YMR018W_p

Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR018W / YMR018W

Click on Significant Values for Screen Details ID:SGTC_160|Compound:3453-0671|FD-Score:-3.34|P-value:7.68E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:4.11|P-value:5.74E-5 ID:SGTC_276|Compound:colchicine|FD-Score:4.24|P-value:3.46E-5 ID:SGTC_493|Compound:zm226600|FD-Score:4.44|P-value:1.52E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.46|P-value:5.18E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.08|P-value:6.43E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.60|P-value:3.20E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.94|P-value:1.07E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.87|P-value:1.42E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.62|P-value:3.44E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.86|P-value:1.44E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.42|P-value:6.68E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.34|P-value:2.64E-7 ID:SGTC_1221|Compound:2958-7315|FD-Score:-3.36|P-value:7.26E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:-3.29|P-value:8.94E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:4.65|P-value:6.20E-6 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.79|P-value:1.64E-4 ID:SGTC_1656|Compound:st012921|FD-Score:-3.40|P-value:6.26E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.72|P-value:2.38E-4 ID:SGTC_1758|Compound:st042942|FD-Score:5.43|P-value:1.69E-7 ID:SGTC_1792|Compound:st045773|FD-Score:4.76|P-value:3.93E-6 ID:SGTC_1999|Compound:st074831|FD-Score:3.78|P-value:1.96E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.00|P-value:8.49E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.31|P-value:9.60E-4 ID:SGTC_2088|Compound:5278280|FD-Score:4.10|P-value:5.90E-5 ID:SGTC_2224|Compound:6650123|FD-Score:-3.31|P-value:8.49E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.03|P-value:7.56E-5 ID:SGTC_2370|Compound:9071495|FD-Score:4.65|P-value:6.29E-6 ID:SGTC_2377|Compound:9073351|FD-Score:5.75|P-value:3.25E-8 ID:SGTC_2385|Compound:9074692|FD-Score:4.51|P-value:1.13E-5 ID:SGTC_2395|Compound:5646831|FD-Score:3.93|P-value:1.12E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.28|P-value:2.56E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.83|P-value:1.44E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.77|P-value:2.00E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.97|P-value:1.47E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:6.68|P-value:1.61E-10 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.77|P-value:1.76E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:3.93|P-value:1.13E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.14|P-value:5.06E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.61|P-value:3.48E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.31|P-value:8.42E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-3.73|P-value:2.04E-4 ID:SGTC_3093|Compound:9117344|FD-Score:-4.02|P-value:7.07E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.34|P-value:7.68E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:4.11|P-value:5.74E-5 ID:SGTC_276|Compound:colchicine|FD-Score:4.24|P-value:3.46E-5 ID:SGTC_493|Compound:zm226600|FD-Score:4.44|P-value:1.52E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.46|P-value:5.18E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.08|P-value:6.43E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.60|P-value:3.20E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.94|P-value:1.07E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.87|P-value:1.42E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.62|P-value:3.44E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.86|P-value:1.44E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.42|P-value:6.68E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.34|P-value:2.64E-7 ID:SGTC_1221|Compound:2958-7315|FD-Score:-3.36|P-value:7.26E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:-3.29|P-value:8.94E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:4.65|P-value:6.20E-6 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.79|P-value:1.64E-4 ID:SGTC_1656|Compound:st012921|FD-Score:-3.40|P-value:6.26E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.72|P-value:2.38E-4 ID:SGTC_1758|Compound:st042942|FD-Score:5.43|P-value:1.69E-7 ID:SGTC_1792|Compound:st045773|FD-Score:4.76|P-value:3.93E-6 ID:SGTC_1999|Compound:st074831|FD-Score:3.78|P-value:1.96E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.00|P-value:8.49E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.31|P-value:9.60E-4 ID:SGTC_2088|Compound:5278280|FD-Score:4.10|P-value:5.90E-5 ID:SGTC_2224|Compound:6650123|FD-Score:-3.31|P-value:8.49E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.03|P-value:7.56E-5 ID:SGTC_2370|Compound:9071495|FD-Score:4.65|P-value:6.29E-6 ID:SGTC_2377|Compound:9073351|FD-Score:5.75|P-value:3.25E-8 ID:SGTC_2385|Compound:9074692|FD-Score:4.51|P-value:1.13E-5 ID:SGTC_2395|Compound:5646831|FD-Score:3.93|P-value:1.12E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.28|P-value:2.56E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.83|P-value:1.44E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.77|P-value:2.00E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.97|P-value:1.47E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:6.68|P-value:1.61E-10 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.77|P-value:1.76E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:3.93|P-value:1.13E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.14|P-value:5.06E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.61|P-value:3.48E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.31|P-value:8.42E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-3.73|P-value:2.04E-4 ID:SGTC_3093|Compound:9117344|FD-Score:-4.02|P-value:7.07E-5

Top fitness defect scores for YMR018W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 6.68 92.6 µM 1.61E-10 3 1.16E-11
2 SGTC_2377 9073351 5.75 62.6 µM 3.25E-8 ergosterol biosynthesis 6 4.53E-9
3 SGTC_1758 st042942 5.43 75.2 µM 1.69E-7 4 2.89E-8
4 SGTC_1130 3454-2858 5.34 15.9 µM 2.64E-7 NEO1 51 4.77E-8
5 SGTC_2506 ethyl hematommate 4.97 54.2 µM 1.47E-6 RPP1 & pyrimidine depletion 5 3.28E-7
6 SGTC_1792 st045773 4.76 43.6 µM 3.93E-6 15 9.92E-7
7 SGTC_1291 0993-0025 4.65 5.8 µM 6.20E-6 7 1.65E-6
8 SGTC_2370 9071495 4.65 200.0 µM 6.29E-6 mitochondrial processes 13 1.68E-6
9 SGTC_2385 9074692 4.51 200.0 µM 1.13E-5 30 3.24E-6
10 SGTC_493 zm226600 4.44 134.0 µM 1.52E-5 mitochondrial processes 9 4.52E-6
11 SGTC_276 colchicine 4.24 750.0 µM 3.46E-5 11 1.14E-5
12 SGTC_2563 tomatine 4.14 8.5 µM 5.06E-5 41 1.74E-5
13 SGTC_164 4100-3994 4.11 89.6 µM 5.74E-5 26 2.01E-5
14 SGTC_2088 5278280 4.10 127.4 µM 5.90E-5 20 2.07E-5
15 SGTC_690 glyoxal 4.08 20.3 µM 6.43E-5 78 2.28E-5
16 SGTC_2340 7987427 4.03 183.4 µM 7.56E-5 30 2.74E-5
17 SGTC_2066 5222451 4.00 176.0 µM 8.49E-5 heme biosynthesis & mitochondrial translocase 29 3.12E-5
18 SGTC_722 3534-0461 3.94 190.0 µM 1.07E-4 PDR1 37 4.04E-5
19 SGTC_2395 5646831 3.93 180.2 µM 1.12E-4 21 4.24E-5
20 SGTC_2559 tetrahydrosappanone a trimethyl ether 3.93 100.0 µM 1.13E-4 14 4.31E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 8.45E-11 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.100 6.65E-9 YGL153W PEX14 hom Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p
0.093 6.80E-8 YMR221C_p YMR221C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
0.090 1.94E-7 YER113C TMN3 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation
0.087 4.18E-7 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.087 4.65E-7 YNL217W_p YNL217W_p hom Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate
0.086 5.96E-7 YIL139C REV7 hom Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.084 9.69E-7 YMR153W NUP53 hom FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication
0.082 1.93E-6 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.082 2.05E-6 YLR077W FMP25 hom Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria
0.081 3.01E-6 YDR018C_p YDR018C_p hom Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication
0.079 5.04E-6 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.078 6.36E-6 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.077 7.79E-6 YOR223W YOR223W hom Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3
0.077 8.33E-6 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress