HIPHOP chemogenomics database
YML126C / ERG13 
3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YML126C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.253 | 3.18E-50 | YGR164W_d | YGR164W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.238 | 2.07E-44 | YIL104C | SHQ1 | het | Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones |
| 0.215 | 1.85E-36 | YPR070W | MED1 | hom | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation |
| 0.214 | 3.96E-36 | YPL042C | SSN3 | hom | Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression |
| 0.212 | 2.03E-35 | YHR070W | TRM5 | het | tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya |
| 0.207 | 9.26E-34 | YMR209C_p | YMR209C_p | hom | Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene |
| 0.204 | 1.05E-32 | YFL013W-A_d | YFL013W-A_d | hom | Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching |
| 0.203 | 1.43E-32 | YDR228C | PCF11 | het | mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping |
| 0.187 | 1.31E-27 | YFL013C | IES1 | hom | Subunit of the INO80 chromatin remodeling complex |
| 0.182 | 2.07E-26 | YEL014C_d | YEL014C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.178 | 3.37E-25 | YJR006W | POL31 | het | Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair |
| 0.178 | 3.80E-25 | YLR065C | ENV10 | hom | Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene |
| 0.177 | 6.14E-25 | YCL031C | RRP7 | het | Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress |
| 0.176 | 1.25E-24 | YOR260W | GCD1 | het | Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression |
| 0.174 | 2.29E-24 | YLR412W | BER1 | hom | Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene |