HIPHOP chemogenomics database

YMR049C / ERB1

Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1

Zygosity: Heterozygous strain

fixedexpanded
Profile for YMR049C / ERB1

Click on Significant Values for Screen Details

Top fitness defect scores for YMR049C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_907	3448-6986	11.50	75.5 µM	2.84E-28		1	4.98E-31	5.67
2	SGTC_1111	tnp00062	5.87	510.7 nM	1.28E-8		2	2.22E-9	0.33
3	SGTC_1820	st053765	5.53	18.6 µM	7.51E-8	RPP1 & pyrimidine depletion	4	1.56E-8	1.35
4	SGTC_177	1327-0068	4.94	8.4 µM	1.39E-6		14	3.89E-7	0.08
5	SGTC_2063	5246145	4.69	200.0 µM	4.34E-6		4	1.36E-6	0.59
6	SGTC_423	5-fluorouracil	4.67	457.0 µM	4.70E-6	exosome	19	1.48E-6	0.05
7	SGTC_1613	st002381	4.62	52.1 µM	5.95E-6		2	1.93E-6	0.08
8	SGTC_1249	0481-0015	4.62	10.2 µM	6.01E-6		4	1.95E-6	0.41
9	SGTC_3193	9111931	4.59	49.5 µM	6.72E-6		4	2.21E-6	0.21
10	SGTC_2086	5274770	4.52	176.6 µM	8.96E-6		8	3.02E-6	0.16
11	SGTC_2977	9011197	4.45	71.4 µM	1.26E-5		7	4.39E-6	0.36
12	SGTC_1719	st032227	4.26	49.2 µM	2.72E-5		8	1.03E-5	0.15
13	SGTC_2674	ligustilide	4.22	100.0 µM	3.25E-5		3	1.25E-5	0.10
14	SGTC_1077	5-fluorocytosine	4.21	377.0 nM	3.33E-5	exosome	16	1.28E-5	0.07
15	SGTC_1074	carmofur	4.14	3.8 µM	4.36E-5	exosome	26	1.73E-5	0.32
16	SGTC_277	nystatin	4.07	15.5 µM	5.76E-5		3	2.35E-5	0.47
17	SGTC_172	1112-0046	4.07	2.6 µM	5.87E-5	NEO1	7	2.39E-5	0.02
18	SGTC_100	0086-0128	4.04	49.6 µM	6.42E-5	copper-dependent oxidative stress	6	2.65E-5	0.32
19	SGTC_1401	3807-4679	4.02	7.6 µM	6.98E-5	tubulin folding & SWR complex	4	2.90E-5	0.27
20	SGTC_1698	5-fluorocytosine	3.90	1.1 µM	1.09E-4	exosome	13	4.74E-5	0.04

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.150	1.85E-18	YDL111C	RRP42	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.150	2.61E-18	YGR195W	SKI6	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.145	2.52E-17	YKL021C	MAK11	het	Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.135	4.86E-15	YER043C	SAH1	het	S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.134	6.78E-15	YPL044C_d	YPL044C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.128	8.06E-14	YBR155W	CNS1	het	TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.127	1.27E-13	YBL004W	UTP20	het	Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.126	2.55E-13	YPR143W	RRP15	het	Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
0.123	8.03E-13	YPR142C_d	YPR142C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.119	4.03E-12	YPL043W	NOP4	het	Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.115	2.93E-11	YOL021C	DIS3	het	Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.113	4.93E-11	YGL111W	NSA1	het	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
0.113	6.25E-11	YDR280W	RRP45	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.112	8.83E-11	YGR158C	MTR3	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.111	1.30E-10	YKL172W	EBP2	het	Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering