YMR029C / FAR8

Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR029C / FAR8

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:13.30|P-value:5.04E-46 ID:SGTC_352|Compound:k048-0007|FD-Score:5.25|P-value:8.86E-9 ID:SGTC_367|Compound:0335-0881|FD-Score:3.38|P-value:1.39E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:4.84|P-value:1.03E-7 ID:SGTC_384|Compound:k007-0144|FD-Score:6.85|P-value:1.08E-13 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.23|P-value:3.01E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.42|P-value:1.05E-6 ID:SGTC_642|Compound:0335-0876|FD-Score:3.27|P-value:2.14E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:5.92|P-value:1.07E-10 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.11|P-value:4.76E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.66|P-value:4.17E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:-4.85|P-value:1.25E-7 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.35|P-value:1.88E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:12.40|P-value:1.41E-40 ID:SGTC_816|Compound:0325-0417|FD-Score:-4.48|P-value:9.27E-7 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.02|P-value:5.82E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.96|P-value:5.01E-8 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.97|P-value:8.26E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.00|P-value:6.13E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.94|P-value:7.71E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:8.87|P-value:1.03E-21 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.72|P-value:3.19E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:2.92|P-value:8.40E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.17|P-value:1.41E-8 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.92|P-value:8.46E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.50|P-value:8.57E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.09|P-value:5.20E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:2.87|P-value:9.95E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.42|P-value:1.20E-4 ID:SGTC_1725|Compound:st036284|FD-Score:4.58|P-value:4.29E-7 ID:SGTC_1739|Compound:st037196|FD-Score:6.23|P-value:1.19E-11 ID:SGTC_1744|Compound:st037937|FD-Score:-2.92|P-value:9.58E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.19|P-value:3.42E-6 ID:SGTC_1916|Compound:st067606|FD-Score:3.25|P-value:2.34E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.01|P-value:1.02E-5 ID:SGTC_2397|Compound:5161689|FD-Score:5.73|P-value:4.02E-10 ID:SGTC_2426|Compound:5582046|FD-Score:5.57|P-value:1.12E-9 ID:SGTC_2429|Compound:5902844|FD-Score:3.14|P-value:3.66E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.64|P-value:4.66E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.47|P-value:1.02E-6 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.22|P-value:3.19E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.79|P-value:2.28E-5 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-3.23|P-value:3.03E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.41|P-value:1.22E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.36|P-value:1.39E-6 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.58|P-value:7.19E-5 ID:SGTC_2733|Compound:amorolfine|FD-Score:3.08|P-value:4.68E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.57|P-value:6.25E-5 ID:SGTC_2790|Compound:5423970|FD-Score:5.22|P-value:1.08E-8 ID:SGTC_2810|Compound:7959871|FD-Score:3.53|P-value:7.41E-5 ID:SGTC_2813|Compound:7971799|FD-Score:3.35|P-value:1.55E-4 ID:SGTC_2844|Compound:9010103|FD-Score:2.95|P-value:7.57E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-4.06|P-value:7.91E-6 ID:SGTC_2888|Compound:9058547|FD-Score:-3.47|P-value:1.13E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.03|P-value:6.49E-4 ID:SGTC_3102|Compound:9121669|FD-Score:2.93|P-value:8.20E-4 ID:SGTC_3104|Compound:9120930|FD-Score:2.97|P-value:6.89E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.95|P-value:1.12E-5 ID:SGTC_3141|Compound:9094609|FD-Score:5.22|P-value:1.06E-8 ID:SGTC_3211|Compound:9128781|FD-Score:4.03|P-value:7.59E-6 ID:SGTC_3214|Compound:9129694|FD-Score:4.12|P-value:4.76E-6 ID:SGTC_3263|Compound:9137018|FD-Score:4.53|P-value:5.65E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:13.30|P-value:5.04E-46 ID:SGTC_352|Compound:k048-0007|FD-Score:5.25|P-value:8.86E-9 ID:SGTC_367|Compound:0335-0881|FD-Score:3.38|P-value:1.39E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:4.84|P-value:1.03E-7 ID:SGTC_384|Compound:k007-0144|FD-Score:6.85|P-value:1.08E-13 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.23|P-value:3.01E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.42|P-value:1.05E-6 ID:SGTC_642|Compound:0335-0876|FD-Score:3.27|P-value:2.14E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:5.92|P-value:1.07E-10 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.11|P-value:4.76E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.66|P-value:4.17E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:-4.85|P-value:1.25E-7 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.35|P-value:1.88E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:12.40|P-value:1.41E-40 ID:SGTC_816|Compound:0325-0417|FD-Score:-4.48|P-value:9.27E-7 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.02|P-value:5.82E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.96|P-value:5.01E-8 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.97|P-value:8.26E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.00|P-value:6.13E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.94|P-value:7.71E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:8.87|P-value:1.03E-21 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.72|P-value:3.19E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:2.92|P-value:8.40E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.17|P-value:1.41E-8 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.92|P-value:8.46E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.50|P-value:8.57E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.09|P-value:5.20E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:2.87|P-value:9.95E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.42|P-value:1.20E-4 ID:SGTC_1725|Compound:st036284|FD-Score:4.58|P-value:4.29E-7 ID:SGTC_1739|Compound:st037196|FD-Score:6.23|P-value:1.19E-11 ID:SGTC_1744|Compound:st037937|FD-Score:-2.92|P-value:9.58E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.19|P-value:3.42E-6 ID:SGTC_1916|Compound:st067606|FD-Score:3.25|P-value:2.34E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.01|P-value:1.02E-5 ID:SGTC_2397|Compound:5161689|FD-Score:5.73|P-value:4.02E-10 ID:SGTC_2426|Compound:5582046|FD-Score:5.57|P-value:1.12E-9 ID:SGTC_2429|Compound:5902844|FD-Score:3.14|P-value:3.66E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.64|P-value:4.66E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.47|P-value:1.02E-6 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.22|P-value:3.19E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.79|P-value:2.28E-5 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-3.23|P-value:3.03E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.41|P-value:1.22E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.36|P-value:1.39E-6 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.58|P-value:7.19E-5 ID:SGTC_2733|Compound:amorolfine|FD-Score:3.08|P-value:4.68E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.57|P-value:6.25E-5 ID:SGTC_2790|Compound:5423970|FD-Score:5.22|P-value:1.08E-8 ID:SGTC_2810|Compound:7959871|FD-Score:3.53|P-value:7.41E-5 ID:SGTC_2813|Compound:7971799|FD-Score:3.35|P-value:1.55E-4 ID:SGTC_2844|Compound:9010103|FD-Score:2.95|P-value:7.57E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-4.06|P-value:7.91E-6 ID:SGTC_2888|Compound:9058547|FD-Score:-3.47|P-value:1.13E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.03|P-value:6.49E-4 ID:SGTC_3102|Compound:9121669|FD-Score:2.93|P-value:8.20E-4 ID:SGTC_3104|Compound:9120930|FD-Score:2.97|P-value:6.89E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.95|P-value:1.12E-5 ID:SGTC_3141|Compound:9094609|FD-Score:5.22|P-value:1.06E-8 ID:SGTC_3211|Compound:9128781|FD-Score:4.03|P-value:7.59E-6 ID:SGTC_3214|Compound:9129694|FD-Score:4.12|P-value:4.76E-6 ID:SGTC_3263|Compound:9137018|FD-Score:4.53|P-value:5.65E-7

Top fitness defect scores for YMR029C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 13.30 51.8 µM 5.04E-46 ERAD & cell cycle 13 1.97E-40
2 SGTC_805 3852-0218 12.40 479.0 µM 1.41E-40 ERAD & cell cycle 2 1.14E-35
3 SGTC_1161 k007-0610 8.87 110.0 µM 1.03E-21 ERAD & cell cycle 19 3.65E-19
4 SGTC_384 k007-0144 6.85 5.2 µM 1.08E-13 ERAD & cell cycle 17 3.80E-12
5 SGTC_1739 st037196 6.23 92.5 µM 1.19E-11 1 2.32E-10
6 SGTC_733 4069-0007 5.92 56.1 µM 1.07E-10 ERAD & cell cycle 41 1.60E-9
7 SGTC_2397 5161689 5.73 200.0 µM 4.02E-10 7 5.07E-9
8 SGTC_2426 5582046 5.57 32.2 µM 1.12E-9 6 1.25E-8
9 SGTC_352 k048-0007 5.25 5.1 µM 8.86E-9 ERAD & cell cycle 43 7.60E-8
10 SGTC_3141 9094609 5.22 49.5 µM 1.06E-8 iron homeostasis 16 8.88E-8
11 SGTC_2790 5423970 5.22 71.4 µM 1.08E-8 endomembrane recycling 35 9.08E-8
12 SGTC_1257 0669-0121 5.17 16.0 µM 1.41E-8 10 1.14E-7
13 SGTC_1026 k007-1105 4.96 30.6 µM 5.01E-8 ERAD & cell cycle 60 3.47E-7
14 SGTC_373 0844-0104 4.84 25.9 µM 1.03E-7 ERAD & cell cycle 33 6.52E-7
15 SGTC_1725 st036284 4.58 20.6 µM 4.29E-7 21 2.27E-6
16 SGTC_3263 9137018 4.53 49.5 µM 5.65E-7 9 2.90E-6
17 SGTC_568 1193-0097 4.42 7.5 µM 1.05E-6 ERAD & cell cycle 118 5.00E-6
18 SGTC_2724 maprotiline 4.36 69.6 µM 1.39E-6 ERG2 6 6.38E-6
19 SGTC_1750 st081859 4.19 2.4 µM 3.42E-6 endomembrane recycling 168 1.41E-5
20 SGTC_3214 9129694 4.12 49.5 µM 4.76E-6 24 1.88E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.472 7.92E-186 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.465 9.10E-180 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.454 1.60E-170 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.441 6.06E-160 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.434 6.27E-154 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.415 2.86E-140 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.388 3.41E-121 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.378 1.62E-114 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.372 1.29E-110 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.358 4.24E-102 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.348 4.48E-96 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.339 4.32E-91 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.312 1.39E-76 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.295 1.86E-68 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.287 9.19E-65 YDR200C VPS64 hom Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance