YMR047C / NUP116

FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR047C / NUP116

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:4.85|P-value:4.40E-8 ID:SGTC_20|Compound:0481-0013|FD-Score:2.87|P-value:7.70E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.80|P-value:1.38E-5 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.12|P-value:2.95E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-6.53|P-value:3.20E-13 ID:SGTC_73|Compound:0327-0325|FD-Score:3.32|P-value:1.28E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:2.99|P-value:4.89E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.27|P-value:1.57E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.29|P-value:1.44E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-2.92|P-value:6.55E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.24|P-value:1.79E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.03|P-value:4.22E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:2.88|P-value:7.57E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:2.84|P-value:8.59E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.54|P-value:4.74E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:4.02|P-value:4.58E-6 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.55|P-value:4.76E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:2.98|P-value:5.06E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-2.94|P-value:5.97E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:-3.06|P-value:3.79E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.21|P-value:1.97E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.30|P-value:1.36E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:-2.94|P-value:6.17E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:2.85|P-value:8.43E-4 ID:SGTC_1609|Compound:st001574|FD-Score:2.93|P-value:6.27E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.96|P-value:6.67E-6 ID:SGTC_1747|Compound:st037496|FD-Score:-4.24|P-value:1.55E-6 ID:SGTC_1799|Compound:st045822|FD-Score:2.83|P-value:9.14E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.13|P-value:2.77E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.23|P-value:1.84E-4 ID:SGTC_2284|Compound:7945075|FD-Score:2.83|P-value:8.90E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-2.92|P-value:6.58E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.01|P-value:4.59E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-2.89|P-value:7.41E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.11|P-value:3.07E-4 ID:SGTC_3319|Compound:9138450|FD-Score:2.82|P-value:9.42E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:4.85|P-value:4.40E-8 ID:SGTC_20|Compound:0481-0013|FD-Score:2.87|P-value:7.70E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.80|P-value:1.38E-5 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.12|P-value:2.95E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-6.53|P-value:3.20E-13 ID:SGTC_73|Compound:0327-0325|FD-Score:3.32|P-value:1.28E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:2.99|P-value:4.89E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.27|P-value:1.57E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.29|P-value:1.44E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-2.92|P-value:6.55E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.24|P-value:1.79E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.03|P-value:4.22E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:2.88|P-value:7.57E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:2.84|P-value:8.59E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.54|P-value:4.74E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:4.02|P-value:4.58E-6 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.55|P-value:4.76E-5 ID:SGTC_988|Compound:1497-1057|FD-Score:2.98|P-value:5.06E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-2.94|P-value:5.97E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:-3.06|P-value:3.79E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.21|P-value:1.97E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.30|P-value:1.36E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:-2.94|P-value:6.17E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:2.85|P-value:8.43E-4 ID:SGTC_1609|Compound:st001574|FD-Score:2.93|P-value:6.27E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.96|P-value:6.67E-6 ID:SGTC_1747|Compound:st037496|FD-Score:-4.24|P-value:1.55E-6 ID:SGTC_1799|Compound:st045822|FD-Score:2.83|P-value:9.14E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.13|P-value:2.77E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.23|P-value:1.84E-4 ID:SGTC_2284|Compound:7945075|FD-Score:2.83|P-value:8.90E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-2.92|P-value:6.58E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.01|P-value:4.59E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-2.89|P-value:7.41E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.11|P-value:3.07E-4 ID:SGTC_3319|Compound:9138450|FD-Score:2.82|P-value:9.42E-4

Top fitness defect scores for YMR047C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_4 0960-0234 4.85 25.7 µM 4.40E-8 Golgi 7 6.09E-7 0.26
2 SGTC_953 1188-0045 4.02 9.7 µM 4.58E-6 60S ribosome export 5 2.87E-5 0.07
3 SGTC_41 0478-0632 3.80 82.6 µM 1.38E-5 15 7.17E-5 0.28
4 SGTC_876 0720-0963 3.54 56.8 µM 4.74E-5 10 2.00E-4 0.09
5 SGTC_73 0327-0325 3.32 16.2 µM 1.28E-4 DNA damage response 4 4.58E-4 0.43
6 SGTC_1376 2910-0861 3.30 41.3 µM 1.36E-4 8 4.82E-4 0.17
7 SGTC_145 3737-0113 3.29 38.4 µM 1.44E-4 DNA intercalators 69 5.06E-4 0.01
8 SGTC_126 0417-1624 3.27 672.5 µM 1.57E-4 DNA intercalators 26 5.42E-4 0.09
9 SGTC_176 1486-1328 3.24 72.8 µM 1.79E-4 19 6.05E-4 0.09
10 SGTC_2150 5556613 3.23 200.0 µM 1.84E-4 13 6.19E-4 0.05
11 SGTC_1198 1612-1005 3.21 86.7 µM 1.97E-4 9 6.54E-4 0.05
12 SGTC_1909 st060837 3.13 51.5 µM 2.77E-4 15 8.70E-4 0.13
13 SGTC_45 0kpi-0036 3.12 14.9 µM 2.95E-4 excess fatty acid 12 9.17E-4 0.03
14 SGTC_2858 9025781 3.11 9.0 µM 3.07E-4 sphingolipid biosynthesis & PDR1 24 9.49E-4 0.06
15 SGTC_665 3914-0008 3.03 307.0 µM 4.22E-4 10 0.00124 0.07
16 SGTC_2428 5615643 3.01 7.8 µM 4.59E-4 21 0.00133 0.01
17 SGTC_115 0527-0192 2.99 112.0 µM 4.89E-4 45 0.00140 0.02
18 SGTC_988 1497-1057 2.98 103.0 µM 5.06E-4 9 0.00144 0.01
19 SGTC_1609 st001574 2.93 46.4 µM 6.27E-4 9 0.00172 0.00
20 SGTC_864 0469-0573 2.88 172.0 µM 7.57E-4 13 0.00201 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.172 1.46E-23 YJL158C CIS3 hom Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
0.164 1.27E-21 YDR054C CDC34 het Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress
0.125 3.67E-13 YER125W RSP5 het E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; ubiquitylates Sec23p
0.121 2.07E-12 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.118 6.18E-12 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.112 7.22E-11 YDR155C CPR1 hom Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress
0.110 2.01E-10 YHR020W YHR020W het Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.104 1.77E-9 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.102 3.12E-9 YLR323C CWC24 het Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p
0.101 4.75E-9 YDR531W CAB1 het Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element
0.100 6.63E-9 YDR295C HDA2 hom Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance
0.100 7.47E-9 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.099 9.69E-9 YBR269C_p FMP21_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.097 1.52E-8 YOR358W HAP5 hom Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex
0.095 3.51E-8 YOR334W MRS2 hom Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns