YMR009W / ADI1

Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR009W / ADI1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:2.95|P-value:9.66E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.39|P-value:1.87E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.41|P-value:1.76E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.42|P-value:1.69E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:2.99|P-value:8.43E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.30|P-value:2.68E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.88|P-value:2.87E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:3.61|P-value:7.75E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:3.35|P-value:2.17E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.07|P-value:6.43E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:-3.00|P-value:9.35E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.70|P-value:5.23E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.18|P-value:4.33E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.37|P-value:2.08E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.62|P-value:7.35E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:4.67|P-value:5.00E-7 ID:SGTC_722|Compound:3534-0461|FD-Score:-3.28|P-value:3.35E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.11|P-value:5.59E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.98|P-value:1.51E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:3.29|P-value:2.78E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-3.77|P-value:4.59E-5 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.02|P-value:7.60E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.06|P-value:6.55E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.11|P-value:8.49E-6 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.35|P-value:2.25E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.40|P-value:2.09E-4 ID:SGTC_1765|Compound:st044815|FD-Score:2.95|P-value:9.93E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.11|P-value:5.51E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-3.70|P-value:6.26E-5 ID:SGTC_1792|Compound:st045773|FD-Score:5.03|P-value:7.11E-8 ID:SGTC_1795|Compound:st049545|FD-Score:7.14|P-value:4.09E-14 ID:SGTC_1796|Compound:st049173|FD-Score:-4.26|P-value:4.90E-6 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.03|P-value:7.39E-4 ID:SGTC_1981|Compound:st071826|FD-Score:-3.93|P-value:2.29E-5 ID:SGTC_1990|Compound:st072050|FD-Score:3.44|P-value:1.55E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-3.07|P-value:7.29E-4 ID:SGTC_2063|Compound:5246145|FD-Score:4.82|P-value:2.28E-7 ID:SGTC_2120|Compound:5538279|FD-Score:-3.23|P-value:3.99E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.60|P-value:7.91E-5 ID:SGTC_2133|Compound:5320837|FD-Score:-3.78|P-value:4.34E-5 ID:SGTC_2264|Compound:7948757|FD-Score:3.24|P-value:3.34E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.54|P-value:1.04E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-3.79|P-value:4.26E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-3.25|P-value:3.80E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-3.35|P-value:2.59E-4 ID:SGTC_2335|Compound:9018011|FD-Score:4.93|P-value:1.22E-7 ID:SGTC_2432|Compound:5630864|FD-Score:3.43|P-value:1.60E-4 ID:SGTC_2439|Compound:5492030|FD-Score:4.22|P-value:4.94E-6 ID:SGTC_2625|Compound:euphol|FD-Score:3.51|P-value:1.18E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.15|P-value:4.83E-4 ID:SGTC_2911|Compound:7942208|FD-Score:3.10|P-value:5.66E-4 ID:SGTC_3010|Compound:9080089|FD-Score:4.68|P-value:4.71E-7 ID:SGTC_3127|Compound:9126946|FD-Score:2.98|P-value:8.98E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-4.16|P-value:7.93E-6 ID:SGTC_3283|Compound:9109332|FD-Score:3.43|P-value:1.64E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:2.95|P-value:9.66E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.39|P-value:1.87E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.41|P-value:1.76E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.42|P-value:1.69E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:2.99|P-value:8.43E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.30|P-value:2.68E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.88|P-value:2.87E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:3.61|P-value:7.75E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:3.35|P-value:2.17E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.07|P-value:6.43E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:-3.00|P-value:9.35E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.70|P-value:5.23E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.18|P-value:4.33E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.37|P-value:2.08E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.62|P-value:7.35E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:4.67|P-value:5.00E-7 ID:SGTC_722|Compound:3534-0461|FD-Score:-3.28|P-value:3.35E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.11|P-value:5.59E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.98|P-value:1.51E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:3.29|P-value:2.78E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-3.77|P-value:4.59E-5 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.02|P-value:7.60E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.06|P-value:6.55E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.11|P-value:8.49E-6 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.35|P-value:2.25E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.40|P-value:2.09E-4 ID:SGTC_1765|Compound:st044815|FD-Score:2.95|P-value:9.93E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.11|P-value:5.51E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-3.70|P-value:6.26E-5 ID:SGTC_1792|Compound:st045773|FD-Score:5.03|P-value:7.11E-8 ID:SGTC_1795|Compound:st049545|FD-Score:7.14|P-value:4.09E-14 ID:SGTC_1796|Compound:st049173|FD-Score:-4.26|P-value:4.90E-6 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.03|P-value:7.39E-4 ID:SGTC_1981|Compound:st071826|FD-Score:-3.93|P-value:2.29E-5 ID:SGTC_1990|Compound:st072050|FD-Score:3.44|P-value:1.55E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-3.07|P-value:7.29E-4 ID:SGTC_2063|Compound:5246145|FD-Score:4.82|P-value:2.28E-7 ID:SGTC_2120|Compound:5538279|FD-Score:-3.23|P-value:3.99E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.60|P-value:7.91E-5 ID:SGTC_2133|Compound:5320837|FD-Score:-3.78|P-value:4.34E-5 ID:SGTC_2264|Compound:7948757|FD-Score:3.24|P-value:3.34E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.54|P-value:1.04E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-3.79|P-value:4.26E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-3.25|P-value:3.80E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-3.35|P-value:2.59E-4 ID:SGTC_2335|Compound:9018011|FD-Score:4.93|P-value:1.22E-7 ID:SGTC_2432|Compound:5630864|FD-Score:3.43|P-value:1.60E-4 ID:SGTC_2439|Compound:5492030|FD-Score:4.22|P-value:4.94E-6 ID:SGTC_2625|Compound:euphol|FD-Score:3.51|P-value:1.18E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.15|P-value:4.83E-4 ID:SGTC_2911|Compound:7942208|FD-Score:3.10|P-value:5.66E-4 ID:SGTC_3010|Compound:9080089|FD-Score:4.68|P-value:4.71E-7 ID:SGTC_3127|Compound:9126946|FD-Score:2.98|P-value:8.98E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-4.16|P-value:7.93E-6 ID:SGTC_3283|Compound:9109332|FD-Score:3.43|P-value:1.64E-4

Top fitness defect scores for YMR009W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1795 st049545 7.14 62.3 µM 4.09E-14 TSC3-RPN4 2 4.59E-13
2 SGTC_1792 st045773 5.03 43.6 µM 7.11E-8 12 2.48E-7
3 SGTC_2335 9018011 4.93 154.2 µM 1.22E-7 13 4.08E-7
4 SGTC_2063 5246145 4.82 200.0 µM 2.28E-7 12 7.26E-7
5 SGTC_3010 9080089 4.68 71.4 µM 4.71E-7 4 1.41E-6
6 SGTC_610 4215-0184 4.67 155.0 µM 5.00E-7 exosome 3 1.49E-6
7 SGTC_2439 5492030 4.22 7.2 µM 4.94E-6 6 1.22E-5
8 SGTC_1370 2001-0092 4.11 44.6 µM 8.49E-6 26 2.01E-5
9 SGTC_780 0109-0199 3.98 192.0 µM 1.51E-5 11 3.41E-5
10 SGTC_238 5hr heat shock (37°C) + nsc-638432 3.70 8.9 µM 5.23E-5 heat shock/prefoldin 51 1.07E-4
11 SGTC_489 paxilline 3.62 115.0 µM 7.35E-5 PDR1 24 1.46E-4
12 SGTC_167 3672-0051 3.61 66.2 µM 7.75E-5 51 1.54E-4
13 SGTC_2131 toluylene red 3.60 5.3 µM 7.91E-5 60S ribosome export 33 1.57E-4
14 SGTC_2286 7945697 3.54 125.0 µM 1.04E-4 72 2.02E-4
15 SGTC_2625 euphol 3.51 100.0 µM 1.18E-4 43 2.26E-4
16 SGTC_1990 st072050 3.44 59.8 µM 1.55E-4 26 2.91E-4
17 SGTC_2432 5630864 3.43 12.2 µM 1.60E-4 46 3.00E-4
18 SGTC_3283 9109332 3.43 35.8 µM 1.64E-4 DNA intercalators 26 3.06E-4
19 SGTC_66 0109-0187 3.42 42.4 µM 1.69E-4 58 3.15E-4
20 SGTC_24 0417-1663 3.41 219.0 µM 1.76E-4 33 3.26E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.95E-11 YOL139C CDC33 het mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth
0.108 3.17E-10 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.106 7.55E-10 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.101 4.92E-9 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.099 8.11E-9 YJL208C NUC1 hom Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
0.095 3.32E-8 YIL117C PRM5 hom Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling
0.088 3.03E-7 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.087 4.16E-7 YBR185C MBA1 hom Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane
0.085 8.94E-7 YLR276C DBP9 het DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.077 8.41E-6 YOR230W WTM1 hom Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
0.076 1.13E-5 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.075 1.49E-5 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.075 1.50E-5 YEL026W SNU13 het RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
0.075 1.53E-5 YOR181W LAS17 het Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
0.074 1.72E-5 YMR172W HOT1 hom Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p