YMR027W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR027W / YMR027W

Click on Significant Values for Screen Details ID:SGTC_404|Compound:fumagillin|FD-Score:4.63|P-value:9.60E-6 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:5.12|P-value:1.13E-6 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.84|P-value:2.43E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:6.59|P-value:6.37E-10 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.50|P-value:7.48E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.50|P-value:6.02E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.66|P-value:3.49E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:-3.50|P-value:7.33E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.98|P-value:1.16E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.72|P-value:2.86E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.78|P-value:2.36E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.53|P-value:5.37E-4 ID:SGTC_1641|Compound:st009299|FD-Score:-3.41|P-value:9.94E-4 ID:SGTC_1650|Compound:st011916|FD-Score:3.44|P-value:7.29E-4 ID:SGTC_1669|Compound:st015249|FD-Score:3.69|P-value:3.15E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.47|P-value:6.66E-4 ID:SGTC_1772|Compound:st048439|FD-Score:3.54|P-value:5.17E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.98|P-value:1.17E-4 ID:SGTC_1908|Compound:st060353|FD-Score:5.57|P-value:1.36E-7 ID:SGTC_2077|Compound:5212015|FD-Score:-3.44|P-value:8.97E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.97|P-value:1.20E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.08|P-value:8.10E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.61|P-value:4.22E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.12|P-value:7.03E-5 ID:SGTC_2870|Compound:9038528|FD-Score:3.46|P-value:6.78E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.58|P-value:4.57E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-4.35|P-value:3.77E-5 ID:SGTC_2920|Compound:7982904|FD-Score:4.29|P-value:3.61E-5 ID:SGTC_2928|Compound:9011484|FD-Score:4.32|P-value:3.30E-5 ID:SGTC_3003|Compound:9075612|FD-Score:3.91|P-value:1.50E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.34|P-value:9.92E-4 ID:SGTC_3031|Compound:9088762|FD-Score:4.16|P-value:5.98E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.95|P-value:1.32E-4 ID:SGTC_3047|Compound:9092122|FD-Score:4.11|P-value:7.23E-5 ID:SGTC_3101|Compound:9120531|FD-Score:-3.48|P-value:8.02E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-3.68|P-value:4.10E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.78|P-value:2.97E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:4.63|P-value:9.60E-6 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:5.12|P-value:1.13E-6 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.84|P-value:2.43E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:6.59|P-value:6.37E-10 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.50|P-value:7.48E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.50|P-value:6.02E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.66|P-value:3.49E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:-3.50|P-value:7.33E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.98|P-value:1.16E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.72|P-value:2.86E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.78|P-value:2.36E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.53|P-value:5.37E-4 ID:SGTC_1641|Compound:st009299|FD-Score:-3.41|P-value:9.94E-4 ID:SGTC_1650|Compound:st011916|FD-Score:3.44|P-value:7.29E-4 ID:SGTC_1669|Compound:st015249|FD-Score:3.69|P-value:3.15E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.47|P-value:6.66E-4 ID:SGTC_1772|Compound:st048439|FD-Score:3.54|P-value:5.17E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.98|P-value:1.17E-4 ID:SGTC_1908|Compound:st060353|FD-Score:5.57|P-value:1.36E-7 ID:SGTC_2077|Compound:5212015|FD-Score:-3.44|P-value:8.97E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.97|P-value:1.20E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.08|P-value:8.10E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.61|P-value:4.22E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.12|P-value:7.03E-5 ID:SGTC_2870|Compound:9038528|FD-Score:3.46|P-value:6.78E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.58|P-value:4.57E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-4.35|P-value:3.77E-5 ID:SGTC_2920|Compound:7982904|FD-Score:4.29|P-value:3.61E-5 ID:SGTC_2928|Compound:9011484|FD-Score:4.32|P-value:3.30E-5 ID:SGTC_3003|Compound:9075612|FD-Score:3.91|P-value:1.50E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.34|P-value:9.92E-4 ID:SGTC_3031|Compound:9088762|FD-Score:4.16|P-value:5.98E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.95|P-value:1.32E-4 ID:SGTC_3047|Compound:9092122|FD-Score:4.11|P-value:7.23E-5 ID:SGTC_3101|Compound:9120531|FD-Score:-3.48|P-value:8.02E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-3.68|P-value:4.10E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.78|P-value:2.97E-4

Top fitness defect scores for YMR027W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1160 4092-0570 6.59 10.5 µM 6.37E-10 plasma membrane duress 12 2.25E-11
2 SGTC_1908 st060353 5.57 56.5 µM 1.36E-7 RPP1 & pyrimidine depletion 13 1.25E-8
3 SGTC_506 n9-isopropylolomoucine 5.12 153.0 µM 1.13E-6 3 1.51E-7
4 SGTC_404 fumagillin 4.63 50.0 µM 9.60E-6 9 1.85E-6
5 SGTC_2928 9011484 4.32 9.8 µM 3.30E-5 heme biosynthesis & mitochondrial translocase 31 7.89E-6
6 SGTC_2920 7982904 4.29 15.8 µM 3.61E-5 14 8.76E-6
7 SGTC_3031 9088762 4.16 49.5 µM 5.98E-5 12 1.58E-5
8 SGTC_2779 methotrexate 4.12 400.0 µM 7.03E-5 26 1.91E-5
9 SGTC_3047 9092122 4.11 49.5 µM 7.23E-5 16 1.98E-5
10 SGTC_2506 ethyl hematommate 4.08 54.2 µM 8.10E-5 RPP1 & pyrimidine depletion 14 2.26E-5
11 SGTC_1444 4112-3581 3.98 28.0 µM 1.16E-4 8 3.43E-5
12 SGTC_1778 st046819 3.98 58.9 µM 1.17E-4 23 3.45E-5
13 SGTC_2177 5811945 3.97 192.0 µM 1.20E-4 27 3.59E-5
14 SGTC_3044 9093193 3.95 49.5 µM 1.32E-4 22 3.98E-5
15 SGTC_3003 9075612 3.91 71.4 µM 1.50E-4 23 4.65E-5
16 SGTC_1522 st012842 3.78 45.6 µM 2.36E-4 RNA pol III & RNase P/MRP 32 7.89E-5
17 SGTC_1500 4488-1866 3.72 171.0 µM 2.86E-4 RPP1 & pyrimidine depletion 23 9.86E-5
18 SGTC_1669 st015249 3.69 58.4 µM 3.15E-4 Golgi 9 1.10E-4
19 SGTC_1419 3993-2473 3.66 62.6 µM 3.49E-4 25 1.24E-4
20 SGTC_2612 dictamnine 3.61 15.5 µM 4.22E-4 RNA pol III & RNase P/MRP 56 1.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.11E-15 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.099 9.13E-9 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.093 5.93E-8 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.089 2.75E-7 YGL098W USE1 het Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
0.080 3.37E-6 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.079 4.04E-6 YJL003W COX16 hom Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase
0.078 6.25E-6 YGR280C PXR1 het Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
0.075 1.41E-5 YLR207W HRD3 hom Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events
0.072 3.06E-5 YNL199C GCR2 hom Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p
0.072 3.13E-5 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.071 3.40E-5 YNL038W GPI15 het Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein
0.069 6.36E-5 YML051W GAL80 hom Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding
0.069 7.13E-5 YPL087W YDC1 hom Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication
0.068 7.93E-5 YNL319W_d YNL319W_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14
0.066 1.17E-4 YOL048C RRT8 hom Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress