YML131W

Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YML131W / YML131W

Click on Significant Values for Screen Details

Top fitness defect scores for YML131W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1257 0669-0121 5.76 16.0 µM 2.51E-10 3 4.30E-9
2 SGTC_986 1493-0483 4.90 84.0 µM 5.67E-8 5 4.74E-7
3 SGTC_1059 3448-6867 4.56 171.0 µM 3.86E-7 3 2.50E-6
4 SGTC_142 0335-0849 4.25 62.7 µM 2.01E-6 ubiquinone biosynthesis & proteasome 110 1.05E-5
5 SGTC_133 0724-0033 3.90 378.9 µM 1.16E-5 33 4.76E-5
6 SGTC_2385 9074692 3.82 200.0 µM 1.74E-5 50 6.77E-5
7 SGTC_388 3',4'-dichloroisocoumarin 3.71 16.7 µM 2.88E-5 20 1.05E-4
8 SGTC_101 0490-5701 3.67 117.5 µM 3.41E-5 17 1.22E-4
9 SGTC_1921 5740136 3.66 50.0 µM 3.55E-5 TRP & mitochondrial translation 72 1.26E-4
10 SGTC_882 0843-0131 3.37 351.0 µM 1.24E-4 31 3.72E-4
11 SGTC_2571 chrysanthemic acid 3.31 100.0 µM 1.60E-4 45 4.65E-4
12 SGTC_2139 5578692 3.27 56.5 µM 1.92E-4 superoxide 37 5.44E-4
13 SGTC_2004 4023728 3.24 41.9 µM 2.10E-4 58 5.90E-4
14 SGTC_2126 5251174 3.23 33.9 µM 2.20E-4 70 6.13E-4
15 SGTC_2061 5245884 3.22 81.0 µM 2.30E-4 tubulin folding & SWR complex 50 6.36E-4
16 SGTC_2603 homopterocarpin 3.22 100.0 µM 2.31E-4 86 6.39E-4
17 SGTC_996 3970-0799 3.17 1.8 µM 2.83E-4 138 7.63E-4
18 SGTC_1792 st045773 3.12 43.6 µM 3.49E-4 65 9.14E-4
19 SGTC_1010 4112-3296 3.11 15.2 µM 3.60E-4 56 9.39E-4
20 SGTC_2396 5342950 3.11 42.8 µM 3.61E-4 RSC complex & mRNA processing 97 9.41E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.87E-15 YKL072W STB6 hom Protein that binds Sin3p in a two-hybrid assay
0.132 1.68E-14 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.132 2.15E-14 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.130 3.59E-14 YEL065W SIT1 hom Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.104 1.29E-9 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.102 3.42E-9 YML090W_d YML090W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
0.101 4.32E-9 YFR025C HIS2 hom Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
0.101 4.52E-9 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.094 5.51E-8 YLL015W BPT1 hom ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p
0.093 6.59E-8 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.091 1.34E-7 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.088 3.06E-7 YHR033W_p YHR033W_p hom Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication
0.086 6.89E-7 YFR011C AIM13 hom Mitochondrial protein peripheral to the inner membrane; component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.085 8.14E-7 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.085 9.13E-7 YOR378W_p YOR378W_p hom Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene