YMR062C / ARG7

Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR062C / ARG7

Click on Significant Values for Screen Details ID:SGTC_54|Compound:0159-0055|FD-Score:4.64|P-value:8.80E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:4.35|P-value:2.92E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:3.93|P-value:1.46E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.37|P-value:9.98E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:4.71|P-value:6.58E-6 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.47|P-value:7.31E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.45|P-value:7.82E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.41|P-value:4.36E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:4.56|P-value:1.26E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:-4.47|P-value:7.16E-6 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.68|P-value:1.64E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:5.17|P-value:7.93E-7 ID:SGTC_831|Compound:k061-1017|FD-Score:3.90|P-value:1.66E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:5.14|P-value:9.40E-7 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.87|P-value:1.83E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.54|P-value:1.32E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:7.23|P-value:7.37E-12 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.74|P-value:5.61E-6 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.42|P-value:2.16E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.33|P-value:3.15E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.34|P-value:5.42E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-4.50|P-value:6.26E-6 ID:SGTC_1289|Compound:0976-0073|FD-Score:-3.35|P-value:5.17E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.61|P-value:4.53E-4 ID:SGTC_1518|Compound:st038567|FD-Score:4.33|P-value:3.21E-5 ID:SGTC_1602|Compound:st001878|FD-Score:3.51|P-value:6.33E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.61|P-value:4.46E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.67|P-value:3.71E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.48|P-value:1.72E-5 ID:SGTC_2470|Compound:5664817|FD-Score:3.46|P-value:7.40E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.57|P-value:5.21E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-4.55|P-value:5.08E-6 ID:SGTC_2809|Compound:7964133|FD-Score:3.73|P-value:2.96E-4 ID:SGTC_2815|Compound:7968870|FD-Score:4.83|P-value:3.77E-6 ID:SGTC_3022|Compound:9087993|FD-Score:3.47|P-value:7.18E-4 ID:SGTC_3023|Compound:9089636|FD-Score:4.45|P-value:1.94E-5 ID:SGTC_3041|Compound:9091929|FD-Score:5.55|P-value:1.27E-7 ID:SGTC_3084|Compound:9116877|FD-Score:-3.16|P-value:9.80E-4 ID:SGTC_3172|Compound:9105863|FD-Score:4.62|P-value:9.43E-6 ID:SGTC_54|Compound:0159-0055|FD-Score:4.64|P-value:8.80E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:4.35|P-value:2.92E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:3.93|P-value:1.46E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.37|P-value:9.98E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:4.71|P-value:6.58E-6 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.47|P-value:7.31E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.45|P-value:7.82E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.41|P-value:4.36E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:4.56|P-value:1.26E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:-4.47|P-value:7.16E-6 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.68|P-value:1.64E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:5.17|P-value:7.93E-7 ID:SGTC_831|Compound:k061-1017|FD-Score:3.90|P-value:1.66E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:5.14|P-value:9.40E-7 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.87|P-value:1.83E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.54|P-value:1.32E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:7.23|P-value:7.37E-12 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.74|P-value:5.61E-6 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.42|P-value:2.16E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.33|P-value:3.15E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.34|P-value:5.42E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-4.50|P-value:6.26E-6 ID:SGTC_1289|Compound:0976-0073|FD-Score:-3.35|P-value:5.17E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.61|P-value:4.53E-4 ID:SGTC_1518|Compound:st038567|FD-Score:4.33|P-value:3.21E-5 ID:SGTC_1602|Compound:st001878|FD-Score:3.51|P-value:6.33E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.61|P-value:4.46E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.67|P-value:3.71E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.48|P-value:1.72E-5 ID:SGTC_2470|Compound:5664817|FD-Score:3.46|P-value:7.40E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.57|P-value:5.21E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-4.55|P-value:5.08E-6 ID:SGTC_2809|Compound:7964133|FD-Score:3.73|P-value:2.96E-4 ID:SGTC_2815|Compound:7968870|FD-Score:4.83|P-value:3.77E-6 ID:SGTC_3022|Compound:9087993|FD-Score:3.47|P-value:7.18E-4 ID:SGTC_3023|Compound:9089636|FD-Score:4.45|P-value:1.94E-5 ID:SGTC_3041|Compound:9091929|FD-Score:5.55|P-value:1.27E-7 ID:SGTC_3084|Compound:9116877|FD-Score:-3.16|P-value:9.80E-4 ID:SGTC_3172|Compound:9105863|FD-Score:4.62|P-value:9.43E-6

Top fitness defect scores for YMR062C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1146 3579-1023 7.23 7.0 µM 7.37E-12 1 2.37E-13
2 SGTC_3041 9091929 5.55 49.5 µM 1.27E-7 redox potentiating 7 1.44E-8
3 SGTC_811 0416-0114 5.17 265.0 µM 7.93E-7 4 1.15E-7
4 SGTC_1037 k284-1091 5.14 78.7 µM 9.40E-7 3 1.39E-7
5 SGTC_2815 7968870 4.83 71.4 µM 3.77E-6 9 6.69E-7
6 SGTC_1147 3809-1045 4.74 12.3 µM 5.61E-6 7 1.05E-6
7 SGTC_355 1311-2252 4.71 105.0 µM 6.58E-6 8 1.26E-6
8 SGTC_54 0159-0055 4.64 9.0 µM 8.80E-6 ERG2 34 1.75E-6
9 SGTC_3172 9105863 4.62 49.5 µM 9.43E-6 ERG2 3 1.89E-6
10 SGTC_684 1140-0066 4.56 328.0 µM 1.26E-5 Golgi 12 2.62E-6
11 SGTC_1145 3546-0597 4.54 10.2 µM 1.32E-5 mitochondrial processes 11 2.77E-6
12 SGTC_2417 cerulenin 4.48 830.0 nM 1.72E-5 22 3.73E-6
13 SGTC_3023 9089636 4.45 49.5 µM 1.94E-5 2 4.28E-6
14 SGTC_1149 3909-7961 4.42 23.3 µM 2.16E-5 9 4.85E-6
15 SGTC_157 1348-1695 4.35 65.8 µM 2.92E-5 iron homeostasis 51 6.82E-6
16 SGTC_1151 3909-8316 4.33 15.3 µM 3.15E-5 10 7.42E-6
17 SGTC_1518 st038567 4.33 90.8 µM 3.21E-5 8 7.58E-6
18 SGTC_204 1543-0184 3.93 62.4 µM 1.46E-4 TRP & mitochondrial translation 33 4.23E-5
19 SGTC_831 k061-1017 3.90 217.0 µM 1.66E-4 translation 66 4.90E-5
20 SGTC_1140 3229-1848 3.87 3.0 µM 1.83E-4 11 5.47E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.32E-12 YOR031W CRS5 hom Copper-binding metallothionein, required for wild-type copper resistance
0.106 6.34E-10 YLR409C UTP21 het Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma
0.106 6.54E-10 YNL071W LAT1 hom Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
0.088 2.96E-7 YOL058W ARG1 hom Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
0.086 5.55E-7 YOR260W GCD1 het Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.081 2.43E-6 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.081 2.92E-6 YJL088W ARG3 hom Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
0.077 8.41E-6 YGL063W PUS2 hom Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification
0.075 1.35E-5 YGL008C PMA1 het Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]
0.075 1.55E-5 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.074 1.73E-5 YKL127W PGM1 hom Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
0.073 2.16E-5 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.072 2.77E-5 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.072 3.15E-5 YOR103C OST2 het Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
0.072 3.26E-5 YCR011C ADP1 hom Putative ATP-dependent permease of the ABC transporter family of proteins