YML126C / ERG13

3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YML126C / ERG13

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-5.53|P-value:2.05E-9 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.39|P-value:1.61E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:2.92|P-value:8.45E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.93|P-value:8.03E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-4.11|P-value:6.36E-6 ID:SGTC_356|Compound:1634-0012|FD-Score:3.14|P-value:3.64E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.43|P-value:1.16E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:5.66|P-value:6.40E-10 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.69|P-value:4.41E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.42|P-value:1.41E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.92|P-value:1.30E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:3.29|P-value:2.02E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.29|P-value:2.05E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:40.10|P-value:0 ID:SGTC_767|Compound:0929-0023|FD-Score:-3.31|P-value:2.21E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.00|P-value:8.94E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:3.10|P-value:4.29E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.15|P-value:3.55E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:-3.66|P-value:5.16E-5 ID:SGTC_1084|Compound:voriconazole|FD-Score:2.90|P-value:9.18E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.86|P-value:9.44E-8 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.26|P-value:2.35E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.43|P-value:1.36E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.43|P-value:1.34E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.48|P-value:1.12E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.51|P-value:8.32E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.05|P-value:6.09E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.39|P-value:1.37E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.30|P-value:1.99E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.12|P-value:4.68E-4 ID:SGTC_1752|Compound:st044819|FD-Score:14.60|P-value:1.88E-55 ID:SGTC_1780|Compound:st038448|FD-Score:-3.13|P-value:4.43E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.03|P-value:5.58E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.13|P-value:3.85E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.41|P-value:1.25E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.04|P-value:5.37E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.13|P-value:3.80E-4 ID:SGTC_2208|Compound:7283366|FD-Score:2.98|P-value:6.88E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-4.05|P-value:8.45E-6 ID:SGTC_2343|Compound:7990716|FD-Score:2.95|P-value:7.51E-4 ID:SGTC_2471|Compound:5466956|FD-Score:4.04|P-value:7.34E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:2.88|P-value:9.85E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:7.03|P-value:2.64E-14 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.48|P-value:7.62E-7 ID:SGTC_2556|Compound:citropten|FD-Score:-3.13|P-value:4.41E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.63|P-value:5.82E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.61|P-value:3.76E-7 ID:SGTC_2647|Compound:atorvastatin|FD-Score:4.80|P-value:1.36E-7 ID:SGTC_2648|Compound:atorvastatin|FD-Score:6.99|P-value:3.48E-14 ID:SGTC_2671|Compound:danthron|FD-Score:3.03|P-value:5.61E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.03|P-value:5.66E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.49|P-value:8.97E-5 ID:SGTC_2948|Compound:9070189|FD-Score:3.50|P-value:8.56E-5 ID:SGTC_2955|Compound:9076254|FD-Score:3.22|P-value:2.69E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.06|P-value:5.90E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-3.13|P-value:4.44E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-3.23|P-value:3.00E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-5.97|P-value:1.03E-10 ID:SGTC_3153|Compound:9100258|FD-Score:-5.32|P-value:7.80E-9 ID:SGTC_3187|Compound:9109394|FD-Score:-3.96|P-value:1.30E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-3.07|P-value:5.61E-4 ID:SGTC_3304|Compound:9125678|FD-Score:2.99|P-value:6.65E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.92|P-value:1.60E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-5.53|P-value:2.05E-9 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.39|P-value:1.61E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:2.92|P-value:8.45E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.93|P-value:8.03E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-4.11|P-value:6.36E-6 ID:SGTC_356|Compound:1634-0012|FD-Score:3.14|P-value:3.64E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.43|P-value:1.16E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:5.66|P-value:6.40E-10 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.69|P-value:4.41E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.42|P-value:1.41E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.92|P-value:1.30E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:3.29|P-value:2.02E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.29|P-value:2.05E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:40.10|P-value:0 ID:SGTC_767|Compound:0929-0023|FD-Score:-3.31|P-value:2.21E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.00|P-value:8.94E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:3.10|P-value:4.29E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.15|P-value:3.55E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:-3.66|P-value:5.16E-5 ID:SGTC_1084|Compound:voriconazole|FD-Score:2.90|P-value:9.18E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.86|P-value:9.44E-8 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.26|P-value:2.35E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.43|P-value:1.36E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.43|P-value:1.34E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.48|P-value:1.12E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.51|P-value:8.32E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.05|P-value:6.09E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.39|P-value:1.37E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.30|P-value:1.99E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.12|P-value:4.68E-4 ID:SGTC_1752|Compound:st044819|FD-Score:14.60|P-value:1.88E-55 ID:SGTC_1780|Compound:st038448|FD-Score:-3.13|P-value:4.43E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.03|P-value:5.58E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.13|P-value:3.85E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.41|P-value:1.25E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.04|P-value:5.37E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.13|P-value:3.80E-4 ID:SGTC_2208|Compound:7283366|FD-Score:2.98|P-value:6.88E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-4.05|P-value:8.45E-6 ID:SGTC_2343|Compound:7990716|FD-Score:2.95|P-value:7.51E-4 ID:SGTC_2471|Compound:5466956|FD-Score:4.04|P-value:7.34E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:2.88|P-value:9.85E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:7.03|P-value:2.64E-14 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.48|P-value:7.62E-7 ID:SGTC_2556|Compound:citropten|FD-Score:-3.13|P-value:4.41E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.63|P-value:5.82E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.61|P-value:3.76E-7 ID:SGTC_2647|Compound:atorvastatin|FD-Score:4.80|P-value:1.36E-7 ID:SGTC_2648|Compound:atorvastatin|FD-Score:6.99|P-value:3.48E-14 ID:SGTC_2671|Compound:danthron|FD-Score:3.03|P-value:5.61E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.03|P-value:5.66E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.49|P-value:8.97E-5 ID:SGTC_2948|Compound:9070189|FD-Score:3.50|P-value:8.56E-5 ID:SGTC_2955|Compound:9076254|FD-Score:3.22|P-value:2.69E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.06|P-value:5.90E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-3.13|P-value:4.44E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-3.23|P-value:3.00E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-5.97|P-value:1.03E-10 ID:SGTC_3153|Compound:9100258|FD-Score:-5.32|P-value:7.80E-9 ID:SGTC_3187|Compound:9109394|FD-Score:-3.96|P-value:1.30E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-3.07|P-value:5.61E-4 ID:SGTC_3304|Compound:9125678|FD-Score:2.99|P-value:6.65E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.92|P-value:1.60E-5

Top fitness defect scores for YML126C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_682 0kpi-0099 40.10 17.0 µM 0 1 0 30.10
2 SGTC_1752 st044819 14.60 83.0 µM 1.88E-55 1 9.01E-49 8.34
3 SGTC_2541 muurolladie-3-one 7.03 83.1 µM 2.64E-14 excess fatty acid 3 1.05E-12 0.70
4 SGTC_2648 atorvastatin 6.99 78.7 µM 3.48E-14 azole & statin 2 1.34E-12 0.12
5 SGTC_369 0957-0393 5.66 4.5 µM 6.40E-10 cell wall signaling 1 7.35E-9 1.04
6 SGTC_1097 itavastatin 4.86 7.2 µM 9.44E-8 azole & statin 6 5.88E-7 0.67
7 SGTC_2647 atorvastatin 4.80 60.2 µM 1.36E-7 azole & statin 2 8.09E-7 0.05
8 SGTC_2629 bisabolol 4.61 100.0 µM 3.76E-7 5 1.98E-6 0.08
9 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 4.48 100.0 µM 7.62E-7 3 3.68E-6 0.26
10 SGTC_2471 5466956 4.04 24.8 µM 7.34E-6 mitochondrial processes 18 2.69E-5 0.12
11 SGTC_769 0302-0231 4.00 76.0 µM 8.94E-6 11 3.20E-5 0.03
12 SGTC_539 4859-0462 3.92 2.5 µM 1.30E-5 RNA pol III & RNase P/MRP 21 4.44E-5 0.07
13 SGTC_2948 9070189 3.50 9.4 µM 8.56E-5 plasma membrane duress 10 2.33E-4 0.30
14 SGTC_2736 butenafine 3.49 14.7 µM 8.97E-5 9 2.43E-4 0.01
15 SGTC_360 0957-0399 3.43 1.0 µM 1.16E-4 cell wall 18 3.04E-4 0.18
16 SGTC_1801 st050089 3.41 28.4 µM 1.25E-4 NEO1-PIK1 16 3.24E-4 0.17
17 SGTC_1520 flindersine 3.39 88.0 µM 1.37E-4 15 3.53E-4 0.01
18 SGTC_1722 st034304 3.30 3.6 µM 1.99E-4 mitochondrial processes 19 4.89E-4 0.07
19 SGTC_617 3770-0098 3.29 35.0 µM 2.02E-4 exosome 28 4.95E-4 0.23
20 SGTC_629 3448-6466 3.29 76.7 µM 2.05E-4 8 5.01E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.253 3.18E-50 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.238 2.07E-44 YIL104C SHQ1 het Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones
0.215 1.85E-36 YPR070W MED1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.214 3.96E-36 YPL042C SSN3 hom Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression
0.212 2.03E-35 YHR070W TRM5 het tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya
0.207 9.26E-34 YMR209C_p YMR209C_p hom Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene
0.204 1.05E-32 YFL013W-A_d YFL013W-A_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
0.203 1.43E-32 YDR228C PCF11 het mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping
0.187 1.31E-27 YFL013C IES1 hom Subunit of the INO80 chromatin remodeling complex
0.182 2.07E-26 YEL014C_d YEL014C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.178 3.37E-25 YJR006W POL31 het Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair
0.178 3.80E-25 YLR065C ENV10 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene
0.177 6.14E-25 YCL031C RRP7 het Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress
0.176 1.25E-24 YOR260W GCD1 het Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.174 2.29E-24 YLR412W BER1 hom Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene