YMR008C / PLB1

Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR008C / PLB1

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:5.14|P-value:7.88E-8 ID:SGTC_39|Compound:0986-0283|FD-Score:4.20|P-value:9.07E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:5.36|P-value:2.31E-8 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.85|P-value:4.28E-5 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.56|P-value:1.54E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.03|P-value:9.94E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.62|P-value:1.19E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.67|P-value:1.00E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.66|P-value:1.13E-6 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.72|P-value:8.21E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:5.47|P-value:1.20E-8 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.13|P-value:7.60E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.65|P-value:1.08E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.12|P-value:1.03E-7 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.10|P-value:8.41E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.47|P-value:2.17E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:-3.11|P-value:8.11E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.79|P-value:5.02E-7 ID:SGTC_1984|Compound:st072354|FD-Score:-3.82|P-value:5.40E-5 ID:SGTC_2304|Compound:7443016|FD-Score:-4.94|P-value:2.71E-7 ID:SGTC_2305|Compound:7443522|FD-Score:-8.22|P-value:3.27E-17 ID:SGTC_2314|Compound:7727897|FD-Score:-3.70|P-value:8.85E-5 ID:SGTC_2359|Compound:9039622|FD-Score:-4.25|P-value:7.94E-6 ID:SGTC_2367|Compound:9070478|FD-Score:-4.27|P-value:7.25E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.13|P-value:7.67E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.27|P-value:4.10E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-4.03|P-value:2.15E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.95|P-value:2.78E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.62|P-value:1.10E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.15|P-value:6.51E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.57|P-value:1.33E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.25|P-value:4.43E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.41|P-value:2.51E-4 ID:SGTC_3273|Compound:9137859|FD-Score:-4.58|P-value:1.64E-6 ID:SGTC_3281|Compound:9140613|FD-Score:3.04|P-value:9.52E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:5.14|P-value:7.88E-8 ID:SGTC_39|Compound:0986-0283|FD-Score:4.20|P-value:9.07E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:5.36|P-value:2.31E-8 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.85|P-value:4.28E-5 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.56|P-value:1.54E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.03|P-value:9.94E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.62|P-value:1.19E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.67|P-value:1.00E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.66|P-value:1.13E-6 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.72|P-value:8.21E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:5.47|P-value:1.20E-8 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.13|P-value:7.60E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.65|P-value:1.08E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.12|P-value:1.03E-7 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.10|P-value:8.41E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.47|P-value:2.17E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:-3.11|P-value:8.11E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.79|P-value:5.02E-7 ID:SGTC_1984|Compound:st072354|FD-Score:-3.82|P-value:5.40E-5 ID:SGTC_2304|Compound:7443016|FD-Score:-4.94|P-value:2.71E-7 ID:SGTC_2305|Compound:7443522|FD-Score:-8.22|P-value:3.27E-17 ID:SGTC_2314|Compound:7727897|FD-Score:-3.70|P-value:8.85E-5 ID:SGTC_2359|Compound:9039622|FD-Score:-4.25|P-value:7.94E-6 ID:SGTC_2367|Compound:9070478|FD-Score:-4.27|P-value:7.25E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.13|P-value:7.67E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.27|P-value:4.10E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-4.03|P-value:2.15E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.95|P-value:2.78E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.62|P-value:1.10E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.15|P-value:6.51E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.57|P-value:1.33E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.25|P-value:4.43E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.41|P-value:2.51E-4 ID:SGTC_3273|Compound:9137859|FD-Score:-4.58|P-value:1.64E-6 ID:SGTC_3281|Compound:9140613|FD-Score:3.04|P-value:9.52E-4

Top fitness defect scores for YMR008C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_964 1287-0107 5.47 19.4 µM 1.20E-8 cell wall 16 2.25E-8
2 SGTC_41 0478-0632 5.36 82.6 µM 2.31E-8 9 4.24E-8
3 SGTC_38 0929-0051 5.14 58.3 µM 7.88E-8 7 1.38E-7
4 SGTC_1522 st012842 4.79 45.6 µM 5.02E-7 RNA pol III & RNase P/MRP 13 8.24E-7
5 SGTC_39 0986-0283 4.20 58.4 µM 9.07E-6 calcium & mitochondrial duress 31 1.34E-5
6 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.95 100.0 µM 2.78E-5 36 3.95E-5
7 SGTC_234 nsc-17383 3.85 10.7 µM 4.28E-5 ERG2 26 5.99E-5
8 SGTC_2697 mebhydrolin 3.62 72.4 µM 1.10E-4 NEO1 84 1.49E-4
9 SGTC_3148 9097893 3.57 49.5 µM 1.33E-4 46 1.78E-4
10 SGTC_3210 9128157 3.41 49.5 µM 2.51E-4 73 3.30E-4
11 SGTC_2588 indole-3-carbinol 3.27 100.0 µM 4.10E-4 81 5.29E-4
12 SGTC_3153 9100258 3.25 49.5 µM 4.43E-4 56 5.70E-4
13 SGTC_3106 9121286 3.15 49.5 µM 6.51E-4 45 8.26E-4
14 SGTC_3281 9140613 3.04 49.5 µM 9.52E-4 RPP1 & pyrimidine depletion 50 0.00119
15 SGTC_381 3461-2219 3.03 42.7 µM 9.94E-4 copper-dependent oxidative stress 58 0.00124
16 SGTC_2888 9058547 2.99 13.0 µM 0.00111 36 0.00138
17 SGTC_2312 7706453 2.99 155.7 µM 0.00113 72 0.00141
18 SGTC_2949 9072542 2.97 2.2 µM 0.00121 TSC3-RPN4 94 0.00150
19 SGTC_1739 st037196 2.92 92.5 µM 0.00143 71 0.00176
20 SGTC_2585 alliin 2.92 100.0 µM 0.00144 90 0.00178

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.243 3.35E-46 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.190 9.59E-29 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.188 5.99E-28 YER067W RGI1 hom Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.187 8.55E-28 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.165 7.44E-22 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.162 4.47E-21 YBR090C_p YBR090C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.157 4.84E-20 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.149 3.77E-18 YML101C CUE4 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication
0.138 1.05E-15 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.135 4.13E-15 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.135 4.46E-15 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.133 8.86E-15 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.133 9.95E-15 YKL100C_p YKL100C_p hom Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene
0.130 4.45E-14 YDR162C NBP2 hom Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)
0.130 4.76E-14 YGR173W RBG2 hom Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein