YMR039C / SUB1

Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR039C / SUB1

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:3.16|P-value:5.77E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.44|P-value:2.09E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.12|P-value:8.14E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:3.66|P-value:8.58E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.40|P-value:2.39E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.93|P-value:3.93E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:-4.24|P-value:9.98E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.47|P-value:2.43E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.54|P-value:1.87E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.22|P-value:6.19E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.66|P-value:8.65E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:3.29|P-value:3.70E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.81|P-value:2.33E-9 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.93|P-value:2.83E-5 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.49|P-value:1.71E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.46|P-value:2.55E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.95|P-value:2.55E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.19|P-value:5.35E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.18|P-value:9.39E-6 ID:SGTC_1270|Compound:0831-1170|FD-Score:5.22|P-value:4.74E-8 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.30|P-value:4.60E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.59|P-value:1.15E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.09|P-value:9.89E-4 ID:SGTC_1612|Compound:st002233|FD-Score:-3.25|P-value:5.54E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-4.02|P-value:2.60E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-3.30|P-value:4.71E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.47|P-value:3.41E-6 ID:SGTC_1974|Compound:st069448|FD-Score:3.26|P-value:4.01E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.58|P-value:1.18E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.14|P-value:8.25E-4 ID:SGTC_2396|Compound:5342950|FD-Score:7.54|P-value:7.05E-15 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.48|P-value:2.29E-6 ID:SGTC_2831|Compound:7999036|FD-Score:3.26|P-value:4.06E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-5.39|P-value:2.85E-8 ID:SGTC_2939|Compound:9044578|FD-Score:-3.83|P-value:5.94E-5 ID:SGTC_3021|Compound:9087658|FD-Score:3.06|P-value:8.19E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.04|P-value:8.88E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-4.31|P-value:7.30E-6 ID:SGTC_3283|Compound:9109332|FD-Score:-4.32|P-value:6.97E-6 ID:SGTC_3297|Compound:9117502|FD-Score:3.23|P-value:4.61E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.21|P-value:4.82E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.16|P-value:5.77E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.44|P-value:2.09E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.12|P-value:8.14E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:3.66|P-value:8.58E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.40|P-value:2.39E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.93|P-value:3.93E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:-4.24|P-value:9.98E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.47|P-value:2.43E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.54|P-value:1.87E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.22|P-value:6.19E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.66|P-value:8.65E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:3.29|P-value:3.70E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.81|P-value:2.33E-9 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.93|P-value:2.83E-5 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.49|P-value:1.71E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.46|P-value:2.55E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.95|P-value:2.55E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.19|P-value:5.35E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.18|P-value:9.39E-6 ID:SGTC_1270|Compound:0831-1170|FD-Score:5.22|P-value:4.74E-8 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.30|P-value:4.60E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.59|P-value:1.15E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.09|P-value:9.89E-4 ID:SGTC_1612|Compound:st002233|FD-Score:-3.25|P-value:5.54E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-4.02|P-value:2.60E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-3.30|P-value:4.71E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.47|P-value:3.41E-6 ID:SGTC_1974|Compound:st069448|FD-Score:3.26|P-value:4.01E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.58|P-value:1.18E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.14|P-value:8.25E-4 ID:SGTC_2396|Compound:5342950|FD-Score:7.54|P-value:7.05E-15 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.48|P-value:2.29E-6 ID:SGTC_2831|Compound:7999036|FD-Score:3.26|P-value:4.06E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-5.39|P-value:2.85E-8 ID:SGTC_2939|Compound:9044578|FD-Score:-3.83|P-value:5.94E-5 ID:SGTC_3021|Compound:9087658|FD-Score:3.06|P-value:8.19E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.04|P-value:8.88E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-4.31|P-value:7.30E-6 ID:SGTC_3283|Compound:9109332|FD-Score:-4.32|P-value:6.97E-6 ID:SGTC_3297|Compound:9117502|FD-Score:3.23|P-value:4.61E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.21|P-value:4.82E-4

Top fitness defect scores for YMR039C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2396 5342950 7.54 42.8 µM 7.05E-15 RSC complex & mRNA processing 6 2.30E-14
2 SGTC_1270 0831-1170 5.22 17.3 µM 4.74E-8 1 8.98E-8
3 SGTC_386 1509-0011 5.12 3.1 µM 8.14E-8 104 1.52E-7
4 SGTC_2536 dehydroabietamide 4.48 32.0 µM 2.29E-6 21 3.79E-6
5 SGTC_1206 3978-0017 4.46 132.0 µM 2.55E-6 ERG2 21 4.19E-6
6 SGTC_1263 0774-1208 4.18 64.8 µM 9.39E-6 40 1.47E-5
7 SGTC_1239 0337-0584 3.95 35.4 µM 2.55E-5 unfolded protein response 52 3.86E-5
8 SGTC_1133 3473-0247 3.93 50.0 µM 2.83E-5 RSC complex & mRNA processing 49 4.27E-5
9 SGTC_435 c-PAF 3.66 6.7 µM 8.58E-5 57 1.24E-4
10 SGTC_986 1493-0483 3.66 84.0 µM 8.65E-5 15 1.25E-4
11 SGTC_1563 conessine 3.59 56.1 µM 1.15E-4 26 1.65E-4
12 SGTC_2143 5623677 3.58 140.5 µM 1.18E-4 8 1.69E-4
13 SGTC_1177 0983-0204 3.49 23.6 µM 1.71E-4 25 2.42E-4
14 SGTC_236 1509-0011 3.44 5.3 µM 2.09E-4 423 2.93E-4
15 SGTC_453 enantio-paf c16 3.40 10.0 µM 2.39E-4 194 3.33E-4
16 SGTC_988 1497-1057 3.29 103.0 µM 3.70E-4 26 5.07E-4
17 SGTC_1974 st069448 3.26 26.9 µM 4.01E-4 50 5.49E-4
18 SGTC_2831 7999036 3.26 19.5 µM 4.06E-4 80 5.56E-4
19 SGTC_3297 9117502 3.23 71.4 µM 4.61E-4 26 6.27E-4
20 SGTC_3313 9133968 3.21 57.0 µM 4.82E-4 21 6.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.274 9.75E-59 YMR150C IMP1 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.202 3.22E-32 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.184 7.29E-27 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.182 2.02E-26 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.179 1.44E-25 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.176 9.15E-25 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.175 1.86E-24 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.174 3.22E-24 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.173 5.03E-24 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.172 1.43E-23 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.170 3.17E-23 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.169 5.87E-23 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.168 1.04E-22 YLR203C MSS51 hom Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis
0.167 2.08E-22 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.166 2.90E-22 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene