YMR021C / MAC1

Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR021C / MAC1

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-5.63|P-value:1.32E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:5.94|P-value:8.38E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:5.86|P-value:1.01E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:-5.55|P-value:1.63E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:15.60|P-value:1.32E-23 ID:SGTC_116|Compound:0155-0182|FD-Score:6.76|P-value:9.01E-6 ID:SGTC_123|Compound:0083-0120|FD-Score:6.74|P-value:9.49E-6 ID:SGTC_128|Compound:0906-2981|FD-Score:4.89|P-value:9.92E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.38|P-value:5.05E-8 ID:SGTC_139|Compound:0099-0334|FD-Score:6.13|P-value:5.04E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:5.64|P-value:1.77E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-5.13|P-value:4.36E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:11.50|P-value:1.47E-13 ID:SGTC_179|Compound:1273-0063|FD-Score:-12.80|P-value:1.09E-16 ID:SGTC_180|Compound:1486-1293|FD-Score:10.10|P-value:7.81E-11 ID:SGTC_208|Compound:k072-0098|FD-Score:5.19|P-value:5.10E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-5.22|P-value:3.57E-4 ID:SGTC_222|Compound:nsc-310342|FD-Score:-4.82|P-value:8.87E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:8.58|P-value:2.47E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:6.02|P-value:6.80E-5 ID:SGTC_328|Compound:k915-0120|FD-Score:5.45|P-value:2.80E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-5.03|P-value:5.47E-4 ID:SGTC_458|Compound:nppb|FD-Score:4.93|P-value:9.19E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:7.13|P-value:3.02E-6 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:7.86|P-value:2.99E-7 ID:SGTC_513|Compound:4245-1575|FD-Score:5.84|P-value:1.08E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:5.35|P-value:3.58E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:-5.76|P-value:9.56E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:-5.35|P-value:2.62E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:9.94|P-value:1.25E-10 ID:SGTC_626|Compound:0214-0009|FD-Score:6.35|P-value:2.84E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:-4.86|P-value:8.06E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:6.74|P-value:9.58E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:5.73|P-value:1.42E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:6.51|P-value:1.81E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:5.37|P-value:3.37E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:-5.97|P-value:5.50E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:5.81|P-value:1.15E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:5.89|P-value:9.44E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:8.27|P-value:7.21E-8 ID:SGTC_975|Compound:1335-0046|FD-Score:5.91|P-value:8.99E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:8.93|P-value:6.82E-9 ID:SGTC_1001|Compound:4048-4355|FD-Score:9.93|P-value:1.33E-10 ID:SGTC_1002|Compound:4049-0206|FD-Score:5.12|P-value:6.04E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-4.93|P-value:6.88E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:6.27|P-value:3.47E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:5.66|P-value:1.67E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:5.16|P-value:5.49E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:-5.58|P-value:1.52E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:6.11|P-value:5.36E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:12.80|P-value:1.66E-16 ID:SGTC_1242|Compound:0402-0103|FD-Score:-5.68|P-value:1.16E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-18.00|P-value:3.35E-31 ID:SGTC_1247|Compound:0448-0043|FD-Score:-5.93|P-value:6.13E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:-6.88|P-value:4.38E-6 ID:SGTC_1392|Compound:3455-1037|FD-Score:8.58|P-value:2.43E-8 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.79|P-value:8.16E-6 ID:SGTC_1524|Compound:corynanthine|FD-Score:6.30|P-value:3.24E-5 ID:SGTC_1530|Compound:rhein|FD-Score:4.92|P-value:9.39E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-5.33|P-value:2.74E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:13.70|P-value:1.43E-18 ID:SGTC_1573|Compound:oleylamine|FD-Score:7.65|P-value:5.88E-7 ID:SGTC_1612|Compound:st002233|FD-Score:5.00|P-value:7.82E-4 ID:SGTC_1643|Compound:st009866|FD-Score:5.11|P-value:6.11E-4 ID:SGTC_1696|Compound:st025591|FD-Score:7.35|P-value:1.52E-6 ID:SGTC_1700|Compound:st030840|FD-Score:5.37|P-value:3.38E-4 ID:SGTC_1763|Compound:st044482|FD-Score:9.66|P-value:3.94E-10 ID:SGTC_1824|Compound:st053723|FD-Score:5.53|P-value:2.29E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.82|P-value:8.72E-4 ID:SGTC_1850|Compound:st056238|FD-Score:5.16|P-value:5.42E-4 ID:SGTC_1884|Compound:5633444|FD-Score:5.89|P-value:9.41E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-5.88|P-value:7.05E-5 ID:SGTC_1919|Compound:st067113|FD-Score:-6.33|P-value:2.13E-5 ID:SGTC_1937|Compound:st074714|FD-Score:7.16|P-value:2.73E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:-5.83|P-value:8.07E-5 ID:SGTC_2054|Compound:5233173|FD-Score:7.01|P-value:4.30E-6 ID:SGTC_2066|Compound:5222451|FD-Score:11.20|P-value:4.06E-13 ID:SGTC_2068|Compound:5226020|FD-Score:9.84|P-value:1.89E-10 ID:SGTC_2080|Compound:5212524|FD-Score:7.67|P-value:5.44E-7 ID:SGTC_2093|Compound:5331342|FD-Score:6.65|P-value:1.21E-5 ID:SGTC_2108|Compound:5365811|FD-Score:4.89|P-value:9.98E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-7.31|P-value:1.17E-6 ID:SGTC_2135|Compound:5326629|FD-Score:6.77|P-value:8.80E-6 ID:SGTC_2144|Compound:5628481|FD-Score:5.69|P-value:1.55E-4 ID:SGTC_2148|Compound:5546263|FD-Score:5.41|P-value:3.06E-4 ID:SGTC_2149|Compound:5554786|FD-Score:5.16|P-value:5.47E-4 ID:SGTC_2151|Compound:5563267|FD-Score:9.32|P-value:1.55E-9 ID:SGTC_2164|Compound:5685496|FD-Score:5.33|P-value:3.67E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-5.45|P-value:2.07E-4 ID:SGTC_2171|Compound:5739187|FD-Score:8.62|P-value:2.10E-8 ID:SGTC_2233|Compound:sulbentine|FD-Score:-5.90|P-value:6.70E-5 ID:SGTC_2246|Compound:7293507|FD-Score:6.03|P-value:6.56E-5 ID:SGTC_2269|Compound:7935389|FD-Score:5.22|P-value:4.73E-4 ID:SGTC_2336|Compound:9001819|FD-Score:5.93|P-value:8.46E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.52|P-value:1.75E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:5.23|P-value:4.69E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.13|P-value:5.81E-4 ID:SGTC_2424|Compound:5537928|FD-Score:4.97|P-value:8.41E-4 ID:SGTC_2434|Compound:5670830|FD-Score:6.25|P-value:3.67E-5 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:6.10|P-value:5.56E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:9.12|P-value:3.31E-9 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-7.18|P-value:1.76E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:6.44|P-value:2.18E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:7.71|P-value:4.77E-7 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:7.56|P-value:7.94E-7 ID:SGTC_2605|Compound:digitonin|FD-Score:-7.48|P-value:6.84E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:6.05|P-value:6.23E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:14.50|P-value:1.20E-20 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:8.34|P-value:5.65E-8 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:8.81|P-value:1.07E-8 ID:SGTC_2630|Compound:antimycin a|FD-Score:-4.90|P-value:7.44E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:12.60|P-value:6.03E-16 ID:SGTC_2681|Compound:menadione|FD-Score:5.69|P-value:1.56E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:5.75|P-value:1.34E-4 ID:SGTC_2781|Compound:5567276|FD-Score:7.80|P-value:3.54E-7 ID:SGTC_2939|Compound:9044578|FD-Score:8.67|P-value:1.78E-8 ID:SGTC_3112|Compound:9123419|FD-Score:5.29|P-value:4.03E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-5.63|P-value:1.32E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:5.94|P-value:8.38E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:5.86|P-value:1.01E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:-5.55|P-value:1.63E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:15.60|P-value:1.32E-23 ID:SGTC_116|Compound:0155-0182|FD-Score:6.76|P-value:9.01E-6 ID:SGTC_123|Compound:0083-0120|FD-Score:6.74|P-value:9.49E-6 ID:SGTC_128|Compound:0906-2981|FD-Score:4.89|P-value:9.92E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.38|P-value:5.05E-8 ID:SGTC_139|Compound:0099-0334|FD-Score:6.13|P-value:5.04E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:5.64|P-value:1.77E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-5.13|P-value:4.36E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:11.50|P-value:1.47E-13 ID:SGTC_179|Compound:1273-0063|FD-Score:-12.80|P-value:1.09E-16 ID:SGTC_180|Compound:1486-1293|FD-Score:10.10|P-value:7.81E-11 ID:SGTC_208|Compound:k072-0098|FD-Score:5.19|P-value:5.10E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-5.22|P-value:3.57E-4 ID:SGTC_222|Compound:nsc-310342|FD-Score:-4.82|P-value:8.87E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:8.58|P-value:2.47E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:6.02|P-value:6.80E-5 ID:SGTC_328|Compound:k915-0120|FD-Score:5.45|P-value:2.80E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-5.03|P-value:5.47E-4 ID:SGTC_458|Compound:nppb|FD-Score:4.93|P-value:9.19E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:7.13|P-value:3.02E-6 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:7.86|P-value:2.99E-7 ID:SGTC_513|Compound:4245-1575|FD-Score:5.84|P-value:1.08E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:5.35|P-value:3.58E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:-5.76|P-value:9.56E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:-5.35|P-value:2.62E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:9.94|P-value:1.25E-10 ID:SGTC_626|Compound:0214-0009|FD-Score:6.35|P-value:2.84E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:-4.86|P-value:8.06E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:6.74|P-value:9.58E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:5.73|P-value:1.42E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:6.51|P-value:1.81E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:5.37|P-value:3.37E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:-5.97|P-value:5.50E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:5.81|P-value:1.15E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:5.89|P-value:9.44E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:8.27|P-value:7.21E-8 ID:SGTC_975|Compound:1335-0046|FD-Score:5.91|P-value:8.99E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:8.93|P-value:6.82E-9 ID:SGTC_1001|Compound:4048-4355|FD-Score:9.93|P-value:1.33E-10 ID:SGTC_1002|Compound:4049-0206|FD-Score:5.12|P-value:6.04E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-4.93|P-value:6.88E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:6.27|P-value:3.47E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:5.66|P-value:1.67E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:5.16|P-value:5.49E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:-5.58|P-value:1.52E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:6.11|P-value:5.36E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:12.80|P-value:1.66E-16 ID:SGTC_1242|Compound:0402-0103|FD-Score:-5.68|P-value:1.16E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-18.00|P-value:3.35E-31 ID:SGTC_1247|Compound:0448-0043|FD-Score:-5.93|P-value:6.13E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:-6.88|P-value:4.38E-6 ID:SGTC_1392|Compound:3455-1037|FD-Score:8.58|P-value:2.43E-8 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.79|P-value:8.16E-6 ID:SGTC_1524|Compound:corynanthine|FD-Score:6.30|P-value:3.24E-5 ID:SGTC_1530|Compound:rhein|FD-Score:4.92|P-value:9.39E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-5.33|P-value:2.74E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:13.70|P-value:1.43E-18 ID:SGTC_1573|Compound:oleylamine|FD-Score:7.65|P-value:5.88E-7 ID:SGTC_1612|Compound:st002233|FD-Score:5.00|P-value:7.82E-4 ID:SGTC_1643|Compound:st009866|FD-Score:5.11|P-value:6.11E-4 ID:SGTC_1696|Compound:st025591|FD-Score:7.35|P-value:1.52E-6 ID:SGTC_1700|Compound:st030840|FD-Score:5.37|P-value:3.38E-4 ID:SGTC_1763|Compound:st044482|FD-Score:9.66|P-value:3.94E-10 ID:SGTC_1824|Compound:st053723|FD-Score:5.53|P-value:2.29E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.82|P-value:8.72E-4 ID:SGTC_1850|Compound:st056238|FD-Score:5.16|P-value:5.42E-4 ID:SGTC_1884|Compound:5633444|FD-Score:5.89|P-value:9.41E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-5.88|P-value:7.05E-5 ID:SGTC_1919|Compound:st067113|FD-Score:-6.33|P-value:2.13E-5 ID:SGTC_1937|Compound:st074714|FD-Score:7.16|P-value:2.73E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:-5.83|P-value:8.07E-5 ID:SGTC_2054|Compound:5233173|FD-Score:7.01|P-value:4.30E-6 ID:SGTC_2066|Compound:5222451|FD-Score:11.20|P-value:4.06E-13 ID:SGTC_2068|Compound:5226020|FD-Score:9.84|P-value:1.89E-10 ID:SGTC_2080|Compound:5212524|FD-Score:7.67|P-value:5.44E-7 ID:SGTC_2093|Compound:5331342|FD-Score:6.65|P-value:1.21E-5 ID:SGTC_2108|Compound:5365811|FD-Score:4.89|P-value:9.98E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-7.31|P-value:1.17E-6 ID:SGTC_2135|Compound:5326629|FD-Score:6.77|P-value:8.80E-6 ID:SGTC_2144|Compound:5628481|FD-Score:5.69|P-value:1.55E-4 ID:SGTC_2148|Compound:5546263|FD-Score:5.41|P-value:3.06E-4 ID:SGTC_2149|Compound:5554786|FD-Score:5.16|P-value:5.47E-4 ID:SGTC_2151|Compound:5563267|FD-Score:9.32|P-value:1.55E-9 ID:SGTC_2164|Compound:5685496|FD-Score:5.33|P-value:3.67E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-5.45|P-value:2.07E-4 ID:SGTC_2171|Compound:5739187|FD-Score:8.62|P-value:2.10E-8 ID:SGTC_2233|Compound:sulbentine|FD-Score:-5.90|P-value:6.70E-5 ID:SGTC_2246|Compound:7293507|FD-Score:6.03|P-value:6.56E-5 ID:SGTC_2269|Compound:7935389|FD-Score:5.22|P-value:4.73E-4 ID:SGTC_2336|Compound:9001819|FD-Score:5.93|P-value:8.46E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.52|P-value:1.75E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:5.23|P-value:4.69E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.13|P-value:5.81E-4 ID:SGTC_2424|Compound:5537928|FD-Score:4.97|P-value:8.41E-4 ID:SGTC_2434|Compound:5670830|FD-Score:6.25|P-value:3.67E-5 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:6.10|P-value:5.56E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:9.12|P-value:3.31E-9 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-7.18|P-value:1.76E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:6.44|P-value:2.18E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:7.71|P-value:4.77E-7 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:7.56|P-value:7.94E-7 ID:SGTC_2605|Compound:digitonin|FD-Score:-7.48|P-value:6.84E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:6.05|P-value:6.23E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:14.50|P-value:1.20E-20 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:8.34|P-value:5.65E-8 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:8.81|P-value:1.07E-8 ID:SGTC_2630|Compound:antimycin a|FD-Score:-4.90|P-value:7.44E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:12.60|P-value:6.03E-16 ID:SGTC_2681|Compound:menadione|FD-Score:5.69|P-value:1.56E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:5.75|P-value:1.34E-4 ID:SGTC_2781|Compound:5567276|FD-Score:7.80|P-value:3.54E-7 ID:SGTC_2939|Compound:9044578|FD-Score:8.67|P-value:1.78E-8 ID:SGTC_3112|Compound:9123419|FD-Score:5.29|P-value:4.03E-4

Top fitness defect scores for YMR021C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_100 0086-0128 15.60 49.6 µM 1.32E-23 copper-dependent oxidative stress 2 4.30E-55
2 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 14.50 70.0 µM 1.20E-20 redox potentiating 2 6.77E-48
3 SGTC_1569 carminic acid 13.70 40.6 µM 1.43E-18 1 7.44E-43
4 SGTC_1239 0337-0584 12.80 35.4 µM 1.66E-16 unfolded protein response 6 7.83E-38
5 SGTC_2640 pentamidine 12.60 10.4 µM 6.03E-16 mitochondrial processes 1 1.78E-36
6 SGTC_177 1327-0068 11.50 8.4 µM 1.47E-13 3 1.11E-30
7 SGTC_2066 5222451 11.20 176.0 µM 4.06E-13 heme biosynthesis & mitochondrial translocase 1 1.30E-29
8 SGTC_180 1486-1293 10.10 102.8 µM 7.81E-11 9 4.44E-24
9 SGTC_612 0302-0167 9.94 22.4 µM 1.25E-10 copper-dependent oxidative stress 5 1.40E-23
10 SGTC_1001 4048-4355 9.93 44.4 µM 1.33E-10 copper-dependent oxidative stress 4 1.62E-23
11 SGTC_2068 5226020 9.84 147.0 µM 1.89E-10 1 3.74E-23
12 SGTC_1763 st044482 9.66 94.5 µM 3.94E-10 copper-dependent oxidative stress 1 2.22E-22
13 SGTC_2151 5563267 9.32 85.4 µM 1.55E-9 2 6.08E-21
14 SGTC_2575 plumbagin 9.12 510.0 nM 3.31E-9 superoxide 6 3.81E-20
15 SGTC_1000 4048-0884 8.93 8.7 µM 6.82E-9 copper-dependent oxidative stress 2 2.19E-19
16 SGTC_2617 dihydrotanshinone i 8.81 20.8 µM 1.07E-8 copper-dependent oxidative stress 6 6.47E-19
17 SGTC_2939 9044578 8.67 71.4 µM 1.78E-8 9 2.22E-18
18 SGTC_2171 5739187 8.62 198.1 µM 2.10E-8 copper-dependent oxidative stress 4 3.30E-18
19 SGTC_1392 3455-1037 8.58 33.9 µM 2.43E-8 1 4.67E-18
20 SGTC_235 0330-0087 8.58 5.0 mM 2.47E-8 TSC3-RPN4 2 4.88E-18

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.422 5.70E-145 YPR124W CTR1 hom High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress
0.416 1.22E-140 YPR123C_d YPR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR
0.292 9.63E-67 YMR038C CCS1 hom Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress
0.263 5.69E-54 YJR104C SOD1 hom Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
0.215 2.58E-36 YGL167C PMR1 hom High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
0.185 3.18E-27 YHR008C SOD2 hom Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
0.162 3.28E-21 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.150 2.78E-18 YPR074C TKL1 hom Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
0.136 2.06E-15 YNL241C ZWF1 hom Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress
0.132 1.39E-14 YGL071W AFT1 hom Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.124 5.49E-13 YJL120W_d YJL120W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
0.124 6.85E-13 YLR044C PDC1 hom Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
0.118 7.54E-12 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.117 1.19E-11 YOR323C PRO2 hom Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis
0.114 3.58E-11 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W