YMR032W / HOF1

Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR032W / HOF1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.65|P-value:1.48E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.25|P-value:6.28E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:4.22|P-value:1.40E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.58|P-value:1.92E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:5.82|P-value:3.90E-9 ID:SGTC_351|Compound:caspofungin|FD-Score:6.58|P-value:3.35E-11 ID:SGTC_354|Compound:2783-3500|FD-Score:5.49|P-value:2.52E-8 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.17|P-value:1.76E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.64|P-value:1.55E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.81|P-value:8.03E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:4.18|P-value:1.70E-5 ID:SGTC_593|Compound:1203-0218|FD-Score:3.98|P-value:3.94E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.12|P-value:2.24E-5 ID:SGTC_699|Compound:0375-0592|FD-Score:5.32|P-value:6.47E-8 ID:SGTC_800|Compound:3448-7362|FD-Score:3.23|P-value:6.93E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.27|P-value:5.95E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.48|P-value:2.80E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.74|P-value:6.13E-9 ID:SGTC_927|Compound:2425-1185|FD-Score:3.48|P-value:2.84E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:6.14|P-value:5.52E-10 ID:SGTC_1034|Compound:k072-0165|FD-Score:4.17|P-value:1.80E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:-3.80|P-value:7.65E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.10|P-value:9.98E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.24|P-value:1.28E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:5.85|P-value:3.15E-9 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.33|P-value:4.84E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:9.49|P-value:2.10E-21 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.72|P-value:1.42E-6 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.23|P-value:6.76E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.60|P-value:1.77E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.18|P-value:8.19E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.24|P-value:6.67E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.76|P-value:9.71E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.84|P-value:7.04E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:4.61|P-value:2.43E-6 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.01|P-value:3.51E-5 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.25|P-value:6.29E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.13|P-value:9.56E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.45|P-value:3.19E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.21|P-value:7.32E-4 ID:SGTC_1755|Compound:st041960|FD-Score:4.22|P-value:1.43E-5 ID:SGTC_1878|Compound:temozolomide|FD-Score:-4.22|P-value:1.32E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:5.54|P-value:1.98E-8 ID:SGTC_1912|Compound:st060209|FD-Score:3.12|P-value:9.85E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.21|P-value:6.83E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.21|P-value:1.49E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.39|P-value:3.97E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.61|P-value:1.70E-4 ID:SGTC_2103|Compound:5378138|FD-Score:4.04|P-value:3.02E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.84|P-value:7.94E-7 ID:SGTC_2145|Compound:5634607|FD-Score:3.39|P-value:3.88E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.14|P-value:9.20E-4 ID:SGTC_2189|Compound:6047310|FD-Score:3.56|P-value:2.11E-4 ID:SGTC_2191|Compound:5911152|FD-Score:5.30|P-value:7.40E-8 ID:SGTC_2194|Compound:5927483|FD-Score:5.46|P-value:3.04E-8 ID:SGTC_2197|Compound:6588183|FD-Score:3.56|P-value:2.11E-4 ID:SGTC_2231|Compound:micatex|FD-Score:-3.62|P-value:1.55E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.51|P-value:3.81E-6 ID:SGTC_2403|Compound:6032726|FD-Score:4.25|P-value:1.27E-5 ID:SGTC_2472|Compound:5377652|FD-Score:3.31|P-value:5.22E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:5.30|P-value:7.09E-8 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.59|P-value:1.85E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.35|P-value:4.46E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.25|P-value:1.24E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.10|P-value:9.87E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.50|P-value:2.63E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.51|P-value:2.50E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:4.52|P-value:3.73E-6 ID:SGTC_2865|Compound:9030313|FD-Score:5.92|P-value:2.05E-9 ID:SGTC_2870|Compound:9038528|FD-Score:6.15|P-value:5.26E-10 ID:SGTC_2912|Compound:7964298|FD-Score:4.05|P-value:2.91E-5 ID:SGTC_2997|Compound:9067075|FD-Score:3.66|P-value:1.41E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.72|P-value:1.12E-4 ID:SGTC_3058|Compound:9093861|FD-Score:5.18|P-value:1.38E-7 ID:SGTC_3159|Compound:9100096|FD-Score:3.62|P-value:1.65E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.33|P-value:4.77E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.61|P-value:1.76E-4 ID:SGTC_3285|Compound:9112818|FD-Score:3.82|P-value:7.47E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.05|P-value:3.01E-5 ID:SGTC_3356|Compound:9151811|FD-Score:3.91|P-value:5.30E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:3.65|P-value:1.48E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.25|P-value:6.28E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:4.22|P-value:1.40E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.58|P-value:1.92E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:5.82|P-value:3.90E-9 ID:SGTC_351|Compound:caspofungin|FD-Score:6.58|P-value:3.35E-11 ID:SGTC_354|Compound:2783-3500|FD-Score:5.49|P-value:2.52E-8 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.17|P-value:1.76E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.64|P-value:1.55E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.81|P-value:8.03E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:4.18|P-value:1.70E-5 ID:SGTC_593|Compound:1203-0218|FD-Score:3.98|P-value:3.94E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.12|P-value:2.24E-5 ID:SGTC_699|Compound:0375-0592|FD-Score:5.32|P-value:6.47E-8 ID:SGTC_800|Compound:3448-7362|FD-Score:3.23|P-value:6.93E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.27|P-value:5.95E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.48|P-value:2.80E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.74|P-value:6.13E-9 ID:SGTC_927|Compound:2425-1185|FD-Score:3.48|P-value:2.84E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:6.14|P-value:5.52E-10 ID:SGTC_1034|Compound:k072-0165|FD-Score:4.17|P-value:1.80E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:-3.80|P-value:7.65E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.10|P-value:9.98E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.24|P-value:1.28E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:5.85|P-value:3.15E-9 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.33|P-value:4.84E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:9.49|P-value:2.10E-21 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.72|P-value:1.42E-6 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.23|P-value:6.76E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.60|P-value:1.77E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.18|P-value:8.19E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.24|P-value:6.67E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.76|P-value:9.71E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.84|P-value:7.04E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:4.61|P-value:2.43E-6 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.01|P-value:3.51E-5 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.25|P-value:6.29E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.13|P-value:9.56E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.45|P-value:3.19E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.21|P-value:7.32E-4 ID:SGTC_1755|Compound:st041960|FD-Score:4.22|P-value:1.43E-5 ID:SGTC_1878|Compound:temozolomide|FD-Score:-4.22|P-value:1.32E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:5.54|P-value:1.98E-8 ID:SGTC_1912|Compound:st060209|FD-Score:3.12|P-value:9.85E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.21|P-value:6.83E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.21|P-value:1.49E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.39|P-value:3.97E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.61|P-value:1.70E-4 ID:SGTC_2103|Compound:5378138|FD-Score:4.04|P-value:3.02E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.84|P-value:7.94E-7 ID:SGTC_2145|Compound:5634607|FD-Score:3.39|P-value:3.88E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.14|P-value:9.20E-4 ID:SGTC_2189|Compound:6047310|FD-Score:3.56|P-value:2.11E-4 ID:SGTC_2191|Compound:5911152|FD-Score:5.30|P-value:7.40E-8 ID:SGTC_2194|Compound:5927483|FD-Score:5.46|P-value:3.04E-8 ID:SGTC_2197|Compound:6588183|FD-Score:3.56|P-value:2.11E-4 ID:SGTC_2231|Compound:micatex|FD-Score:-3.62|P-value:1.55E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.51|P-value:3.81E-6 ID:SGTC_2403|Compound:6032726|FD-Score:4.25|P-value:1.27E-5 ID:SGTC_2472|Compound:5377652|FD-Score:3.31|P-value:5.22E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:5.30|P-value:7.09E-8 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.59|P-value:1.85E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.35|P-value:4.46E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.25|P-value:1.24E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.10|P-value:9.87E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.50|P-value:2.63E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.51|P-value:2.50E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:4.52|P-value:3.73E-6 ID:SGTC_2865|Compound:9030313|FD-Score:5.92|P-value:2.05E-9 ID:SGTC_2870|Compound:9038528|FD-Score:6.15|P-value:5.26E-10 ID:SGTC_2912|Compound:7964298|FD-Score:4.05|P-value:2.91E-5 ID:SGTC_2997|Compound:9067075|FD-Score:3.66|P-value:1.41E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.72|P-value:1.12E-4 ID:SGTC_3058|Compound:9093861|FD-Score:5.18|P-value:1.38E-7 ID:SGTC_3159|Compound:9100096|FD-Score:3.62|P-value:1.65E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.33|P-value:4.77E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.61|P-value:1.76E-4 ID:SGTC_3285|Compound:9112818|FD-Score:3.82|P-value:7.47E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.05|P-value:3.01E-5 ID:SGTC_3356|Compound:9151811|FD-Score:3.91|P-value:5.30E-5

Top fitness defect scores for YMR032W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1133 3473-0247 9.49 50.0 µM 2.10E-21 RSC complex & mRNA processing 1 1.12E-21
2 SGTC_351 caspofungin 6.58 25.0 nM 3.35E-11 cell wall 34 2.42E-11
3 SGTC_2870 9038528 6.15 13.0 µM 5.26E-10 1 3.93E-10
4 SGTC_951 1171-0579 6.14 82.7 µM 5.52E-10 cell wall 31 4.13E-10
5 SGTC_2865 9030313 5.92 52.0 µM 2.05E-9 3 1.56E-9
6 SGTC_1069 diphenylcyclopropenone 5.85 8.5 µM 3.15E-9 9 2.41E-9
7 SGTC_138 0850-0259 5.82 40.9 µM 3.90E-9 cell wall 112 3.00E-9
8 SGTC_915 methyl methanesulfonate (MMS) 5.74 110.0 mM 6.13E-9 DNA damage response 13 4.74E-9
9 SGTC_1880 MG-132 5.54 525.0 µM 1.98E-8 7 1.55E-8
10 SGTC_354 2783-3500 5.49 4.9 µM 2.52E-8 cell wall 22 1.98E-8
11 SGTC_2194 5927483 5.46 104.5 µM 3.04E-8 9 2.40E-8
12 SGTC_699 0375-0592 5.32 111.0 µM 6.47E-8 iron homeostasis 5 5.16E-8
13 SGTC_2533 agelasine 5.30 13.7 µM 7.09E-8 ERG2 16 5.66E-8
14 SGTC_2191 5911152 5.30 200.0 µM 7.40E-8 4 5.91E-8
15 SGTC_3058 9093861 5.18 49.5 µM 1.38E-7 7 1.11E-7
16 SGTC_2111 5486399 4.84 200.0 µM 7.94E-7 18 6.55E-7
17 SGTC_1157 4092-0394 4.72 27.6 µM 1.42E-6 15 1.18E-6
18 SGTC_1384 3089-0840 4.61 101.0 µM 2.43E-6 8 2.03E-6
19 SGTC_2761 levamisole 4.52 97.9 µM 3.73E-6 7 3.14E-6
20 SGTC_2274 7947094 4.51 46.1 µM 3.81E-6 16 3.21E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.197 1.13E-30 YMR242C RPL20A hom Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication
0.181 3.65E-26 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.179 1.77E-25 YKL114C APN1 hom Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
0.178 3.52E-25 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.175 1.44E-24 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.174 3.42E-24 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.173 7.14E-24 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.171 2.17E-23 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.171 2.66E-23 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.163 1.60E-21 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.156 1.15E-19 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.152 7.91E-19 YBL062W_d YBL062W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.152 1.06E-18 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.150 2.67E-18 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.149 3.47E-18 YPR165W RHO1 het GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)