SGTC_58 0957-0393 8.08 9.0 µM 4.36E-8 cell wall 121 3.20E-16
13 SGTC_879 0831-1030 8.00 162.0 µM 5.94E-8 7 6.36E-16
14 SGTC_2232 chlorophetanol 7.99 41.5 µM 6.12E-8 TRP & mitochondrial translation 19 6.82E-16
15 SGTC_1192 1488-0095 7.98 21.4 µM 6.23E-8 1 7.07E-16
16 SGTC_841 0251-0215 7.92 91.2 µM 7.99E-8 21 1.23E-15
17 SGTC_2741 miltefosine 7.90 3.0 µM 8.55E-8 10 1.43E-15
18 SGTC_356 1634-0012 7.72 32.5 µM 1.58E-7 2 5.64E-15
19 SGTC_3119 9125183 7.60 49.5 µM 2.41E-7 1 1.44E-14
20 SGTC_1872 amphotericin b 7.51 148.0 nM 3.32E-7 RNA pol III & RNase P/MRP 8 2.92E-14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 7.01E-31 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.198 8.28E-31 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.188 5.08E-28 YML123C PHO84 hom High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity
0.184 5.40E-27 YKL077W_p YKL077W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.175 2.01E-24 YOL051W GAL11 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator
0.173 7.45E-24 YGR064W_d YGR064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C
0.167 2.65E-22 YLR372W SUR4 hom Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
0.162 5.53E-21 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.161 7.88E-21 YNL235C_d YNL235C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex
0.158 4.83E-20 YDR028C REG1 hom Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p
0.146 2.26E-17 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.143 8.30E-17 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.140 3.67E-16 YJR074W MOG1 hom Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
0.139 8.43E-16 YGR063C SPT4 hom Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions
0.137 1.92E-15 YJR059W PTK2 hom Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake