YMR057C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR057C / YMR057C

Click on Significant Values for Screen Details ID:SGTC_62|Compound:0180-0423|FD-Score:3.09|P-value:7.28E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:5.25|P-value:2.91E-8 ID:SGTC_197|Compound:4544-0043|FD-Score:3.69|P-value:7.02E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:3.52|P-value:1.39E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.08|P-value:7.40E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:3.04|P-value:8.47E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.37|P-value:3.23E-6 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.06|P-value:8.08E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.72|P-value:5.49E-7 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.19|P-value:4.96E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.44|P-value:1.81E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.19|P-value:4.69E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-4.09|P-value:1.14E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.62|P-value:9.27E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:3.16|P-value:5.59E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:-3.14|P-value:5.58E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.91|P-value:2.69E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:3.84|P-value:3.62E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:4.05|P-value:1.47E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:3.28|P-value:3.56E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.64|P-value:8.50E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.56|P-value:1.18E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.48|P-value:1.66E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.28|P-value:3.57E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.18|P-value:4.89E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.39|P-value:2.97E-6 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.28|P-value:3.59E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.23|P-value:4.26E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.69|P-value:6.99E-5 ID:SGTC_1658|Compound:st012944|FD-Score:8.18|P-value:1.38E-17 ID:SGTC_1768|Compound:st044301|FD-Score:3.35|P-value:2.74E-4 ID:SGTC_1900|Compound:st060200|FD-Score:4.11|P-value:1.12E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.03|P-value:8.97E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.13|P-value:9.82E-6 ID:SGTC_2067|Compound:5224629|FD-Score:-3.13|P-value:5.79E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.53|P-value:1.36E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.41|P-value:2.18E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.82|P-value:3.98E-5 ID:SGTC_2193|Compound:5925765|FD-Score:3.93|P-value:2.44E-5 ID:SGTC_2217|Compound:6934799|FD-Score:3.18|P-value:5.14E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.27|P-value:3.70E-4 ID:SGTC_2275|Compound:7947463|FD-Score:4.94|P-value:1.69E-7 ID:SGTC_2291|Compound:7917025|FD-Score:3.91|P-value:2.73E-5 ID:SGTC_2389|Compound:9091542|FD-Score:4.87|P-value:2.48E-7 ID:SGTC_2431|Compound:5490079|FD-Score:3.64|P-value:8.65E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.98|P-value:1.98E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:4.50|P-value:1.68E-6 ID:SGTC_2868|Compound:9035608|FD-Score:3.52|P-value:1.38E-4 ID:SGTC_2908|Compound:7930301|FD-Score:4.68|P-value:6.76E-7 ID:SGTC_2989|Compound:9073649|FD-Score:-3.10|P-value:6.58E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.46|P-value:1.81E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.26|P-value:5.37E-6 ID:SGTC_3245|Compound:9134821|FD-Score:3.31|P-value:3.22E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.56|P-value:1.19E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.09|P-value:7.28E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:5.25|P-value:2.91E-8 ID:SGTC_197|Compound:4544-0043|FD-Score:3.69|P-value:7.02E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:3.52|P-value:1.39E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.08|P-value:7.40E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:3.04|P-value:8.47E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.37|P-value:3.23E-6 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.06|P-value:8.08E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.72|P-value:5.49E-7 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.19|P-value:4.96E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.44|P-value:1.81E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.19|P-value:4.69E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-4.09|P-value:1.14E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.62|P-value:9.27E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:3.16|P-value:5.59E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:-3.14|P-value:5.58E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.91|P-value:2.69E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:3.84|P-value:3.62E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:4.05|P-value:1.47E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:3.28|P-value:3.56E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.64|P-value:8.50E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.56|P-value:1.18E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.48|P-value:1.66E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.28|P-value:3.57E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.18|P-value:4.89E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.39|P-value:2.97E-6 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.28|P-value:3.59E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.23|P-value:4.26E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.69|P-value:6.99E-5 ID:SGTC_1658|Compound:st012944|FD-Score:8.18|P-value:1.38E-17 ID:SGTC_1768|Compound:st044301|FD-Score:3.35|P-value:2.74E-4 ID:SGTC_1900|Compound:st060200|FD-Score:4.11|P-value:1.12E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.03|P-value:8.97E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.13|P-value:9.82E-6 ID:SGTC_2067|Compound:5224629|FD-Score:-3.13|P-value:5.79E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.53|P-value:1.36E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.41|P-value:2.18E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.82|P-value:3.98E-5 ID:SGTC_2193|Compound:5925765|FD-Score:3.93|P-value:2.44E-5 ID:SGTC_2217|Compound:6934799|FD-Score:3.18|P-value:5.14E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.27|P-value:3.70E-4 ID:SGTC_2275|Compound:7947463|FD-Score:4.94|P-value:1.69E-7 ID:SGTC_2291|Compound:7917025|FD-Score:3.91|P-value:2.73E-5 ID:SGTC_2389|Compound:9091542|FD-Score:4.87|P-value:2.48E-7 ID:SGTC_2431|Compound:5490079|FD-Score:3.64|P-value:8.65E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.98|P-value:1.98E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:4.50|P-value:1.68E-6 ID:SGTC_2868|Compound:9035608|FD-Score:3.52|P-value:1.38E-4 ID:SGTC_2908|Compound:7930301|FD-Score:4.68|P-value:6.76E-7 ID:SGTC_2989|Compound:9073649|FD-Score:-3.10|P-value:6.58E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.46|P-value:1.81E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.26|P-value:5.37E-6 ID:SGTC_3245|Compound:9134821|FD-Score:3.31|P-value:3.22E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.56|P-value:1.19E-4

Top fitness defect scores for YMR057C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1658 st012944 8.18 20.0 µM 1.38E-17 iron homeostasis 9 1.37E-16
2 SGTC_157 1348-1695 5.25 65.8 µM 2.91E-8 iron homeostasis 30 7.52E-8
3 SGTC_2275 7947463 4.94 200.0 µM 1.69E-7 iron homeostasis 23 3.92E-7
4 SGTC_2389 9091542 4.87 195.5 µM 2.48E-7 iron homeostasis 20 5.62E-7
5 SGTC_473 2-arachidonoylglycerol 4.72 10.0 µM 5.49E-7 9 1.18E-6
6 SGTC_2908 7930301 4.68 100.0 µM 6.76E-7 11 1.44E-6
7 SGTC_2754 granisetron 4.50 64.0 µM 1.68E-6 23 3.37E-6
8 SGTC_1161 k007-0610 4.39 110.0 µM 2.97E-6 ERAD & cell cycle 102 5.77E-6
9 SGTC_444 curcumin 4.37 90.4 µM 3.23E-6 iron homeostasis 19 6.25E-6
10 SGTC_3142 9086498 4.26 49.5 µM 5.37E-6 iron homeostasis 31 1.01E-5
11 SGTC_1933 st074711 4.13 15.9 µM 9.82E-6 37 1.78E-5
12 SGTC_1900 st060200 4.11 72.8 µM 1.12E-5 19 2.01E-5
13 SGTC_885 0865-0106 4.05 16.8 µM 1.47E-5 TSC3-RPN4 25 2.60E-5
14 SGTC_2749 bexarotene 3.98 57.4 µM 1.98E-5 22 3.42E-5
15 SGTC_2193 5925765 3.93 200.0 µM 2.44E-5 6 4.17E-5
16 SGTC_795 0685-0265 3.91 78.0 µM 2.69E-5 excess fatty acid 28 4.57E-5
17 SGTC_2291 7917025 3.91 104.3 µM 2.73E-5 iron homeostasis 49 4.65E-5
18 SGTC_798 1287-0182 3.84 476.0 µM 3.62E-5 24 6.05E-5
19 SGTC_2191 5911152 3.82 200.0 µM 3.98E-5 18 6.61E-5
20 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 3.69 61.9 µM 6.99E-5 25 1.12E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.267 4.89E-56 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.244 1.21E-46 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.243 3.23E-46 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.238 1.40E-44 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.238 3.36E-44 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.224 1.64E-39 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.217 3.97E-37 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.163 2.18E-21 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.152 9.42E-19 YDR203W_d YDR203W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.125 3.21E-13 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.118 5.89E-12 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.114 4.13E-11 YOL127W RPL25 het Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23
0.106 7.74E-10 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.102 2.79E-9 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.102 3.38E-9 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase