YML128C / MSC1

Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated

Zygosity: Homozygous strain
fixedexpanded
Profile for YML128C / MSC1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.48|P-value:4.89E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.28|P-value:1.19E-9 ID:SGTC_138|Compound:0850-0259|FD-Score:6.73|P-value:8.14E-11 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.33|P-value:7.59E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:5.33|P-value:2.02E-7 ID:SGTC_369|Compound:0957-0393|FD-Score:3.47|P-value:4.83E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.31|P-value:8.22E-4 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.38|P-value:6.52E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.40|P-value:6.04E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:8.82|P-value:2.64E-17 ID:SGTC_533|Compound:1222-0222|FD-Score:-3.80|P-value:1.59E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:5.25|P-value:3.08E-7 ID:SGTC_556|Compound:4058-0063|FD-Score:-4.83|P-value:2.37E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.32|P-value:8.21E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.44|P-value:5.38E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.02|P-value:6.60E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:3.48|P-value:4.74E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:10.90|P-value:1.97E-25 ID:SGTC_709|Compound:3807-1509|FD-Score:3.28|P-value:8.92E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.62|P-value:2.90E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:9.21|P-value:1.13E-18 ID:SGTC_811|Compound:0416-0114|FD-Score:-4.28|P-value:2.54E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:3.34|P-value:7.34E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.34|P-value:7.52E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:5.66|P-value:3.77E-8 ID:SGTC_975|Compound:1335-0046|FD-Score:4.31|P-value:2.12E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.33|P-value:7.62E-4 ID:SGTC_1516|Compound:st013856|FD-Score:3.98|P-value:7.76E-5 ID:SGTC_1548|Compound:st061468|FD-Score:3.37|P-value:6.70E-4 ID:SGTC_1626|Compound:st003712|FD-Score:4.01|P-value:6.93E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.14|P-value:4.17E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.79|P-value:1.56E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.56|P-value:3.51E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.44|P-value:1.23E-5 ID:SGTC_1846|Compound:st056244|FD-Score:5.04|P-value:8.17E-7 ID:SGTC_1959|Compound:st077091|FD-Score:6.67|P-value:1.18E-10 ID:SGTC_2017|Compound:5132927|FD-Score:-3.30|P-value:8.87E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.43|P-value:5.58E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.97|P-value:1.18E-6 ID:SGTC_2111|Compound:5486399|FD-Score:3.34|P-value:7.43E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:5.63|P-value:4.32E-8 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.87|P-value:1.23E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.84|P-value:1.29E-4 ID:SGTC_2257|Compound:7960413|FD-Score:5.15|P-value:5.00E-7 ID:SGTC_2259|Compound:7964009|FD-Score:3.65|P-value:2.58E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.10|P-value:4.93E-5 ID:SGTC_2282|Compound:7944268|FD-Score:4.23|P-value:2.93E-5 ID:SGTC_2346|Compound:9031566|FD-Score:3.59|P-value:3.23E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.49|P-value:4.44E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.47|P-value:4.82E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.82|P-value:1.38E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.43|P-value:5.46E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.25|P-value:2.72E-5 ID:SGTC_2704|Compound:st078022|FD-Score:-3.63|P-value:2.95E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-4.30|P-value:2.30E-5 ID:SGTC_2817|Compound:7995342|FD-Score:-3.27|P-value:9.81E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.29|P-value:8.80E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.77|P-value:2.89E-6 ID:SGTC_2942|Compound:9052777|FD-Score:-4.29|P-value:2.45E-5 ID:SGTC_2950|Compound:9072895|FD-Score:-3.72|P-value:2.12E-4 ID:SGTC_3120|Compound:9124077|FD-Score:3.48|P-value:4.72E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.33|P-value:7.81E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.41|P-value:5.93E-4 ID:SGTC_3266|Compound:9136860|FD-Score:8.05|P-value:1.03E-14 ID:SGTC_3276|Compound:9139060|FD-Score:-3.57|P-value:3.64E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.34|P-value:1.84E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.32|P-value:1.97E-5 ID:SGTC_3321|Compound:9137793|FD-Score:5.46|P-value:1.04E-7 ID:SGTC_3322|Compound:9139058|FD-Score:4.45|P-value:1.18E-5 ID:SGTC_3356|Compound:9151811|FD-Score:4.52|P-value:8.84E-6 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.48|P-value:4.89E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.28|P-value:1.19E-9 ID:SGTC_138|Compound:0850-0259|FD-Score:6.73|P-value:8.14E-11 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.33|P-value:7.59E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:5.33|P-value:2.02E-7 ID:SGTC_369|Compound:0957-0393|FD-Score:3.47|P-value:4.83E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.31|P-value:8.22E-4 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.38|P-value:6.52E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.40|P-value:6.04E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:8.82|P-value:2.64E-17 ID:SGTC_533|Compound:1222-0222|FD-Score:-3.80|P-value:1.59E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:5.25|P-value:3.08E-7 ID:SGTC_556|Compound:4058-0063|FD-Score:-4.83|P-value:2.37E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.32|P-value:8.21E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.44|P-value:5.38E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.02|P-value:6.60E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:3.48|P-value:4.74E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:10.90|P-value:1.97E-25 ID:SGTC_709|Compound:3807-1509|FD-Score:3.28|P-value:8.92E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.62|P-value:2.90E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:9.21|P-value:1.13E-18 ID:SGTC_811|Compound:0416-0114|FD-Score:-4.28|P-value:2.54E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:3.34|P-value:7.34E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.34|P-value:7.52E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:5.66|P-value:3.77E-8 ID:SGTC_975|Compound:1335-0046|FD-Score:4.31|P-value:2.12E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.33|P-value:7.62E-4 ID:SGTC_1516|Compound:st013856|FD-Score:3.98|P-value:7.76E-5 ID:SGTC_1548|Compound:st061468|FD-Score:3.37|P-value:6.70E-4 ID:SGTC_1626|Compound:st003712|FD-Score:4.01|P-value:6.93E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.14|P-value:4.17E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.79|P-value:1.56E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.56|P-value:3.51E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.44|P-value:1.23E-5 ID:SGTC_1846|Compound:st056244|FD-Score:5.04|P-value:8.17E-7 ID:SGTC_1959|Compound:st077091|FD-Score:6.67|P-value:1.18E-10 ID:SGTC_2017|Compound:5132927|FD-Score:-3.30|P-value:8.87E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.43|P-value:5.58E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.97|P-value:1.18E-6 ID:SGTC_2111|Compound:5486399|FD-Score:3.34|P-value:7.43E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:5.63|P-value:4.32E-8 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.87|P-value:1.23E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.84|P-value:1.29E-4 ID:SGTC_2257|Compound:7960413|FD-Score:5.15|P-value:5.00E-7 ID:SGTC_2259|Compound:7964009|FD-Score:3.65|P-value:2.58E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.10|P-value:4.93E-5 ID:SGTC_2282|Compound:7944268|FD-Score:4.23|P-value:2.93E-5 ID:SGTC_2346|Compound:9031566|FD-Score:3.59|P-value:3.23E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.49|P-value:4.44E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.47|P-value:4.82E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.82|P-value:1.38E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.43|P-value:5.46E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:4.25|P-value:2.72E-5 ID:SGTC_2704|Compound:st078022|FD-Score:-3.63|P-value:2.95E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-4.30|P-value:2.30E-5 ID:SGTC_2817|Compound:7995342|FD-Score:-3.27|P-value:9.81E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.29|P-value:8.80E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.77|P-value:2.89E-6 ID:SGTC_2942|Compound:9052777|FD-Score:-4.29|P-value:2.45E-5 ID:SGTC_2950|Compound:9072895|FD-Score:-3.72|P-value:2.12E-4 ID:SGTC_3120|Compound:9124077|FD-Score:3.48|P-value:4.72E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.33|P-value:7.81E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.41|P-value:5.93E-4 ID:SGTC_3266|Compound:9136860|FD-Score:8.05|P-value:1.03E-14 ID:SGTC_3276|Compound:9139060|FD-Score:-3.57|P-value:3.64E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.34|P-value:1.84E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.32|P-value:1.97E-5 ID:SGTC_3321|Compound:9137793|FD-Score:5.46|P-value:1.04E-7 ID:SGTC_3322|Compound:9139058|FD-Score:4.45|P-value:1.18E-5 ID:SGTC_3356|Compound:9151811|FD-Score:4.52|P-value:8.84E-6

Top fitness defect scores for YML128C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_673 1082-0474 10.90 110.0 µM 1.97E-25 RSC complex & mRNA processing 6 5.53E-28
2 SGTC_800 3448-7362 9.21 155.0 µM 1.13E-18 translation 10 1.71E-20
3 SGTC_514 4466-0038 8.82 2.6 nM 2.64E-17 cell wall 30 5.59E-19
4 SGTC_3266 9136860 8.05 49.5 µM 1.03E-14 cell wall 13 4.15E-16
5 SGTC_138 0850-0259 6.73 40.9 µM 8.14E-11 cell wall 83 8.58E-12
6 SGTC_1959 st077091 6.67 55.8 µM 1.18E-10 RPP1 & pyrimidine depletion 3 1.29E-11
7 SGTC_58 0957-0393 6.28 9.0 µM 1.19E-9 cell wall 197 1.67E-10
8 SGTC_928 2764-0428 5.66 58.7 µM 3.77E-8 cell wall 19 7.61E-9
9 SGTC_2130 NSC 7 5.63 2.5 µM 4.32E-8 copper-dependent oxidative stress 6 8.84E-9
10 SGTC_3321 9137793 5.46 26.8 µM 1.04E-7 cell wall 35 2.35E-8
11 SGTC_351 caspofungin 5.33 25.0 nM 2.02E-7 cell wall 50 4.88E-8
12 SGTC_546 peri-Naphthalide 5.25 147.0 µM 3.08E-7 DNA damage response 6 7.76E-8
13 SGTC_2257 7960413 5.15 200.0 µM 5.00E-7 NEO1-PIK1 24 1.32E-7
14 SGTC_1846 st056244 5.04 14.8 µM 8.17E-7 10 2.28E-7
15 SGTC_2021 4019055 4.97 173.0 µM 1.18E-6 endomembrane recycling 65 3.43E-7
16 SGTC_2912 7964298 4.77 10.9 µM 2.89E-6 cell wall 73 9.21E-7
17 SGTC_3356 9151811 4.52 4.5 µM 8.84E-6 cell wall 15 3.16E-6
18 SGTC_3322 9139058 4.45 2.1 µM 1.18E-5 cell wall 20 4.36E-6
19 SGTC_1803 st050068 4.44 52.4 µM 1.23E-5 NEO1-PIK1 145 4.53E-6
20 SGTC_3304 9125678 4.34 46.1 µM 1.84E-5 35 7.12E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.332 5.04E-87 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.330 3.88E-86 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.297 3.53E-69 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.290 4.04E-66 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.289 1.96E-65 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.278 1.20E-60 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.267 4.66E-56 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.264 1.65E-54 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.257 9.11E-52 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.257 1.07E-51 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.254 1.37E-50 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.253 3.69E-50 YMR242C RPL20A hom Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication
0.251 1.82E-49 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.251 3.04E-49 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.249 1.03E-48 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane