YMR049C / ERB1

Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR049C / ERB1

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:-3.51|P-value:3.78E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.71|P-value:1.82E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.28|P-value:9.52E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.04|P-value:6.42E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.38|P-value:1.26E-7 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.83|P-value:1.17E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-4.24|P-value:2.38E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:4.07|P-value:5.87E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:4.94|P-value:1.39E-6 ID:SGTC_277|Compound:nystatin|FD-Score:4.07|P-value:5.76E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.28|P-value:9.57E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.67|P-value:4.70E-6 ID:SGTC_504|Compound:lovastatin|FD-Score:3.88|P-value:1.20E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.34|P-value:6.68E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.49|P-value:4.76E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:11.50|P-value:2.84E-28 ID:SGTC_910|Compound:3454-3003|FD-Score:3.31|P-value:8.66E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.78|P-value:1.71E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.32|P-value:8.56E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.53|P-value:4.12E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.14|P-value:4.36E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.21|P-value:3.33E-5 ID:SGTC_1111|Compound:tnp00062|FD-Score:5.87|P-value:1.28E-8 ID:SGTC_1176|Compound:0848-0131|FD-Score:-3.87|P-value:1.02E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.62|P-value:6.01E-6 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.30|P-value:8.90E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.02|P-value:6.98E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.29|P-value:9.34E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.36|P-value:7.50E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.41|P-value:6.23E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.78|P-value:1.71E-4 ID:SGTC_1613|Compound:st002381|FD-Score:4.62|P-value:5.95E-6 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.90|P-value:1.09E-4 ID:SGTC_1719|Compound:st032227|FD-Score:4.26|P-value:2.72E-5 ID:SGTC_1758|Compound:st042942|FD-Score:-3.23|P-value:9.54E-4 ID:SGTC_1820|Compound:st053765|FD-Score:5.53|P-value:7.51E-8 ID:SGTC_1891|Compound:st059073|FD-Score:3.31|P-value:8.64E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.87|P-value:1.23E-4 ID:SGTC_2063|Compound:5246145|FD-Score:4.69|P-value:4.34E-6 ID:SGTC_2081|Compound:5214970|FD-Score:3.31|P-value:8.66E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.52|P-value:8.96E-6 ID:SGTC_2278|Compound:7948257|FD-Score:-3.84|P-value:1.12E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.46|P-value:5.30E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.45|P-value:4.57E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:4.22|P-value:3.25E-5 ID:SGTC_2806|Compound:7952793|FD-Score:3.71|P-value:2.26E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.80|P-value:1.62E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.34|P-value:8.02E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-3.69|P-value:1.94E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-4.01|P-value:5.87E-5 ID:SGTC_2977|Compound:9011197|FD-Score:4.45|P-value:1.26E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-5.18|P-value:3.45E-7 ID:SGTC_3193|Compound:9111931|FD-Score:4.59|P-value:6.72E-6 ID:SGTC_3203|Compound:9113543|FD-Score:-3.49|P-value:3.94E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-3.39|P-value:5.54E-4 ID:SGTC_3236|Compound:9132701|FD-Score:-3.36|P-value:6.27E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:-3.51|P-value:3.78E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.71|P-value:1.82E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.28|P-value:9.52E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.04|P-value:6.42E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.38|P-value:1.26E-7 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.83|P-value:1.17E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-4.24|P-value:2.38E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:4.07|P-value:5.87E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:4.94|P-value:1.39E-6 ID:SGTC_277|Compound:nystatin|FD-Score:4.07|P-value:5.76E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.28|P-value:9.57E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.67|P-value:4.70E-6 ID:SGTC_504|Compound:lovastatin|FD-Score:3.88|P-value:1.20E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.34|P-value:6.68E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.49|P-value:4.76E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:11.50|P-value:2.84E-28 ID:SGTC_910|Compound:3454-3003|FD-Score:3.31|P-value:8.66E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.78|P-value:1.71E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.32|P-value:8.56E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.53|P-value:4.12E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.14|P-value:4.36E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.21|P-value:3.33E-5 ID:SGTC_1111|Compound:tnp00062|FD-Score:5.87|P-value:1.28E-8 ID:SGTC_1176|Compound:0848-0131|FD-Score:-3.87|P-value:1.02E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.62|P-value:6.01E-6 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.30|P-value:8.90E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.02|P-value:6.98E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.29|P-value:9.34E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.36|P-value:7.50E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.41|P-value:6.23E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.78|P-value:1.71E-4 ID:SGTC_1613|Compound:st002381|FD-Score:4.62|P-value:5.95E-6 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.90|P-value:1.09E-4 ID:SGTC_1719|Compound:st032227|FD-Score:4.26|P-value:2.72E-5 ID:SGTC_1758|Compound:st042942|FD-Score:-3.23|P-value:9.54E-4 ID:SGTC_1820|Compound:st053765|FD-Score:5.53|P-value:7.51E-8 ID:SGTC_1891|Compound:st059073|FD-Score:3.31|P-value:8.64E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.87|P-value:1.23E-4 ID:SGTC_2063|Compound:5246145|FD-Score:4.69|P-value:4.34E-6 ID:SGTC_2081|Compound:5214970|FD-Score:3.31|P-value:8.66E-4 ID:SGTC_2086|Compound:5274770|FD-Score:4.52|P-value:8.96E-6 ID:SGTC_2278|Compound:7948257|FD-Score:-3.84|P-value:1.12E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.46|P-value:5.30E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.45|P-value:4.57E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:4.22|P-value:3.25E-5 ID:SGTC_2806|Compound:7952793|FD-Score:3.71|P-value:2.26E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.80|P-value:1.62E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.34|P-value:8.02E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-3.69|P-value:1.94E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-4.01|P-value:5.87E-5 ID:SGTC_2977|Compound:9011197|FD-Score:4.45|P-value:1.26E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-5.18|P-value:3.45E-7 ID:SGTC_3193|Compound:9111931|FD-Score:4.59|P-value:6.72E-6 ID:SGTC_3203|Compound:9113543|FD-Score:-3.49|P-value:3.94E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-3.39|P-value:5.54E-4 ID:SGTC_3236|Compound:9132701|FD-Score:-3.36|P-value:6.27E-4

Top fitness defect scores for YMR049C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_907 3448-6986 11.50 75.5 µM 2.84E-28 1 4.98E-31 5.67
2 SGTC_1111 tnp00062 5.87 510.7 nM 1.28E-8 2 2.22E-9 0.33
3 SGTC_1820 st053765 5.53 18.6 µM 7.51E-8 RPP1 & pyrimidine depletion 4 1.56E-8 1.35
4 SGTC_177 1327-0068 4.94 8.4 µM 1.39E-6 14 3.89E-7 0.08
5 SGTC_2063 5246145 4.69 200.0 µM 4.34E-6 4 1.36E-6 0.59
6 SGTC_423 5-fluorouracil 4.67 457.0 µM 4.70E-6 exosome 19 1.48E-6 0.05
7 SGTC_1613 st002381 4.62 52.1 µM 5.95E-6 2 1.93E-6 0.08
8 SGTC_1249 0481-0015 4.62 10.2 µM 6.01E-6 4 1.95E-6 0.41
9 SGTC_3193 9111931 4.59 49.5 µM 6.72E-6 4 2.21E-6 0.21
10 SGTC_2086 5274770 4.52 176.6 µM 8.96E-6 8 3.02E-6 0.16
11 SGTC_2977 9011197 4.45 71.4 µM 1.26E-5 7 4.39E-6 0.36
12 SGTC_1719 st032227 4.26 49.2 µM 2.72E-5 8 1.03E-5 0.15
13 SGTC_2674 ligustilide 4.22 100.0 µM 3.25E-5 3 1.25E-5 0.10
14 SGTC_1077 5-fluorocytosine 4.21 377.0 nM 3.33E-5 exosome 16 1.28E-5 0.07
15 SGTC_1074 carmofur 4.14 3.8 µM 4.36E-5 exosome 26 1.73E-5 0.32
16 SGTC_277 nystatin 4.07 15.5 µM 5.76E-5 3 2.35E-5 0.47
17 SGTC_172 1112-0046 4.07 2.6 µM 5.87E-5 NEO1 7 2.39E-5 0.02
18 SGTC_100 0086-0128 4.04 49.6 µM 6.42E-5 copper-dependent oxidative stress 6 2.65E-5 0.32
19 SGTC_1401 3807-4679 4.02 7.6 µM 6.98E-5 tubulin folding & SWR complex 4 2.90E-5 0.27
20 SGTC_1698 5-fluorocytosine 3.90 1.1 µM 1.09E-4 exosome 13 4.74E-5 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 1.85E-18 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.150 2.61E-18 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.145 2.52E-17 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.135 4.86E-15 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.134 6.78E-15 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.128 8.06E-14 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.127 1.27E-13 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.126 2.55E-13 YPR143W RRP15 het Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
0.123 8.03E-13 YPR142C_d YPR142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.119 4.03E-12 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.115 2.93E-11 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.113 4.93E-11 YGL111W NSA1 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
0.113 6.25E-11 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.112 8.83E-11 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.111 1.30E-10 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering