YMR037C / MSN2

Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR037C / MSN2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-4.05|P-value:4.08E-5 ID:SGTC_398|Compound:bronopol|FD-Score:3.32|P-value:5.03E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.42|P-value:1.90E-10 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.28|P-value:7.22E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.26|P-value:6.24E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.52|P-value:3.12E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:-3.24|P-value:8.17E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.31|P-value:1.05E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.78|P-value:1.16E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.23|P-value:6.81E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.32|P-value:5.01E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.79|P-value:1.54E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:-6.11|P-value:1.28E-9 ID:SGTC_1162|Compound:k048-0130|FD-Score:-3.71|P-value:1.55E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.42|P-value:3.53E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.10|P-value:2.54E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.41|P-value:3.62E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.50|P-value:3.38E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.43|P-value:3.43E-4 ID:SGTC_1855|Compound:st056195|FD-Score:5.63|P-value:1.43E-8 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.18|P-value:2.31E-5 ID:SGTC_2078|Compound:5212016|FD-Score:-3.29|P-value:6.96E-4 ID:SGTC_2116|Compound:5511452|FD-Score:-3.31|P-value:6.54E-4 ID:SGTC_2202|Compound:7226349|FD-Score:4.10|P-value:2.53E-5 ID:SGTC_2294|Compound:7971431|FD-Score:-7.30|P-value:4.94E-13 ID:SGTC_2301|Compound:7769476|FD-Score:-4.15|P-value:2.73E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.43|P-value:4.34E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.41|P-value:3.73E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.16|P-value:8.72E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.51|P-value:3.24E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.76|P-value:1.01E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.00|P-value:4.93E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.10|P-value:2.35E-7 ID:SGTC_2761|Compound:levamisole|FD-Score:-3.45|P-value:4.02E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.14|P-value:9.21E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-3.67|P-value:1.79E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.34|P-value:4.70E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.47|P-value:2.93E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.12|P-value:9.83E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.50|P-value:2.68E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.05|P-value:4.08E-5 ID:SGTC_398|Compound:bronopol|FD-Score:3.32|P-value:5.03E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.42|P-value:1.90E-10 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.28|P-value:7.22E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.26|P-value:6.24E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.52|P-value:3.12E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:-3.24|P-value:8.17E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.31|P-value:1.05E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.78|P-value:1.16E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.23|P-value:6.81E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.32|P-value:5.01E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.79|P-value:1.54E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:-6.11|P-value:1.28E-9 ID:SGTC_1162|Compound:k048-0130|FD-Score:-3.71|P-value:1.55E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.42|P-value:3.53E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.10|P-value:2.54E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.41|P-value:3.62E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.50|P-value:3.38E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.43|P-value:3.43E-4 ID:SGTC_1855|Compound:st056195|FD-Score:5.63|P-value:1.43E-8 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.18|P-value:2.31E-5 ID:SGTC_2078|Compound:5212016|FD-Score:-3.29|P-value:6.96E-4 ID:SGTC_2116|Compound:5511452|FD-Score:-3.31|P-value:6.54E-4 ID:SGTC_2202|Compound:7226349|FD-Score:4.10|P-value:2.53E-5 ID:SGTC_2294|Compound:7971431|FD-Score:-7.30|P-value:4.94E-13 ID:SGTC_2301|Compound:7769476|FD-Score:-4.15|P-value:2.73E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.43|P-value:4.34E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.41|P-value:3.73E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.16|P-value:8.72E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.51|P-value:3.24E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.76|P-value:1.01E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.00|P-value:4.93E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.10|P-value:2.35E-7 ID:SGTC_2761|Compound:levamisole|FD-Score:-3.45|P-value:4.02E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.14|P-value:9.21E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-3.67|P-value:1.79E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.34|P-value:4.70E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.47|P-value:2.93E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.12|P-value:9.83E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.50|P-value:2.68E-4

Top fitness defect scores for YMR037C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1855 st056195 5.63 39.6 µM 1.43E-8 60S ribosome export 2 9.20E-9
2 SGTC_2604 4'-hydroxychalcone 5.10 11.3 µM 2.35E-7 16 1.65E-7
3 SGTC_690 glyoxal 4.31 20.3 µM 1.05E-5 70 8.32E-6
4 SGTC_2202 7226349 4.10 200.0 µM 2.53E-5 5 2.06E-5
5 SGTC_1336 1486-0901 4.10 104.0 µM 2.54E-5 21 2.07E-5
6 SGTC_2442 5158906 3.76 48.5 µM 1.01E-4 25 8.56E-5
7 SGTC_3353 9151644 3.50 39.3 µM 2.68E-4 25 2.34E-4
8 SGTC_3103 9120822 3.47 49.5 µM 2.93E-4 28 2.57E-4
9 SGTC_1620 st003704 3.43 16.5 µM 3.43E-4 32 3.02E-4
10 SGTC_1331 1472-0049 3.42 76.2 µM 3.53E-4 45 3.11E-4
11 SGTC_1409 3909-8004 3.41 61.9 µM 3.62E-4 42 3.19E-4
12 SGTC_2339 9000433 3.41 200.0 µM 3.73E-4 53 3.29E-4
13 SGTC_3082 9117008 3.34 49.5 µM 4.70E-4 36 4.17E-4
14 SGTC_964 1287-0107 3.32 19.4 µM 5.01E-4 cell wall 73 4.46E-4
15 SGTC_398 bronopol 3.32 33.3 µM 5.03E-4 RNA processing & uracil transport 40 4.48E-4
16 SGTC_554 4483-2211 3.26 187.0 µM 6.24E-4 38 5.59E-4
17 SGTC_924 2046-0044 3.23 21.3 µM 6.81E-4 35 6.11E-4
18 SGTC_2379 9035213 3.16 200.0 µM 8.72E-4 52 7.88E-4
19 SGTC_2799 7812892 3.14 81.8 µM 9.21E-4 superoxide 60 8.33E-4
20 SGTC_3233 9132340 3.12 49.5 µM 9.83E-4 51 8.91E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 4.23E-18 YLR360W VPS38 hom Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated
0.131 2.98E-14 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.129 5.79E-14 YDR242W AMD2 hom Putative amidase
0.129 6.80E-14 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.128 8.10E-14 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.118 6.96E-12 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.118 8.27E-12 YAL068C PAU8 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
0.116 1.69E-11 YOR018W ROD1 hom Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication
0.115 2.43E-11 YOR008C-A_p YOR008C-A_p hom Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
0.112 9.28E-11 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.107 4.94E-10 YGR023W MTL1 hom Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p
0.105 1.25E-9 YLR203C MSS51 hom Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis
0.104 1.40E-9 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.104 1.63E-9 YDR480W DIG2 hom MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p
0.104 1.73E-9 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data