YMR053C / STB2

Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR053C / STB2

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.40|P-value:2.22E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.22|P-value:4.40E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.56|P-value:1.20E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.89|P-value:3.04E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:3.63|P-value:9.14E-5 ID:SGTC_645|Compound:0845-0943|FD-Score:3.60|P-value:1.00E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:-3.09|P-value:8.09E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.27|P-value:3.71E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.22|P-value:4.38E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.78|P-value:4.85E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:5.56|P-value:5.02E-9 ID:SGTC_814|Compound:3342-0569|FD-Score:3.41|P-value:2.13E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:4.66|P-value:7.79E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:3.68|P-value:7.22E-5 ID:SGTC_886|Compound:0866-0150|FD-Score:-3.07|P-value:8.84E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.11|P-value:6.60E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.29|P-value:3.97E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.36|P-value:2.60E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.92|P-value:1.98E-7 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.48|P-value:1.91E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:2.99|P-value:9.88E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.12|P-value:6.43E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.14|P-value:6.02E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:6.00|P-value:3.35E-10 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.29|P-value:3.46E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.41|P-value:2.13E-4 ID:SGTC_1801|Compound:st050089|FD-Score:-3.09|P-value:8.19E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.73|P-value:6.02E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:-3.04|P-value:9.84E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.19|P-value:5.81E-4 ID:SGTC_1895|Compound:st058434|FD-Score:4.58|P-value:1.18E-6 ID:SGTC_1952|Compound:st077036|FD-Score:3.81|P-value:4.28E-5 ID:SGTC_1953|Compound:st076800|FD-Score:3.01|P-value:9.49E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.00|P-value:9.69E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.68|P-value:7.40E-5 ID:SGTC_2013|Compound:4024628|FD-Score:5.46|P-value:9.53E-9 ID:SGTC_2015|Compound:5119600|FD-Score:4.36|P-value:3.54E-6 ID:SGTC_2021|Compound:4019055|FD-Score:3.12|P-value:6.40E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.17|P-value:5.23E-4 ID:SGTC_2226|Compound:7298446|FD-Score:3.02|P-value:9.12E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.04|P-value:8.41E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.19|P-value:4.96E-4 ID:SGTC_2261|Compound:9010538|FD-Score:4.52|P-value:1.61E-6 ID:SGTC_2323|Compound:6148992|FD-Score:3.16|P-value:5.41E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.54|P-value:1.28E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.32|P-value:3.00E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.76|P-value:4.65E-7 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.11|P-value:7.59E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.69|P-value:6.60E-7 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.22|P-value:5.25E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.19|P-value:5.00E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:4.07|P-value:1.38E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.23|P-value:6.33E-6 ID:SGTC_2682|Compound:pyrogallin|FD-Score:2.99|P-value:9.90E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.02|P-value:8.96E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.68|P-value:7.34E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.04|P-value:8.46E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.15|P-value:5.63E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.96|P-value:2.21E-5 ID:SGTC_2923|Compound:7992654|FD-Score:3.68|P-value:7.47E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.94|P-value:2.38E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-3.89|P-value:3.62E-5 ID:SGTC_2947|Compound:9072639|FD-Score:5.19|P-value:4.51E-8 ID:SGTC_2949|Compound:9072542|FD-Score:3.18|P-value:5.15E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.09|P-value:6.99E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.28|P-value:3.54E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.46|P-value:1.79E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-6.75|P-value:2.50E-12 ID:SGTC_3216|Compound:9129716|FD-Score:6.50|P-value:1.15E-11 ID:SGTC_3224|Compound:9130643|FD-Score:5.06|P-value:9.19E-8 ID:SGTC_3232|Compound:9132874|FD-Score:3.94|P-value:2.37E-5 ID:SGTC_3290|Compound:9121031|FD-Score:-3.18|P-value:5.93E-4 ID:SGTC_3347|Compound:9188721|FD-Score:4.25|P-value:5.76E-6 ID:SGTC_3349|Compound:9149703|FD-Score:5.83|P-value:9.86E-10 ID:SGTC_38|Compound:0929-0051|FD-Score:3.40|P-value:2.22E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.22|P-value:4.40E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.56|P-value:1.20E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.89|P-value:3.04E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:3.63|P-value:9.14E-5 ID:SGTC_645|Compound:0845-0943|FD-Score:3.60|P-value:1.00E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:-3.09|P-value:8.09E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.27|P-value:3.71E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.22|P-value:4.38E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.78|P-value:4.85E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:5.56|P-value:5.02E-9 ID:SGTC_814|Compound:3342-0569|FD-Score:3.41|P-value:2.13E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:4.66|P-value:7.79E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:3.68|P-value:7.22E-5 ID:SGTC_886|Compound:0866-0150|FD-Score:-3.07|P-value:8.84E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.11|P-value:6.60E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.29|P-value:3.97E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.36|P-value:2.60E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.92|P-value:1.98E-7 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.48|P-value:1.91E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:2.99|P-value:9.88E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.12|P-value:6.43E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.14|P-value:6.02E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:6.00|P-value:3.35E-10 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.29|P-value:3.46E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.41|P-value:2.13E-4 ID:SGTC_1801|Compound:st050089|FD-Score:-3.09|P-value:8.19E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.73|P-value:6.02E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:-3.04|P-value:9.84E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.19|P-value:5.81E-4 ID:SGTC_1895|Compound:st058434|FD-Score:4.58|P-value:1.18E-6 ID:SGTC_1952|Compound:st077036|FD-Score:3.81|P-value:4.28E-5 ID:SGTC_1953|Compound:st076800|FD-Score:3.01|P-value:9.49E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.00|P-value:9.69E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.68|P-value:7.40E-5 ID:SGTC_2013|Compound:4024628|FD-Score:5.46|P-value:9.53E-9 ID:SGTC_2015|Compound:5119600|FD-Score:4.36|P-value:3.54E-6 ID:SGTC_2021|Compound:4019055|FD-Score:3.12|P-value:6.40E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.17|P-value:5.23E-4 ID:SGTC_2226|Compound:7298446|FD-Score:3.02|P-value:9.12E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.04|P-value:8.41E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.19|P-value:4.96E-4 ID:SGTC_2261|Compound:9010538|FD-Score:4.52|P-value:1.61E-6 ID:SGTC_2323|Compound:6148992|FD-Score:3.16|P-value:5.41E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.54|P-value:1.28E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.32|P-value:3.00E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.76|P-value:4.65E-7 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.11|P-value:7.59E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.69|P-value:6.60E-7 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.22|P-value:5.25E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.19|P-value:5.00E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:4.07|P-value:1.38E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.23|P-value:6.33E-6 ID:SGTC_2682|Compound:pyrogallin|FD-Score:2.99|P-value:9.90E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.02|P-value:8.96E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.68|P-value:7.34E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.04|P-value:8.46E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.15|P-value:5.63E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.96|P-value:2.21E-5 ID:SGTC_2923|Compound:7992654|FD-Score:3.68|P-value:7.47E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.94|P-value:2.38E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-3.89|P-value:3.62E-5 ID:SGTC_2947|Compound:9072639|FD-Score:5.19|P-value:4.51E-8 ID:SGTC_2949|Compound:9072542|FD-Score:3.18|P-value:5.15E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.09|P-value:6.99E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.28|P-value:3.54E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.46|P-value:1.79E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-6.75|P-value:2.50E-12 ID:SGTC_3216|Compound:9129716|FD-Score:6.50|P-value:1.15E-11 ID:SGTC_3224|Compound:9130643|FD-Score:5.06|P-value:9.19E-8 ID:SGTC_3232|Compound:9132874|FD-Score:3.94|P-value:2.37E-5 ID:SGTC_3290|Compound:9121031|FD-Score:-3.18|P-value:5.93E-4 ID:SGTC_3347|Compound:9188721|FD-Score:4.25|P-value:5.76E-6 ID:SGTC_3349|Compound:9149703|FD-Score:5.83|P-value:9.86E-10

Top fitness defect scores for YMR053C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3216 9129716 6.50 49.5 µM 1.15E-11 RPP1 & pyrimidine depletion 4 4.11E-11
2 SGTC_1157 4092-0394 6.00 27.6 µM 3.35E-10 5 1.01E-9
3 SGTC_3349 9149703 5.83 23.0 µM 9.86E-10 1 2.81E-9
4 SGTC_792 4534-1957 5.56 155.0 µM 5.02E-9 13 1.31E-8
5 SGTC_2013 4024628 5.46 200.0 µM 9.53E-9 21 2.41E-8
6 SGTC_2947 9072639 5.19 7.7 µM 4.51E-8 tubulin folding & SWR complex 15 1.05E-7
7 SGTC_3224 9130643 5.06 49.5 µM 9.19E-8 RPP1 & pyrimidine depletion 8 2.07E-7
8 SGTC_1053 3366-3204 4.92 134.0 µM 1.98E-7 cell wall 17 4.28E-7
9 SGTC_2451 5856223 4.76 45.7 µM 4.65E-7 11 9.63E-7
10 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 4.69 54.6 µM 6.60E-7 RPP1 & pyrimidine depletion 18 1.34E-6
11 SGTC_817 1391-0715 4.66 46.0 µM 7.79E-7 9 1.57E-6
12 SGTC_1895 st058434 4.58 18.3 µM 1.18E-6 10 2.32E-6
13 SGTC_2261 9010538 4.52 184.7 µM 1.61E-6 11 3.13E-6
14 SGTC_2015 5119600 4.36 184.0 µM 3.54E-6 21 6.60E-6
15 SGTC_3347 9188721 4.25 44.7 µM 5.76E-6 19 1.05E-5
16 SGTC_2627 acetyl isogambogic acid 4.23 100.0 µM 6.33E-6 TSC3-RPN4 36 1.14E-5
17 SGTC_2524 avocatin b 4.07 10.6 µM 1.38E-5 23 2.40E-5
18 SGTC_2919 7978188 3.96 46.4 µM 2.21E-5 18 3.75E-5
19 SGTC_3232 9132874 3.94 49.5 µM 2.37E-5 RPP1 & pyrimidine depletion 13 3.99E-5
20 SGTC_2939 9044578 3.94 71.4 µM 2.38E-5 37 4.01E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.80E-10 YPL272C_p YPL272C_p hom Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene
0.093 7.67E-8 YKL079W SMY1 hom Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins
0.091 1.18E-7 YBR300C_d YBR300C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene
0.081 2.95E-6 YOL124C TRM11 hom Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
0.080 3.18E-6 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein
0.080 3.24E-6 YGR124W ASN2 hom Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication
0.080 3.77E-6 YOR068C VAM10 hom Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering
0.079 4.61E-6 YNL068C FKH2 hom Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; FKH2 has a paralog, FKH1, that arose from the whole genome duplication
0.078 6.33E-6 YGR288W MAL13 hom MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C
0.072 3.31E-5 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.070 4.57E-5 YOR076C SKI7 hom Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype
0.069 6.34E-5 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.069 6.65E-5 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress
0.069 7.05E-5 YOR270C VPH1 hom Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress
0.069 7.05E-5 YLR086W SMC4 het Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate