HIPHOP chemogenomics database

YMR054W / STV1

Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR054W / STV1

Click on Significant Values for Screen Details

Top fitness defect scores for YMR054W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2347	9049783	8.94	174.8 µM	2.85E-19		4	1.96E-19
2	SGTC_1958	st076513	8.07	41.9 µM	4.87E-16	60S ribosome export	4	3.56E-16
3	SGTC_3306	9127676	8.01	59.8 µM	7.92E-16		2	5.82E-16
4	SGTC_1110	3-hydroxy-3'-methoxyflavone	5.48	1.2 µM	2.49E-8	iron homeostasis	18	2.12E-8
5	SGTC_1916	st067606	5.14	49.2 µM	1.56E-7		15	1.35E-7
6	SGTC_1792	st045773	5.09	43.6 µM	2.06E-7		11	1.79E-7
7	SGTC_2273	7815444	4.89	169.1 µM	5.75E-7		10	5.04E-7
8	SGTC_1402	3909-7673	4.85	35.9 µM	6.89E-7		9	6.04E-7
9	SGTC_2401	5128683	4.83	200.0 µM	7.73E-7		16	6.79E-7
10	SGTC_1731	st035964	4.58	63.0 µM	2.63E-6		12	2.33E-6
11	SGTC_3069	9117009	4.50	49.5 µM	3.73E-6	60S ribosome export	6	3.32E-6
12	SGTC_2562	3',7'-dimethoxyflavone	4.45	64.9 µM	4.81E-6		17	4.29E-6
13	SGTC_803	4488-1585	4.43	147.0 µM	5.38E-6		9	4.80E-6
14	SGTC_3028	9087778	4.41	49.5 µM	5.73E-6		9	5.12E-6
15	SGTC_1092	toremifene	4.40	6.3 µM	6.15E-6		15	5.50E-6
16	SGTC_2102	5377816	4.21	72.8 µM	1.41E-5		21	1.27E-5
17	SGTC_2537	larixol	4.19	68.9 µM	1.56E-5		19	1.41E-5
18	SGTC_154	3389-1638	4.15	511.1 µM	1.81E-5		20	1.63E-5
19	SGTC_3175	9106517	4.15	49.5 µM	1.85E-5	iron homeostasis	16	1.67E-5
20	SGTC_809	3998-0021	4.14	90.0 µM	1.90E-5	RNA processing & uracil transport	12	1.72E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.177	5.77E-25	YDR371W_p	CTS2_p	hom	Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.106	6.90E-10	YMR125W	STO1	hom	Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
0.091	1.23E-7	YIR020C_p	YIR020C_p	hom	Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.091	1.31E-7	YDR287W	INM2	hom	Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
0.091	1.33E-7	YML076C	WAR1	hom	Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
0.089	2.38E-7	YOR333C_d	YOR333C_d	hom	Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth
0.087	4.60E-7	YOL104C	NDJ1	hom	Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement
0.085	7.68E-7	YDR032C	PST2	hom	Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.083	1.47E-6	YDL118W_d	YDL118W_d	hom	Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein
0.083	1.48E-6	YGL134W	PCL10	hom	Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
0.079	4.15E-6	YBR296C-A_p	YBR296C-A_p	hom	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.078	6.39E-6	YLR062C_d	BUD28_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.077	9.06E-6	YJL189W	RPL39	hom	Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.077	9.08E-6	YML028W	TSA1	hom	Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.076	9.62E-6	YGR078C	PAC10	hom	Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding