YMR031W-A_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR031W-A / YMR031W-A

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.33|P-value:3.73E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.10|P-value:8.47E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.48|P-value:2.16E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.13|P-value:7.37E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.69|P-value:1.04E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:3.69|P-value:9.50E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.86|P-value:4.77E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:3.55|P-value:1.68E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.28|P-value:4.49E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.33|P-value:5.86E-6 ID:SGTC_187|Compound:1488-2104|FD-Score:3.30|P-value:4.30E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.60|P-value:1.37E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.76|P-value:7.12E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.20|P-value:5.86E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.69|P-value:9.31E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:3.30|P-value:4.26E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.33|P-value:3.83E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:10.10|P-value:1.19E-24 ID:SGTC_447|Compound:ml7|FD-Score:3.65|P-value:1.10E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.08|P-value:1.86E-5 ID:SGTC_459|Compound:nigericin|FD-Score:5.64|P-value:5.69E-9 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.19|P-value:1.15E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.77|P-value:6.63E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:9.31|P-value:2.13E-21 ID:SGTC_513|Compound:4245-1575|FD-Score:3.47|P-value:2.26E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:8.30|P-value:2.30E-17 ID:SGTC_543|Compound:3844-1095|FD-Score:5.14|P-value:9.68E-8 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.06|P-value:9.54E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.11|P-value:8.19E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:6.34|P-value:6.78E-11 ID:SGTC_743|Compound:1275-0778|FD-Score:6.04|P-value:4.78E-10 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.83|P-value:5.10E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.38|P-value:2.98E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.70|P-value:9.09E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:-4.02|P-value:2.33E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:4.90|P-value:3.48E-7 ID:SGTC_893|Compound:0958-0369|FD-Score:5.26|P-value:5.21E-8 ID:SGTC_897|Compound:1000-0139|FD-Score:3.09|P-value:8.86E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:5.13|P-value:1.02E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:7.87|P-value:8.50E-16 ID:SGTC_960|Compound:1222-0186|FD-Score:3.33|P-value:3.75E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.99|P-value:2.72E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.56|P-value:1.59E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.42|P-value:2.58E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.50|P-value:2.02E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.33|P-value:5.95E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.21|P-value:6.80E-8 ID:SGTC_1277|Compound:0873-0036|FD-Score:4.34|P-value:5.65E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:9.85|P-value:1.07E-23 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.49|P-value:2.61E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.36|P-value:5.25E-6 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.53|P-value:1.71E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.68|P-value:9.75E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.50|P-value:1.93E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.46|P-value:2.37E-4 ID:SGTC_1687|Compound:st020778|FD-Score:8.36|P-value:1.34E-17 ID:SGTC_1712|Compound:st032288|FD-Score:3.66|P-value:1.05E-4 ID:SGTC_1801|Compound:st050089|FD-Score:6.44|P-value:3.55E-11 ID:SGTC_1803|Compound:st050068|FD-Score:6.40|P-value:4.82E-11 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.55|P-value:1.63E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.69|P-value:9.64E-5 ID:SGTC_1941|Compound:st076221|FD-Score:6.22|P-value:1.53E-10 ID:SGTC_1956|Compound:st077085|FD-Score:5.36|P-value:2.87E-8 ID:SGTC_2021|Compound:4019055|FD-Score:3.46|P-value:2.36E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.24|P-value:9.04E-6 ID:SGTC_2077|Compound:5212015|FD-Score:3.75|P-value:7.42E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-3.50|P-value:1.95E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.20|P-value:6.16E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.40|P-value:2.80E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.51|P-value:1.93E-4 ID:SGTC_2482|Compound:5981709|FD-Score:5.01|P-value:2.05E-7 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.52|P-value:1.78E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.20|P-value:1.06E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.81|P-value:5.77E-5 ID:SGTC_2716|Compound:st080858|FD-Score:-3.31|P-value:3.90E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.64|P-value:1.33E-6 ID:SGTC_2807|Compound:7945238|FD-Score:-3.68|P-value:9.33E-5 ID:SGTC_2835|Compound:9006588|FD-Score:3.64|P-value:1.18E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.84|P-value:4.88E-7 ID:SGTC_2871|Compound:9038510|FD-Score:3.85|P-value:4.99E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-3.58|P-value:1.39E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.36|P-value:3.39E-4 ID:SGTC_2893|Compound:9048488|FD-Score:4.19|P-value:1.10E-5 ID:SGTC_2894|Compound:9048625|FD-Score:4.11|P-value:1.62E-5 ID:SGTC_2895|Compound:9054447|FD-Score:3.70|P-value:9.18E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-3.26|P-value:4.68E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-4.32|P-value:6.02E-6 ID:SGTC_2946|Compound:9065502|FD-Score:-3.55|P-value:1.61E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-5.18|P-value:7.44E-8 ID:SGTC_3025|Compound:9087895|FD-Score:5.54|P-value:1.02E-8 ID:SGTC_3074|Compound:9116018|FD-Score:3.15|P-value:7.13E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.06|P-value:9.51E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.49|P-value:2.08E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-4.51|P-value:2.39E-6 ID:SGTC_6|Compound:0844-0013|FD-Score:3.33|P-value:3.73E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.10|P-value:8.47E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.48|P-value:2.16E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.13|P-value:7.37E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.69|P-value:1.04E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:3.69|P-value:9.50E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.86|P-value:4.77E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:3.55|P-value:1.68E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.28|P-value:4.49E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.33|P-value:5.86E-6 ID:SGTC_187|Compound:1488-2104|FD-Score:3.30|P-value:4.30E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.60|P-value:1.37E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.76|P-value:7.12E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.20|P-value:5.86E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.69|P-value:9.31E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:3.30|P-value:4.26E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.33|P-value:3.83E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:10.10|P-value:1.19E-24 ID:SGTC_447|Compound:ml7|FD-Score:3.65|P-value:1.10E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.08|P-value:1.86E-5 ID:SGTC_459|Compound:nigericin|FD-Score:5.64|P-value:5.69E-9 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.19|P-value:1.15E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.77|P-value:6.63E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:9.31|P-value:2.13E-21 ID:SGTC_513|Compound:4245-1575|FD-Score:3.47|P-value:2.26E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:8.30|P-value:2.30E-17 ID:SGTC_543|Compound:3844-1095|FD-Score:5.14|P-value:9.68E-8 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.06|P-value:9.54E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.11|P-value:8.19E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:6.34|P-value:6.78E-11 ID:SGTC_743|Compound:1275-0778|FD-Score:6.04|P-value:4.78E-10 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.83|P-value:5.10E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.38|P-value:2.98E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.70|P-value:9.09E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:-4.02|P-value:2.33E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:4.90|P-value:3.48E-7 ID:SGTC_893|Compound:0958-0369|FD-Score:5.26|P-value:5.21E-8 ID:SGTC_897|Compound:1000-0139|FD-Score:3.09|P-value:8.86E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:5.13|P-value:1.02E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:7.87|P-value:8.50E-16 ID:SGTC_960|Compound:1222-0186|FD-Score:3.33|P-value:3.75E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.99|P-value:2.72E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.56|P-value:1.59E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.42|P-value:2.58E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.50|P-value:2.02E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.33|P-value:5.95E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.21|P-value:6.80E-8 ID:SGTC_1277|Compound:0873-0036|FD-Score:4.34|P-value:5.65E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:9.85|P-value:1.07E-23 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.49|P-value:2.61E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.36|P-value:5.25E-6 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.53|P-value:1.71E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.68|P-value:9.75E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.50|P-value:1.93E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.46|P-value:2.37E-4 ID:SGTC_1687|Compound:st020778|FD-Score:8.36|P-value:1.34E-17 ID:SGTC_1712|Compound:st032288|FD-Score:3.66|P-value:1.05E-4 ID:SGTC_1801|Compound:st050089|FD-Score:6.44|P-value:3.55E-11 ID:SGTC_1803|Compound:st050068|FD-Score:6.40|P-value:4.82E-11 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.55|P-value:1.63E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.69|P-value:9.64E-5 ID:SGTC_1941|Compound:st076221|FD-Score:6.22|P-value:1.53E-10 ID:SGTC_1956|Compound:st077085|FD-Score:5.36|P-value:2.87E-8 ID:SGTC_2021|Compound:4019055|FD-Score:3.46|P-value:2.36E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.24|P-value:9.04E-6 ID:SGTC_2077|Compound:5212015|FD-Score:3.75|P-value:7.42E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-3.50|P-value:1.95E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.20|P-value:6.16E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.40|P-value:2.80E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.51|P-value:1.93E-4 ID:SGTC_2482|Compound:5981709|FD-Score:5.01|P-value:2.05E-7 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.52|P-value:1.78E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.20|P-value:1.06E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.81|P-value:5.77E-5 ID:SGTC_2716|Compound:st080858|FD-Score:-3.31|P-value:3.90E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.64|P-value:1.33E-6 ID:SGTC_2807|Compound:7945238|FD-Score:-3.68|P-value:9.33E-5 ID:SGTC_2835|Compound:9006588|FD-Score:3.64|P-value:1.18E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.84|P-value:4.88E-7 ID:SGTC_2871|Compound:9038510|FD-Score:3.85|P-value:4.99E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-3.58|P-value:1.39E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.36|P-value:3.39E-4 ID:SGTC_2893|Compound:9048488|FD-Score:4.19|P-value:1.10E-5 ID:SGTC_2894|Compound:9048625|FD-Score:4.11|P-value:1.62E-5 ID:SGTC_2895|Compound:9054447|FD-Score:3.70|P-value:9.18E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-3.26|P-value:4.68E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-4.32|P-value:6.02E-6 ID:SGTC_2946|Compound:9065502|FD-Score:-3.55|P-value:1.61E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-5.18|P-value:7.44E-8 ID:SGTC_3025|Compound:9087895|FD-Score:5.54|P-value:1.02E-8 ID:SGTC_3074|Compound:9116018|FD-Score:3.15|P-value:7.13E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.06|P-value:9.51E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.49|P-value:2.08E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-4.51|P-value:2.39E-6

Top fitness defect scores for YMR031W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_377 3970-0964 10.10 33.1 µM 1.19E-24 1 4.21E-24
2 SGTC_1287 0971-0001 9.85 34.6 µM 1.07E-23 sphingolipid biosynthesis & PDR1 10 3.59E-23
3 SGTC_505 gw-5074 9.31 63.9 µM 2.13E-21 14 6.27E-21
4 SGTC_1687 st020778 8.36 55.4 µM 1.34E-17 64 3.20E-17
5 SGTC_528 3492-0019 8.30 172.0 µM 2.30E-17 calcium & mitochondrial duress 65 5.41E-17
6 SGTC_955 1216-0110 7.87 33.0 µM 8.50E-16 sphingolipid biosynthesis & PDR1 21 1.83E-15
7 SGTC_1801 st050089 6.44 28.4 µM 3.55E-11 NEO1-PIK1 44 5.92E-11
8 SGTC_1803 st050068 6.40 52.4 µM 4.82E-11 NEO1-PIK1 68 7.98E-11
9 SGTC_682 0kpi-0099 6.34 17.0 µM 6.78E-11 21 1.11E-10
10 SGTC_1941 st076221 6.22 61.8 µM 1.53E-10 sphingolipid biosynthesis & PDR1 30 2.47E-10
11 SGTC_743 1275-0778 6.04 158.0 µM 4.78E-10 excess fatty acid 12 7.50E-10
12 SGTC_459 nigericin 5.64 15.3 µM 5.69E-9 38 8.42E-9
13 SGTC_3025 9087895 5.54 49.5 µM 1.02E-8 PDR1 17 1.49E-8
14 SGTC_1956 st077085 5.36 54.0 µM 2.87E-8 3 4.09E-8
15 SGTC_893 0958-0369 5.26 48.9 µM 5.21E-8 9 7.32E-8
16 SGTC_1263 0774-1208 5.21 64.8 µM 6.80E-8 18 9.50E-8
17 SGTC_543 3844-1095 5.14 191.0 µM 9.68E-8 ERG2 24 1.34E-7
18 SGTC_951 1171-0579 5.13 82.7 µM 1.02E-7 cell wall 42 1.41E-7
19 SGTC_2482 5981709 5.01 142.7 µM 2.05E-7 PDR1 20 2.79E-7
20 SGTC_829 1635-0120 4.90 117.0 µM 3.48E-7 DNA damage response 23 4.67E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.428 3.68E-149 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.403 9.04E-131 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.342 2.67E-92 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.331 1.41E-86 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.326 9.40E-84 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.324 7.45E-83 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.307 3.25E-74 YNL237W YTP1 hom Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.295 4.49E-68 YJR074W MOG1 hom Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
0.294 8.18E-68 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.291 2.03E-66 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.271 2.45E-57 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.257 1.24E-51 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
0.248 2.76E-48 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.243 2.61E-46 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.236 1.66E-43 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase