Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YMR054W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.177 | 5.77E-25 | YDR371W_p | CTS2_p | hom | Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect |
0.106 | 6.90E-10 | YMR125W | STO1 | hom | Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80 |
0.091 | 1.23E-7 | YIR020C_p | YIR020C_p | hom | Protein of unknown function; mRNA identified as translated by ribosome profiling data |
0.091 | 1.31E-7 | YDR287W | INM2 | hom | Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy |
0.091 | 1.33E-7 | YML076C | WAR1 | hom | Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively |
0.089 | 2.38E-7 | YOR333C_d | YOR333C_d | hom | Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth |
0.087 | 4.60E-7 | YOL104C | NDJ1 | hom | Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement |
0.085 | 7.68E-7 | YDR032C | PST2 | hom | Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication |
0.083 | 1.47E-6 | YDL118W_d | YDL118W_d | hom | Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein |
0.083 | 1.48E-6 | YGL134W | PCL10 | hom | Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate |
0.079 | 4.15E-6 | YBR296C-A_p | YBR296C-A_p | hom | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
0.078 | 6.39E-6 | YLR062C_d | BUD28_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay |
0.077 | 9.06E-6 | YJL189W | RPL39 | hom | Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog |
0.077 | 9.08E-6 | YML028W | TSA1 | hom | Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress |
0.076 | 9.62E-6 | YGR078C | PAC10 | hom | Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding |