HIPHOP chemogenomics database

YMR028W / TAP42

Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits

Zygosity: Heterozygous strain

fixedexpanded
Profile for YMR028W / TAP42

Click on Significant Values for Screen Details

Top fitness defect scores for YMR028W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2751	anetholtrithion	5.29	17.2 µM	1.39E-8		1	6.05E-8	0.63
2	SGTC_2973	9094665	5.23	18.0 µM	1.98E-8	NEO1	9	8.36E-8	0.12
3	SGTC_3058	9093861	4.44	49.5 µM	1.56E-6		4	4.54E-6	0.54
4	SGTC_1586	deoxycorticosterone acetate	4.43	53.7 µM	1.65E-6		2	4.79E-6	0.94
5	SGTC_1577	3(2'-chlorophenyl)-7-ethoxycoumarin	4.31	66.5 µM	2.91E-6		1	8.05E-6	0.77
6	SGTC_1634	st006576	3.98	41.0 µM	1.44E-5	TSC3-RPN4	5	3.47E-5	0.21
7	SGTC_1133	3473-0247	3.90	50.0 µM	2.06E-5	RSC complex & mRNA processing	47	4.82E-5	0.02
8	SGTC_1351	1496-0003	3.72	46.5 µM	4.47E-5		5	9.80E-5	0.14
9	SGTC_2574	2',4'-dihydroxychalcone	3.63	14.6 µM	6.70E-5		14	1.42E-4	0.03
10	SGTC_3133	9127736	3.43	49.5 µM	1.51E-4		3	2.99E-4	0.45
11	SGTC_2638	epoxomicin	3.43	18.0 µM	1.54E-4		5	3.04E-4	0.23
12	SGTC_38	0929-0051	3.39	58.3 µM	1.82E-4		8	3.55E-4	0.10
13	SGTC_3217	9129673	3.39	49.5 µM	1.82E-4		19	3.55E-4	0.11
14	SGTC_886	0866-0150	3.35	153.0 µM	2.11E-4		7	4.06E-4	0.00
15	SGTC_255	tunicamycin	3.31	200.5 nM	2.41E-4	unfolded protein response	18	4.59E-4	0.06
16	SGTC_313	3474-0040	3.31	5.0 µM	2.44E-4	NEO1-PIK1	17	4.64E-4	2.37E-4
17	SGTC_1136	pergolide	3.31	1.1 µM	2.45E-4		31	4.65E-4	0.08
18	SGTC_2835	9006588	3.30	71.4 µM	2.52E-4		15	4.78E-4	0.04
19	SGTC_1580	hydrocortisone 21-hemisuccinate	3.27	43.2 µM	2.92E-4		10	5.46E-4	0.16
20	SGTC_2204	7233102	3.16	200.0 µM	4.34E-4	60S ribosome export	10	7.86E-4	0.02

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.117	1.06E-11	YER043C	SAH1	het	S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.114	4.14E-11	YOR029W_d	YOR029W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.113	5.29E-11	YGR173W	RBG2	hom	Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein
0.104	1.68E-9	YOL032W	OPI10	hom	Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress
0.101	4.74E-9	YBR243C	ALG7	het	UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.096	2.50E-8	YDR006C	SOK1	hom	Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13
0.093	6.20E-8	YGR216C	GPI1	het	Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.092	1.03E-7	YHR110W	ERP5	hom	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.092	1.07E-7	YEL015W	EDC3	hom	Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress
0.087	4.06E-7	YIL114C	POR2	hom	Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication
0.086	5.76E-7	YLL045C	RPL8B	hom	Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.084	1.00E-6	YKL144C	RPC25	het	RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p
0.084	1.21E-6	YEL068C_p	YEL068C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.082	1.73E-6	YPL218W	SAR1	het	GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport
0.082	2.17E-6	YIR002C	MPH1	hom	3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases