YML129C / COX14

Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes

Zygosity: Homozygous strain
fixedexpanded
Profile for YML129C / COX14

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:4.59|P-value:7.26E-6 ID:SGTC_72|Compound:0744-0168|FD-Score:3.26|P-value:9.93E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.61|P-value:3.98E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:7.88|P-value:5.63E-14 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.52|P-value:5.32E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:22.30|P-value:5.54E-98 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.43|P-value:2.10E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:5.50|P-value:1.07E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:6.86|P-value:5.15E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:31.90|P-value:1.66E-197 ID:SGTC_310|Compound:1273-0058|FD-Score:4.95|P-value:1.49E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:9.85|P-value:9.46E-21 ID:SGTC_744|Compound:1594-0068|FD-Score:-4.08|P-value:7.32E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:-4.08|P-value:7.43E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:5.14|P-value:6.11E-7 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.51|P-value:5.46E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.61|P-value:3.12E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.42|P-value:6.08E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.76|P-value:1.88E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.39|P-value:6.69E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:-3.79|P-value:2.13E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.66|P-value:3.35E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.57|P-value:3.65E-4 ID:SGTC_1635|Compound:st007035|FD-Score:16.00|P-value:3.58E-51 ID:SGTC_1754|Compound:st042065|FD-Score:-3.43|P-value:7.20E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.99|P-value:1.03E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.57|P-value:3.67E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.74|P-value:2.52E-4 ID:SGTC_2118|Compound:5526350|FD-Score:4.11|P-value:5.14E-5 ID:SGTC_2120|Compound:5538279|FD-Score:6.30|P-value:1.40E-9 ID:SGTC_2151|Compound:5563267|FD-Score:-3.38|P-value:8.37E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.67|P-value:3.22E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.29|P-value:2.46E-5 ID:SGTC_2256|Compound:7954252|FD-Score:3.37|P-value:7.09E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.70|P-value:2.91E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.68|P-value:2.47E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.51|P-value:5.61E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.43|P-value:1.41E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:5.26|P-value:3.36E-7 ID:SGTC_2557|Compound:derrustone|FD-Score:4.01|P-value:7.43E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.25|P-value:2.91E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.27|P-value:9.64E-4 ID:SGTC_2696|Compound:st077691|FD-Score:-4.30|P-value:3.07E-5 ID:SGTC_2969|Compound:9091408|FD-Score:-6.24|P-value:2.84E-9 ID:SGTC_2971|Compound:9092186|FD-Score:3.64|P-value:2.83E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.92|P-value:1.31E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.14|P-value:4.61E-5 ID:SGTC_2982|Compound:9019404|FD-Score:5.53|P-value:8.90E-8 ID:SGTC_2985|Compound:9022375|FD-Score:-3.70|P-value:2.94E-4 ID:SGTC_3103|Compound:9120822|FD-Score:-3.57|P-value:4.61E-4 ID:SGTC_3110|Compound:9122132|FD-Score:-4.22|P-value:4.29E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:4.59|P-value:7.26E-6 ID:SGTC_72|Compound:0744-0168|FD-Score:3.26|P-value:9.93E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.61|P-value:3.98E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:7.88|P-value:5.63E-14 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.52|P-value:5.32E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:22.30|P-value:5.54E-98 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.43|P-value:2.10E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:5.50|P-value:1.07E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:6.86|P-value:5.15E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:31.90|P-value:1.66E-197 ID:SGTC_310|Compound:1273-0058|FD-Score:4.95|P-value:1.49E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:9.85|P-value:9.46E-21 ID:SGTC_744|Compound:1594-0068|FD-Score:-4.08|P-value:7.32E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:-4.08|P-value:7.43E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:5.14|P-value:6.11E-7 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.51|P-value:5.46E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.61|P-value:3.12E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.42|P-value:6.08E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.76|P-value:1.88E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.39|P-value:6.69E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:-3.79|P-value:2.13E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.66|P-value:3.35E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.57|P-value:3.65E-4 ID:SGTC_1635|Compound:st007035|FD-Score:16.00|P-value:3.58E-51 ID:SGTC_1754|Compound:st042065|FD-Score:-3.43|P-value:7.20E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.99|P-value:1.03E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.57|P-value:3.67E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.74|P-value:2.52E-4 ID:SGTC_2118|Compound:5526350|FD-Score:4.11|P-value:5.14E-5 ID:SGTC_2120|Compound:5538279|FD-Score:6.30|P-value:1.40E-9 ID:SGTC_2151|Compound:5563267|FD-Score:-3.38|P-value:8.37E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.67|P-value:3.22E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.29|P-value:2.46E-5 ID:SGTC_2256|Compound:7954252|FD-Score:3.37|P-value:7.09E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.70|P-value:2.91E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.68|P-value:2.47E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.51|P-value:5.61E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.43|P-value:1.41E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:5.26|P-value:3.36E-7 ID:SGTC_2557|Compound:derrustone|FD-Score:4.01|P-value:7.43E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.25|P-value:2.91E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.27|P-value:9.64E-4 ID:SGTC_2696|Compound:st077691|FD-Score:-4.30|P-value:3.07E-5 ID:SGTC_2969|Compound:9091408|FD-Score:-6.24|P-value:2.84E-9 ID:SGTC_2971|Compound:9092186|FD-Score:3.64|P-value:2.83E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.92|P-value:1.31E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.14|P-value:4.61E-5 ID:SGTC_2982|Compound:9019404|FD-Score:5.53|P-value:8.90E-8 ID:SGTC_2985|Compound:9022375|FD-Score:-3.70|P-value:2.94E-4 ID:SGTC_3103|Compound:9120822|FD-Score:-3.57|P-value:4.61E-4 ID:SGTC_3110|Compound:9122132|FD-Score:-4.22|P-value:4.29E-5

Top fitness defect scores for YML129C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 31.90 5.3 µM 1.66E-197 9 1.19E-223
2 SGTC_134 0269-0018 22.30 6.9 µM 5.54E-98 4 1.03E-110
3 SGTC_1635 st007035 16.00 42.4 µM 3.58E-51 32 1.24E-57
4 SGTC_386 1509-0011 9.85 3.1 µM 9.46E-21 46 3.54E-23
5 SGTC_100 0086-0128 7.88 49.6 µM 5.63E-14 copper-dependent oxidative stress 9 1.61E-15
6 SGTC_173 1273-0061 6.86 2.7 µM 5.15E-11 mitochondrial stress 92 3.55E-12
7 SGTC_2120 5538279 6.30 152.0 µM 1.40E-9 1 1.47E-10
8 SGTC_2982 9019404 5.53 26.0 µM 8.90E-8 8 1.58E-8
9 SGTC_168 3970-0862 5.50 530.5 µM 1.07E-7 57 1.94E-8
10 SGTC_2498 4'-Methoxychalcone 5.26 54.6 µM 3.36E-7 RPP1 & pyrimidine depletion 10 7.04E-8
11 SGTC_852 0418-0143 5.14 439.0 µM 6.11E-7 calcium & mitochondrial duress 38 1.38E-7
12 SGTC_310 1273-0058 4.95 1.1 µM 1.49E-6 mitochondrial stress 185 3.75E-7
13 SGTC_70 0141-0289 4.59 43.3 µM 7.26E-6 mitochondrial stress 132 2.23E-6
14 SGTC_2420 aureobasidin a 4.43 50.0 nM 1.41E-5 30 4.70E-6
15 SGTC_2250 alverine citrate 4.29 130.0 µM 2.46E-5 135 8.76E-6
16 SGTC_2588 indole-3-carbinol 4.25 100.0 µM 2.91E-5 37 1.06E-5
17 SGTC_2981 9013952 4.14 39.0 µM 4.61E-5 40 1.77E-5
18 SGTC_2118 5526350 4.11 200.0 µM 5.14E-5 13 2.00E-5
19 SGTC_2557 derrustone 4.01 83.8 µM 7.43E-5 31 3.03E-5
20 SGTC_996 3970-0799 3.76 1.8 µM 1.88E-4 90 8.58E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.709 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.682 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.680 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.677 0 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.667 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.663 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.656 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.656 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.636 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.635 0 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.633 0 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.631 0 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.631 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.629 0 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.620 0 YHL038C CBP2 hom Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene