YMR038C / CCS1

Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR038C / CCS1

Click on Significant Values for Screen Details ID:SGTC_100|Compound:0086-0128|FD-Score:10.00|P-value:4.22E-15 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.85|P-value:9.65E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:5.94|P-value:2.39E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:6.84|P-value:6.66E-8 ID:SGTC_134|Compound:0269-0018|FD-Score:6.16|P-value:1.03E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:7.11|P-value:2.07E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:10.20|P-value:1.55E-15 ID:SGTC_156|Compound:3474-0145|FD-Score:6.86|P-value:6.12E-8 ID:SGTC_210|Compound:3551-0445|FD-Score:4.73|P-value:1.40E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.26|P-value:3.54E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:5.88|P-value:2.97E-6 ID:SGTC_394|Compound:menadione|FD-Score:6.76|P-value:9.09E-8 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.75|P-value:1.33E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.08|P-value:8.93E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:4.53|P-value:2.55E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-4.30|P-value:3.18E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-4.03|P-value:6.76E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:4.94|P-value:7.38E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:4.74|P-value:1.35E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:6.15|P-value:1.07E-6 ID:SGTC_670|Compound:4204-0025|FD-Score:6.85|P-value:6.39E-8 ID:SGTC_754|Compound:3474-0146|FD-Score:4.54|P-value:2.45E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.94|P-value:7.31E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:4.53|P-value:2.58E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.50|P-value:1.78E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.49|P-value:2.85E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:4.74|P-value:1.35E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:6.89|P-value:5.31E-8 ID:SGTC_1001|Compound:4048-4355|FD-Score:5.71|P-value:5.45E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.28|P-value:5.21E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.91|P-value:8.14E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:-5.59|P-value:4.86E-6 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.83|P-value:1.03E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.70|P-value:1.53E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:-5.80|P-value:2.24E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:6.51|P-value:2.58E-7 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.12|P-value:8.01E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.67|P-value:1.68E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:5.99|P-value:2.00E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.37|P-value:4.07E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-4.71|P-value:9.32E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:16.00|P-value:1.25E-35 ID:SGTC_1556|Compound:plumbagin|FD-Score:7.94|P-value:4.25E-10 ID:SGTC_1608|Compound:st001473|FD-Score:7.21|P-value:1.28E-8 ID:SGTC_1629|Compound:st005085|FD-Score:5.44|P-value:1.44E-5 ID:SGTC_1635|Compound:st007035|FD-Score:4.16|P-value:7.28E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-5.15|P-value:2.31E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-8.48|P-value:1.23E-11 ID:SGTC_1728|Compound:st035614|FD-Score:-5.59|P-value:4.91E-6 ID:SGTC_1750|Compound:st081859|FD-Score:5.24|P-value:2.84E-5 ID:SGTC_1763|Compound:st044482|FD-Score:5.28|P-value:2.49E-5 ID:SGTC_1813|Compound:st051246|FD-Score:4.42|P-value:3.50E-4 ID:SGTC_1816|Compound:st051957|FD-Score:4.74|P-value:1.36E-4 ID:SGTC_1820|Compound:st053765|FD-Score:4.51|P-value:2.71E-4 ID:SGTC_1830|Compound:st055982|FD-Score:-4.53|P-value:1.64E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.53|P-value:1.63E-4 ID:SGTC_1845|Compound:st056753|FD-Score:8.52|P-value:2.26E-11 ID:SGTC_1891|Compound:st059073|FD-Score:4.50|P-value:2.80E-4 ID:SGTC_2001|Compound:4023502|FD-Score:4.09|P-value:8.73E-4 ID:SGTC_2054|Compound:5233173|FD-Score:13.40|P-value:8.66E-26 ID:SGTC_2066|Compound:5222451|FD-Score:4.40|P-value:3.70E-4 ID:SGTC_2080|Compound:5212524|FD-Score:4.22|P-value:6.13E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:6.41|P-value:3.84E-7 ID:SGTC_2135|Compound:5326629|FD-Score:4.12|P-value:7.96E-4 ID:SGTC_2171|Compound:5739187|FD-Score:7.67|P-value:1.59E-9 ID:SGTC_2188|Compound:6126565|FD-Score:4.64|P-value:1.82E-4 ID:SGTC_2189|Compound:6047310|FD-Score:5.91|P-value:2.65E-6 ID:SGTC_2196|Compound:6573537|FD-Score:6.52|P-value:2.44E-7 ID:SGTC_2218|Compound:6965428|FD-Score:-4.46|P-value:2.00E-4 ID:SGTC_2225|Compound:6654152|FD-Score:4.19|P-value:6.70E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.90|P-value:8.43E-5 ID:SGTC_2246|Compound:7293507|FD-Score:6.27|P-value:6.81E-7 ID:SGTC_2259|Compound:7964009|FD-Score:8.54|P-value:2.00E-11 ID:SGTC_2269|Compound:7935389|FD-Score:5.14|P-value:3.85E-5 ID:SGTC_2296|Compound:7971656|FD-Score:5.49|P-value:1.20E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.59|P-value:2.15E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-6.36|P-value:2.58E-7 ID:SGTC_2398|Compound:5228213|FD-Score:4.37|P-value:4.05E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:5.74|P-value:4.89E-6 ID:SGTC_2446|Compound:5162541|FD-Score:4.32|P-value:4.63E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-5.23|P-value:1.71E-5 ID:SGTC_2482|Compound:5981709|FD-Score:-4.42|P-value:2.24E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.82|P-value:1.06E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:17.00|P-value:5.32E-40 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.99|P-value:6.20E-5 ID:SGTC_2511|Compound:berberine|FD-Score:-3.92|P-value:9.13E-4 ID:SGTC_2526|Compound:patulin|FD-Score:12.30|P-value:1.04E-21 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:8.60|P-value:1.48E-11 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.39|P-value:1.68E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.94|P-value:4.62E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:11.70|P-value:6.07E-20 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.95|P-value:4.03E-8 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.26|P-value:2.59E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:10.10|P-value:2.47E-15 ID:SGTC_2671|Compound:danthron|FD-Score:5.96|P-value:2.20E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-6.77|P-value:4.71E-8 ID:SGTC_2681|Compound:menadione|FD-Score:5.73|P-value:5.09E-6 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.88|P-value:3.02E-6 ID:SGTC_2695|Compound:st077686|FD-Score:6.87|P-value:5.69E-8 ID:SGTC_2741|Compound:miltefosine|FD-Score:9.09|P-value:1.01E-12 ID:SGTC_2759|Compound:disulfiram|FD-Score:5.47|P-value:1.28E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:5.41|P-value:1.59E-5 ID:SGTC_2796|Compound:7949634|FD-Score:4.15|P-value:7.32E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.67|P-value:1.67E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.11|P-value:4.34E-5 ID:SGTC_2916|Compound:7875993|FD-Score:7.45|P-value:4.37E-9 ID:SGTC_2947|Compound:9072639|FD-Score:4.79|P-value:1.17E-4 ID:SGTC_2952|Compound:9073731|FD-Score:7.28|P-value:9.51E-9 ID:SGTC_3000|Compound:9075062|FD-Score:-4.35|P-value:2.79E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-4.24|P-value:3.75E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.06|P-value:9.42E-4 ID:SGTC_3062|Compound:9077494|FD-Score:7.95|P-value:4.01E-10 ID:SGTC_3211|Compound:9128781|FD-Score:4.60|P-value:2.11E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-4.01|P-value:7.22E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:10.00|P-value:4.22E-15 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.85|P-value:9.65E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:5.94|P-value:2.39E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:6.84|P-value:6.66E-8 ID:SGTC_134|Compound:0269-0018|FD-Score:6.16|P-value:1.03E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:7.11|P-value:2.07E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:10.20|P-value:1.55E-15 ID:SGTC_156|Compound:3474-0145|FD-Score:6.86|P-value:6.12E-8 ID:SGTC_210|Compound:3551-0445|FD-Score:4.73|P-value:1.40E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.26|P-value:3.54E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:5.88|P-value:2.97E-6 ID:SGTC_394|Compound:menadione|FD-Score:6.76|P-value:9.09E-8 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.75|P-value:1.33E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.08|P-value:8.93E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:4.53|P-value:2.55E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-4.30|P-value:3.18E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-4.03|P-value:6.76E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:4.94|P-value:7.38E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:4.74|P-value:1.35E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:6.15|P-value:1.07E-6 ID:SGTC_670|Compound:4204-0025|FD-Score:6.85|P-value:6.39E-8 ID:SGTC_754|Compound:3474-0146|FD-Score:4.54|P-value:2.45E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.94|P-value:7.31E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:4.53|P-value:2.58E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.50|P-value:1.78E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.49|P-value:2.85E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:4.74|P-value:1.35E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:6.89|P-value:5.31E-8 ID:SGTC_1001|Compound:4048-4355|FD-Score:5.71|P-value:5.45E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.28|P-value:5.21E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.91|P-value:8.14E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:-5.59|P-value:4.86E-6 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.83|P-value:1.03E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.70|P-value:1.53E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:-5.80|P-value:2.24E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:6.51|P-value:2.58E-7 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.12|P-value:8.01E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.67|P-value:1.68E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:5.99|P-value:2.00E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.37|P-value:4.07E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-4.71|P-value:9.32E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:16.00|P-value:1.25E-35 ID:SGTC_1556|Compound:plumbagin|FD-Score:7.94|P-value:4.25E-10 ID:SGTC_1608|Compound:st001473|FD-Score:7.21|P-value:1.28E-8 ID:SGTC_1629|Compound:st005085|FD-Score:5.44|P-value:1.44E-5 ID:SGTC_1635|Compound:st007035|FD-Score:4.16|P-value:7.28E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-5.15|P-value:2.31E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-8.48|P-value:1.23E-11 ID:SGTC_1728|Compound:st035614|FD-Score:-5.59|P-value:4.91E-6 ID:SGTC_1750|Compound:st081859|FD-Score:5.24|P-value:2.84E-5 ID:SGTC_1763|Compound:st044482|FD-Score:5.28|P-value:2.49E-5 ID:SGTC_1813|Compound:st051246|FD-Score:4.42|P-value:3.50E-4 ID:SGTC_1816|Compound:st051957|FD-Score:4.74|P-value:1.36E-4 ID:SGTC_1820|Compound:st053765|FD-Score:4.51|P-value:2.71E-4 ID:SGTC_1830|Compound:st055982|FD-Score:-4.53|P-value:1.64E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.53|P-value:1.63E-4 ID:SGTC_1845|Compound:st056753|FD-Score:8.52|P-value:2.26E-11 ID:SGTC_1891|Compound:st059073|FD-Score:4.50|P-value:2.80E-4 ID:SGTC_2001|Compound:4023502|FD-Score:4.09|P-value:8.73E-4 ID:SGTC_2054|Compound:5233173|FD-Score:13.40|P-value:8.66E-26 ID:SGTC_2066|Compound:5222451|FD-Score:4.40|P-value:3.70E-4 ID:SGTC_2080|Compound:5212524|FD-Score:4.22|P-value:6.13E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:6.41|P-value:3.84E-7 ID:SGTC_2135|Compound:5326629|FD-Score:4.12|P-value:7.96E-4 ID:SGTC_2171|Compound:5739187|FD-Score:7.67|P-value:1.59E-9 ID:SGTC_2188|Compound:6126565|FD-Score:4.64|P-value:1.82E-4 ID:SGTC_2189|Compound:6047310|FD-Score:5.91|P-value:2.65E-6 ID:SGTC_2196|Compound:6573537|FD-Score:6.52|P-value:2.44E-7 ID:SGTC_2218|Compound:6965428|FD-Score:-4.46|P-value:2.00E-4 ID:SGTC_2225|Compound:6654152|FD-Score:4.19|P-value:6.70E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.90|P-value:8.43E-5 ID:SGTC_2246|Compound:7293507|FD-Score:6.27|P-value:6.81E-7 ID:SGTC_2259|Compound:7964009|FD-Score:8.54|P-value:2.00E-11 ID:SGTC_2269|Compound:7935389|FD-Score:5.14|P-value:3.85E-5 ID:SGTC_2296|Compound:7971656|FD-Score:5.49|P-value:1.20E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.59|P-value:2.15E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-6.36|P-value:2.58E-7 ID:SGTC_2398|Compound:5228213|FD-Score:4.37|P-value:4.05E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:5.74|P-value:4.89E-6 ID:SGTC_2446|Compound:5162541|FD-Score:4.32|P-value:4.63E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-5.23|P-value:1.71E-5 ID:SGTC_2482|Compound:5981709|FD-Score:-4.42|P-value:2.24E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.82|P-value:1.06E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:17.00|P-value:5.32E-40 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:4.99|P-value:6.20E-5 ID:SGTC_2511|Compound:berberine|FD-Score:-3.92|P-value:9.13E-4 ID:SGTC_2526|Compound:patulin|FD-Score:12.30|P-value:1.04E-21 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:8.60|P-value:1.48E-11 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.39|P-value:1.68E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.94|P-value:4.62E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:11.70|P-value:6.07E-20 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.95|P-value:4.03E-8 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.26|P-value:2.59E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:10.10|P-value:2.47E-15 ID:SGTC_2671|Compound:danthron|FD-Score:5.96|P-value:2.20E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-6.77|P-value:4.71E-8 ID:SGTC_2681|Compound:menadione|FD-Score:5.73|P-value:5.09E-6 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.88|P-value:3.02E-6 ID:SGTC_2695|Compound:st077686|FD-Score:6.87|P-value:5.69E-8 ID:SGTC_2741|Compound:miltefosine|FD-Score:9.09|P-value:1.01E-12 ID:SGTC_2759|Compound:disulfiram|FD-Score:5.47|P-value:1.28E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:5.41|P-value:1.59E-5 ID:SGTC_2796|Compound:7949634|FD-Score:4.15|P-value:7.32E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.67|P-value:1.67E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.11|P-value:4.34E-5 ID:SGTC_2916|Compound:7875993|FD-Score:7.45|P-value:4.37E-9 ID:SGTC_2947|Compound:9072639|FD-Score:4.79|P-value:1.17E-4 ID:SGTC_2952|Compound:9073731|FD-Score:7.28|P-value:9.51E-9 ID:SGTC_3000|Compound:9075062|FD-Score:-4.35|P-value:2.79E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-4.24|P-value:3.75E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.06|P-value:9.42E-4 ID:SGTC_3062|Compound:9077494|FD-Score:7.95|P-value:4.01E-10 ID:SGTC_3211|Compound:9128781|FD-Score:4.60|P-value:2.11E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-4.01|P-value:7.22E-4

Top fitness defect scores for YMR038C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2507 purpurin 17.00 79.7 µM 5.32E-40 copper-dependent oxidative stress 1 6.21E-65
2 SGTC_1552 6-methylflavone 16.00 10.6 µM 1.25E-35 superoxide 1 9.76E-58
3 SGTC_2054 5233173 13.40 129.0 µM 8.66E-26 mitochondrial response to ROS 1 1.56E-41
4 SGTC_2526 patulin 12.30 37.6 µM 1.04E-21 7 8.14E-35
5 SGTC_2575 plumbagin 11.70 510.0 nM 6.07E-20 superoxide 3 6.53E-32
6 SGTC_151 3013-0144 10.20 2.3 µM 1.55E-15 iron homeostasis 1 1.17E-24
7 SGTC_2617 dihydrotanshinone i 10.10 20.8 µM 2.47E-15 copper-dependent oxidative stress 5 2.51E-24
8 SGTC_100 0086-0128 10.00 49.6 µM 4.22E-15 copper-dependent oxidative stress 7 6.06E-24
9 SGTC_2741 miltefosine 9.09 3.0 µM 1.01E-12 7 4.97E-20
10 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 8.60 63.6 µM 1.48E-11 3 4.10E-18
11 SGTC_2259 7964009 8.54 200.0 µM 2.00E-11 superoxide 7 6.72E-18
12 SGTC_1845 st056753 8.52 3.0 µM 2.26E-11 TSC3-RPN4 5 8.18E-18
13 SGTC_3062 9077494 7.95 49.5 µM 4.01E-10 mitochondrial response to ROS 4 9.23E-16
14 SGTC_1556 plumbagin 7.94 1.5 µM 4.25E-10 superoxide 8 1.02E-15
15 SGTC_2171 5739187 7.67 198.1 µM 1.59E-9 copper-dependent oxidative stress 5 8.87E-15
16 SGTC_2916 7875993 7.45 68.8 µM 4.37E-9 3 4.66E-14
17 SGTC_2952 9073731 7.28 13.8 µM 9.51E-9 tubulin folding & SWR complex 4 1.67E-13
18 SGTC_1608 st001473 7.21 40.5 µM 1.28E-8 10 2.74E-13
19 SGTC_141 0443-0274 7.11 32.3 µM 2.07E-8 mitochondrial response to ROS 13 5.98E-13
20 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 6.95 70.0 µM 4.03E-8 redox potentiating 18 1.79E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.509 6.05E-220 YJR104C SOD1 hom Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
0.327 6.71E-84 YPR123C_d YPR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR
0.313 6.20E-77 YPR124W CTR1 hom High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress
0.292 9.63E-67 YMR021C MAC1 hom Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
0.262 1.83E-53 YJL120W_d YJL120W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
0.258 9.63E-52 YGL167C PMR1 hom High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
0.247 1.58E-47 YOR209C NPT1 hom Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus
0.242 1.43E-45 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.221 3.37E-38 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.202 6.60E-32 YHR008C SOD2 hom Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
0.200 1.70E-31 YPR074C TKL1 hom Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
0.192 5.98E-29 YMR073C IRC21 hom Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study
0.171 2.02E-23 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.145 3.55E-17 YNL241C ZWF1 hom Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress
0.143 9.45E-17 YJL121C RPE1 hom D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress