YMR060C / SAM37

Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR060C / SAM37

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-3.46|P-value:9.60E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.84|P-value:2.95E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.72|P-value:2.04E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:4.94|P-value:8.63E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.53|P-value:7.88E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-7.51|P-value:1.32E-11 ID:SGTC_206|Compound:4546-0025|FD-Score:4.03|P-value:2.35E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.96|P-value:3.04E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.74|P-value:1.93E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:6.56|P-value:5.31E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.55|P-value:7.40E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:6.18|P-value:3.57E-8 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.50|P-value:8.50E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:5.11|P-value:4.37E-6 ID:SGTC_929|Compound:2805-0021|FD-Score:4.50|P-value:4.63E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:5.26|P-value:2.35E-6 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.57|P-value:3.59E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:6.01|P-value:8.03E-8 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.69|P-value:6.97E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.63|P-value:8.36E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.64|P-value:8.28E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:4.74|P-value:1.93E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.73|P-value:4.18E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.79|P-value:5.09E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:4.62|P-value:2.96E-5 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.99|P-value:2.74E-4 ID:SGTC_1683|Compound:st010134|FD-Score:4.18|P-value:1.46E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.59|P-value:9.53E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.89|P-value:3.81E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-4.25|P-value:7.40E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:4.10|P-value:1.87E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-4.57|P-value:2.31E-5 ID:SGTC_1896|Compound:st058441|FD-Score:5.24|P-value:2.55E-6 ID:SGTC_1898|Compound:st060199|FD-Score:3.88|P-value:3.91E-4 ID:SGTC_1980|Compound:st071811|FD-Score:4.06|P-value:2.17E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.58|P-value:9.88E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.86|P-value:4.10E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.07|P-value:2.11E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.37|P-value:7.37E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.83|P-value:4.58E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:7.49|P-value:3.03E-11 ID:SGTC_2835|Compound:9006588|FD-Score:3.73|P-value:6.27E-4 ID:SGTC_2872|Compound:9044037|FD-Score:3.96|P-value:2.99E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.25|P-value:1.13E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.75|P-value:5.75E-4 ID:SGTC_3233|Compound:9132340|FD-Score:4.75|P-value:1.84E-5 ID:SGTC_3340|Compound:9146634|FD-Score:-4.53|P-value:2.68E-5 ID:SGTC_3346|Compound:9158254|FD-Score:3.87|P-value:4.06E-4 ID:SGTC_3351|Compound:9150312|FD-Score:5.29|P-value:2.11E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.46|P-value:9.60E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.84|P-value:2.95E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.72|P-value:2.04E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:4.94|P-value:8.63E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.53|P-value:7.88E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-7.51|P-value:1.32E-11 ID:SGTC_206|Compound:4546-0025|FD-Score:4.03|P-value:2.35E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.96|P-value:3.04E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.74|P-value:1.93E-5 ID:SGTC_449|Compound:xestospongin c|FD-Score:6.56|P-value:5.31E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.55|P-value:7.40E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:6.18|P-value:3.57E-8 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.50|P-value:8.50E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:5.11|P-value:4.37E-6 ID:SGTC_929|Compound:2805-0021|FD-Score:4.50|P-value:4.63E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:5.26|P-value:2.35E-6 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.57|P-value:3.59E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:6.01|P-value:8.03E-8 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.69|P-value:6.97E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.63|P-value:8.36E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.64|P-value:8.28E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:4.74|P-value:1.93E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.73|P-value:4.18E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.79|P-value:5.09E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:4.62|P-value:2.96E-5 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.99|P-value:2.74E-4 ID:SGTC_1683|Compound:st010134|FD-Score:4.18|P-value:1.46E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.59|P-value:9.53E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.89|P-value:3.81E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-4.25|P-value:7.40E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:4.10|P-value:1.87E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-4.57|P-value:2.31E-5 ID:SGTC_1896|Compound:st058441|FD-Score:5.24|P-value:2.55E-6 ID:SGTC_1898|Compound:st060199|FD-Score:3.88|P-value:3.91E-4 ID:SGTC_1980|Compound:st071811|FD-Score:4.06|P-value:2.17E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.58|P-value:9.88E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.86|P-value:4.10E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.07|P-value:2.11E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.37|P-value:7.37E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.83|P-value:4.58E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:7.49|P-value:3.03E-11 ID:SGTC_2835|Compound:9006588|FD-Score:3.73|P-value:6.27E-4 ID:SGTC_2872|Compound:9044037|FD-Score:3.96|P-value:2.99E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.25|P-value:1.13E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.75|P-value:5.75E-4 ID:SGTC_3233|Compound:9132340|FD-Score:4.75|P-value:1.84E-5 ID:SGTC_3340|Compound:9146634|FD-Score:-4.53|P-value:2.68E-5 ID:SGTC_3346|Compound:9158254|FD-Score:3.87|P-value:4.06E-4 ID:SGTC_3351|Compound:9150312|FD-Score:5.29|P-value:2.11E-6

Top fitness defect scores for YMR060C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2755 lomerizine 7.49 42.7 µM 3.03E-11 3 3.34E-14
2 SGTC_449 xestospongin c 6.56 11.2 µM 5.31E-9 NEO1-PIK1 16 2.69E-11
3 SGTC_666 0272-0154 6.18 136.0 µM 3.57E-8 cell wall 19 3.16E-10
4 SGTC_1099 5-nonyloxytryptamine 6.01 2.9 µM 8.03E-8 3 9.03E-10
5 SGTC_3351 9150312 5.29 21.6 µM 2.11E-6 cell wall 14 6.20E-8
6 SGTC_1035 k081-0041 5.26 55.2 µM 2.35E-6 Golgi 9 7.13E-8
7 SGTC_1896 st058441 5.24 89.0 µM 2.55E-6 2 7.90E-8
8 SGTC_905 2-aminofluorene 5.11 215.0 µM 4.37E-6 cell wall signaling 8 1.59E-7
9 SGTC_148 3253-0744 4.94 288.0 µM 8.63E-6 9 3.83E-7
10 SGTC_3233 9132340 4.75 49.5 µM 1.84E-5 7 1.02E-6
11 SGTC_1185 1319-0113 4.74 81.3 µM 1.93E-5 DNA damage response 4 1.08E-6
12 SGTC_313 3474-0040 4.74 5.0 µM 1.93E-5 NEO1-PIK1 44 1.08E-6
13 SGTC_146 3448-8650 4.72 53.1 µM 2.04E-5 NEO1-PIK1 100 1.17E-6
14 SGTC_1528 arabinosylhypoxanthine 4.62 74.6 µM 2.96E-5 13 1.88E-6
15 SGTC_1090 efavirenz 4.57 20.7 µM 3.59E-5 10 2.41E-6
16 SGTC_929 2805-0021 4.50 398.0 µM 4.63E-5 10 3.35E-6
17 SGTC_2697 mebhydrolin 4.37 72.4 µM 7.37E-5 NEO1 54 6.12E-6
18 SGTC_3020 9089140 4.25 49.5 µM 1.13E-4 21 1.06E-5
19 SGTC_1683 st010134 4.18 710.0 nM 1.46E-4 20 1.48E-5
20 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 4.10 14.9 µM 1.87E-4 8 2.03E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.186 1.69E-27 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.179 1.24E-25 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.174 2.99E-24 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.170 3.08E-23 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.169 4.89E-23 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.167 1.67E-22 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.158 3.75E-20 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.157 6.23E-20 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.149 3.67E-18 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.141 2.77E-16 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.141 2.67E-16 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.138 9.73E-16 YDL033C SLM3 hom tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
0.127 1.59E-13 YCR077C PAT1 hom Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress
0.123 1.21E-12 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.122 1.16E-12 YML094C-A_d YML094C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO