YMR028W / TAP42

Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR028W / TAP42

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.39|P-value:1.82E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.23|P-value:4.20E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.69|P-value:6.56E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.31|P-value:2.41E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.31|P-value:2.44E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:-3.40|P-value:2.15E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.12|P-value:4.98E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.35|P-value:2.11E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:-3.95|P-value:2.18E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:3.02|P-value:7.38E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.16|P-value:5.49E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.66|P-value:6.86E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.90|P-value:2.06E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.31|P-value:2.45E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.13|P-value:4.81E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.72|P-value:4.47E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.31|P-value:2.91E-6 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.27|P-value:2.92E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:4.43|P-value:1.65E-6 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.63|P-value:8.46E-5 ID:SGTC_1594|Compound:piperine|FD-Score:-3.67|P-value:7.25E-5 ID:SGTC_1634|Compound:st006576|FD-Score:3.98|P-value:1.44E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.34|P-value:2.71E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.05|P-value:6.48E-4 ID:SGTC_2030|Compound:5175110|FD-Score:2.94|P-value:9.57E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.11|P-value:5.30E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.16|P-value:4.34E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.05|P-value:7.95E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.63|P-value:6.70E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.43|P-value:1.54E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:5.29|P-value:1.39E-8 ID:SGTC_2835|Compound:9006588|FD-Score:3.30|P-value:2.52E-4 ID:SGTC_2973|Compound:9094665|FD-Score:5.23|P-value:1.98E-8 ID:SGTC_3006|Compound:9075424|FD-Score:-3.36|P-value:2.54E-4 ID:SGTC_3013|Compound:9080133|FD-Score:-3.19|P-value:4.88E-4 ID:SGTC_3058|Compound:9093861|FD-Score:4.44|P-value:1.56E-6 ID:SGTC_3133|Compound:9127736|FD-Score:3.43|P-value:1.51E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.10|P-value:5.54E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.39|P-value:1.82E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-3.02|P-value:8.86E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.35|P-value:2.63E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.39|P-value:1.82E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.23|P-value:4.20E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.69|P-value:6.56E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.31|P-value:2.41E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.31|P-value:2.44E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:-3.40|P-value:2.15E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.12|P-value:4.98E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.35|P-value:2.11E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:-3.95|P-value:2.18E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:3.02|P-value:7.38E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.16|P-value:5.49E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.66|P-value:6.86E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.90|P-value:2.06E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.31|P-value:2.45E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.13|P-value:4.81E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.72|P-value:4.47E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.31|P-value:2.91E-6 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.27|P-value:2.92E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:4.43|P-value:1.65E-6 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.63|P-value:8.46E-5 ID:SGTC_1594|Compound:piperine|FD-Score:-3.67|P-value:7.25E-5 ID:SGTC_1634|Compound:st006576|FD-Score:3.98|P-value:1.44E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.34|P-value:2.71E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.05|P-value:6.48E-4 ID:SGTC_2030|Compound:5175110|FD-Score:2.94|P-value:9.57E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.11|P-value:5.30E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.16|P-value:4.34E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.05|P-value:7.95E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.63|P-value:6.70E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.43|P-value:1.54E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:5.29|P-value:1.39E-8 ID:SGTC_2835|Compound:9006588|FD-Score:3.30|P-value:2.52E-4 ID:SGTC_2973|Compound:9094665|FD-Score:5.23|P-value:1.98E-8 ID:SGTC_3006|Compound:9075424|FD-Score:-3.36|P-value:2.54E-4 ID:SGTC_3013|Compound:9080133|FD-Score:-3.19|P-value:4.88E-4 ID:SGTC_3058|Compound:9093861|FD-Score:4.44|P-value:1.56E-6 ID:SGTC_3133|Compound:9127736|FD-Score:3.43|P-value:1.51E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.10|P-value:5.54E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.39|P-value:1.82E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-3.02|P-value:8.86E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.35|P-value:2.63E-4

Top fitness defect scores for YMR028W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2751 anetholtrithion 5.29 17.2 µM 1.39E-8 1 6.05E-8 0.63
2 SGTC_2973 9094665 5.23 18.0 µM 1.98E-8 NEO1 9 8.36E-8 0.12
3 SGTC_3058 9093861 4.44 49.5 µM 1.56E-6 4 4.54E-6 0.54
4 SGTC_1586 deoxycorticosterone acetate 4.43 53.7 µM 1.65E-6 2 4.79E-6 0.94
5 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 4.31 66.5 µM 2.91E-6 1 8.05E-6 0.77
6 SGTC_1634 st006576 3.98 41.0 µM 1.44E-5 TSC3-RPN4 5 3.47E-5 0.21
7 SGTC_1133 3473-0247 3.90 50.0 µM 2.06E-5 RSC complex & mRNA processing 47 4.82E-5 0.02
8 SGTC_1351 1496-0003 3.72 46.5 µM 4.47E-5 5 9.80E-5 0.14
9 SGTC_2574 2',4'-dihydroxychalcone 3.63 14.6 µM 6.70E-5 14 1.42E-4 0.03
10 SGTC_3133 9127736 3.43 49.5 µM 1.51E-4 3 2.99E-4 0.45
11 SGTC_2638 epoxomicin 3.43 18.0 µM 1.54E-4 5 3.04E-4 0.23
12 SGTC_38 0929-0051 3.39 58.3 µM 1.82E-4 8 3.55E-4 0.10
13 SGTC_3217 9129673 3.39 49.5 µM 1.82E-4 19 3.55E-4 0.11
14 SGTC_886 0866-0150 3.35 153.0 µM 2.11E-4 7 4.06E-4 0.00
15 SGTC_255 tunicamycin 3.31 200.5 nM 2.41E-4 unfolded protein response 18 4.59E-4 0.06
16 SGTC_313 3474-0040 3.31 5.0 µM 2.44E-4 NEO1-PIK1 17 4.64E-4 2.37E-4
17 SGTC_1136 pergolide 3.31 1.1 µM 2.45E-4 31 4.65E-4 0.08
18 SGTC_2835 9006588 3.30 71.4 µM 2.52E-4 15 4.78E-4 0.04
19 SGTC_1580 hydrocortisone 21-hemisuccinate 3.27 43.2 µM 2.92E-4 10 5.46E-4 0.16
20 SGTC_2204 7233102 3.16 200.0 µM 4.34E-4 60S ribosome export 10 7.86E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.06E-11 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.114 4.14E-11 YOR029W_d YOR029W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.113 5.29E-11 YGR173W RBG2 hom Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein
0.104 1.68E-9 YOL032W OPI10 hom Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress
0.101 4.74E-9 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.096 2.50E-8 YDR006C SOK1 hom Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13
0.093 6.20E-8 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.092 1.03E-7 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.092 1.07E-7 YEL015W EDC3 hom Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress
0.087 4.06E-7 YIL114C POR2 hom Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication
0.086 5.76E-7 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.084 1.00E-6 YKL144C RPC25 het RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p
0.084 1.21E-6 YEL068C_p YEL068C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.082 1.73E-6 YPL218W SAR1 het GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport
0.082 2.17E-6 YIR002C MPH1 hom 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases