YMR007W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR007W / YMR007W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.10|P-value:1.46E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:5.20|P-value:7.23E-10 ID:SGTC_59|Compound:0330-0160|FD-Score:2.82|P-value:4.99E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:2.79|P-value:5.66E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:10.20|P-value:7.00E-33 ID:SGTC_164|Compound:4100-3994|FD-Score:3.89|P-value:2.91E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.77|P-value:6.84E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.64|P-value:1.11E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:5.37|P-value:1.99E-10 ID:SGTC_405|Compound:ebelactone b|FD-Score:-2.84|P-value:5.18E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.76|P-value:7.02E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:8.38|P-value:9.83E-23 ID:SGTC_626|Compound:0214-0009|FD-Score:2.86|P-value:4.20E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.47|P-value:2.56E-5 ID:SGTC_681|Compound:1642-0006|FD-Score:-2.90|P-value:4.07E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-3.65|P-value:1.20E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:2.75|P-value:6.51E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.46|P-value:3.12E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-7.55|P-value:1.03E-18 ID:SGTC_751|Compound:0833-0568|FD-Score:3.13|P-value:1.33E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:2.97|P-value:2.65E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:2.73|P-value:7.29E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.08|P-value:1.88E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.40|P-value:1.80E-7 ID:SGTC_1126|Compound:isoteolin|FD-Score:-2.69|P-value:9.33E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.08|P-value:1.60E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-5.02|P-value:3.13E-9 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.80|P-value:6.01E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.28|P-value:7.61E-5 ID:SGTC_1750|Compound:st081859|FD-Score:10.10|P-value:2.39E-32 ID:SGTC_1789|Compound:tunicamycin|FD-Score:2.79|P-value:5.69E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.82|P-value:5.64E-4 ID:SGTC_1960|Compound:st011366|FD-Score:4.85|P-value:8.17E-9 ID:SGTC_1973|Compound:st070275|FD-Score:2.79|P-value:5.63E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.44|P-value:3.07E-5 ID:SGTC_2146|Compound:5545642|FD-Score:-2.92|P-value:3.64E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.83|P-value:3.94E-6 ID:SGTC_2331|Compound:7980721|FD-Score:-2.92|P-value:3.66E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.67|P-value:9.42E-6 ID:SGTC_2371|Compound:9071574|FD-Score:3.71|P-value:7.46E-6 ID:SGTC_2391|Compound:6285546|FD-Score:-2.69|P-value:9.50E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.13|P-value:1.47E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.95|P-value:2.11E-6 ID:SGTC_2445|Compound:5742597|FD-Score:-3.76|P-value:6.68E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.56|P-value:1.66E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.15|P-value:1.38E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.24|P-value:7.82E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.56|P-value:1.92E-5 ID:SGTC_2709|Compound:st078560|FD-Score:3.09|P-value:1.53E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.82|P-value:4.29E-6 ID:SGTC_2769|Compound:toremifene|FD-Score:2.65|P-value:9.74E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.04|P-value:2.21E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.05|P-value:1.37E-6 ID:SGTC_2837|Compound:9008476|FD-Score:2.85|P-value:4.41E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-3.54|P-value:2.09E-5 ID:SGTC_2924|Compound:9010168|FD-Score:3.01|P-value:2.25E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-2.71|P-value:8.63E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-2.85|P-value:4.90E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-3.79|P-value:5.94E-6 ID:SGTC_3207|Compound:9114163|FD-Score:3.84|P-value:3.86E-6 ID:SGTC_3209|Compound:9113616|FD-Score:3.32|P-value:5.36E-5 ID:SGTC_3225|Compound:9130819|FD-Score:2.72|P-value:7.53E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.85|P-value:3.51E-6 ID:SGTC_3254|Compound:9136651|FD-Score:-2.79|P-value:6.44E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.46|P-value:2.70E-5 ID:SGTC_3342|Compound:9147791|FD-Score:3.01|P-value:2.20E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.10|P-value:1.46E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:5.20|P-value:7.23E-10 ID:SGTC_59|Compound:0330-0160|FD-Score:2.82|P-value:4.99E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:2.79|P-value:5.66E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:10.20|P-value:7.00E-33 ID:SGTC_164|Compound:4100-3994|FD-Score:3.89|P-value:2.91E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.77|P-value:6.84E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.64|P-value:1.11E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:5.37|P-value:1.99E-10 ID:SGTC_405|Compound:ebelactone b|FD-Score:-2.84|P-value:5.18E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.76|P-value:7.02E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:8.38|P-value:9.83E-23 ID:SGTC_626|Compound:0214-0009|FD-Score:2.86|P-value:4.20E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.47|P-value:2.56E-5 ID:SGTC_681|Compound:1642-0006|FD-Score:-2.90|P-value:4.07E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-3.65|P-value:1.20E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:2.75|P-value:6.51E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.46|P-value:3.12E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-7.55|P-value:1.03E-18 ID:SGTC_751|Compound:0833-0568|FD-Score:3.13|P-value:1.33E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:2.97|P-value:2.65E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:2.73|P-value:7.29E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.08|P-value:1.88E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.40|P-value:1.80E-7 ID:SGTC_1126|Compound:isoteolin|FD-Score:-2.69|P-value:9.33E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.08|P-value:1.60E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-5.02|P-value:3.13E-9 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.80|P-value:6.01E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.28|P-value:7.61E-5 ID:SGTC_1750|Compound:st081859|FD-Score:10.10|P-value:2.39E-32 ID:SGTC_1789|Compound:tunicamycin|FD-Score:2.79|P-value:5.69E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.82|P-value:5.64E-4 ID:SGTC_1960|Compound:st011366|FD-Score:4.85|P-value:8.17E-9 ID:SGTC_1973|Compound:st070275|FD-Score:2.79|P-value:5.63E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.44|P-value:3.07E-5 ID:SGTC_2146|Compound:5545642|FD-Score:-2.92|P-value:3.64E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.83|P-value:3.94E-6 ID:SGTC_2331|Compound:7980721|FD-Score:-2.92|P-value:3.66E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.67|P-value:9.42E-6 ID:SGTC_2371|Compound:9071574|FD-Score:3.71|P-value:7.46E-6 ID:SGTC_2391|Compound:6285546|FD-Score:-2.69|P-value:9.50E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.13|P-value:1.47E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.95|P-value:2.11E-6 ID:SGTC_2445|Compound:5742597|FD-Score:-3.76|P-value:6.68E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.56|P-value:1.66E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.15|P-value:1.38E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.24|P-value:7.82E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.56|P-value:1.92E-5 ID:SGTC_2709|Compound:st078560|FD-Score:3.09|P-value:1.53E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.82|P-value:4.29E-6 ID:SGTC_2769|Compound:toremifene|FD-Score:2.65|P-value:9.74E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.04|P-value:2.21E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.05|P-value:1.37E-6 ID:SGTC_2837|Compound:9008476|FD-Score:2.85|P-value:4.41E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-3.54|P-value:2.09E-5 ID:SGTC_2924|Compound:9010168|FD-Score:3.01|P-value:2.25E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-2.71|P-value:8.63E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-2.85|P-value:4.90E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-3.79|P-value:5.94E-6 ID:SGTC_3207|Compound:9114163|FD-Score:3.84|P-value:3.86E-6 ID:SGTC_3209|Compound:9113616|FD-Score:3.32|P-value:5.36E-5 ID:SGTC_3225|Compound:9130819|FD-Score:2.72|P-value:7.53E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.85|P-value:3.51E-6 ID:SGTC_3254|Compound:9136651|FD-Score:-2.79|P-value:6.44E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.46|P-value:2.70E-5 ID:SGTC_3342|Compound:9147791|FD-Score:3.01|P-value:2.20E-4

Top fitness defect scores for YMR007W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_163 1327-0036 10.20 7.5 µM 7.00E-33 13 7.98E-25
2 SGTC_1750 st081859 10.10 2.4 µM 2.39E-32 endomembrane recycling 44 1.99E-24
3 SGTC_562 3772-2733 8.38 112.0 µM 9.83E-23 ERG2 14 2.74E-17
4 SGTC_352 k048-0007 5.37 5.1 µM 1.99E-10 ERAD & cell cycle 40 3.90E-8
5 SGTC_43 0570-0105 5.20 72.5 µM 7.23E-10 ERG2 49 1.02E-7
6 SGTC_1960 st011366 4.85 51.8 µM 8.17E-9 4 6.23E-7
7 SGTC_2415 st077333 3.95 57.7 µM 2.11E-6 46 3.96E-5
8 SGTC_164 4100-3994 3.89 89.6 µM 2.91E-6 36 5.03E-5
9 SGTC_3237 9133362 3.85 49.5 µM 3.51E-6 35 5.80E-5
10 SGTC_3207 9114163 3.84 49.5 µM 3.86E-6 32 6.23E-5
11 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 3.83 122.8 µM 3.94E-6 12 6.32E-5
12 SGTC_2768 sulfasalazine 3.82 50.2 µM 4.29E-6 19 6.73E-5
13 SGTC_2371 9071574 3.71 200.0 µM 7.46E-6 14 1.02E-4
14 SGTC_2369 9071472 3.67 200.0 µM 9.42E-6 21 1.22E-4
15 SGTC_255 tunicamycin 3.64 200.5 nM 1.11E-5 unfolded protein response 91 1.37E-4
16 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.56 3.7 µM 1.66E-5 119 1.85E-4
17 SGTC_658 3253-0951 3.47 102.0 µM 2.56E-5 calcium & mitochondrial duress 81 2.57E-4
18 SGTC_3336 9143619 3.46 71.4 µM 2.70E-5 32 2.68E-4
19 SGTC_2103 5378138 3.44 10.0 µM 3.07E-5 32 2.95E-4
20 SGTC_3209 9113616 3.32 49.5 µM 5.36E-5 54 4.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.408 6.57E-135 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.318 1.08E-79 YKL207W EMC3 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111
0.303 4.75E-72 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.296 6.28E-69 YCL045C EMC1 hom Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090
0.280 1.35E-61 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.261 3.07E-53 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.258 4.99E-52 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.256 2.42E-51 YPR153W YPR153W hom Putative protein of unknown function
0.254 1.27E-50 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.248 4.40E-48 YLL014W EMC6 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93
0.247 5.27E-48 YJR087W_d YJR087W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2
0.214 4.07E-36 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.213 1.09E-35 YHR006W STP2 hom Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication
0.212 1.61E-35 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.208 3.27E-34 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7