YMR043W / MCM1

Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR043W / MCM1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:3.17|P-value:7.22E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.62|P-value:1.59E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.22|P-value:8.45E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:3.67|P-value:1.13E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.69|P-value:1.05E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:9.28|P-value:8.18E-21 ID:SGTC_208|Compound:k072-0098|FD-Score:3.82|P-value:6.27E-5 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.08|P-value:9.77E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.56|P-value:1.74E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:4.01|P-value:2.81E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:4.58|P-value:2.17E-6 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.52|P-value:2.37E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.55|P-value:2.14E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.94|P-value:3.85E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.22|P-value:6.17E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.42|P-value:3.43E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:7.10|P-value:5.87E-13 ID:SGTC_516|Compound:3992-2719|FD-Score:3.56|P-value:1.78E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.83|P-value:2.54E-9 ID:SGTC_528|Compound:3492-0019|FD-Score:3.67|P-value:1.17E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.21|P-value:7.15E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.30|P-value:5.32E-8 ID:SGTC_598|Compound:3937-0236|FD-Score:3.58|P-value:1.61E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.95|P-value:3.71E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.44|P-value:2.80E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.89|P-value:4.75E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:5.27|P-value:6.50E-8 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.12|P-value:9.63E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.33|P-value:4.17E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:7.73|P-value:5.17E-15 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.98|P-value:3.28E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.75|P-value:8.51E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.12|P-value:8.48E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.27|P-value:5.87E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.97|P-value:3.37E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.14|P-value:8.10E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.29|P-value:4.78E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.53|P-value:1.96E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.11|P-value:8.81E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:5.43|P-value:2.59E-8 ID:SGTC_1635|Compound:st007035|FD-Score:4.07|P-value:2.19E-5 ID:SGTC_1712|Compound:st032288|FD-Score:5.51|P-value:1.65E-8 ID:SGTC_1783|Compound:st039459|FD-Score:3.42|P-value:2.95E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.79|P-value:7.13E-5 ID:SGTC_1833|Compound:st055984|FD-Score:-3.16|P-value:8.54E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.31|P-value:4.47E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.93|P-value:1.44E-9 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.95|P-value:1.73E-12 ID:SGTC_1900|Compound:st060200|FD-Score:-3.17|P-value:8.34E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.22|P-value:6.19E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.59|P-value:1.09E-8 ID:SGTC_2036|Compound:5160441|FD-Score:6.14|P-value:3.72E-10 ID:SGTC_2249|Compound:haloperidol|FD-Score:8.00|P-value:5.64E-16 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.11|P-value:8.91E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.76|P-value:8.00E-5 ID:SGTC_2348|Compound:9022543|FD-Score:3.13|P-value:8.40E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.54|P-value:2.62E-6 ID:SGTC_2403|Compound:6032726|FD-Score:3.70|P-value:1.02E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.11|P-value:8.82E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.65|P-value:1.23E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:5.99|P-value:9.54E-10 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.68|P-value:1.12E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:5.34|P-value:4.42E-8 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.28|P-value:4.95E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.31|P-value:5.09E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.69|P-value:1.05E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.85|P-value:6.46E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:7.40|P-value:6.25E-14 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.78|P-value:7.40E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.61|P-value:1.45E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.85|P-value:2.32E-9 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.83|P-value:5.96E-5 ID:SGTC_2718|Compound:lomofungin|FD-Score:4.26|P-value:9.46E-6 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.18|P-value:7.05E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:-3.79|P-value:8.17E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.79|P-value:7.13E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:3.18|P-value:7.03E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.38|P-value:3.43E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.43|P-value:2.91E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.45|P-value:4.10E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-4.07|P-value:2.58E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-7.53|P-value:3.21E-14 ID:SGTC_3233|Compound:9132340|FD-Score:3.19|P-value:6.65E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:3.17|P-value:7.22E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.62|P-value:1.59E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.22|P-value:8.45E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:3.67|P-value:1.13E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.69|P-value:1.05E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:9.28|P-value:8.18E-21 ID:SGTC_208|Compound:k072-0098|FD-Score:3.82|P-value:6.27E-5 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.08|P-value:9.77E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.56|P-value:1.74E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:4.01|P-value:2.81E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:4.58|P-value:2.17E-6 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.52|P-value:2.37E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.55|P-value:2.14E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.94|P-value:3.85E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.22|P-value:6.17E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.42|P-value:3.43E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:7.10|P-value:5.87E-13 ID:SGTC_516|Compound:3992-2719|FD-Score:3.56|P-value:1.78E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.83|P-value:2.54E-9 ID:SGTC_528|Compound:3492-0019|FD-Score:3.67|P-value:1.17E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.21|P-value:7.15E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.30|P-value:5.32E-8 ID:SGTC_598|Compound:3937-0236|FD-Score:3.58|P-value:1.61E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.95|P-value:3.71E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.44|P-value:2.80E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.89|P-value:4.75E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:5.27|P-value:6.50E-8 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.12|P-value:9.63E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.33|P-value:4.17E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:7.73|P-value:5.17E-15 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.98|P-value:3.28E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.75|P-value:8.51E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.12|P-value:8.48E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.27|P-value:5.87E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.97|P-value:3.37E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.14|P-value:8.10E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.29|P-value:4.78E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.53|P-value:1.96E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.11|P-value:8.81E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:5.43|P-value:2.59E-8 ID:SGTC_1635|Compound:st007035|FD-Score:4.07|P-value:2.19E-5 ID:SGTC_1712|Compound:st032288|FD-Score:5.51|P-value:1.65E-8 ID:SGTC_1783|Compound:st039459|FD-Score:3.42|P-value:2.95E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.79|P-value:7.13E-5 ID:SGTC_1833|Compound:st055984|FD-Score:-3.16|P-value:8.54E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.31|P-value:4.47E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.93|P-value:1.44E-9 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.95|P-value:1.73E-12 ID:SGTC_1900|Compound:st060200|FD-Score:-3.17|P-value:8.34E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.22|P-value:6.19E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.59|P-value:1.09E-8 ID:SGTC_2036|Compound:5160441|FD-Score:6.14|P-value:3.72E-10 ID:SGTC_2249|Compound:haloperidol|FD-Score:8.00|P-value:5.64E-16 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.11|P-value:8.91E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.76|P-value:8.00E-5 ID:SGTC_2348|Compound:9022543|FD-Score:3.13|P-value:8.40E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.54|P-value:2.62E-6 ID:SGTC_2403|Compound:6032726|FD-Score:3.70|P-value:1.02E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.11|P-value:8.82E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.65|P-value:1.23E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:5.99|P-value:9.54E-10 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.68|P-value:1.12E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:5.34|P-value:4.42E-8 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.28|P-value:4.95E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.31|P-value:5.09E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.69|P-value:1.05E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.85|P-value:6.46E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:7.40|P-value:6.25E-14 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.78|P-value:7.40E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.61|P-value:1.45E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.85|P-value:2.32E-9 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.83|P-value:5.96E-5 ID:SGTC_2718|Compound:lomofungin|FD-Score:4.26|P-value:9.46E-6 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.18|P-value:7.05E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:-3.79|P-value:8.17E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.79|P-value:7.13E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:3.18|P-value:7.03E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.38|P-value:3.43E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.43|P-value:2.91E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.45|P-value:4.10E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-4.07|P-value:2.58E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-7.53|P-value:3.21E-14 ID:SGTC_3233|Compound:9132340|FD-Score:3.19|P-value:6.65E-4

Top fitness defect scores for YMR043W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_178 4092-0806 9.28 87.5 µM 8.18E-21 ergosterol depletion effects on membrane 2 8.78E-21 0.48
2 SGTC_2249 haloperidol 8.00 116.4 µM 5.64E-16 ergosterol depletion effects on membrane 8 6.07E-16 0.59
3 SGTC_1044 1222-0021 7.73 1.8 µM 5.17E-15 heme biosynthesis & mitochondrial translocase 7 5.57E-15 0.12
4 SGTC_2612 dictamnine 7.40 15.5 µM 6.25E-14 RNA pol III & RNase P/MRP 14 6.73E-14 0.36
5 SGTC_515 4092-1064 7.10 102.0 µM 5.87E-13 plasma membrane duress 6 6.33E-13 1.69
6 SGTC_1873 rapamycin 6.95 2.0 nM 1.73E-12 7 1.87E-12 0.41
7 SGTC_2036 5160441 6.14 105.0 µM 3.72E-10 NEO1 11 4.00E-10 0.25
8 SGTC_2495 cafestol 5.99 54.5 µM 9.54E-10 Golgi 2 1.02E-9 0.88
9 SGTC_1844 rapamycin 5.93 4.0 nM 1.44E-9 22 1.54E-9 0.13
10 SGTC_2640 pentamidine 5.85 10.4 µM 2.32E-9 mitochondrial processes 7 2.49E-9 0.71
11 SGTC_525 k781-2675 5.83 26.7 µM 2.54E-9 redox potentiating 24 2.73E-9 0.14
12 SGTC_2021 4019055 5.59 173.0 µM 1.09E-8 endomembrane recycling 21 1.17E-8 0.08
13 SGTC_1712 st032288 5.51 53.4 µM 1.65E-8 calcium & mitochondrial duress 15 1.76E-8 0.02
14 SGTC_1562 morin hydrate 5.43 59.1 µM 2.59E-8 1 2.77E-8 0.42
15 SGTC_2561 acetosyringone 5.34 100.0 µM 4.42E-8 3 4.74E-8 0.73
16 SGTC_576 1073-0113 5.30 22.7 µM 5.32E-8 redox potentiating 21 5.69E-8 0.16
17 SGTC_902 1120-0002 5.27 2.1 µM 6.50E-8 azole & statin 12 6.96E-8 0.34
18 SGTC_63 0099-0242 5.22 26.7 µM 8.45E-8 mitochondrial stress 13 9.04E-8 0.21
19 SGTC_327 1273-0057 4.58 4.0 µM 2.17E-6 azole & statin 4 2.31E-6 0.05
20 SGTC_2396 5342950 4.54 42.8 µM 2.62E-6 RSC complex & mRNA processing 25 2.79E-6 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.224 2.54E-39 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.218 1.77E-37 YOR194C TOA1 het TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA
0.195 5.72E-30 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.189 2.54E-28 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.184 5.16E-27 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.181 3.54E-26 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.180 6.53E-26 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.172 1.42E-23 YDR213W UPC2 hom Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.169 7.56E-23 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.167 1.86E-22 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.166 2.91E-22 YDR407C TRS120 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.162 3.21E-21 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.155 1.39E-19 YDL196W_d YDL196W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
0.152 1.20E-18 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.151 1.34E-18 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family