YMR001C / CDC5

Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR001C / CDC5

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.17|P-value:6.53E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.73|P-value:1.24E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.78|P-value:6.59E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:3.11|P-value:8.01E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.44|P-value:2.48E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.96|P-value:3.15E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:6.04|P-value:6.32E-10 ID:SGTC_171|Compound:k064-0041|FD-Score:3.25|P-value:4.94E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.41|P-value:2.75E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.17|P-value:1.29E-5 ID:SGTC_264|Compound:promethazine|FD-Score:3.31|P-value:3.96E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.92|P-value:5.83E-5 ID:SGTC_615|Compound:k087-0205|FD-Score:3.56|P-value:1.59E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.43|P-value:2.57E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.77|P-value:6.97E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:3.20|P-value:5.90E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:6.25|P-value:1.67E-10 ID:SGTC_919|Compound:tnp00227|FD-Score:3.29|P-value:4.24E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.24|P-value:5.22E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.16|P-value:9.85E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:-3.38|P-value:4.57E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.69|P-value:9.66E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:-3.93|P-value:5.64E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:-4.41|P-value:7.17E-6 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.40|P-value:2.90E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:-4.12|P-value:2.50E-5 ID:SGTC_1554|Compound:st069299|FD-Score:3.66|P-value:1.05E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:4.45|P-value:3.57E-6 ID:SGTC_1672|Compound:st016598|FD-Score:-4.30|P-value:1.17E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-7.08|P-value:1.23E-12 ID:SGTC_1724|Compound:st037281|FD-Score:-3.71|P-value:1.36E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.67|P-value:1.26E-6 ID:SGTC_1921|Compound:5740136|FD-Score:-4.13|P-value:2.43E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.84|P-value:5.30E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.96|P-value:3.22E-5 ID:SGTC_2075|Compound:5212009|FD-Score:3.75|P-value:7.42E-5 ID:SGTC_2469|Compound:5655019|FD-Score:3.06|P-value:9.54E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.44|P-value:3.81E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:5.89|P-value:1.58E-9 ID:SGTC_2619|Compound:obliquin|FD-Score:5.57|P-value:1.03E-8 ID:SGTC_2902|Compound:5787006|FD-Score:3.80|P-value:6.27E-5 ID:SGTC_2914|Compound:7968218|FD-Score:3.46|P-value:2.27E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.68|P-value:1.01E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.18|P-value:6.35E-4 ID:SGTC_3003|Compound:9075612|FD-Score:4.44|P-value:3.70E-6 ID:SGTC_3012|Compound:9080433|FD-Score:3.22|P-value:5.47E-4 ID:SGTC_3013|Compound:9080133|FD-Score:5.63|P-value:7.44E-9 ID:SGTC_3029|Compound:9088683|FD-Score:3.68|P-value:9.85E-5 ID:SGTC_3034|Compound:9090421|FD-Score:6.24|P-value:1.77E-10 ID:SGTC_3037|Compound:9091026|FD-Score:-4.17|P-value:2.09E-5 ID:SGTC_3043|Compound:9092303|FD-Score:6.30|P-value:1.25E-10 ID:SGTC_3150|Compound:9097574|FD-Score:4.67|P-value:1.23E-6 ID:SGTC_3155|Compound:9099265|FD-Score:3.66|P-value:1.07E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.51|P-value:1.92E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.23|P-value:5.31E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.26|P-value:4.76E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.20|P-value:1.14E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:3.17|P-value:6.53E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.73|P-value:1.24E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.78|P-value:6.59E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:3.11|P-value:8.01E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.44|P-value:2.48E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.96|P-value:3.15E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:6.04|P-value:6.32E-10 ID:SGTC_171|Compound:k064-0041|FD-Score:3.25|P-value:4.94E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.41|P-value:2.75E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.17|P-value:1.29E-5 ID:SGTC_264|Compound:promethazine|FD-Score:3.31|P-value:3.96E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.92|P-value:5.83E-5 ID:SGTC_615|Compound:k087-0205|FD-Score:3.56|P-value:1.59E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.43|P-value:2.57E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.77|P-value:6.97E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:3.20|P-value:5.90E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:6.25|P-value:1.67E-10 ID:SGTC_919|Compound:tnp00227|FD-Score:3.29|P-value:4.24E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.24|P-value:5.22E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.16|P-value:9.85E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:-3.38|P-value:4.57E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.69|P-value:9.66E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:-3.93|P-value:5.64E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:-4.41|P-value:7.17E-6 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.40|P-value:2.90E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:-4.12|P-value:2.50E-5 ID:SGTC_1554|Compound:st069299|FD-Score:3.66|P-value:1.05E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:4.45|P-value:3.57E-6 ID:SGTC_1672|Compound:st016598|FD-Score:-4.30|P-value:1.17E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-7.08|P-value:1.23E-12 ID:SGTC_1724|Compound:st037281|FD-Score:-3.71|P-value:1.36E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.67|P-value:1.26E-6 ID:SGTC_1921|Compound:5740136|FD-Score:-4.13|P-value:2.43E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.84|P-value:5.30E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.96|P-value:3.22E-5 ID:SGTC_2075|Compound:5212009|FD-Score:3.75|P-value:7.42E-5 ID:SGTC_2469|Compound:5655019|FD-Score:3.06|P-value:9.54E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.44|P-value:3.81E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:5.89|P-value:1.58E-9 ID:SGTC_2619|Compound:obliquin|FD-Score:5.57|P-value:1.03E-8 ID:SGTC_2902|Compound:5787006|FD-Score:3.80|P-value:6.27E-5 ID:SGTC_2914|Compound:7968218|FD-Score:3.46|P-value:2.27E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.68|P-value:1.01E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.18|P-value:6.35E-4 ID:SGTC_3003|Compound:9075612|FD-Score:4.44|P-value:3.70E-6 ID:SGTC_3012|Compound:9080433|FD-Score:3.22|P-value:5.47E-4 ID:SGTC_3013|Compound:9080133|FD-Score:5.63|P-value:7.44E-9 ID:SGTC_3029|Compound:9088683|FD-Score:3.68|P-value:9.85E-5 ID:SGTC_3034|Compound:9090421|FD-Score:6.24|P-value:1.77E-10 ID:SGTC_3037|Compound:9091026|FD-Score:-4.17|P-value:2.09E-5 ID:SGTC_3043|Compound:9092303|FD-Score:6.30|P-value:1.25E-10 ID:SGTC_3150|Compound:9097574|FD-Score:4.67|P-value:1.23E-6 ID:SGTC_3155|Compound:9099265|FD-Score:3.66|P-value:1.07E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.51|P-value:1.92E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.23|P-value:5.31E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.26|P-value:4.76E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.20|P-value:1.14E-5

Top fitness defect scores for YMR001C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3043 9092303 6.30 49.5 µM 1.25E-10 1 1.53E-10 0.99
2 SGTC_916 4466-0038 6.25 42.0 nM 1.67E-10 cell wall 13 2.04E-10 0.77
3 SGTC_3034 9090421 6.24 49.5 µM 1.77E-10 60S ribosome export 2 2.16E-10 2.47
4 SGTC_145 3737-0113 6.04 38.4 µM 6.32E-10 DNA intercalators 18 7.72E-10 0.40
5 SGTC_2584 androsterone 5.89 48.7 µM 1.58E-9 cell wall 11 1.93E-9 0.01
6 SGTC_3013 9080133 5.63 71.4 µM 7.44E-9 1 9.05E-9 1.40
7 SGTC_2619 obliquin 5.57 87.9 µM 1.03E-8 cell wall 17 1.25E-8 0.04
8 SGTC_3150 9097574 4.67 49.5 µM 1.23E-6 1 1.47E-6 0.50
9 SGTC_1800 st050079 4.67 29.1 µM 1.26E-6 NEO1-PIK1 16 1.51E-6 0.07
10 SGTC_1561 5-methoxyflavone 4.45 52.9 µM 3.57E-6 2 4.27E-6 1.03
11 SGTC_3003 9075612 4.44 71.4 µM 3.70E-6 5 4.42E-6 0.34
12 SGTC_2489 cantharidin 4.44 73.4 µM 3.81E-6 cell wall signaling 5 4.55E-6 0.05
13 SGTC_3350 9150499 4.20 3.6 µM 1.14E-5 cell wall 13 1.36E-5 0.00
14 SGTC_256 clotrimazole 4.17 625.0 nM 1.29E-5 ergosterol depletion effects on membrane 17 1.53E-5 0.03
15 SGTC_144 4161-2749 3.96 112.4 µM 3.15E-5 DNA intercalators 18 3.72E-5 0.09
16 SGTC_2006 4011487 3.96 200.0 µM 3.22E-5 endomembrane recycling 17 3.80E-5 0.09
17 SGTC_1926 methyl fluorone black 3.84 53.6 µM 5.30E-5 DNA intercalators 29 6.24E-5 0.04
18 SGTC_2902 5787006 3.80 60.5 µM 6.27E-5 Golgi 5 7.38E-5 0.15
19 SGTC_58 0957-0393 3.78 9.0 µM 6.59E-5 cell wall 53 7.75E-5 0.09
20 SGTC_775 4577-0580 3.77 57.3 µM 6.97E-5 6 8.20E-5 0.18

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.268 5.13E-56 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.246 1.93E-47 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.228 1.52E-40 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.221 3.51E-38 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.216 1.34E-36 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.215 2.92E-36 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.193 1.56E-29 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.181 4.01E-26 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.181 5.02E-26 YEL061C CIN8 hom Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
0.178 3.73E-25 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.177 4.59E-25 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.176 8.95E-25 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.175 2.18E-24 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.171 2.61E-23 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.170 4.41E-23 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis