YMR054W / STV1

Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR054W / STV1

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.53|P-value:2.26E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.52|P-value:2.31E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.61|P-value:1.66E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:4.15|P-value:1.81E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.18|P-value:7.86E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.33|P-value:4.75E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.40|P-value:3.60E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.89|P-value:5.53E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:3.83|P-value:6.96E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.73|P-value:9.70E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:-4.05|P-value:2.68E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:3.38|P-value:3.84E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:4.43|P-value:5.38E-6 ID:SGTC_809|Compound:3998-0021|FD-Score:4.14|P-value:1.90E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:3.66|P-value:1.39E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:4.00|P-value:3.53E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.40|P-value:3.68E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.74|P-value:1.00E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:4.40|P-value:6.15E-6 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:5.48|P-value:2.49E-8 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.43|P-value:3.30E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.46|P-value:2.95E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:4.03|P-value:3.02E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.01|P-value:3.36E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.93|P-value:4.73E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.85|P-value:6.89E-7 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.26|P-value:5.99E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.61|P-value:1.67E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.20|P-value:7.48E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.84|P-value:6.29E-5 ID:SGTC_1731|Compound:st035964|FD-Score:4.58|P-value:2.63E-6 ID:SGTC_1735|Compound:st034310|FD-Score:3.15|P-value:8.62E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.66|P-value:1.39E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.29|P-value:5.36E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.65|P-value:1.40E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.49|P-value:2.62E-4 ID:SGTC_1792|Compound:st045773|FD-Score:5.09|P-value:2.06E-7 ID:SGTC_1916|Compound:st067606|FD-Score:5.14|P-value:1.56E-7 ID:SGTC_1958|Compound:st076513|FD-Score:8.07|P-value:4.87E-16 ID:SGTC_2102|Compound:5377816|FD-Score:4.21|P-value:1.41E-5 ID:SGTC_2168|Compound:5727979|FD-Score:3.82|P-value:7.41E-5 ID:SGTC_2223|Compound:6903751|FD-Score:3.29|P-value:5.46E-4 ID:SGTC_2273|Compound:7815444|FD-Score:4.89|P-value:5.75E-7 ID:SGTC_2341|Compound:7987486|FD-Score:3.66|P-value:1.36E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.13|P-value:2.00E-5 ID:SGTC_2347|Compound:9049783|FD-Score:8.94|P-value:2.85E-19 ID:SGTC_2349|Compound:9023730|FD-Score:-3.54|P-value:2.03E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.83|P-value:7.73E-7 ID:SGTC_2537|Compound:larixol|FD-Score:4.19|P-value:1.56E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.45|P-value:4.81E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.26|P-value:5.96E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.48|P-value:2.73E-4 ID:SGTC_2696|Compound:st077691|FD-Score:-3.41|P-value:3.36E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.14|P-value:8.54E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.79|P-value:8.38E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-3.69|P-value:1.15E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.12|P-value:9.28E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.01|P-value:3.31E-5 ID:SGTC_3028|Compound:9087778|FD-Score:4.41|P-value:5.73E-6 ID:SGTC_3045|Compound:9092950|FD-Score:3.15|P-value:8.67E-4 ID:SGTC_3069|Compound:9117009|FD-Score:4.50|P-value:3.73E-6 ID:SGTC_3117|Compound:9124945|FD-Score:-3.77|P-value:8.52E-5 ID:SGTC_3121|Compound:9125696|FD-Score:-3.71|P-value:1.07E-4 ID:SGTC_3175|Compound:9106517|FD-Score:4.15|P-value:1.85E-5 ID:SGTC_3306|Compound:9127676|FD-Score:8.01|P-value:7.92E-16 ID:SGTC_20|Compound:0481-0013|FD-Score:3.53|P-value:2.26E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.52|P-value:2.31E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.61|P-value:1.66E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:4.15|P-value:1.81E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.18|P-value:7.86E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.33|P-value:4.75E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.40|P-value:3.60E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.89|P-value:5.53E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:3.83|P-value:6.96E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.73|P-value:9.70E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:-4.05|P-value:2.68E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:3.38|P-value:3.84E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:4.43|P-value:5.38E-6 ID:SGTC_809|Compound:3998-0021|FD-Score:4.14|P-value:1.90E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:3.66|P-value:1.39E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:4.00|P-value:3.53E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.40|P-value:3.68E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.74|P-value:1.00E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:4.40|P-value:6.15E-6 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:5.48|P-value:2.49E-8 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.43|P-value:3.30E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.46|P-value:2.95E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:4.03|P-value:3.02E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.01|P-value:3.36E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.93|P-value:4.73E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.85|P-value:6.89E-7 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.26|P-value:5.99E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.61|P-value:1.67E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.20|P-value:7.48E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.84|P-value:6.29E-5 ID:SGTC_1731|Compound:st035964|FD-Score:4.58|P-value:2.63E-6 ID:SGTC_1735|Compound:st034310|FD-Score:3.15|P-value:8.62E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.66|P-value:1.39E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.29|P-value:5.36E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.65|P-value:1.40E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.49|P-value:2.62E-4 ID:SGTC_1792|Compound:st045773|FD-Score:5.09|P-value:2.06E-7 ID:SGTC_1916|Compound:st067606|FD-Score:5.14|P-value:1.56E-7 ID:SGTC_1958|Compound:st076513|FD-Score:8.07|P-value:4.87E-16 ID:SGTC_2102|Compound:5377816|FD-Score:4.21|P-value:1.41E-5 ID:SGTC_2168|Compound:5727979|FD-Score:3.82|P-value:7.41E-5 ID:SGTC_2223|Compound:6903751|FD-Score:3.29|P-value:5.46E-4 ID:SGTC_2273|Compound:7815444|FD-Score:4.89|P-value:5.75E-7 ID:SGTC_2341|Compound:7987486|FD-Score:3.66|P-value:1.36E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.13|P-value:2.00E-5 ID:SGTC_2347|Compound:9049783|FD-Score:8.94|P-value:2.85E-19 ID:SGTC_2349|Compound:9023730|FD-Score:-3.54|P-value:2.03E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.83|P-value:7.73E-7 ID:SGTC_2537|Compound:larixol|FD-Score:4.19|P-value:1.56E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.45|P-value:4.81E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.26|P-value:5.96E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.48|P-value:2.73E-4 ID:SGTC_2696|Compound:st077691|FD-Score:-3.41|P-value:3.36E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.14|P-value:8.54E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.79|P-value:8.38E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-3.69|P-value:1.15E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.12|P-value:9.28E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.01|P-value:3.31E-5 ID:SGTC_3028|Compound:9087778|FD-Score:4.41|P-value:5.73E-6 ID:SGTC_3045|Compound:9092950|FD-Score:3.15|P-value:8.67E-4 ID:SGTC_3069|Compound:9117009|FD-Score:4.50|P-value:3.73E-6 ID:SGTC_3117|Compound:9124945|FD-Score:-3.77|P-value:8.52E-5 ID:SGTC_3121|Compound:9125696|FD-Score:-3.71|P-value:1.07E-4 ID:SGTC_3175|Compound:9106517|FD-Score:4.15|P-value:1.85E-5 ID:SGTC_3306|Compound:9127676|FD-Score:8.01|P-value:7.92E-16

Top fitness defect scores for YMR054W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2347 9049783 8.94 174.8 µM 2.85E-19 4 1.96E-19
2 SGTC_1958 st076513 8.07 41.9 µM 4.87E-16 60S ribosome export 4 3.56E-16
3 SGTC_3306 9127676 8.01 59.8 µM 7.92E-16 2 5.82E-16
4 SGTC_1110 3-hydroxy-3'-methoxyflavone 5.48 1.2 µM 2.49E-8 iron homeostasis 18 2.12E-8
5 SGTC_1916 st067606 5.14 49.2 µM 1.56E-7 15 1.35E-7
6 SGTC_1792 st045773 5.09 43.6 µM 2.06E-7 11 1.79E-7
7 SGTC_2273 7815444 4.89 169.1 µM 5.75E-7 10 5.04E-7
8 SGTC_1402 3909-7673 4.85 35.9 µM 6.89E-7 9 6.04E-7
9 SGTC_2401 5128683 4.83 200.0 µM 7.73E-7 16 6.79E-7
10 SGTC_1731 st035964 4.58 63.0 µM 2.63E-6 12 2.33E-6
11 SGTC_3069 9117009 4.50 49.5 µM 3.73E-6 60S ribosome export 6 3.32E-6
12 SGTC_2562 3',7'-dimethoxyflavone 4.45 64.9 µM 4.81E-6 17 4.29E-6
13 SGTC_803 4488-1585 4.43 147.0 µM 5.38E-6 9 4.80E-6
14 SGTC_3028 9087778 4.41 49.5 µM 5.73E-6 9 5.12E-6
15 SGTC_1092 toremifene 4.40 6.3 µM 6.15E-6 15 5.50E-6
16 SGTC_2102 5377816 4.21 72.8 µM 1.41E-5 21 1.27E-5
17 SGTC_2537 larixol 4.19 68.9 µM 1.56E-5 19 1.41E-5
18 SGTC_154 3389-1638 4.15 511.1 µM 1.81E-5 20 1.63E-5
19 SGTC_3175 9106517 4.15 49.5 µM 1.85E-5 iron homeostasis 16 1.67E-5
20 SGTC_809 3998-0021 4.14 90.0 µM 1.90E-5 RNA processing & uracil transport 12 1.72E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.177 5.77E-25 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.106 6.90E-10 YMR125W STO1 hom Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
0.091 1.23E-7 YIR020C_p YIR020C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.091 1.31E-7 YDR287W INM2 hom Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
0.091 1.33E-7 YML076C WAR1 hom Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
0.089 2.38E-7 YOR333C_d YOR333C_d hom Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth
0.087 4.60E-7 YOL104C NDJ1 hom Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement
0.085 7.68E-7 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.083 1.47E-6 YDL118W_d YDL118W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein
0.083 1.48E-6 YGL134W PCL10 hom Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
0.079 4.15E-6 YBR296C-A_p YBR296C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.078 6.39E-6 YLR062C_d BUD28_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.077 9.06E-6 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.077 9.08E-6 YML028W TSA1 hom Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.076 9.62E-6 YGR078C PAC10 hom Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding