YMR044W / IOC4

Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR044W / IOC4

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.74|P-value:2.96E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.04|P-value:1.05E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.29|P-value:4.13E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.48|P-value:1.86E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:-4.14|P-value:6.74E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:12.30|P-value:7.65E-30 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:11.20|P-value:2.66E-25 ID:SGTC_313|Compound:3474-0040|FD-Score:4.57|P-value:1.35E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:4.43|P-value:2.42E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:3.89|P-value:1.79E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.38|P-value:2.88E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:-4.67|P-value:8.51E-6 ID:SGTC_512|Compound:prima-1|FD-Score:4.04|P-value:1.05E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.63|P-value:4.08E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.47|P-value:7.24E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.86|P-value:1.97E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.79|P-value:2.56E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.69|P-value:8.22E-6 ID:SGTC_998|Compound:3996-0085|FD-Score:3.38|P-value:9.77E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.73|P-value:3.11E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.74|P-value:6.78E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.18|P-value:9.92E-7 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.46|P-value:2.11E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:-4.73|P-value:6.54E-6 ID:SGTC_1198|Compound:1612-1005|FD-Score:-3.40|P-value:8.66E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.91|P-value:1.68E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.02|P-value:1.12E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.58|P-value:5.12E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.77|P-value:2.72E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.61|P-value:4.64E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-4.20|P-value:5.36E-5 ID:SGTC_1754|Compound:st042065|FD-Score:5.30|P-value:5.61E-7 ID:SGTC_1773|Compound:st048542|FD-Score:3.49|P-value:6.82E-4 ID:SGTC_1800|Compound:st050079|FD-Score:9.15|P-value:2.10E-17 ID:SGTC_1803|Compound:st050068|FD-Score:7.71|P-value:7.23E-13 ID:SGTC_1818|Compound:st052136|FD-Score:7.42|P-value:4.78E-12 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:7.85|P-value:2.82E-13 ID:SGTC_1934|Compound:st074720|FD-Score:3.54|P-value:5.79E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.03|P-value:1.08E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.62|P-value:4.46E-4 ID:SGTC_2673|Compound:kobusone|FD-Score:-3.45|P-value:7.26E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.74|P-value:2.81E-4 ID:SGTC_2806|Compound:7952793|FD-Score:4.02|P-value:1.12E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.60|P-value:4.52E-4 ID:SGTC_2905|Compound:7799065|FD-Score:4.02|P-value:1.14E-4 ID:SGTC_2906|Compound:7926292|FD-Score:6.39|P-value:2.21E-9 ID:SGTC_2916|Compound:7875993|FD-Score:-3.49|P-value:6.40E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.42|P-value:2.46E-5 ID:SGTC_2965|Compound:9082772|FD-Score:4.11|P-value:8.20E-5 ID:SGTC_3037|Compound:9091026|FD-Score:4.82|P-value:4.90E-6 ID:SGTC_3127|Compound:9126946|FD-Score:-8.97|P-value:7.35E-17 ID:SGTC_3135|Compound:9127742|FD-Score:-9.17|P-value:1.54E-17 ID:SGTC_3274|Compound:9138298|FD-Score:4.27|P-value:4.51E-5 ID:SGTC_3283|Compound:9109332|FD-Score:3.99|P-value:1.27E-4 ID:SGTC_3323|Compound:9138564|FD-Score:-3.37|P-value:9.46E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.74|P-value:2.96E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.04|P-value:1.05E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.29|P-value:4.13E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.48|P-value:1.86E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:-4.14|P-value:6.74E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:12.30|P-value:7.65E-30 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:11.20|P-value:2.66E-25 ID:SGTC_313|Compound:3474-0040|FD-Score:4.57|P-value:1.35E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:4.43|P-value:2.42E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:3.89|P-value:1.79E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.38|P-value:2.88E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:-4.67|P-value:8.51E-6 ID:SGTC_512|Compound:prima-1|FD-Score:4.04|P-value:1.05E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.63|P-value:4.08E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.47|P-value:7.24E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.86|P-value:1.97E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.79|P-value:2.56E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.69|P-value:8.22E-6 ID:SGTC_998|Compound:3996-0085|FD-Score:3.38|P-value:9.77E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.73|P-value:3.11E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.74|P-value:6.78E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.18|P-value:9.92E-7 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.46|P-value:2.11E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:-4.73|P-value:6.54E-6 ID:SGTC_1198|Compound:1612-1005|FD-Score:-3.40|P-value:8.66E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.91|P-value:1.68E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.02|P-value:1.12E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.58|P-value:5.12E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.77|P-value:2.72E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.61|P-value:4.64E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-4.20|P-value:5.36E-5 ID:SGTC_1754|Compound:st042065|FD-Score:5.30|P-value:5.61E-7 ID:SGTC_1773|Compound:st048542|FD-Score:3.49|P-value:6.82E-4 ID:SGTC_1800|Compound:st050079|FD-Score:9.15|P-value:2.10E-17 ID:SGTC_1803|Compound:st050068|FD-Score:7.71|P-value:7.23E-13 ID:SGTC_1818|Compound:st052136|FD-Score:7.42|P-value:4.78E-12 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:7.85|P-value:2.82E-13 ID:SGTC_1934|Compound:st074720|FD-Score:3.54|P-value:5.79E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.03|P-value:1.08E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.62|P-value:4.46E-4 ID:SGTC_2673|Compound:kobusone|FD-Score:-3.45|P-value:7.26E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.74|P-value:2.81E-4 ID:SGTC_2806|Compound:7952793|FD-Score:4.02|P-value:1.12E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.60|P-value:4.52E-4 ID:SGTC_2905|Compound:7799065|FD-Score:4.02|P-value:1.14E-4 ID:SGTC_2906|Compound:7926292|FD-Score:6.39|P-value:2.21E-9 ID:SGTC_2916|Compound:7875993|FD-Score:-3.49|P-value:6.40E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.42|P-value:2.46E-5 ID:SGTC_2965|Compound:9082772|FD-Score:4.11|P-value:8.20E-5 ID:SGTC_3037|Compound:9091026|FD-Score:4.82|P-value:4.90E-6 ID:SGTC_3127|Compound:9126946|FD-Score:-8.97|P-value:7.35E-17 ID:SGTC_3135|Compound:9127742|FD-Score:-9.17|P-value:1.54E-17 ID:SGTC_3274|Compound:9138298|FD-Score:4.27|P-value:4.51E-5 ID:SGTC_3283|Compound:9109332|FD-Score:3.99|P-value:1.27E-4 ID:SGTC_3323|Compound:9138564|FD-Score:-3.37|P-value:9.46E-4

Top fitness defect scores for YMR044W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_184 1494-0393 12.30 24.7 µM 7.65E-30 5 5.60E-35
2 SGTC_219 mitoxanthrone 11.20 164.4 µM 2.66E-25 DNA intercalators 5 1.31E-29
3 SGTC_1800 st050079 9.15 29.1 µM 2.10E-17 NEO1-PIK1 8 2.81E-20
4 SGTC_1926 methyl fluorone black 7.85 53.6 µM 2.82E-13 DNA intercalators 8 2.11E-15
5 SGTC_1803 st050068 7.71 52.4 µM 7.23E-13 NEO1-PIK1 44 6.40E-15
6 SGTC_1818 st052136 7.42 56.3 µM 4.78E-12 NEO1-PIK1 4 5.95E-14
7 SGTC_2906 7926292 6.39 26.4 µM 2.21E-9 2 8.32E-11
8 SGTC_1754 st042065 5.30 16.1 µM 5.61E-7 NEO1-PIK1 114 5.67E-8
9 SGTC_1107 amlodipine 5.18 47.0 µM 9.92E-7 11 1.11E-7
10 SGTC_3037 9091026 4.82 49.5 µM 4.90E-6 NEO1-PIK1 82 7.27E-7
11 SGTC_1089 terbinafine 4.74 2.2 µM 6.78E-6 7 1.07E-6
12 SGTC_794 k038-0031 4.69 316.0 µM 8.22E-6 ubiquinone biosynthesis & proteasome 87 1.34E-6
13 SGTC_313 3474-0040 4.57 5.0 µM 1.35E-5 NEO1-PIK1 50 2.39E-6
14 SGTC_1172 0370-0043 4.46 85.0 µM 2.11E-5 11 4.06E-6
15 SGTC_316 k060-0003 4.43 58.6 µM 2.42E-5 6 4.76E-6
16 SGTC_2960 9079389 4.42 6.0 µM 2.46E-5 15 4.85E-6
17 SGTC_471 1-acyl-paf 4.38 4.0 µM 2.88E-5 DNA intercalators 25 5.84E-6
18 SGTC_145 3737-0113 4.29 38.4 µM 4.13E-5 DNA intercalators 60 8.93E-6
19 SGTC_3274 9138298 4.27 49.5 µM 4.51E-5 16 9.89E-6
20 SGTC_2965 9082772 4.11 38.6 µM 8.20E-5 mitochondrial response to ROS 37 2.00E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.241 2.21E-45 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.216 1.05E-36 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.201 1.00E-31 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.199 2.29E-31 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.197 1.30E-30 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.196 2.00E-30 YPR059C_d YPR059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
0.195 5.39E-30 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.193 2.50E-29 YHL009C YAP3 hom Basic leucine zipper (bZIP) transcription factor
0.187 8.72E-28 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.183 1.41E-26 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.182 2.99E-26 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.177 4.56E-25 YPL197C_d YPL197C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
0.175 1.80E-24 YBR182C-A_p YBR182C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.172 9.66E-24 YPL202C AFT2 hom Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication
0.169 6.12E-23 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress