YMR026C / PEX12

C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR026C / PEX12

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-3.34|P-value:9.07E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.87|P-value:1.51E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-4.19|P-value:4.61E-5 ID:SGTC_92|Compound:0063-0024|FD-Score:3.35|P-value:9.81E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.05|P-value:8.83E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:3.78|P-value:2.39E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:5.17|P-value:8.39E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:4.77|P-value:4.97E-6 ID:SGTC_233|Compound:rapamycin|FD-Score:3.55|P-value:5.15E-4 ID:SGTC_476|Compound:mead acid|FD-Score:3.43|P-value:7.54E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.73|P-value:2.83E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.58|P-value:4.72E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:-3.69|P-value:2.87E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.59|P-value:4.56E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.63|P-value:3.53E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.98|P-value:1.74E-6 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.63|P-value:3.97E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.47|P-value:1.76E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-4.55|P-value:1.11E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.99|P-value:9.75E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.44|P-value:2.01E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:4.45|P-value:1.89E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:-3.34|P-value:9.24E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-3.37|P-value:8.19E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.59|P-value:4.02E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.85|P-value:1.85E-4 ID:SGTC_1793|Compound:st048256|FD-Score:-4.19|P-value:4.65E-5 ID:SGTC_1796|Compound:st049173|FD-Score:-3.70|P-value:2.75E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-3.45|P-value:6.42E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.42|P-value:7.83E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.60|P-value:4.31E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-3.94|P-value:1.18E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.37|P-value:8.39E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.32|P-value:3.26E-5 ID:SGTC_2018|Compound:5133068|FD-Score:4.51|P-value:1.51E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-5.82|P-value:3.03E-8 ID:SGTC_2167|Compound:5876490|FD-Score:-6.17|P-value:4.44E-9 ID:SGTC_2491|Compound:paeonol|FD-Score:-3.85|P-value:1.65E-4 ID:SGTC_2820|Compound:7989630|FD-Score:-6.74|P-value:1.75E-10 ID:SGTC_2828|Compound:7998861|FD-Score:-5.97|P-value:1.32E-8 ID:SGTC_2935|Compound:9038016|FD-Score:-3.39|P-value:7.82E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.85|P-value:1.64E-4 ID:SGTC_3230|Compound:9131665|FD-Score:-3.34|P-value:9.15E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.50|P-value:5.49E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-4.63|P-value:7.89E-6 ID:SGTC_3354|Compound:9151612|FD-Score:-3.85|P-value:1.67E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.34|P-value:9.07E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.87|P-value:1.51E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-4.19|P-value:4.61E-5 ID:SGTC_92|Compound:0063-0024|FD-Score:3.35|P-value:9.81E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.05|P-value:8.83E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:3.78|P-value:2.39E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:5.17|P-value:8.39E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:4.77|P-value:4.97E-6 ID:SGTC_233|Compound:rapamycin|FD-Score:3.55|P-value:5.15E-4 ID:SGTC_476|Compound:mead acid|FD-Score:3.43|P-value:7.54E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.73|P-value:2.83E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.58|P-value:4.72E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:-3.69|P-value:2.87E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.59|P-value:4.56E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.63|P-value:3.53E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.98|P-value:1.74E-6 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.63|P-value:3.97E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.47|P-value:1.76E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-4.55|P-value:1.11E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.99|P-value:9.75E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.44|P-value:2.01E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:4.45|P-value:1.89E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:-3.34|P-value:9.24E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-3.37|P-value:8.19E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.59|P-value:4.02E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.85|P-value:1.85E-4 ID:SGTC_1793|Compound:st048256|FD-Score:-4.19|P-value:4.65E-5 ID:SGTC_1796|Compound:st049173|FD-Score:-3.70|P-value:2.75E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-3.45|P-value:6.42E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.42|P-value:7.83E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.60|P-value:4.31E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-3.94|P-value:1.18E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.37|P-value:8.39E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.32|P-value:3.26E-5 ID:SGTC_2018|Compound:5133068|FD-Score:4.51|P-value:1.51E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-5.82|P-value:3.03E-8 ID:SGTC_2167|Compound:5876490|FD-Score:-6.17|P-value:4.44E-9 ID:SGTC_2491|Compound:paeonol|FD-Score:-3.85|P-value:1.65E-4 ID:SGTC_2820|Compound:7989630|FD-Score:-6.74|P-value:1.75E-10 ID:SGTC_2828|Compound:7998861|FD-Score:-5.97|P-value:1.32E-8 ID:SGTC_2935|Compound:9038016|FD-Score:-3.39|P-value:7.82E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.85|P-value:1.64E-4 ID:SGTC_3230|Compound:9131665|FD-Score:-3.34|P-value:9.15E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.50|P-value:5.49E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-4.63|P-value:7.89E-6 ID:SGTC_3354|Compound:9151612|FD-Score:-3.85|P-value:1.67E-4

Top fitness defect scores for YMR026C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_131 0141-0277 5.17 33.9 µM 8.39E-7 13 1.15E-7
2 SGTC_145 3737-0113 4.77 38.4 µM 4.97E-6 DNA intercalators 51 9.02E-7
3 SGTC_2018 5133068 4.51 143.0 µM 1.51E-5 12 3.27E-6
4 SGTC_1376 2910-0861 4.47 41.3 µM 1.76E-5 10 3.89E-6
5 SGTC_1570 verbenone 4.45 133.0 µM 1.89E-5 10 4.22E-6
6 SGTC_1564 D-Arginine 4.44 115.0 µM 2.01E-5 18 4.53E-6
7 SGTC_2016 5121758 4.32 140.0 µM 3.26E-5 redox potentiating 40 7.93E-6
8 SGTC_128 0906-2981 4.05 13.4 µM 8.83E-5 13 2.51E-5
9 SGTC_1777 st045864 3.85 34.8 µM 1.85E-4 10 5.90E-5
10 SGTC_129 0088-0017 3.78 176.6 µM 2.39E-4 68 7.91E-5
11 SGTC_555 4296-0685 3.73 37.0 µM 2.83E-4 ergosterol biosynthesis 13 9.61E-5
12 SGTC_1172 0370-0043 3.63 85.0 µM 3.97E-4 32 1.42E-4
13 SGTC_1819 st053448 3.60 58.6 µM 4.31E-4 amide catabolism 30 1.56E-4
14 SGTC_1028 k015-0029 3.59 4.8 µM 4.56E-4 34 1.67E-4
15 SGTC_573 3702-0553 3.58 84.7 µM 4.72E-4 23 1.74E-4
16 SGTC_233 rapamycin 3.55 362.0 pM 5.15E-4 19 1.92E-4
17 SGTC_476 mead acid 3.43 10.0 µM 7.54E-4 8 2.98E-4
18 SGTC_1803 st050068 3.42 52.4 µM 7.83E-4 NEO1-PIK1 223 3.11E-4
19 SGTC_92 0063-0024 3.35 660.9 µM 9.81E-4 26 4.03E-4
20 SGTC_765 1319-0117 3.31 244.0 µM 0.00112 60S ribosome export 24 4.72E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.248 3.97E-48 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.179 1.82E-25 YLR084C RAX2 hom N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p
0.121 2.02E-12 YPL041C_p YPL041C_p hom Protein of unknown function involved in maintenance of proper telomere length
0.117 9.26E-12 YLR335W NUP2 hom Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
0.113 4.61E-11 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.111 1.39E-10 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.108 3.50E-10 YJL077W-B_p YJL077W-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.107 5.40E-10 YMR040W YET2 hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.106 7.95E-10 YKR071C DRE2 het Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress
0.101 4.54E-9 YER173W RAD24 hom Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
0.100 7.66E-9 YNR032W PPG1 hom Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
0.097 1.78E-8 YPR022C_p YPR022C_p hom Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.096 2.53E-8 YGL125W MET13 hom Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
0.096 2.57E-8 YMR031C EIS1 hom Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.095 3.94E-8 YIL100W_d YIL100W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A