HIPHOP chemogenomics database
YMR053C / STB2 
Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YMR053C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.107 | 4.80E-10 | YPL272C_p | YPL272C_p | hom | Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene |
| 0.093 | 7.67E-8 | YKL079W | SMY1 | hom | Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins |
| 0.091 | 1.18E-7 | YBR300C_d | YBR300C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene |
| 0.081 | 2.95E-6 | YOL124C | TRM11 | hom | Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain |
| 0.080 | 3.18E-6 | YGR149W_p | YGR149W_p | hom | Putative protein of unknown function; predicted to be an integal membrane protein |
| 0.080 | 3.24E-6 | YGR124W | ASN2 | hom | Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication |
| 0.080 | 3.77E-6 | YOR068C | VAM10 | hom | Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering |
| 0.079 | 4.61E-6 | YNL068C | FKH2 | hom | Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; FKH2 has a paralog, FKH1, that arose from the whole genome duplication |
| 0.078 | 6.33E-6 | YGR288W | MAL13 | hom | MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C |
| 0.072 | 3.31E-5 | YPR126C_d | YPR126C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.070 | 4.57E-5 | YOR076C | SKI7 | hom | Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype |
| 0.069 | 6.34E-5 | YNL268W | LYP1 | hom | Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids |
| 0.069 | 6.65E-5 | YLR034C | SMF3 | hom | Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress |
| 0.069 | 7.05E-5 | YOR270C | VPH1 | hom | Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress |
| 0.069 | 7.05E-5 | YLR086W | SMC4 | het | Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate |