YMR010W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR010W / YMR010W

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:-3.55|P-value:1.35E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:-5.20|P-value:4.84E-8 ID:SGTC_16|Compound:erodoxin|FD-Score:3.07|P-value:8.53E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:4.79|P-value:5.03E-7 ID:SGTC_36|Compound:0335-0881|FD-Score:3.10|P-value:7.84E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.85|P-value:4.16E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:3.36|P-value:3.04E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.29|P-value:5.83E-6 ID:SGTC_164|Compound:4100-3994|FD-Score:4.85|P-value:3.66E-7 ID:SGTC_299|Compound:1273-0059|FD-Score:5.09|P-value:1.00E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:4.82|P-value:4.19E-7 ID:SGTC_327|Compound:1273-0057|FD-Score:5.75|P-value:2.11E-9 ID:SGTC_352|Compound:k048-0007|FD-Score:3.46|P-value:2.04E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.65|P-value:1.03E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.25|P-value:4.24E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.08|P-value:8.26E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.03|P-value:1.93E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:7.65|P-value:2.67E-15 ID:SGTC_637|Compound:1181-0519|FD-Score:3.68|P-value:8.67E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.63|P-value:9.96E-5 ID:SGTC_640|Compound:3381-0960|FD-Score:-3.89|P-value:3.38E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.52|P-value:1.51E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.54|P-value:1.73E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:3.24|P-value:4.66E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.44|P-value:2.21E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:5.35|P-value:2.26E-8 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.49|P-value:1.75E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:10.40|P-value:1.36E-26 ID:SGTC_875|Compound:0709-0210|FD-Score:3.51|P-value:1.66E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.53|P-value:1.57E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.68|P-value:8.08E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.80|P-value:5.26E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.33|P-value:3.23E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.64|P-value:1.02E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.71|P-value:7.27E-5 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.59|P-value:1.25E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.26|P-value:4.29E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.40|P-value:2.46E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.12|P-value:7.12E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.27|P-value:4.06E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.53|P-value:7.99E-9 ID:SGTC_1609|Compound:st001574|FD-Score:3.56|P-value:1.38E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.64|P-value:9.90E-5 ID:SGTC_1670|Compound:st016595|FD-Score:-3.17|P-value:5.68E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.35|P-value:4.22E-6 ID:SGTC_1754|Compound:st042065|FD-Score:-5.04|P-value:1.23E-7 ID:SGTC_1763|Compound:st044482|FD-Score:-3.41|P-value:2.38E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.10|P-value:7.39E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.65|P-value:9.04E-5 ID:SGTC_1867|Compound:st057372|FD-Score:3.32|P-value:3.49E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-4.69|P-value:7.87E-7 ID:SGTC_2052|Compound:5265182|FD-Score:4.54|P-value:1.78E-6 ID:SGTC_2057|Compound:5236571|FD-Score:3.97|P-value:2.45E-5 ID:SGTC_2077|Compound:5212015|FD-Score:3.34|P-value:3.27E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.29|P-value:3.85E-4 ID:SGTC_2398|Compound:5228213|FD-Score:4.79|P-value:4.95E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.13|P-value:7.02E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-5.07|P-value:1.01E-7 ID:SGTC_2643|Compound:anethole|FD-Score:3.98|P-value:2.36E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:3.17|P-value:5.99E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.30|P-value:3.63E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.76|P-value:6.25E-5 ID:SGTC_2959|Compound:9079155|FD-Score:3.73|P-value:6.89E-5 ID:SGTC_2960|Compound:9079389|FD-Score:3.99|P-value:2.26E-5 ID:SGTC_5|Compound:0352-0601|FD-Score:-3.55|P-value:1.35E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:-5.20|P-value:4.84E-8 ID:SGTC_16|Compound:erodoxin|FD-Score:3.07|P-value:8.53E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:4.79|P-value:5.03E-7 ID:SGTC_36|Compound:0335-0881|FD-Score:3.10|P-value:7.84E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.85|P-value:4.16E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:3.36|P-value:3.04E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.29|P-value:5.83E-6 ID:SGTC_164|Compound:4100-3994|FD-Score:4.85|P-value:3.66E-7 ID:SGTC_299|Compound:1273-0059|FD-Score:5.09|P-value:1.00E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:4.82|P-value:4.19E-7 ID:SGTC_327|Compound:1273-0057|FD-Score:5.75|P-value:2.11E-9 ID:SGTC_352|Compound:k048-0007|FD-Score:3.46|P-value:2.04E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.65|P-value:1.03E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.25|P-value:4.24E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.08|P-value:8.26E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.03|P-value:1.93E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:7.65|P-value:2.67E-15 ID:SGTC_637|Compound:1181-0519|FD-Score:3.68|P-value:8.67E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.63|P-value:9.96E-5 ID:SGTC_640|Compound:3381-0960|FD-Score:-3.89|P-value:3.38E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.52|P-value:1.51E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.54|P-value:1.73E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:3.24|P-value:4.66E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.44|P-value:2.21E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:5.35|P-value:2.26E-8 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.49|P-value:1.75E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:10.40|P-value:1.36E-26 ID:SGTC_875|Compound:0709-0210|FD-Score:3.51|P-value:1.66E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.53|P-value:1.57E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.68|P-value:8.08E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.80|P-value:5.26E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.33|P-value:3.23E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.64|P-value:1.02E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.71|P-value:7.27E-5 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.59|P-value:1.25E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.26|P-value:4.29E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.40|P-value:2.46E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.12|P-value:7.12E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.27|P-value:4.06E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.53|P-value:7.99E-9 ID:SGTC_1609|Compound:st001574|FD-Score:3.56|P-value:1.38E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.64|P-value:9.90E-5 ID:SGTC_1670|Compound:st016595|FD-Score:-3.17|P-value:5.68E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.35|P-value:4.22E-6 ID:SGTC_1754|Compound:st042065|FD-Score:-5.04|P-value:1.23E-7 ID:SGTC_1763|Compound:st044482|FD-Score:-3.41|P-value:2.38E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.10|P-value:7.39E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.65|P-value:9.04E-5 ID:SGTC_1867|Compound:st057372|FD-Score:3.32|P-value:3.49E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-4.69|P-value:7.87E-7 ID:SGTC_2052|Compound:5265182|FD-Score:4.54|P-value:1.78E-6 ID:SGTC_2057|Compound:5236571|FD-Score:3.97|P-value:2.45E-5 ID:SGTC_2077|Compound:5212015|FD-Score:3.34|P-value:3.27E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.29|P-value:3.85E-4 ID:SGTC_2398|Compound:5228213|FD-Score:4.79|P-value:4.95E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.13|P-value:7.02E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-5.07|P-value:1.01E-7 ID:SGTC_2643|Compound:anethole|FD-Score:3.98|P-value:2.36E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:3.17|P-value:5.99E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.30|P-value:3.63E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.76|P-value:6.25E-5 ID:SGTC_2959|Compound:9079155|FD-Score:3.73|P-value:6.89E-5 ID:SGTC_2960|Compound:9079389|FD-Score:3.99|P-value:2.26E-5

Top fitness defect scores for YMR010W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_768 0384-0033 10.40 77.3 µM 1.36E-26 fatty acid desaturase (OLE1) 11 1.63E-25
2 SGTC_634 1611-4317 7.65 11.2 µM 2.67E-15 ERG2 4 1.02E-14
3 SGTC_327 1273-0057 5.75 4.0 µM 2.11E-9 azole & statin 6 4.51E-9
4 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 5.53 54.9 µM 7.99E-9 redox potentiating 38 1.61E-8
5 SGTC_748 0136-0228 5.35 77.9 µM 2.26E-8 redox potentiating 46 4.36E-8
6 SGTC_299 1273-0059 5.09 1.4 µM 1.00E-7 14 1.81E-7
7 SGTC_164 4100-3994 4.85 89.6 µM 3.66E-7 12 6.27E-7
8 SGTC_310 1273-0058 4.82 1.1 µM 4.19E-7 mitochondrial stress 188 7.14E-7
9 SGTC_2398 5228213 4.79 48.8 µM 4.95E-7 iron homeostasis 19 8.39E-7
10 SGTC_30 5-(2-thienylidene)-Rhodanine 4.79 28.7 µM 5.03E-7 4 8.50E-7
11 SGTC_363 0455-0021 4.65 3.1 µM 1.03E-6 azole & statin 44 1.69E-6
12 SGTC_669 0108-0021 4.54 26.2 µM 1.73E-6 fatty acid desaturase (OLE1) 55 2.77E-6
13 SGTC_2052 5265182 4.54 7.1 µM 1.78E-6 15 2.85E-6
14 SGTC_137 0438-0332 4.29 85.4 µM 5.83E-6 ubiquinone biosynthesis & proteasome 105 8.90E-6
15 SGTC_459 nigericin 4.03 15.3 µM 1.93E-5 63 2.81E-5
16 SGTC_2960 9079389 3.99 6.0 µM 2.26E-5 29 3.27E-5
17 SGTC_2643 anethole 3.98 100.0 µM 2.36E-5 15 3.40E-5
18 SGTC_2057 5236571 3.97 38.3 µM 2.45E-5 RPP1 & pyrimidine depletion 31 3.53E-5
19 SGTC_102 gallobenzophenone 3.85 83.6 µM 4.16E-5 redox potentiating 47 5.85E-5
20 SGTC_1039 k821-0043 3.80 94.0 µM 5.26E-5 Golgi 29 7.33E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.170 4.83E-23 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.146 1.62E-17 YLR350W ORM2 hom Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress
0.136 2.23E-15 YKR034W DAL80 hom Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication
0.135 4.84E-15 YNL231C PDR16 hom Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress
0.131 2.14E-14 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.129 7.39E-14 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.126 2.26E-13 YPR173C VPS4 hom AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.122 1.50E-12 YDR213W UPC2 hom Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.120 2.61E-12 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.120 3.20E-12 YOR070C GYP1 hom Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
0.118 7.89E-12 YDR414C ERD1 hom Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.117 1.05E-11 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.113 4.89E-11 YOR109W INP53 hom Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
0.113 6.38E-11 YIL115C NUP159 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
0.112 9.45E-11 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress