YMR013W-A_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR013W-A / YMR013W-A

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-3.24|P-value:5.93E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.51|P-value:2.18E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.03|P-value:9.66E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:3.61|P-value:1.14E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.83|P-value:6.31E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:3.83|P-value:4.56E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.73|P-value:9.26E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.91|P-value:3.32E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.74|P-value:6.68E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:-4.82|P-value:6.64E-7 ID:SGTC_779|Compound:1360-0071|FD-Score:3.05|P-value:8.90E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.29|P-value:3.88E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.66|P-value:1.24E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.30|P-value:3.67E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.18|P-value:5.68E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.34|P-value:3.21E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.55|P-value:1.45E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.20|P-value:5.32E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.57|P-value:1.31E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.03|P-value:9.63E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.55|P-value:1.42E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:5.04|P-value:1.39E-7 ID:SGTC_1927|Compound:st060202|FD-Score:-3.26|P-value:5.62E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-4.40|P-value:5.18E-6 ID:SGTC_2023|Compound:5144124|FD-Score:-4.03|P-value:2.67E-5 ID:SGTC_2270|Compound:7924575|FD-Score:4.17|P-value:1.07E-5 ID:SGTC_2381|Compound:9035592|FD-Score:3.79|P-value:5.49E-5 ID:SGTC_2385|Compound:9074692|FD-Score:-3.67|P-value:1.18E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.23|P-value:6.13E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.05|P-value:9.13E-4 ID:SGTC_2484|Compound:5809818|FD-Score:4.26|P-value:6.81E-6 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.07|P-value:8.28E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.60|P-value:1.20E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.35|P-value:4.02E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:5.29|P-value:3.49E-8 ID:SGTC_2712|Compound:st079126|FD-Score:3.31|P-value:3.52E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.26|P-value:4.33E-4 ID:SGTC_3044|Compound:9093193|FD-Score:4.96|P-value:2.18E-7 ID:SGTC_3218|Compound:9131285|FD-Score:3.21|P-value:5.08E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.43|P-value:3.13E-6 ID:SGTC_3326|Compound:9140064|FD-Score:3.10|P-value:7.62E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.24|P-value:5.93E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.51|P-value:2.18E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.03|P-value:9.66E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:3.61|P-value:1.14E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.83|P-value:6.31E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:3.83|P-value:4.56E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.73|P-value:9.26E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.91|P-value:3.32E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.74|P-value:6.68E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:-4.82|P-value:6.64E-7 ID:SGTC_779|Compound:1360-0071|FD-Score:3.05|P-value:8.90E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.29|P-value:3.88E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.66|P-value:1.24E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.30|P-value:3.67E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.18|P-value:5.68E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.34|P-value:3.21E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.55|P-value:1.45E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.20|P-value:5.32E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.57|P-value:1.31E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.03|P-value:9.63E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.55|P-value:1.42E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:5.04|P-value:1.39E-7 ID:SGTC_1927|Compound:st060202|FD-Score:-3.26|P-value:5.62E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-4.40|P-value:5.18E-6 ID:SGTC_2023|Compound:5144124|FD-Score:-4.03|P-value:2.67E-5 ID:SGTC_2270|Compound:7924575|FD-Score:4.17|P-value:1.07E-5 ID:SGTC_2381|Compound:9035592|FD-Score:3.79|P-value:5.49E-5 ID:SGTC_2385|Compound:9074692|FD-Score:-3.67|P-value:1.18E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.23|P-value:6.13E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.05|P-value:9.13E-4 ID:SGTC_2484|Compound:5809818|FD-Score:4.26|P-value:6.81E-6 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.07|P-value:8.28E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.60|P-value:1.20E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.35|P-value:4.02E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:5.29|P-value:3.49E-8 ID:SGTC_2712|Compound:st079126|FD-Score:3.31|P-value:3.52E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.26|P-value:4.33E-4 ID:SGTC_3044|Compound:9093193|FD-Score:4.96|P-value:2.18E-7 ID:SGTC_3218|Compound:9131285|FD-Score:3.21|P-value:5.08E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.43|P-value:3.13E-6 ID:SGTC_3326|Compound:9140064|FD-Score:3.10|P-value:7.62E-4

Top fitness defect scores for YMR013W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2686 alizarin 5.29 95.4 µM 3.49E-8 RPP1 & pyrimidine depletion 14 5.98E-8
2 SGTC_1514 1189-1591 5.04 158.0 µM 1.39E-7 20 2.29E-7
3 SGTC_3044 9093193 4.96 49.5 µM 2.18E-7 10 3.56E-7
4 SGTC_3222 9128301 4.43 49.5 µM 3.13E-6 60S ribosome export 16 4.72E-6
5 SGTC_2484 5809818 4.26 12.0 µM 6.81E-6 13 1.00E-5
6 SGTC_2270 7924575 4.17 90.9 µM 1.07E-5 RPP1 & pyrimidine depletion 10 1.56E-5
7 SGTC_451 chloral hydrate 3.91 100.0 µM 3.32E-5 53 4.67E-5
8 SGTC_381 3461-2219 3.83 42.7 µM 4.56E-5 copper-dependent oxidative stress 20 6.36E-5
9 SGTC_2381 9035592 3.79 200.0 µM 5.49E-5 23 7.61E-5
10 SGTC_769 0302-0231 3.74 76.0 µM 6.68E-5 49 9.21E-5
11 SGTC_311 1315-0136 3.61 58.0 µM 1.14E-4 15 1.55E-4
12 SGTC_2524 avocatin b 3.60 10.6 µM 1.20E-4 33 1.62E-4
13 SGTC_1248 0469-0687 3.57 58.6 µM 1.31E-4 39 1.76E-4
14 SGTC_1416 3966-0321 3.55 25.3 µM 1.42E-4 30 1.92E-4
15 SGTC_978 1416-0512 3.55 87.4 µM 1.45E-4 redox potentiating 38 1.96E-4
16 SGTC_958 1222-0007 3.34 33.0 µM 3.21E-4 51 4.22E-4
17 SGTC_2712 st079126 3.31 47.7 µM 3.52E-4 37 4.61E-4
18 SGTC_869 0564-0080 3.30 44.1 µM 3.67E-4 40 4.81E-4
19 SGTC_789 1309-1135 3.29 70.6 µM 3.88E-4 ERG2 57 5.08E-4
20 SGTC_2935 9038016 3.26 30.0 µM 4.33E-4 46 5.64E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 5.48E-11 YFR035C_p YFR035C_p hom Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein
0.110 1.44E-10 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.105 9.24E-10 YLR249W YEF3 het Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex; contains two ABC cassettes; binds and hydrolyzes ATP; YEF3 has a paralog, HEF3, that arose from the whole genome duplication
0.099 9.70E-9 YLR082C SRL2 hom Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
0.097 1.92E-8 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.092 1.06E-7 YCL001W-B_p YCL001W-B_p hom Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication
0.090 1.76E-7 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.089 2.82E-7 YDR252W BTT1 hom Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3
0.087 4.56E-7 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.086 6.60E-7 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.084 9.52E-7 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress
0.084 9.96E-7 YMR269W TMA23 hom Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan
0.082 1.73E-6 YOR166C SWT1 hom RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain
0.082 1.74E-6 YBR273C UBX7 hom UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication
0.080 3.36E-6 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress