YML124C / TUB3

Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YML124C / TUB3

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:5.20|P-value:5.38E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:5.07|P-value:7.89E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:6.45|P-value:7.26E-7 ID:SGTC_23|Compound:0213-0011|FD-Score:4.27|P-value:7.56E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.28|P-value:4.17E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.88|P-value:1.41E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:6.64|P-value:3.61E-7 ID:SGTC_71|Compound:0417-1750|FD-Score:6.81|P-value:1.87E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:5.07|P-value:8.03E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:4.22|P-value:8.53E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:4.51|P-value:3.93E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.94|P-value:1.17E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:5.29|P-value:3.97E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:13.70|P-value:4.66E-25 ID:SGTC_161|Compound:4065-0411|FD-Score:4.17|P-value:9.64E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:7.46|P-value:1.25E-8 ID:SGTC_210|Compound:3551-0445|FD-Score:17.60|P-value:4.02E-40 ID:SGTC_212|Compound:3807-4682|FD-Score:10.00|P-value:3.32E-14 ID:SGTC_229|Compound:benomyl|FD-Score:20.80|P-value:4.66E-55 ID:SGTC_286|Compound:k060-0067|FD-Score:12.30|P-value:1.78E-20 ID:SGTC_375|Compound:3970-0961|FD-Score:7.98|P-value:1.21E-9 ID:SGTC_376|Compound:3970-0862|FD-Score:6.57|P-value:4.71E-7 ID:SGTC_377|Compound:3970-0964|FD-Score:6.58|P-value:4.48E-7 ID:SGTC_379|Compound:3970-0972|FD-Score:9.52|P-value:5.30E-13 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.23|P-value:8.35E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:6.21|P-value:1.78E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:7.78|P-value:2.99E-9 ID:SGTC_524|Compound:r073-0010|FD-Score:5.47|P-value:2.27E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:5.86|P-value:6.22E-6 ID:SGTC_580|Compound:1123-0028|FD-Score:5.51|P-value:1.97E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:15.00|P-value:1.03E-29 ID:SGTC_638|Compound:3970-0837|FD-Score:16.20|P-value:3.27E-34 ID:SGTC_639|Compound:0833-0042|FD-Score:4.91|P-value:1.28E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:8.81|P-value:2.25E-11 ID:SGTC_735|Compound:3076-0345|FD-Score:5.41|P-value:2.73E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:5.20|P-value:5.34E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:6.58|P-value:4.44E-7 ID:SGTC_829|Compound:1635-0120|FD-Score:4.53|P-value:3.78E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:6.00|P-value:3.84E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:5.19|P-value:5.59E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:4.98|P-value:1.05E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:11.80|P-value:4.45E-19 ID:SGTC_923|Compound:1900-2434|FD-Score:-4.11|P-value:9.05E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:6.62|P-value:3.85E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:5.03|P-value:8.84E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:9.01|P-value:7.94E-12 ID:SGTC_1132|Compound:3456-3614|FD-Score:9.96|P-value:4.54E-14 ID:SGTC_1179|Compound:1021-1431|FD-Score:6.96|P-value:9.94E-8 ID:SGTC_1189|Compound:1431-2119|FD-Score:5.93|P-value:4.88E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:5.56|P-value:1.69E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.71|P-value:2.24E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:5.53|P-value:1.85E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.18|P-value:9.48E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:9.41|P-value:9.59E-13 ID:SGTC_1352|Compound:1496-0991|FD-Score:14.80|P-value:4.75E-29 ID:SGTC_1374|Compound:2889-5571|FD-Score:6.84|P-value:1.61E-7 ID:SGTC_1379|Compound:2144-0755|FD-Score:4.40|P-value:5.29E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:8.38|P-value:1.85E-10 ID:SGTC_1433|Compound:4060-0023|FD-Score:6.10|P-value:2.64E-6 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.82|P-value:1.68E-4 ID:SGTC_1643|Compound:st009866|FD-Score:9.56|P-value:4.26E-13 ID:SGTC_1661|Compound:st013063|FD-Score:5.09|P-value:7.54E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:4.80|P-value:1.77E-4 ID:SGTC_1773|Compound:st048542|FD-Score:5.58|P-value:1.60E-5 ID:SGTC_1802|Compound:st050112|FD-Score:4.53|P-value:3.71E-4 ID:SGTC_1870|Compound:st057514|FD-Score:5.64|P-value:1.29E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:10.60|P-value:1.39E-15 ID:SGTC_1891|Compound:st059073|FD-Score:4.29|P-value:7.10E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.61|P-value:2.98E-4 ID:SGTC_1953|Compound:st076800|FD-Score:16.30|P-value:1.72E-34 ID:SGTC_1955|Compound:wogonin|FD-Score:4.25|P-value:7.85E-4 ID:SGTC_1958|Compound:st076513|FD-Score:6.25|P-value:1.55E-6 ID:SGTC_2040|Compound:5100729|FD-Score:5.23|P-value:4.82E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-5.72|P-value:7.44E-6 ID:SGTC_2061|Compound:5245884|FD-Score:9.46|P-value:7.31E-13 ID:SGTC_2071|Compound:5230951|FD-Score:4.86|P-value:1.48E-4 ID:SGTC_2077|Compound:5212015|FD-Score:7.72|P-value:4.01E-9 ID:SGTC_2089|Compound:5281248|FD-Score:4.23|P-value:8.23E-4 ID:SGTC_2090|Compound:5301565|FD-Score:10.40|P-value:3.18E-15 ID:SGTC_2092|Compound:5303694|FD-Score:4.40|P-value:5.25E-4 ID:SGTC_2125|Compound:5246583|FD-Score:12.10|P-value:4.84E-20 ID:SGTC_2135|Compound:5326629|FD-Score:4.74|P-value:2.11E-4 ID:SGTC_2141|Compound:5621638|FD-Score:7.81|P-value:2.64E-9 ID:SGTC_2161|Compound:5662504|FD-Score:7.35|P-value:2.03E-8 ID:SGTC_2166|Compound:5933061|FD-Score:4.89|P-value:1.35E-4 ID:SGTC_2173|Compound:5763948|FD-Score:5.79|P-value:7.98E-6 ID:SGTC_2174|Compound:5790901|FD-Score:6.80|P-value:1.93E-7 ID:SGTC_2176|Compound:5809774|FD-Score:6.22|P-value:1.73E-6 ID:SGTC_2188|Compound:6126565|FD-Score:4.28|P-value:7.32E-4 ID:SGTC_2200|Compound:6600604|FD-Score:14.50|P-value:6.60E-28 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:9.09|P-value:5.42E-12 ID:SGTC_2233|Compound:sulbentine|FD-Score:10.20|P-value:1.36E-14 ID:SGTC_2254|Compound:7938975|FD-Score:11.80|P-value:6.69E-19 ID:SGTC_2255|Compound:7941087|FD-Score:7.31|P-value:2.34E-8 ID:SGTC_2269|Compound:7935389|FD-Score:5.69|P-value:1.11E-5 ID:SGTC_2302|Compound:7771753|FD-Score:6.64|P-value:3.54E-7 ID:SGTC_2304|Compound:7443016|FD-Score:4.35|P-value:6.04E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-4.83|P-value:1.26E-4 ID:SGTC_2316|Compound:5844804|FD-Score:5.56|P-value:1.68E-5 ID:SGTC_2319|Compound:6033012|FD-Score:18.10|P-value:4.71E-42 ID:SGTC_2322|Compound:7413319|FD-Score:-5.14|P-value:4.84E-5 ID:SGTC_2323|Compound:6148992|FD-Score:8.04|P-value:9.29E-10 ID:SGTC_2352|Compound:9027995|FD-Score:5.04|P-value:8.81E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:5.47|P-value:2.25E-5 ID:SGTC_2430|Compound:5571206|FD-Score:6.23|P-value:1.69E-6 ID:SGTC_2458|Compound:5808907|FD-Score:5.69|P-value:1.10E-5 ID:SGTC_2461|Compound:5755302|FD-Score:6.27|P-value:1.42E-6 ID:SGTC_2466|Compound:5983409|FD-Score:4.72|P-value:2.22E-4 ID:SGTC_2469|Compound:5655019|FD-Score:7.15|P-value:4.60E-8 ID:SGTC_2470|Compound:5664817|FD-Score:5.16|P-value:5.98E-5 ID:SGTC_2479|Compound:5617353|FD-Score:5.13|P-value:6.53E-5 ID:SGTC_2483|Compound:5729050|FD-Score:4.51|P-value:3.94E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:7.16|P-value:4.46E-8 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:13.40|P-value:4.49E-24 ID:SGTC_2532|Compound:xanthone|FD-Score:4.49|P-value:4.21E-4 ID:SGTC_2534|Compound:helenine|FD-Score:10.60|P-value:1.09E-15 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.83|P-value:1.62E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.63|P-value:2.88E-4 ID:SGTC_2832|Compound:7992762|FD-Score:4.26|P-value:7.61E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.32|P-value:5.20E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-8.64|P-value:3.36E-11 ID:SGTC_2845|Compound:9003024|FD-Score:11.10|P-value:6.46E-17 ID:SGTC_2921|Compound:7974240|FD-Score:8.66|P-value:4.84E-11 ID:SGTC_2947|Compound:9072639|FD-Score:8.41|P-value:1.59E-10 ID:SGTC_2952|Compound:9073731|FD-Score:10.90|P-value:1.82E-16 ID:SGTC_2997|Compound:9067075|FD-Score:7.78|P-value:3.06E-9 ID:SGTC_3101|Compound:9120531|FD-Score:4.81|P-value:1.70E-4 ID:SGTC_3166|Compound:9102297|FD-Score:5.89|P-value:5.51E-6 ID:SGTC_3242|Compound:9133940|FD-Score:4.46|P-value:4.55E-4 ID:SGTC_3253|Compound:9135987|FD-Score:5.17|P-value:5.81E-5 ID:SGTC_3267|Compound:9137951|FD-Score:4.41|P-value:5.21E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-5.35|P-value:2.54E-5 ID:SGTC_3274|Compound:9138298|FD-Score:-4.92|P-value:9.45E-5 ID:SGTC_3282|Compound:9108498|FD-Score:11.10|P-value:5.72E-17 ID:SGTC_3294|Compound:9122953|FD-Score:11.00|P-value:8.90E-17 ID:SGTC_3317|Compound:9138495|FD-Score:10.40|P-value:2.65E-15 ID:SGTC_3350|Compound:9150499|FD-Score:4.42|P-value:4.98E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:5.20|P-value:5.38E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:5.07|P-value:7.89E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:6.45|P-value:7.26E-7 ID:SGTC_23|Compound:0213-0011|FD-Score:4.27|P-value:7.56E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.28|P-value:4.17E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.88|P-value:1.41E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:6.64|P-value:3.61E-7 ID:SGTC_71|Compound:0417-1750|FD-Score:6.81|P-value:1.87E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:5.07|P-value:8.03E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:4.22|P-value:8.53E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:4.51|P-value:3.93E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.94|P-value:1.17E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:5.29|P-value:3.97E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:13.70|P-value:4.66E-25 ID:SGTC_161|Compound:4065-0411|FD-Score:4.17|P-value:9.64E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:7.46|P-value:1.25E-8 ID:SGTC_210|Compound:3551-0445|FD-Score:17.60|P-value:4.02E-40 ID:SGTC_212|Compound:3807-4682|FD-Score:10.00|P-value:3.32E-14 ID:SGTC_229|Compound:benomyl|FD-Score:20.80|P-value:4.66E-55 ID:SGTC_286|Compound:k060-0067|FD-Score:12.30|P-value:1.78E-20 ID:SGTC_375|Compound:3970-0961|FD-Score:7.98|P-value:1.21E-9 ID:SGTC_376|Compound:3970-0862|FD-Score:6.57|P-value:4.71E-7 ID:SGTC_377|Compound:3970-0964|FD-Score:6.58|P-value:4.48E-7 ID:SGTC_379|Compound:3970-0972|FD-Score:9.52|P-value:5.30E-13 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.23|P-value:8.35E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:6.21|P-value:1.78E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:7.78|P-value:2.99E-9 ID:SGTC_524|Compound:r073-0010|FD-Score:5.47|P-value:2.27E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:5.86|P-value:6.22E-6 ID:SGTC_580|Compound:1123-0028|FD-Score:5.51|P-value:1.97E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:15.00|P-value:1.03E-29 ID:SGTC_638|Compound:3970-0837|FD-Score:16.20|P-value:3.27E-34 ID:SGTC_639|Compound:0833-0042|FD-Score:4.91|P-value:1.28E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:8.81|P-value:2.25E-11 ID:SGTC_735|Compound:3076-0345|FD-Score:5.41|P-value:2.73E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:5.20|P-value:5.34E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:6.58|P-value:4.44E-7 ID:SGTC_829|Compound:1635-0120|FD-Score:4.53|P-value:3.78E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:6.00|P-value:3.84E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:5.19|P-value:5.59E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:4.98|P-value:1.05E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:11.80|P-value:4.45E-19 ID:SGTC_923|Compound:1900-2434|FD-Score:-4.11|P-value:9.05E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:6.62|P-value:3.85E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:5.03|P-value:8.84E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:9.01|P-value:7.94E-12 ID:SGTC_1132|Compound:3456-3614|FD-Score:9.96|P-value:4.54E-14 ID:SGTC_1179|Compound:1021-1431|FD-Score:6.96|P-value:9.94E-8 ID:SGTC_1189|Compound:1431-2119|FD-Score:5.93|P-value:4.88E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:5.56|P-value:1.69E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.71|P-value:2.24E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:5.53|P-value:1.85E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.18|P-value:9.48E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:9.41|P-value:9.59E-13 ID:SGTC_1352|Compound:1496-0991|FD-Score:14.80|P-value:4.75E-29 ID:SGTC_1374|Compound:2889-5571|FD-Score:6.84|P-value:1.61E-7 ID:SGTC_1379|Compound:2144-0755|FD-Score:4.40|P-value:5.29E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:8.38|P-value:1.85E-10 ID:SGTC_1433|Compound:4060-0023|FD-Score:6.10|P-value:2.64E-6 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.82|P-value:1.68E-4 ID:SGTC_1643|Compound:st009866|FD-Score:9.56|P-value:4.26E-13 ID:SGTC_1661|Compound:st013063|FD-Score:5.09|P-value:7.54E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:4.80|P-value:1.77E-4 ID:SGTC_1773|Compound:st048542|FD-Score:5.58|P-value:1.60E-5 ID:SGTC_1802|Compound:st050112|FD-Score:4.53|P-value:3.71E-4 ID:SGTC_1870|Compound:st057514|FD-Score:5.64|P-value:1.29E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:10.60|P-value:1.39E-15 ID:SGTC_1891|Compound:st059073|FD-Score:4.29|P-value:7.10E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.61|P-value:2.98E-4 ID:SGTC_1953|Compound:st076800|FD-Score:16.30|P-value:1.72E-34 ID:SGTC_1955|Compound:wogonin|FD-Score:4.25|P-value:7.85E-4 ID:SGTC_1958|Compound:st076513|FD-Score:6.25|P-value:1.55E-6 ID:SGTC_2040|Compound:5100729|FD-Score:5.23|P-value:4.82E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-5.72|P-value:7.44E-6 ID:SGTC_2061|Compound:5245884|FD-Score:9.46|P-value:7.31E-13 ID:SGTC_2071|Compound:5230951|FD-Score:4.86|P-value:1.48E-4 ID:SGTC_2077|Compound:5212015|FD-Score:7.72|P-value:4.01E-9 ID:SGTC_2089|Compound:5281248|FD-Score:4.23|P-value:8.23E-4 ID:SGTC_2090|Compound:5301565|FD-Score:10.40|P-value:3.18E-15 ID:SGTC_2092|Compound:5303694|FD-Score:4.40|P-value:5.25E-4 ID:SGTC_2125|Compound:5246583|FD-Score:12.10|P-value:4.84E-20 ID:SGTC_2135|Compound:5326629|FD-Score:4.74|P-value:2.11E-4 ID:SGTC_2141|Compound:5621638|FD-Score:7.81|P-value:2.64E-9 ID:SGTC_2161|Compound:5662504|FD-Score:7.35|P-value:2.03E-8 ID:SGTC_2166|Compound:5933061|FD-Score:4.89|P-value:1.35E-4 ID:SGTC_2173|Compound:5763948|FD-Score:5.79|P-value:7.98E-6 ID:SGTC_2174|Compound:5790901|FD-Score:6.80|P-value:1.93E-7 ID:SGTC_2176|Compound:5809774|FD-Score:6.22|P-value:1.73E-6 ID:SGTC_2188|Compound:6126565|FD-Score:4.28|P-value:7.32E-4 ID:SGTC_2200|Compound:6600604|FD-Score:14.50|P-value:6.60E-28 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:9.09|P-value:5.42E-12 ID:SGTC_2233|Compound:sulbentine|FD-Score:10.20|P-value:1.36E-14 ID:SGTC_2254|Compound:7938975|FD-Score:11.80|P-value:6.69E-19 ID:SGTC_2255|Compound:7941087|FD-Score:7.31|P-value:2.34E-8 ID:SGTC_2269|Compound:7935389|FD-Score:5.69|P-value:1.11E-5 ID:SGTC_2302|Compound:7771753|FD-Score:6.64|P-value:3.54E-7 ID:SGTC_2304|Compound:7443016|FD-Score:4.35|P-value:6.04E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-4.83|P-value:1.26E-4 ID:SGTC_2316|Compound:5844804|FD-Score:5.56|P-value:1.68E-5 ID:SGTC_2319|Compound:6033012|FD-Score:18.10|P-value:4.71E-42 ID:SGTC_2322|Compound:7413319|FD-Score:-5.14|P-value:4.84E-5 ID:SGTC_2323|Compound:6148992|FD-Score:8.04|P-value:9.29E-10 ID:SGTC_2352|Compound:9027995|FD-Score:5.04|P-value:8.81E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:5.47|P-value:2.25E-5 ID:SGTC_2430|Compound:5571206|FD-Score:6.23|P-value:1.69E-6 ID:SGTC_2458|Compound:5808907|FD-Score:5.69|P-value:1.10E-5 ID:SGTC_2461|Compound:5755302|FD-Score:6.27|P-value:1.42E-6 ID:SGTC_2466|Compound:5983409|FD-Score:4.72|P-value:2.22E-4 ID:SGTC_2469|Compound:5655019|FD-Score:7.15|P-value:4.60E-8 ID:SGTC_2470|Compound:5664817|FD-Score:5.16|P-value:5.98E-5 ID:SGTC_2479|Compound:5617353|FD-Score:5.13|P-value:6.53E-5 ID:SGTC_2483|Compound:5729050|FD-Score:4.51|P-value:3.94E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:7.16|P-value:4.46E-8 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:13.40|P-value:4.49E-24 ID:SGTC_2532|Compound:xanthone|FD-Score:4.49|P-value:4.21E-4 ID:SGTC_2534|Compound:helenine|FD-Score:10.60|P-value:1.09E-15 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.83|P-value:1.62E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.63|P-value:2.88E-4 ID:SGTC_2832|Compound:7992762|FD-Score:4.26|P-value:7.61E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-4.32|P-value:5.20E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-8.64|P-value:3.36E-11 ID:SGTC_2845|Compound:9003024|FD-Score:11.10|P-value:6.46E-17 ID:SGTC_2921|Compound:7974240|FD-Score:8.66|P-value:4.84E-11 ID:SGTC_2947|Compound:9072639|FD-Score:8.41|P-value:1.59E-10 ID:SGTC_2952|Compound:9073731|FD-Score:10.90|P-value:1.82E-16 ID:SGTC_2997|Compound:9067075|FD-Score:7.78|P-value:3.06E-9 ID:SGTC_3101|Compound:9120531|FD-Score:4.81|P-value:1.70E-4 ID:SGTC_3166|Compound:9102297|FD-Score:5.89|P-value:5.51E-6 ID:SGTC_3242|Compound:9133940|FD-Score:4.46|P-value:4.55E-4 ID:SGTC_3253|Compound:9135987|FD-Score:5.17|P-value:5.81E-5 ID:SGTC_3267|Compound:9137951|FD-Score:4.41|P-value:5.21E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-5.35|P-value:2.54E-5 ID:SGTC_3274|Compound:9138298|FD-Score:-4.92|P-value:9.45E-5 ID:SGTC_3282|Compound:9108498|FD-Score:11.10|P-value:5.72E-17 ID:SGTC_3294|Compound:9122953|FD-Score:11.00|P-value:8.90E-17 ID:SGTC_3317|Compound:9138495|FD-Score:10.40|P-value:2.65E-15 ID:SGTC_3350|Compound:9150499|FD-Score:4.42|P-value:4.98E-4

Top fitness defect scores for YML124C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_229 benomyl 20.80 22.9 µM 4.66E-55 tubulin folding & SWR complex 2 3.24E-96
2 SGTC_2319 6033012 18.10 152.6 µM 4.71E-42 tubulin folding & SWR complex 4 3.48E-73
3 SGTC_210 3551-0445 17.60 56.8 µM 4.02E-40 5 9.13E-70
4 SGTC_1953 st076800 16.30 12.1 µM 1.72E-34 1 8.55E-60
5 SGTC_638 3970-0837 16.20 4.1 µM 3.27E-34 1 2.66E-59
6 SGTC_589 1227-0070 15.00 34.1 µM 1.03E-29 3 2.44E-51
7 SGTC_1352 1496-0991 14.80 99.0 µM 4.75E-29 tubulin folding & SWR complex 1 3.65E-50
8 SGTC_2200 6600604 14.50 21.9 µM 6.60E-28 tubulin folding & SWR complex 6 3.83E-48
9 SGTC_149 3970-0822 13.70 46.1 µM 4.66E-25 tubulin folding & SWR complex 6 4.21E-43
10 SGTC_2510 benzyl isothiocyanate 13.40 8.3 µM 4.49E-24 1 2.32E-41
11 SGTC_286 k060-0067 12.30 22.9 µM 1.78E-20 tubulin folding & SWR complex 2 5.36E-35
12 SGTC_2125 5246583 12.10 200.0 µM 4.84E-20 tubulin folding & SWR complex 2 3.14E-34
13 SGTC_897 1000-0139 11.80 31.4 µM 4.45E-19 3 1.59E-32
14 SGTC_2254 7938975 11.80 95.2 µM 6.69E-19 9 3.25E-32
15 SGTC_3282 9108498 11.10 15.5 µM 5.72E-17 3 8.46E-29
16 SGTC_2845 9003024 11.10 43.0 µM 6.46E-17 amide catabolism 3 1.05E-28
17 SGTC_3294 9122953 11.00 26.3 µM 8.90E-17 tubulin folding & SWR complex 1 1.85E-28
18 SGTC_2952 9073731 10.90 13.8 µM 1.82E-16 tubulin folding & SWR complex 2 6.50E-28
19 SGTC_2534 helenine 10.60 20.1 µM 1.09E-15 RSC complex & mRNA processing 1 1.54E-26
20 SGTC_1875 nocodazole 10.60 6.0 µM 1.39E-15 tubulin folding & SWR complex 13 2.38E-26

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.648 0 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.608 0 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.529 3.68E-241 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.524 3.22E-236 YLR085C ARP6 hom Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.494 4.56E-205 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.485 1.44E-197 YDR485C VPS72 hom Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.481 1.85E-193 YAL011W SWC3 hom Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.451 6.02E-168 YDR334W SWR1 hom Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.367 2.77E-107 YBR231C SWC5 hom Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.360 2.49E-103 YOL012C HTZ1 hom Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
0.312 2.48E-76 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.276 1.40E-59 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.271 3.35E-57 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.244 1.07E-46 YNL148C ALF1 hom Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
0.240 3.52E-45 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p