YMR033W / ARP9

Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR033W / ARP9

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:8.68|P-value:3.18E-9 ID:SGTC_49|Compound:0717-0965|FD-Score:-5.05|P-value:4.03E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:5.58|P-value:9.12E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.94|P-value:4.61E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:-4.72|P-value:8.76E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:6.01|P-value:2.80E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.78|P-value:6.69E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:6.49|P-value:6.81E-6 ID:SGTC_288|Compound:1315-0019|FD-Score:5.16|P-value:2.69E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:4.84|P-value:5.86E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:5.53|P-value:1.03E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.89|P-value:6.00E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-5.73|P-value:7.22E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.81|P-value:6.20E-4 ID:SGTC_462|Compound:ag-879|FD-Score:4.65|P-value:9.02E-4 ID:SGTC_483|Compound:fpl-64176|FD-Score:5.36|P-value:1.63E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:6.98|P-value:1.46E-6 ID:SGTC_605|Compound:1315-0399|FD-Score:4.83|P-value:5.93E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:5.84|P-value:4.51E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:9.72|P-value:3.96E-11 ID:SGTC_682|Compound:0kpi-0099|FD-Score:8.85|P-value:1.58E-9 ID:SGTC_695|Compound:3505-6186|FD-Score:5.01|P-value:3.89E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:6.34|P-value:1.08E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:6.40|P-value:8.90E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:5.80|P-value:5.01E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:7.08|P-value:1.07E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:8.56|P-value:5.06E-9 ID:SGTC_863|Compound:0466-0191|FD-Score:4.94|P-value:4.60E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:5.34|P-value:1.70E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.61|P-value:9.89E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:5.72|P-value:6.26E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:5.15|P-value:2.79E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.75|P-value:7.08E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:6.82|P-value:2.46E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:6.08|P-value:2.31E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:6.88|P-value:2.06E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:6.60|P-value:4.90E-6 ID:SGTC_1229|Compound:0139-0193|FD-Score:5.89|P-value:3.89E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:5.24|P-value:2.18E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-5.75|P-value:6.74E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.97|P-value:3.16E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:6.20|P-value:1.62E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:5.70|P-value:6.70E-5 ID:SGTC_1547|Compound:harmine|FD-Score:14.00|P-value:4.91E-21 ID:SGTC_1550|Compound:gossypolone|FD-Score:-5.36|P-value:1.90E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:9.72|P-value:3.95E-11 ID:SGTC_1652|Compound:st011932|FD-Score:6.32|P-value:1.15E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:7.29|P-value:5.29E-7 ID:SGTC_1773|Compound:st048542|FD-Score:4.80|P-value:6.35E-4 ID:SGTC_1783|Compound:st039459|FD-Score:4.78|P-value:6.70E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.65|P-value:7.62E-5 ID:SGTC_1884|Compound:5633444|FD-Score:5.55|P-value:1.00E-4 ID:SGTC_1915|Compound:st067105|FD-Score:7.52|P-value:2.37E-7 ID:SGTC_1949|Compound:st076024|FD-Score:-4.86|P-value:6.45E-4 ID:SGTC_1952|Compound:st077036|FD-Score:5.36|P-value:1.61E-4 ID:SGTC_1991|Compound:st073000|FD-Score:5.59|P-value:8.97E-5 ID:SGTC_2066|Compound:5222451|FD-Score:5.04|P-value:3.57E-4 ID:SGTC_2067|Compound:5224629|FD-Score:6.55|P-value:5.71E-6 ID:SGTC_2109|Compound:5483026|FD-Score:8.40|P-value:9.44E-9 ID:SGTC_2111|Compound:5486399|FD-Score:7.30|P-value:5.12E-7 ID:SGTC_2180|Compound:6301957|FD-Score:4.99|P-value:4.03E-4 ID:SGTC_2186|Compound:6124449|FD-Score:5.77|P-value:5.53E-5 ID:SGTC_2225|Compound:6654152|FD-Score:8.50|P-value:6.46E-9 ID:SGTC_2229|Compound:7354935|FD-Score:10.30|P-value:2.37E-12 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:-4.71|P-value:9.09E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.18|P-value:2.57E-4 ID:SGTC_2308|Compound:7584454|FD-Score:5.84|P-value:4.53E-5 ID:SGTC_2336|Compound:9001819|FD-Score:5.38|P-value:1.54E-4 ID:SGTC_2344|Compound:7990960|FD-Score:5.26|P-value:2.12E-4 ID:SGTC_2346|Compound:9031566|FD-Score:5.25|P-value:2.12E-4 ID:SGTC_2348|Compound:9022543|FD-Score:6.82|P-value:2.45E-6 ID:SGTC_2361|Compound:9034121|FD-Score:6.82|P-value:2.45E-6 ID:SGTC_2378|Compound:9074213|FD-Score:5.19|P-value:2.46E-4 ID:SGTC_2396|Compound:5342950|FD-Score:10.20|P-value:5.24E-12 ID:SGTC_2400|Compound:5203494|FD-Score:6.37|P-value:9.73E-6 ID:SGTC_2424|Compound:5537928|FD-Score:-4.88|P-value:6.16E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:13.10|P-value:1.28E-18 ID:SGTC_2575|Compound:plumbagin|FD-Score:5.42|P-value:1.38E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.09|P-value:3.17E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:6.23|P-value:1.49E-5 ID:SGTC_2647|Compound:atorvastatin|FD-Score:4.75|P-value:7.17E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:6.42|P-value:8.43E-6 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:5.68|P-value:6.98E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:7.15|P-value:8.27E-7 ID:SGTC_2671|Compound:danthron|FD-Score:6.91|P-value:1.84E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.22|P-value:2.34E-4 ID:SGTC_2704|Compound:st078022|FD-Score:5.08|P-value:3.28E-4 ID:SGTC_2830|Compound:7992007|FD-Score:5.57|P-value:9.30E-5 ID:SGTC_2837|Compound:9008476|FD-Score:7.54|P-value:2.24E-7 ID:SGTC_2867|Compound:9039098|FD-Score:-7.24|P-value:7.53E-7 ID:SGTC_2912|Compound:7964298|FD-Score:7.96|P-value:4.96E-8 ID:SGTC_2928|Compound:9011484|FD-Score:5.57|P-value:9.44E-5 ID:SGTC_2930|Compound:9013230|FD-Score:6.98|P-value:1.49E-6 ID:SGTC_3027|Compound:9089541|FD-Score:5.36|P-value:1.61E-4 ID:SGTC_3037|Compound:9091026|FD-Score:7.32|P-value:4.71E-7 ID:SGTC_3059|Compound:1327-0034|FD-Score:5.00|P-value:4.00E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.89|P-value:5.94E-4 ID:SGTC_3110|Compound:9122132|FD-Score:5.10|P-value:3.10E-4 ID:SGTC_3120|Compound:9124077|FD-Score:10.00|P-value:1.03E-11 ID:SGTC_3154|Compound:9100113|FD-Score:5.59|P-value:8.80E-5 ID:SGTC_3247|Compound:9135149|FD-Score:5.58|P-value:9.12E-5 ID:SGTC_3279|Compound:9140807|FD-Score:5.87|P-value:4.17E-5 ID:SGTC_3285|Compound:9112818|FD-Score:6.92|P-value:1.78E-6 ID:SGTC_3288|Compound:9119690|FD-Score:9.07|P-value:6.38E-10 ID:SGTC_3304|Compound:9125678|FD-Score:15.40|P-value:2.88E-25 ID:SGTC_45|Compound:0kpi-0036|FD-Score:8.68|P-value:3.18E-9 ID:SGTC_49|Compound:0717-0965|FD-Score:-5.05|P-value:4.03E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:5.58|P-value:9.12E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.94|P-value:4.61E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:-4.72|P-value:8.76E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:6.01|P-value:2.80E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.78|P-value:6.69E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:6.49|P-value:6.81E-6 ID:SGTC_288|Compound:1315-0019|FD-Score:5.16|P-value:2.69E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:4.84|P-value:5.86E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:5.53|P-value:1.03E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.89|P-value:6.00E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-5.73|P-value:7.22E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.81|P-value:6.20E-4 ID:SGTC_462|Compound:ag-879|FD-Score:4.65|P-value:9.02E-4 ID:SGTC_483|Compound:fpl-64176|FD-Score:5.36|P-value:1.63E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:6.98|P-value:1.46E-6 ID:SGTC_605|Compound:1315-0399|FD-Score:4.83|P-value:5.93E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:5.84|P-value:4.51E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:9.72|P-value:3.96E-11 ID:SGTC_682|Compound:0kpi-0099|FD-Score:8.85|P-value:1.58E-9 ID:SGTC_695|Compound:3505-6186|FD-Score:5.01|P-value:3.89E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:6.34|P-value:1.08E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:6.40|P-value:8.90E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:5.80|P-value:5.01E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:7.08|P-value:1.07E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:8.56|P-value:5.06E-9 ID:SGTC_863|Compound:0466-0191|FD-Score:4.94|P-value:4.60E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:5.34|P-value:1.70E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.61|P-value:9.89E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:5.72|P-value:6.26E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:5.15|P-value:2.79E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.75|P-value:7.08E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:6.82|P-value:2.46E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:6.08|P-value:2.31E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:6.88|P-value:2.06E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:6.60|P-value:4.90E-6 ID:SGTC_1229|Compound:0139-0193|FD-Score:5.89|P-value:3.89E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:5.24|P-value:2.18E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-5.75|P-value:6.74E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.97|P-value:3.16E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:6.20|P-value:1.62E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:5.70|P-value:6.70E-5 ID:SGTC_1547|Compound:harmine|FD-Score:14.00|P-value:4.91E-21 ID:SGTC_1550|Compound:gossypolone|FD-Score:-5.36|P-value:1.90E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:9.72|P-value:3.95E-11 ID:SGTC_1652|Compound:st011932|FD-Score:6.32|P-value:1.15E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:7.29|P-value:5.29E-7 ID:SGTC_1773|Compound:st048542|FD-Score:4.80|P-value:6.35E-4 ID:SGTC_1783|Compound:st039459|FD-Score:4.78|P-value:6.70E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.65|P-value:7.62E-5 ID:SGTC_1884|Compound:5633444|FD-Score:5.55|P-value:1.00E-4 ID:SGTC_1915|Compound:st067105|FD-Score:7.52|P-value:2.37E-7 ID:SGTC_1949|Compound:st076024|FD-Score:-4.86|P-value:6.45E-4 ID:SGTC_1952|Compound:st077036|FD-Score:5.36|P-value:1.61E-4 ID:SGTC_1991|Compound:st073000|FD-Score:5.59|P-value:8.97E-5 ID:SGTC_2066|Compound:5222451|FD-Score:5.04|P-value:3.57E-4 ID:SGTC_2067|Compound:5224629|FD-Score:6.55|P-value:5.71E-6 ID:SGTC_2109|Compound:5483026|FD-Score:8.40|P-value:9.44E-9 ID:SGTC_2111|Compound:5486399|FD-Score:7.30|P-value:5.12E-7 ID:SGTC_2180|Compound:6301957|FD-Score:4.99|P-value:4.03E-4 ID:SGTC_2186|Compound:6124449|FD-Score:5.77|P-value:5.53E-5 ID:SGTC_2225|Compound:6654152|FD-Score:8.50|P-value:6.46E-9 ID:SGTC_2229|Compound:7354935|FD-Score:10.30|P-value:2.37E-12 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:-4.71|P-value:9.09E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.18|P-value:2.57E-4 ID:SGTC_2308|Compound:7584454|FD-Score:5.84|P-value:4.53E-5 ID:SGTC_2336|Compound:9001819|FD-Score:5.38|P-value:1.54E-4 ID:SGTC_2344|Compound:7990960|FD-Score:5.26|P-value:2.12E-4 ID:SGTC_2346|Compound:9031566|FD-Score:5.25|P-value:2.12E-4 ID:SGTC_2348|Compound:9022543|FD-Score:6.82|P-value:2.45E-6 ID:SGTC_2361|Compound:9034121|FD-Score:6.82|P-value:2.45E-6 ID:SGTC_2378|Compound:9074213|FD-Score:5.19|P-value:2.46E-4 ID:SGTC_2396|Compound:5342950|FD-Score:10.20|P-value:5.24E-12 ID:SGTC_2400|Compound:5203494|FD-Score:6.37|P-value:9.73E-6 ID:SGTC_2424|Compound:5537928|FD-Score:-4.88|P-value:6.16E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:13.10|P-value:1.28E-18 ID:SGTC_2575|Compound:plumbagin|FD-Score:5.42|P-value:1.38E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.09|P-value:3.17E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:6.23|P-value:1.49E-5 ID:SGTC_2647|Compound:atorvastatin|FD-Score:4.75|P-value:7.17E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:6.42|P-value:8.43E-6 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:5.68|P-value:6.98E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:7.15|P-value:8.27E-7 ID:SGTC_2671|Compound:danthron|FD-Score:6.91|P-value:1.84E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.22|P-value:2.34E-4 ID:SGTC_2704|Compound:st078022|FD-Score:5.08|P-value:3.28E-4 ID:SGTC_2830|Compound:7992007|FD-Score:5.57|P-value:9.30E-5 ID:SGTC_2837|Compound:9008476|FD-Score:7.54|P-value:2.24E-7 ID:SGTC_2867|Compound:9039098|FD-Score:-7.24|P-value:7.53E-7 ID:SGTC_2912|Compound:7964298|FD-Score:7.96|P-value:4.96E-8 ID:SGTC_2928|Compound:9011484|FD-Score:5.57|P-value:9.44E-5 ID:SGTC_2930|Compound:9013230|FD-Score:6.98|P-value:1.49E-6 ID:SGTC_3027|Compound:9089541|FD-Score:5.36|P-value:1.61E-4 ID:SGTC_3037|Compound:9091026|FD-Score:7.32|P-value:4.71E-7 ID:SGTC_3059|Compound:1327-0034|FD-Score:5.00|P-value:4.00E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.89|P-value:5.94E-4 ID:SGTC_3110|Compound:9122132|FD-Score:5.10|P-value:3.10E-4 ID:SGTC_3120|Compound:9124077|FD-Score:10.00|P-value:1.03E-11 ID:SGTC_3154|Compound:9100113|FD-Score:5.59|P-value:8.80E-5 ID:SGTC_3247|Compound:9135149|FD-Score:5.58|P-value:9.12E-5 ID:SGTC_3279|Compound:9140807|FD-Score:5.87|P-value:4.17E-5 ID:SGTC_3285|Compound:9112818|FD-Score:6.92|P-value:1.78E-6 ID:SGTC_3288|Compound:9119690|FD-Score:9.07|P-value:6.38E-10 ID:SGTC_3304|Compound:9125678|FD-Score:15.40|P-value:2.88E-25

Top fitness defect scores for YMR033W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3304 9125678 15.40 46.1 µM 2.88E-25 9 4.13E-54 1.44
2 SGTC_1547 harmine 14.00 94.2 µM 4.91E-21 ergosterol biosynthesis 2 1.15E-44 5.00
3 SGTC_2567 aureobasidin a 13.10 60.0 nM 1.28E-18 8 2.79E-39 1.00
4 SGTC_2229 7354935 10.30 190.0 µM 2.37E-12 RSC complex & mRNA processing 2 2.42E-25 0.49
5 SGTC_2396 5342950 10.20 42.8 µM 5.24E-12 RSC complex & mRNA processing 5 1.40E-24 0.17
6 SGTC_3120 9124077 10.00 49.5 µM 1.03E-11 5 6.29E-24 0.45
7 SGTC_1556 plumbagin 9.72 1.5 µM 3.95E-11 superoxide 4 1.23E-22 1.65
8 SGTC_673 1082-0474 9.72 110.0 µM 3.96E-11 RSC complex & mRNA processing 13 1.24E-22 0.08
9 SGTC_3288 9119690 9.07 36.2 µM 6.38E-10 5 5.82E-20 0.41
10 SGTC_682 0kpi-0099 8.85 17.0 µM 1.58E-9 5 4.33E-19 0.33
11 SGTC_45 0kpi-0036 8.68 14.9 µM 3.18E-9 excess fatty acid 1 2.02E-18 3.14
12 SGTC_829 1635-0120 8.56 117.0 µM 5.06E-9 DNA damage response 11 5.64E-18 0.10
13 SGTC_2225 6654152 8.50 15.4 µM 6.46E-9 12 9.67E-18 1.00
14 SGTC_2109 5483026 8.40 200.0 µM 9.44E-9 RSC complex & mRNA processing 12 2.23E-17 0.03
15 SGTC_2912 7964298 7.96 10.9 µM 4.96E-8 cell wall 18 8.65E-16 0.35
16 SGTC_2837 9008476 7.54 45.5 µM 2.24E-7 1 2.38E-14 2.19
17 SGTC_1915 st067105 7.52 30.6 µM 2.37E-7 RNA pol III & RNase P/MRP 13 2.69E-14 0.00
18 SGTC_3037 9091026 7.32 49.5 µM 4.71E-7 NEO1-PIK1 9 1.22E-13 0.71
19 SGTC_2111 5486399 7.30 200.0 µM 5.12E-7 10 1.46E-13 0.13
20 SGTC_1679 4130-1276 7.29 6.7 µM 5.29E-7 Golgi 11 1.57E-13 0.60

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.551 3.28E-266 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.542 4.05E-255 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.474 7.39E-188 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.469 1.63E-183 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.401 8.14E-130 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.365 2.05E-106 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.350 3.58E-97 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.349 1.93E-96 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.329 2.08E-85 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.285 1.02E-63 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.264 1.11E-54 YAL001C TFC3 het Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
0.261 3.55E-53 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.253 5.74E-50 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.252 7.77E-50 YDR404C RPB7 het RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
0.249 1.34E-48 YDR016C DAD1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis