YMR030W / RSF1

Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR030W / RSF1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.52|P-value:9.57E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.62|P-value:6.32E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:3.40|P-value:1.60E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.40|P-value:1.66E-6 ID:SGTC_126|Compound:0417-1624|FD-Score:4.18|P-value:5.01E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:2.95|P-value:8.67E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.99|P-value:1.23E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:6.38|P-value:8.59E-12 ID:SGTC_184|Compound:1494-0393|FD-Score:3.71|P-value:4.19E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.63|P-value:6.15E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.74|P-value:3.68E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.88|P-value:2.56E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:2.94|P-value:9.16E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.05|P-value:9.02E-6 ID:SGTC_818|Compound:4072-2707|FD-Score:5.81|P-value:4.33E-10 ID:SGTC_823|Compound:0417-1665|FD-Score:4.57|P-value:6.94E-7 ID:SGTC_910|Compound:3454-3003|FD-Score:-5.10|P-value:5.05E-8 ID:SGTC_1119|Compound:parthenolide|FD-Score:-4.09|P-value:1.00E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:4.70|P-value:3.34E-7 ID:SGTC_1126|Compound:isoteolin|FD-Score:-2.99|P-value:9.19E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.03|P-value:6.57E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.42|P-value:1.83E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:2.92|P-value:9.63E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:-3.71|P-value:5.49E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.28|P-value:2.50E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.25|P-value:2.83E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.16|P-value:3.97E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.15|P-value:7.53E-6 ID:SGTC_1731|Compound:st035964|FD-Score:3.34|P-value:1.97E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.60|P-value:8.62E-5 ID:SGTC_1759|Compound:st043059|FD-Score:-3.34|P-value:2.57E-4 ID:SGTC_1773|Compound:st048542|FD-Score:-3.11|P-value:6.05E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.23|P-value:3.14E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.86|P-value:2.16E-5 ID:SGTC_1852|Compound:st056254|FD-Score:2.99|P-value:7.65E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-4.27|P-value:4.14E-6 ID:SGTC_2117|Compound:5521686|FD-Score:3.04|P-value:6.39E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.74|P-value:3.80E-5 ID:SGTC_2325|Compound:6158266|FD-Score:-4.80|P-value:2.74E-7 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.59|P-value:9.11E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.13|P-value:5.55E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-5.45|P-value:6.16E-9 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.19|P-value:4.64E-6 ID:SGTC_2810|Compound:7959871|FD-Score:2.98|P-value:7.80E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.40|P-value:1.58E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-4.06|P-value:1.12E-5 ID:SGTC_3066|Compound:9117245|FD-Score:3.30|P-value:2.33E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-7.66|P-value:5.38E-16 ID:SGTC_3142|Compound:9086498|FD-Score:-4.72|P-value:4.08E-7 ID:SGTC_3217|Compound:9129673|FD-Score:3.70|P-value:4.54E-5 ID:SGTC_3220|Compound:9131269|FD-Score:3.91|P-value:1.73E-5 ID:SGTC_3221|Compound:9128209|FD-Score:2.99|P-value:7.68E-4 ID:SGTC_3222|Compound:9128301|FD-Score:6.61|P-value:1.55E-12 ID:SGTC_9|Compound:0092-0002|FD-Score:3.52|P-value:9.57E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.62|P-value:6.32E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:3.40|P-value:1.60E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.40|P-value:1.66E-6 ID:SGTC_126|Compound:0417-1624|FD-Score:4.18|P-value:5.01E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:2.95|P-value:8.67E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.99|P-value:1.23E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:6.38|P-value:8.59E-12 ID:SGTC_184|Compound:1494-0393|FD-Score:3.71|P-value:4.19E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.63|P-value:6.15E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.74|P-value:3.68E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.88|P-value:2.56E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:2.94|P-value:9.16E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.05|P-value:9.02E-6 ID:SGTC_818|Compound:4072-2707|FD-Score:5.81|P-value:4.33E-10 ID:SGTC_823|Compound:0417-1665|FD-Score:4.57|P-value:6.94E-7 ID:SGTC_910|Compound:3454-3003|FD-Score:-5.10|P-value:5.05E-8 ID:SGTC_1119|Compound:parthenolide|FD-Score:-4.09|P-value:1.00E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:4.70|P-value:3.34E-7 ID:SGTC_1126|Compound:isoteolin|FD-Score:-2.99|P-value:9.19E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.03|P-value:6.57E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.42|P-value:1.83E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:2.92|P-value:9.63E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:-3.71|P-value:5.49E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.28|P-value:2.50E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.25|P-value:2.83E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.16|P-value:3.97E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.15|P-value:7.53E-6 ID:SGTC_1731|Compound:st035964|FD-Score:3.34|P-value:1.97E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.60|P-value:8.62E-5 ID:SGTC_1759|Compound:st043059|FD-Score:-3.34|P-value:2.57E-4 ID:SGTC_1773|Compound:st048542|FD-Score:-3.11|P-value:6.05E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.23|P-value:3.14E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.86|P-value:2.16E-5 ID:SGTC_1852|Compound:st056254|FD-Score:2.99|P-value:7.65E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-4.27|P-value:4.14E-6 ID:SGTC_2117|Compound:5521686|FD-Score:3.04|P-value:6.39E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.74|P-value:3.80E-5 ID:SGTC_2325|Compound:6158266|FD-Score:-4.80|P-value:2.74E-7 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.59|P-value:9.11E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.13|P-value:5.55E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-5.45|P-value:6.16E-9 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.19|P-value:4.64E-6 ID:SGTC_2810|Compound:7959871|FD-Score:2.98|P-value:7.80E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.40|P-value:1.58E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-4.06|P-value:1.12E-5 ID:SGTC_3066|Compound:9117245|FD-Score:3.30|P-value:2.33E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-7.66|P-value:5.38E-16 ID:SGTC_3142|Compound:9086498|FD-Score:-4.72|P-value:4.08E-7 ID:SGTC_3217|Compound:9129673|FD-Score:3.70|P-value:4.54E-5 ID:SGTC_3220|Compound:9131269|FD-Score:3.91|P-value:1.73E-5 ID:SGTC_3221|Compound:9128209|FD-Score:2.99|P-value:7.68E-4 ID:SGTC_3222|Compound:9128301|FD-Score:6.61|P-value:1.55E-12

Top fitness defect scores for YMR030W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3222 9128301 6.61 49.5 µM 1.55E-12 60S ribosome export 3 1.94E-11
2 SGTC_145 3737-0113 6.38 38.4 µM 8.59E-12 DNA intercalators 22 9.12E-11
3 SGTC_818 4072-2707 5.81 53.5 µM 4.33E-10 1 3.16E-9
4 SGTC_1120 ficusin 4.70 1.8 µM 3.34E-7 12 1.29E-6
5 SGTC_823 0417-1665 4.57 178.0 µM 6.94E-7 31 2.49E-6
6 SGTC_115 0527-0192 4.40 112.0 µM 1.66E-6 53 5.48E-6
7 SGTC_2762 leflunomide 4.19 42.1 µM 4.64E-6 22 1.39E-5
8 SGTC_126 0417-1624 4.18 672.5 µM 5.01E-6 DNA intercalators 23 1.49E-5
9 SGTC_733 4069-0007 4.05 56.1 µM 9.02E-6 ERAD & cell cycle 80 2.54E-5
10 SGTC_144 4161-2749 3.99 112.4 µM 1.23E-5 DNA intercalators 24 3.37E-5
11 SGTC_3220 9131269 3.91 49.5 µM 1.73E-5 9 4.57E-5
12 SGTC_1785 bathophenanthroline 3.86 24.0 µM 2.16E-5 heme requiring 53 5.58E-5
13 SGTC_417 st075190 3.74 100.0 µM 3.68E-5 12 9.03E-5
14 SGTC_2167 5876490 3.74 200.0 µM 3.80E-5 40 9.31E-5
15 SGTC_184 1494-0393 3.71 24.7 µM 4.19E-5 69 1.02E-4
16 SGTC_3217 9129673 3.70 49.5 µM 4.54E-5 48 1.09E-4
17 SGTC_373 0844-0104 3.63 25.9 µM 6.15E-5 ERAD & cell cycle 59 1.44E-4
18 SGTC_103 0844-0104 3.62 51.8 µM 6.32E-5 ERAD & cell cycle 160 1.47E-4
19 SGTC_9 0092-0002 3.52 10.4 µM 9.57E-5 49 2.15E-4
20 SGTC_2835 9006588 3.40 71.4 µM 1.58E-4 69 3.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.211 4.49E-35 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.211 6.87E-35 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.211 6.39E-35 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.179 1.63E-25 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.155 2.32E-19 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.154 2.98E-19 YKR064W OAF3 hom Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.152 7.74E-19 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.151 1.24E-18 YOR079C ATX2 hom Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation
0.151 1.45E-18 YHR020W YHR020W het Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.150 2.05E-18 YDR054C CDC34 het Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress
0.140 4.14E-16 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.140 4.33E-16 YPR059C_d YPR059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
0.130 5.41E-14 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.129 7.21E-14 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.127 1.59E-13 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain