YMR052C-A_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR052C-A / YMR052C-A

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.36|P-value:4.75E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:5.59|P-value:6.44E-9 ID:SGTC_103|Compound:0844-0104|FD-Score:11.30|P-value:5.32E-31 ID:SGTC_105|Compound:0111-0055|FD-Score:4.09|P-value:1.61E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.95|P-value:2.68E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:-3.62|P-value:1.07E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.45|P-value:2.30E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.31|P-value:3.44E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:-3.38|P-value:2.67E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.78|P-value:6.26E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:3.26|P-value:4.64E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.11|P-value:7.19E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:9.73|P-value:2.02E-23 ID:SGTC_373|Compound:0844-0104|FD-Score:6.10|P-value:2.85E-10 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.11|P-value:7.31E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:10.70|P-value:4.64E-28 ID:SGTC_404|Compound:fumagillin|FD-Score:4.28|P-value:6.83E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:5.89|P-value:1.05E-9 ID:SGTC_579|Compound:4491-1009|FD-Score:5.17|P-value:7.29E-8 ID:SGTC_654|Compound:1124-0271|FD-Score:-3.06|P-value:8.75E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:6.24|P-value:1.09E-10 ID:SGTC_805|Compound:3852-0218|FD-Score:4.65|P-value:1.15E-6 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.43|P-value:2.19E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.06|P-value:1.91E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.02|P-value:2.26E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.82|P-value:4.89E-7 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.20|P-value:5.89E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.33|P-value:3.64E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.61|P-value:1.25E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.50|P-value:2.46E-6 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.41|P-value:2.68E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.52|P-value:1.75E-4 ID:SGTC_1558|Compound:st069300|FD-Score:3.53|P-value:1.67E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.64|P-value:9.68E-5 ID:SGTC_1637|Compound:st007924|FD-Score:3.78|P-value:6.28E-5 ID:SGTC_1642|Compound:st009582|FD-Score:3.75|P-value:6.91E-5 ID:SGTC_1661|Compound:st013063|FD-Score:3.35|P-value:3.43E-4 ID:SGTC_1750|Compound:st081859|FD-Score:5.03|P-value:1.56E-7 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.28|P-value:6.85E-6 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.50|P-value:1.90E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.75|P-value:6.94E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-3.36|P-value:2.86E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-3.26|P-value:4.16E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.28|P-value:4.38E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.51|P-value:1.84E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.64|P-value:1.11E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.62|P-value:1.20E-4 ID:SGTC_2523|Compound:spermine|FD-Score:5.30|P-value:3.67E-8 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.46|P-value:2.96E-6 ID:SGTC_2549|Compound:cedrol|FD-Score:5.63|P-value:5.09E-9 ID:SGTC_2557|Compound:derrustone|FD-Score:4.08|P-value:1.70E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.86|P-value:3.95E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.63|P-value:1.16E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:4.06|P-value:1.85E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.24|P-value:5.05E-4 ID:SGTC_2707|Compound:st078556|FD-Score:4.76|P-value:6.61E-7 ID:SGTC_2714|Compound:st079313|FD-Score:4.01|P-value:2.35E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:-4.08|P-value:1.50E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:6.50|P-value:1.94E-11 ID:SGTC_2786|Compound:7743617|FD-Score:-3.84|P-value:4.27E-5 ID:SGTC_2918|Compound:7977171|FD-Score:3.67|P-value:9.74E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-3.97|P-value:2.45E-5 ID:SGTC_2949|Compound:9072542|FD-Score:3.31|P-value:3.92E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.52|P-value:1.77E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.31|P-value:3.97E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.29|P-value:4.29E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.83|P-value:5.06E-5 ID:SGTC_3264|Compound:9137442|FD-Score:-3.07|P-value:8.28E-4 ID:SGTC_3273|Compound:9137859|FD-Score:3.57|P-value:1.47E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.36|P-value:4.75E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:5.59|P-value:6.44E-9 ID:SGTC_103|Compound:0844-0104|FD-Score:11.30|P-value:5.32E-31 ID:SGTC_105|Compound:0111-0055|FD-Score:4.09|P-value:1.61E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.95|P-value:2.68E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:-3.62|P-value:1.07E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.45|P-value:2.30E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.31|P-value:3.44E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:-3.38|P-value:2.67E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.78|P-value:6.26E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:3.26|P-value:4.64E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.11|P-value:7.19E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:9.73|P-value:2.02E-23 ID:SGTC_373|Compound:0844-0104|FD-Score:6.10|P-value:2.85E-10 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.11|P-value:7.31E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:10.70|P-value:4.64E-28 ID:SGTC_404|Compound:fumagillin|FD-Score:4.28|P-value:6.83E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:5.89|P-value:1.05E-9 ID:SGTC_579|Compound:4491-1009|FD-Score:5.17|P-value:7.29E-8 ID:SGTC_654|Compound:1124-0271|FD-Score:-3.06|P-value:8.75E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:6.24|P-value:1.09E-10 ID:SGTC_805|Compound:3852-0218|FD-Score:4.65|P-value:1.15E-6 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.43|P-value:2.19E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.06|P-value:1.91E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.02|P-value:2.26E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.82|P-value:4.89E-7 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.20|P-value:5.89E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.33|P-value:3.64E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.61|P-value:1.25E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:4.50|P-value:2.46E-6 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.41|P-value:2.68E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.52|P-value:1.75E-4 ID:SGTC_1558|Compound:st069300|FD-Score:3.53|P-value:1.67E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.64|P-value:9.68E-5 ID:SGTC_1637|Compound:st007924|FD-Score:3.78|P-value:6.28E-5 ID:SGTC_1642|Compound:st009582|FD-Score:3.75|P-value:6.91E-5 ID:SGTC_1661|Compound:st013063|FD-Score:3.35|P-value:3.43E-4 ID:SGTC_1750|Compound:st081859|FD-Score:5.03|P-value:1.56E-7 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.28|P-value:6.85E-6 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.50|P-value:1.90E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.75|P-value:6.94E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-3.36|P-value:2.86E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-3.26|P-value:4.16E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.28|P-value:4.38E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.51|P-value:1.84E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.64|P-value:1.11E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.62|P-value:1.20E-4 ID:SGTC_2523|Compound:spermine|FD-Score:5.30|P-value:3.67E-8 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.46|P-value:2.96E-6 ID:SGTC_2549|Compound:cedrol|FD-Score:5.63|P-value:5.09E-9 ID:SGTC_2557|Compound:derrustone|FD-Score:4.08|P-value:1.70E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.86|P-value:3.95E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.63|P-value:1.16E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:4.06|P-value:1.85E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.24|P-value:5.05E-4 ID:SGTC_2707|Compound:st078556|FD-Score:4.76|P-value:6.61E-7 ID:SGTC_2714|Compound:st079313|FD-Score:4.01|P-value:2.35E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:-4.08|P-value:1.50E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:6.50|P-value:1.94E-11 ID:SGTC_2786|Compound:7743617|FD-Score:-3.84|P-value:4.27E-5 ID:SGTC_2918|Compound:7977171|FD-Score:3.67|P-value:9.74E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-3.97|P-value:2.45E-5 ID:SGTC_2949|Compound:9072542|FD-Score:3.31|P-value:3.92E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.52|P-value:1.77E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.31|P-value:3.97E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.29|P-value:4.29E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.83|P-value:5.06E-5 ID:SGTC_3264|Compound:9137442|FD-Score:-3.07|P-value:8.28E-4 ID:SGTC_3273|Compound:9137859|FD-Score:3.57|P-value:1.47E-4

Top fitness defect scores for YMR052C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 11.30 51.8 µM 5.32E-31 ERAD & cell cycle 24 5.51E-30
2 SGTC_384 k007-0144 10.70 5.2 µM 4.64E-28 ERAD & cell cycle 10 3.77E-27
3 SGTC_352 k048-0007 9.73 5.1 µM 2.02E-23 ERAD & cell cycle 12 1.12E-22
4 SGTC_2765 myclobutanil 6.50 7.7 µM 1.94E-11 azole & statin 8 4.06E-11
5 SGTC_733 4069-0007 6.24 56.1 µM 1.09E-10 ERAD & cell cycle 37 2.15E-10
6 SGTC_373 0844-0104 6.10 25.9 µM 2.85E-10 ERAD & cell cycle 22 5.44E-10
7 SGTC_568 1193-0097 5.89 7.5 µM 1.05E-9 ERAD & cell cycle 63 1.91E-9
8 SGTC_2549 cedrol 5.63 20.9 µM 5.09E-9 3 8.79E-9
9 SGTC_64 000l-0018 5.59 272.1 µM 6.44E-9 ubiquinone biosynthesis & proteasome 89 1.10E-8
10 SGTC_2523 spermine 5.30 47.7 µM 3.67E-8 calcium & mitochondrial duress 13 5.93E-8
11 SGTC_579 4491-1009 5.17 110.0 µM 7.29E-8 60S ribosome export 5 1.15E-7
12 SGTC_1750 st081859 5.03 2.4 µM 1.56E-7 endomembrane recycling 136 2.40E-7
13 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 4.86 15.3 µM 3.95E-7 16 5.89E-7
14 SGTC_1161 k007-0610 4.82 110.0 µM 4.89E-7 ERAD & cell cycle 85 7.24E-7
15 SGTC_2707 st078556 4.76 66.6 µM 6.61E-7 5 9.69E-7
16 SGTC_805 3852-0218 4.65 479.0 µM 1.15E-6 ERAD & cell cycle 46 1.66E-6
17 SGTC_1300 1094-0077 4.50 113.0 µM 2.46E-6 8 3.46E-6
18 SGTC_2541 muurolladie-3-one 4.46 83.1 µM 2.96E-6 excess fatty acid 16 4.13E-6
19 SGTC_58 0957-0393 4.36 9.0 µM 4.75E-6 cell wall 337 6.52E-6
20 SGTC_404 fumagillin 4.28 50.0 µM 6.83E-6 13 9.26E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.475 1.41E-188 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.425 3.58E-147 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.423 1.06E-145 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.416 7.30E-141 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.415 2.86E-140 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.406 9.28E-134 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.397 2.56E-127 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.350 3.79E-97 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.328 4.28E-85 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.311 5.91E-76 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.294 5.55E-68 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.277 5.56E-60 YLR065C ENV10 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene
0.272 1.02E-57 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.264 2.02E-54 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.259 1.89E-52 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress